{"id":"https://openalex.org/W2057488525","doi":"https://doi.org/10.1109/bibm.2012.6392653","title":"SiS: Significant subnetworks in massive number of network topologies","display_name":"SiS: Significant subnetworks in massive number of network topologies","publication_year":2012,"publication_date":"2012-10-01","ids":{"openalex":"https://openalex.org/W2057488525","doi":"https://doi.org/10.1109/bibm.2012.6392653","mag":"2057488525"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2012.6392653","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2012.6392653","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE International Conference on Bioinformatics and Biomedicine","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101484407","display_name":"Md Mahmudul Hasan","orcid":"https://orcid.org/0000-0001-5899-793X"},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Md Mahmudul Hasan","raw_affiliation_strings":["Department of Computer and Information Science and Engineering, University of Florida, Gainesville, FL, USA","Department of Computer and Information Science and Engineering, University of Florida, Gainesville, Florida 32611, USA#TAB#"],"affiliations":[{"raw_affiliation_string":"Department of Computer and Information Science and Engineering, University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Department of Computer and Information Science and Engineering, University of Florida, Gainesville, Florida 32611, USA#TAB#","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106133937","display_name":"Yusuf Kavurucu","orcid":null},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yusuf Kavurucu","raw_affiliation_strings":["Department of Computer and Information Science and Engineering, University of Florida, Gainesville, FL, USA","Department of Computer and Information Science and Engineering, University of Florida, Gainesville, Florida 32611, USA#TAB#"],"affiliations":[{"raw_affiliation_string":"Department of Computer and Information Science and Engineering, University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Department of Computer and Information Science and Engineering, University of Florida, Gainesville, Florida 32611, USA#TAB#","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091769289","display_name":"Tamer Kahveci","orcid":"https://orcid.org/0000-0002-4403-8612"},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tamer Kahveci","raw_affiliation_strings":["Department of Computer and Information Science and Engineering, University of Florida, Gainesville, FL, USA","Department of Computer and Information Science and Engineering, University of Florida, Gainesville, Florida 32611, USA#TAB#"],"affiliations":[{"raw_affiliation_string":"Department of Computer and Information Science and Engineering, University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Department of Computer and Information Science and Engineering, University of Florida, Gainesville, Florida 32611, USA#TAB#","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101484407"],"corresponding_institution_ids":["https://openalex.org/I33213144"],"apc_list":null,"apc_paid":null,"fwci":0.1313,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.51392102,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"3692","issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9941999912261963,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9908000230789185,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/subnetwork","display_name":"Subnetwork","score":0.9798102378845215},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7411218285560608},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.6316347122192383},{"id":"https://openalex.org/keywords/key","display_name":"Key (lock)","score":0.6241241693496704},{"id":"https://openalex.org/keywords/network-topology","display_name":"Network topology","score":0.6091843247413635},{"id":"https://openalex.org/keywords/node","display_name":"Node (physics)","score":0.5752944350242615},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.5559866428375244},{"id":"https://openalex.org/keywords/eukaryote","display_name":"Eukaryote","score":0.5385753512382507},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4097726345062256},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.39333653450012207},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3685827851295471},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.33440688252449036},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.19625604152679443},{"id":"https://openalex.org/keywords/computer-network","display_name":"Computer network","score":0.19028827548027039},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.14878982305526733},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.14164415001869202},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.12414398789405823},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.07022485136985779}],"concepts":[{"id":"https://openalex.org/C2780186347","wikidata":"https://www.wikidata.org/wiki/Q11414","display_name":"Subnetwork","level":2,"score":0.9798102378845215},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7411218285560608},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.6316347122192383},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.6241241693496704},{"id":"https://openalex.org/C199845137","wikidata":"https://www.wikidata.org/wiki/Q145490","display_name":"Network topology","level":2,"score":0.6091843247413635},{"id":"https://openalex.org/C62611344","wikidata":"https://www.wikidata.org/wiki/Q1062658","display_name":"Node (physics)","level":2,"score":0.5752944350242615},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.5559866428375244},{"id":"https://openalex.org/C2779413310","wikidata":"https://www.wikidata.org/wiki/Q19088","display_name":"Eukaryote","level":4,"score":0.5385753512382507},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4097726345062256},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.39333653450012207},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3685827851295471},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.33440688252449036},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.19625604152679443},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.19028827548027039},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14878982305526733},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.14164415001869202},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12414398789405823},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.07022485136985779},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C66938386","wikidata":"https://www.wikidata.org/wiki/Q633538","display_name":"Structural engineering","level":1,"score":0.0},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2012.6392653","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2012.6392653","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE International Conference on Bioinformatics and Biomedicine","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1490787220","https://openalex.org/W1529898704","https://openalex.org/W1605319014","https://openalex.org/W1644749979","https://openalex.org/W1850739480","https://openalex.org/W2033459252","https://openalex.org/W2036265926","https://openalex.org/W2118349699","https://openalex.org/W2119740363","https://openalex.org/W2124996875","https://openalex.org/W2126969584","https://openalex.org/W2146771637","https://openalex.org/W2152613879","https://openalex.org/W2159482845","https://openalex.org/W2170726034","https://openalex.org/W2400499165","https://openalex.org/W3194776842","https://openalex.org/W4256259619","https://openalex.org/W4294216483","https://openalex.org/W6638950445","https://openalex.org/W6678773695","https://openalex.org/W6685146747"],"related_works":["https://openalex.org/W2060724872","https://openalex.org/W2082094785","https://openalex.org/W2202198356","https://openalex.org/W15348386","https://openalex.org/W2028552635","https://openalex.org/W2478888221","https://openalex.org/W2095452756","https://openalex.org/W2521885831","https://openalex.org/W1979360205","https://openalex.org/W2494457055"],"abstract_inverted_index":{"Availability":[0],"of":[1,34,63,90,104,126],"abundant":[2],"biological":[3,64],"network":[4,84],"data":[5],"and":[6,119],"its":[7],"noisy":[8],"nature":[9],"necessitates":[10],"extracting":[11],"reliable":[12],"subnetworks":[13,27,49,51,96,120,174],"hidden":[14],"in":[15,31,59],"it.":[16],"One":[17],"key":[18],"step":[19],"towards":[20],"that":[21,28,52,97,111,170],"goal":[22],"is":[23,69],"to":[24,45,57,115,137],"discover":[25,46],"the":[26,54,72,87,102,123,127,143,151,163,171,177],"appear":[29],"frequently":[30],"a":[32,39,60,82,134,138],"collection":[33,62],"networks.":[35,92],"This":[36],"paper":[37],"presents":[38],"method,":[40],"named":[41],"SiS":[42,80],"(Significant":[43],"Subnetworks),":[44],"most":[47,99,172,178],"probable":[48,100,173],"(i.e.,":[50],"have":[53],"highest":[55],"chance":[56],"exist)":[58],"large":[61,117],"networks":[65,125],"where":[66],"each":[67],"node":[68],"labeled":[70],"with":[71,101],"corresponding":[73],"molecule":[74],"(such":[75],"as":[76,181],"gene":[77],"or":[78,156],"protein).":[79],"builds":[81],"template":[83,106],"which":[85],"summarizes":[86],"entire":[88],"set":[89],"input":[91],"It":[93],"then":[94],"grows":[95],"are":[98,175],"guidance":[103],"this":[105],"network.":[107],"Our":[108,166],"experiments":[109],"demonstrate":[110],"our":[112,130],"method":[113,131,149],"scales":[114],"very":[116],"datasets":[118],"easily.":[121],"On":[122],"metabolic":[124],"eukaryote":[128],"organisms,":[129],"runs":[132],"from":[133],"few":[135,139],"seconds":[136],"minutes":[140],"depending":[141],"on":[142,162],"subnetwork":[144],"size.":[145],"MULE,":[146],"an":[147],"existing":[148],"for":[150,160],"same":[152,164],"problem,":[153],"takes":[154],"hours":[155],"does":[157],"not":[158],"complete":[159],"days":[161],"dataset.":[165],"results":[167],"also":[168],"suggest":[169],"often":[176],"frequent":[179],"ones":[180],"well.":[182]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}