{"id":"https://openalex.org/W2045809485","doi":"https://doi.org/10.1109/bibm.2012.6392616","title":"Using gene sets to identify putative drugs for breast cancer","display_name":"Using gene sets to identify putative drugs for breast cancer","publication_year":2012,"publication_date":"2012-10-01","ids":{"openalex":"https://openalex.org/W2045809485","doi":"https://doi.org/10.1109/bibm.2012.6392616","mag":"2045809485"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2012.6392616","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2012.6392616","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE International Conference on Bioinformatics and Biomedicine","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102940992","display_name":"Tzu\u2010Hung Hsiao","orcid":"https://orcid.org/0000-0003-0365-9970"},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas Health Science Center at San Antonio","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tzu-Hung Hsiao","raw_affiliation_strings":["Greehey Childrens Cancer Research Institute, University of Texas Health Science Center, San Antonio, San Antonio, TX, USA","Greehey Children's Cancer Research Institute; University of Texas Health Science Center at San Antonio; San Antonio Texas"],"affiliations":[{"raw_affiliation_string":"Greehey Childrens Cancer Research Institute, University of Texas Health Science Center, San Antonio, San Antonio, TX, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Greehey Children's Cancer Research Institute; University of Texas Health Science Center at San Antonio; San Antonio Texas","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042774574","display_name":"Hung-I Harry Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas Health Science Center at San Antonio","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hung-I Harry Chen","raw_affiliation_strings":["Greehey Childrens Cancer Research Institute, University of Texas Health Science Center, San Antonio, San Antonio, TX, USA","Greehey Children's Cancer Research Institute; University of Texas Health Science Center at San Antonio; San Antonio Texas"],"affiliations":[{"raw_affiliation_string":"Greehey Childrens Cancer Research Institute, University of Texas Health Science Center, San Antonio, San Antonio, TX, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Greehey Children's Cancer Research Institute; University of Texas Health Science Center at San Antonio; San Antonio Texas","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100689057","display_name":"Yidong Chen","orcid":"https://orcid.org/0000-0001-6806-2185"},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas Health Science Center at San Antonio","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966"]}],"countries":["TW","US"],"is_corresponding":false,"raw_author_name":"Yidong Chen","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, University of Texas Health Science Center, San Antonio, San Antonio, TX, USA","Graduate Institute of Biomedical Electronics and Bioinfomatics, National Taiwan University, Taiwan","Greehey Children's Cancer Research Institute; University of Texas Health Science Center at San Antonio; San Antonio Texas"],"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, University of Texas Health Science Center, San Antonio, San Antonio, TX, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Graduate Institute of Biomedical Electronics and Bioinfomatics, National Taiwan University, Taiwan","institution_ids":["https://openalex.org/I16733864"]},{"raw_affiliation_string":"Greehey Children's Cancer Research Institute; University of Texas Health Science Center at San Antonio; San Antonio Texas","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108058575","display_name":"Yuheng Chen","orcid":"https://orcid.org/0009-0008-2896-6831"},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas Health Science Center at San Antonio","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966"]},{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW","US"],"is_corresponding":false,"raw_author_name":"Yu-Heng Chen","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, University of Texas Health Science Center, San Antonio, San Antonio, TX, USA","Graduate Institute of Biomedical Electronics and Bioinfomatics, National Taiwan University, Taiwan","Graduate Institute of Biomedicai Electronics and Bioinfomatics, National Taiwan University, Taiwan"],"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, University of Texas Health Science Center, San Antonio, San Antonio, TX, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Graduate Institute of Biomedical Electronics and Bioinfomatics, National Taiwan University, Taiwan","institution_ids":["https://openalex.org/I16733864"]},{"raw_affiliation_string":"Graduate Institute of Biomedicai Electronics and Bioinfomatics, National Taiwan University, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062893898","display_name":"Eric Y. Chuang","orcid":"https://orcid.org/0000-0003-2530-0096"},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Eric Y. Chuang","raw_affiliation_strings":["Graduate Institute of Biomedical Electronics and Bioinfomatics, National Taiwan University, Taiwan","Graduate Institute of Biomedicai Electronics and Bioinfomatics, National Taiwan University, Taiwan"],"affiliations":[{"raw_affiliation_string":"Graduate Institute of Biomedical Electronics and Bioinfomatics, National Taiwan University, Taiwan","institution_ids":["https://openalex.org/I16733864"]},{"raw_affiliation_string":"Graduate Institute of Biomedicai Electronics and Bioinfomatics, National Taiwan University, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5102940992"],"corresponding_institution_ids":["https://openalex.org/I165951966"],"apc_list":null,"apc_paid":null,"fwci":0.3369,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.61051301,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9904000163078308,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.75788414478302},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.7134386301040649},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.542402446269989},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4606803059577942},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.42247694730758667},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.40694183111190796},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.33258599042892456},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.21368339657783508},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.14591124653816223}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.75788414478302},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.7134386301040649},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.542402446269989},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4606803059577942},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42247694730758667},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.40694183111190796},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33258599042892456},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21368339657783508},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14591124653816223}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2012.6392616","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2012.6392616","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE International Conference on Bioinformatics and Biomedicine","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8399999737739563}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1580788756","https://openalex.org/W1871475547","https://openalex.org/W1979924529","https://openalex.org/W1980037409","https://openalex.org/W1998558839","https://openalex.org/W2012108057","https://openalex.org/W2016710415","https://openalex.org/W2029980980","https://openalex.org/W2034373020","https://openalex.org/W2055324014","https://openalex.org/W2061016350","https://openalex.org/W2061050600","https://openalex.org/W2072834181","https://openalex.org/W2075897300","https://openalex.org/W2094791588","https://openalex.org/W2098134455","https://openalex.org/W2113072832","https://openalex.org/W2121604817","https://openalex.org/W2123015794","https://openalex.org/W2130410032","https://openalex.org/W2130850760","https://openalex.org/W2133105825","https://openalex.org/W2134773678","https://openalex.org/W2137632714","https://openalex.org/W2143251418","https://openalex.org/W2150178760","https://openalex.org/W2167119716","https://openalex.org/W3147894994","https://openalex.org/W6679585901"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2375584271","https://openalex.org/W1997105855","https://openalex.org/W4301030387","https://openalex.org/W2414286769","https://openalex.org/W2013223288","https://openalex.org/W2186113122","https://openalex.org/W1523310174","https://openalex.org/W3015743358","https://openalex.org/W2037827305"],"abstract_inverted_index":{"The":[0],"number":[1],"of":[2,72,92,128,141],"current":[3],"anti-cancer":[4,21,109,142],"drugs":[5,19,22,37,73,110,122,143],"was":[6,53,65],"limited":[7],"and":[8,106,123],"the":[9,25,59,69,80,97,116,120,124,139],"response":[10],"rates":[11],"were":[12,87,111],"also":[13],"not":[14],"high.":[15],"To":[16],"\"reposition\"":[17,121],"known":[18],"as":[20,43],"to":[23,34,118,136,146],"increase":[24],"therapeutic":[26],"efficiency,":[27],"we":[28],"presented":[29],"a":[30,45],"novel":[31],"analysis":[32,91],"framework":[33],"identify":[35,119],"putative":[36,108],"for":[38,74],"cancer.":[39],"Using":[40],"breast":[41,81],"cancer":[42,82],"example,":[44],"\"cancer":[46],"-":[47,50,62],"gene":[48,75,85,104],"sets":[49,61,86,105],"drugs\"":[51,63],"network":[52,64],"constructed":[54],"through":[55],"two":[56,98],"procedures.":[57],"First,":[58],"\"gene":[60],"built":[66],"by":[67,89],"applying":[68],"expression":[70],"pattern":[71],"set":[76],"enrichment":[77],"analysis.":[78],"Secondly,":[79],"progression":[83,102,130],"associated":[84,103],"identified":[88],"survival":[90],"patient":[93],"cohorts.":[94],"By":[95],"integrating":[96],"results,":[99],"25":[100],"tumor":[101,129],"360":[107],"identified.":[112],"Our":[113],"method":[114],"has":[115],"ability":[117],"potential":[125],"affected":[126],"mechanisms":[127],"concurrently.":[131],"It":[132],"will":[133],"be":[134],"useful":[135],"speed":[137],"up":[138],"development":[140],"from":[144],"bench":[145],"clinical":[147],"application.":[148]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
