{"id":"https://openalex.org/W2052675076","doi":"https://doi.org/10.1109/bibm.2012.6392675","title":"Combining gene expression and function in a spatially localized approach","display_name":"Combining gene expression and function in a spatially localized approach","publication_year":2012,"publication_date":"2012-10-01","ids":{"openalex":"https://openalex.org/W2052675076","doi":"https://doi.org/10.1109/bibm.2012.6392675","mag":"2052675076"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2012.6392675","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2012.6392675","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE International Conference on Bioinformatics and Biomedicine","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048652955","display_name":"Evangelia I. Zacharaki","orcid":"https://orcid.org/0000-0001-8228-0437"},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Evangelia I. Zacharaki","raw_affiliation_strings":["Department of Computer Engineering and Informatics, University of Patras, Patras, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Engineering and Informatics, University of Patras, Patras, Greece","institution_ids":["https://openalex.org/I174878644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086124543","display_name":"Angeliki Skoura","orcid":"https://orcid.org/0000-0002-6381-8155"},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Angeliki Skoura","raw_affiliation_strings":["Department of Computer Engineering and Informatics, University of Patras, Patras, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Engineering and Informatics, University of Patras, Patras, Greece","institution_ids":["https://openalex.org/I174878644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051619512","display_name":"Desmond Smith","orcid":null},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Desmond J. Smith","raw_affiliation_strings":["Data Engineering Laboratory, Center for Data Analytics and Biomedical Informatics, Temple University, Philadelphia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Data Engineering Laboratory, Center for Data Analytics and Biomedical Informatics, Temple University, Philadelphia, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101401831","display_name":"Scott H. Faro","orcid":"https://orcid.org/0000-0003-0027-8806"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott H. Faro","raw_affiliation_strings":["Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101631695","display_name":"Li An","orcid":"https://orcid.org/0000-0002-8297-7776"},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["GR","US"],"is_corresponding":false,"raw_author_name":"Li An","raw_affiliation_strings":["Data Engineering Laboratory, Center for Data Analytics and Biomedical Informatics, Temple University, Philadelphia, USA","Department of Computer Engineering and Informatics, University of Patras, Patras, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Data Engineering Laboratory, Center for Data Analytics and Biomedical Informatics, Temple University, Philadelphia, USA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Department of Computer Engineering and Informatics, University of Patras, Patras, Greece","institution_ids":["https://openalex.org/I174878644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046892627","display_name":"Vasileios Megalooikonomou","orcid":null},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vasileios Megalooikonomou","raw_affiliation_strings":["Department of Radiology, Temple University School of Medicine, Philadelphia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Temple University School of Medicine, Philadelphia, USA","institution_ids":["https://openalex.org/I84392919"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09267983,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9894999861717224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9764000177383423,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.7355253100395203},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6571462154388428},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.6435180902481079},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.6052393317222595},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4979710578918457},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.4398956298828125},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3921963572502136}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7355253100395203},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6571462154388428},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.6435180902481079},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.6052393317222595},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4979710578918457},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.4398956298828125},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3921963572502136},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2012.6392675","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2012.6392675","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE International Conference on Bioinformatics and Biomedicine","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321038","display_name":"Fonds National de la Recherche Luxembourg","ror":"https://ror.org/039z13y21"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1647729745","https://openalex.org/W2097749211","https://openalex.org/W2127218421","https://openalex.org/W2137977238","https://openalex.org/W2146227808","https://openalex.org/W2146455987","https://openalex.org/W2161482120","https://openalex.org/W6636975626","https://openalex.org/W6678914141"],"related_works":["https://openalex.org/W2898732673","https://openalex.org/W2410053581","https://openalex.org/W2383658677","https://openalex.org/W3123203398","https://openalex.org/W2803323662","https://openalex.org/W2464653720","https://openalex.org/W3032874291","https://openalex.org/W2005057264","https://openalex.org/W2363156284","https://openalex.org/W2415025170"],"abstract_inverted_index":{"The":[0],"integration":[1],"of":[2,18,31,56,60,103,121],"gene":[3,7,24,66,69,85,94],"expression":[4,25,67,106],"datasets":[5],"with":[6],"function":[8,53,77,119],"information":[9,43],"provides":[10],"valuable":[11],"insights":[12],"in":[13,49,117],"unraveling":[14],"the":[15,19,29,40,61,73,84,93,99,118],"molecular":[16],"mechanisms":[17],"brain.":[20],"In":[21,71],"this":[22],"paper,":[23],"maps,":[26],"acquired":[27],"by":[28],"technique":[30],"voxelation,":[32],"are":[33],"analyzed":[34],"using":[35],"an":[36],"atlas-based":[37],"framework":[38],"and":[39,68,89],"extracted":[41],"spatial":[42,105],"is":[44],"employed":[45],"to":[46],"organize":[47],"genes":[48,102],"significant":[50],"clusters.":[51],"Gene":[52],"enrichment":[54],"analysis":[55,74],"clusters":[57],"enabled":[58],"exploration":[59],"relationships":[62],"among":[63],"brain":[64],"regions,":[65],"function.":[70],"addition,":[72],"revealed":[75],"new":[76],"categories,":[78],"for":[79,83,92],"example":[80],"biological":[81,90],"process":[82,91],"Pbx3,":[86],"cellular":[87],"component":[88],"Ppplrlb.":[95],"Our":[96],"work":[97],"confirms":[98],"hypothesis":[100],"that":[101,112],"similar":[104,109],"patterns":[107],"display":[108],"functions":[110],"indicating":[111],"our":[113],"methodology":[114],"could":[115],"assist":[116],"identification":[120],"unannotated":[122],"genes.":[123]},"counts_by_year":[],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}