{"id":"https://openalex.org/W2154137682","doi":"https://doi.org/10.1109/bibm.2010.5706655","title":"Gene clustering by structural prior based local factor analysis model under Bayesian Ying-Yang harmony learning","display_name":"Gene clustering by structural prior based local factor analysis model under Bayesian Ying-Yang harmony learning","publication_year":2010,"publication_date":"2010-12-01","ids":{"openalex":"https://openalex.org/W2154137682","doi":"https://doi.org/10.1109/bibm.2010.5706655","mag":"2154137682"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2010.5706655","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2010.5706655","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100666184","display_name":"Lei Shi","orcid":"https://orcid.org/0000-0002-5215-025X"},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"CN","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lei Shi","raw_affiliation_strings":["Department of Computer Science and Engineering, Chinese University of Hong Kong, New Territories, Hong Kong, China"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, Chinese University of Hong Kong, New Territories, Hong Kong, China","institution_ids":["https://openalex.org/I177725633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073963268","display_name":"Shikui Tu","orcid":"https://orcid.org/0000-0001-6270-0449"},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"CN","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shikui Tu","raw_affiliation_strings":["Department of Computer Science and Engineering, Chinese University of Hong Kong, New Territories, Hong Kong, China"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, Chinese University of Hong Kong, New Territories, Hong Kong, China","institution_ids":["https://openalex.org/I177725633"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069972085","display_name":"Lei Xu","orcid":"https://orcid.org/0000-0002-2752-1573"},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"CN","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Xu","raw_affiliation_strings":["Department of Computer Science and Engineering, Chinese University of Hong Kong, New Territories, Hong Kong, China"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, Chinese University of Hong Kong, New Territories, Hong Kong, China","institution_ids":["https://openalex.org/I177725633"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100666184"],"corresponding_institution_ids":["https://openalex.org/I177725633"],"apc_list":null,"apc_paid":null,"fwci":0.1322,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.54179559,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"5","issue":null,"first_page":"696","last_page":"699"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.7143889665603638},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6389545202255249},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.6300298571586609},{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.5975055694580078},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5355223417282104},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.43367016315460205},{"id":"https://openalex.org/keywords/hierarchical-clustering","display_name":"Hierarchical clustering","score":0.4173542857170105},{"id":"https://openalex.org/keywords/nonlinear-dimensionality-reduction","display_name":"Nonlinear dimensionality reduction","score":0.4151993989944458},{"id":"https://openalex.org/keywords/manifold-alignment","display_name":"Manifold alignment","score":0.41393354535102844},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.34345293045043945},{"id":"https://openalex.org/keywords/dimensionality-reduction","display_name":"Dimensionality reduction","score":0.08953285217285156}],"concepts":[{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.7143889665603638},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6389545202255249},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.6300298571586609},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.5975055694580078},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5355223417282104},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.43367016315460205},{"id":"https://openalex.org/C92835128","wikidata":"https://www.wikidata.org/wiki/Q1277447","display_name":"Hierarchical clustering","level":3,"score":0.4173542857170105},{"id":"https://openalex.org/C151876577","wikidata":"https://www.wikidata.org/wiki/Q7049464","display_name":"Nonlinear dimensionality reduction","level":3,"score":0.4151993989944458},{"id":"https://openalex.org/C153120616","wikidata":"https://www.wikidata.org/wiki/Q17068315","display_name":"Manifold alignment","level":4,"score":0.41393354535102844},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.34345293045043945},{"id":"https://openalex.org/C70518039","wikidata":"https://www.wikidata.org/wiki/Q16000077","display_name":"Dimensionality reduction","level":2,"score":0.08953285217285156}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2010.5706655","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2010.5706655","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1727290854","https://openalex.org/W1751616979","https://openalex.org/W1755985346","https://openalex.org/W1967053372","https://openalex.org/W1982486391","https://openalex.org/W2033403400","https://openalex.org/W2044139911","https://openalex.org/W2097463421","https://openalex.org/W2109363337","https://openalex.org/W2147246240","https://openalex.org/W2150962169","https://openalex.org/W2478738321","https://openalex.org/W4244030505","https://openalex.org/W6674527804","https://openalex.org/W6682190839"],"related_works":["https://openalex.org/W3109610583","https://openalex.org/W2387045723","https://openalex.org/W2375518579","https://openalex.org/W3200375535","https://openalex.org/W117517268","https://openalex.org/W2944373987","https://openalex.org/W65619410","https://openalex.org/W2112684860","https://openalex.org/W2391701611","https://openalex.org/W2149544245"],"abstract_inverted_index":{"We":[0],"propose":[1],"a":[2,7,43,51,74,112],"clustering":[3,66],"algorithm":[4],"based":[5,10],"on":[6,55,73,111],"structural":[8],"prior":[9],"Local":[11],"Factor":[12],"Analysis":[13],"(spLFA)":[14],"model":[15],"under":[16],"the":[17,25,32,39,48,56,64,80,86,93],"Bayesian":[18],"Ying-Yang":[19],"harmony":[20],"learning,":[21,30],"which":[22],"automatically":[23],"determines":[24],"hidden":[26],"dimensionalities":[27],"during":[28],"parameter":[29],"reduces":[31],"number":[33,87],"of":[34,88],"free":[35],"parameters":[36],"by":[37,50],"projecting":[38],"mean":[40],"vectors":[41],"onto":[42],"low":[44],"dimensional":[45],"manifold,":[46],"imposes":[47],"sparseness":[49],"Normal-Jeffreys":[52],"prior.":[53],"Experiments":[54],"diagnostic":[57],"research":[58],"dataset":[59],"show":[60],"that":[61],"BYY-spLFA":[62,81,101],"outperforms":[63],"k-means":[65],"and":[67,91,106],"single-link":[68],"hierarchical":[69],"clustering.":[70],"The":[71],"experiments":[72],"lymphoma":[75],"cancer":[76],"datset":[77],"further":[78],"indicate":[79],"is":[82],"able":[83],"to":[84,102],"uncover":[85],"phenotypes":[89,94],"correctly":[90],"cluster":[92],"more":[95],"accurately.":[96],"In":[97],"addition,":[98],"we":[99],"modify":[100],"implement":[103],"supervised":[104],"learning":[105],"preliminarily":[107],"demonstrate":[108],"its":[109],"effectiveness":[110],"Leukemia":[113],"data":[114],"for":[115],"classification.":[116]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}