{"id":"https://openalex.org/W2147762421","doi":"https://doi.org/10.1109/bibm.2010.5706636","title":"Concurrent analysis of copy number variation and gene expression: Application in paired non-smoking female lung cancer patients","display_name":"Concurrent analysis of copy number variation and gene expression: Application in paired non-smoking female lung cancer patients","publication_year":2010,"publication_date":"2010-12-01","ids":{"openalex":"https://openalex.org/W2147762421","doi":"https://doi.org/10.1109/bibm.2010.5706636","mag":"2147762421"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2010.5706636","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2010.5706636","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111583526","display_name":"Jung-Chih Chang","orcid":null},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Jung-Chih Chang","raw_affiliation_strings":["Graduate Institute of Biomedical Graduate Institute of Biomedical, National Taiwan University, Taiwan"],"affiliations":[{"raw_affiliation_string":"Graduate Institute of Biomedical Graduate Institute of Biomedical, National Taiwan University, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025739002","display_name":"Tzu\u2010Pin Lu","orcid":"https://orcid.org/0000-0003-3697-0386"},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Tzu-Pin Lu","raw_affiliation_strings":["Institute of Biotechnology, National Taiwan University, Taiwan"],"affiliations":[{"raw_affiliation_string":"Institute of Biotechnology, National Taiwan University, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062893898","display_name":"Eric Y. Chuang","orcid":"https://orcid.org/0000-0003-2530-0096"},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Eric Y. Chuang","raw_affiliation_strings":["Graduate Institute of Biomedical Graduate Institute of Biomedical, National Taiwan University, Taiwan"],"affiliations":[{"raw_affiliation_string":"Graduate Institute of Biomedical Graduate Institute of Biomedical, National Taiwan University, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069812755","display_name":"Liang\u2010Chuan Lai","orcid":"https://orcid.org/0000-0002-3913-5338"},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Liang-Chuan Lai","raw_affiliation_strings":["Institute of Biotechnology, National Taiwan University, Taiwan"],"affiliations":[{"raw_affiliation_string":"Institute of Biotechnology, National Taiwan University, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008173365","display_name":"Mong\u2010Hsun Tsai","orcid":"https://orcid.org/0000-0001-8777-5818"},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Mong-Hsun Tsai","raw_affiliation_strings":["Institute of Biotechnology, National Taiwan University, Taiwan"],"affiliations":[{"raw_affiliation_string":"Institute of Biotechnology, National Taiwan University, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040081412","display_name":"Chuhsing Kate Hsiao","orcid":"https://orcid.org/0000-0003-4905-8484"},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chuhsing Kate Hsiao","raw_affiliation_strings":["Graduate Institute of Biomedical Graduate Institute of Biomedical, National Taiwan University, Taiwan"],"affiliations":[{"raw_affiliation_string":"Graduate Institute of Biomedical Graduate Institute of Biomedical, National Taiwan University, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064383488","display_name":"Pei\u2010Chun Chen","orcid":"https://orcid.org/0000-0002-8713-8816"},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Pei-Chun Chen","raw_affiliation_strings":["Institute of Biotechnology, National Taiwan University, Taiwan"],"affiliations":[{"raw_affiliation_string":"Institute of Biotechnology, National Taiwan University, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5111583526"],"corresponding_institution_ids":["https://openalex.org/I16733864"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14917408,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"599","last_page":"602"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/copy-number-variation","display_name":"Copy-number variation","score":0.7080422639846802},{"id":"https://openalex.org/keywords/correlation","display_name":"Correlation","score":0.6648958921432495},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6326066851615906},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"Lung cancer","score":0.6320333480834961},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.4991483688354492},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.44005635380744934},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.43820473551750183},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4182756841182709},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3796910047531128},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.30443936586380005},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.2996552586555481},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.2947614789009094},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.21181270480155945},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.14907106757164001}],"concepts":[{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.7080422639846802},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.6648958921432495},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6326066851615906},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6320333480834961},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4991483688354492},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44005635380744934},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.43820473551750183},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4182756841182709},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3796910047531128},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30443936586380005},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2996552586555481},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.2947614789009094},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21181270480155945},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.14907106757164001},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2010.5706636","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2010.5706636","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8700000047683716}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1612990831","https://openalex.org/W1966327575","https://openalex.org/W1987024849","https://openalex.org/W1997733964","https://openalex.org/W2014606320","https://openalex.org/W2048862998","https://openalex.org/W2061908600","https://openalex.org/W2076310052","https://openalex.org/W2096318664","https://openalex.org/W2108408366","https://openalex.org/W2111413196","https://openalex.org/W2117632905","https://openalex.org/W2118769864","https://openalex.org/W2130410032","https://openalex.org/W2135915970","https://openalex.org/W2138755755","https://openalex.org/W2140548491","https://openalex.org/W2143890777","https://openalex.org/W2148591031","https://openalex.org/W2156138784","https://openalex.org/W2161433585","https://openalex.org/W2282938450","https://openalex.org/W6636585409","https://openalex.org/W6695469772"],"related_works":["https://openalex.org/W3118014344","https://openalex.org/W2160911017","https://openalex.org/W2763474833","https://openalex.org/W2387464095","https://openalex.org/W2507940864","https://openalex.org/W1526237818","https://openalex.org/W4281746656","https://openalex.org/W2157937412","https://openalex.org/W2005336569","https://openalex.org/W2106650442"],"abstract_inverted_index":{"This":[0],"study":[1],"developed":[2],"a":[3,26,61],"method":[4,137],"to":[5,41,63,90],"identify":[6,42],"disease-correlated":[7],"pathways":[8,45,57,115],"by":[9,32,46,109,117],"integrating":[10],"copy":[11,119],"numbers":[12],"(CN)":[13],"and":[14,24,49,70,85,124,128,142],"gene":[15,122],"expression":[16,123],"(GE).":[17],"To":[18,97],"evaluate":[19,91],"the":[20,43,65,92,100,114,135],"correlation":[21],"between":[22],"CN":[23],"GE,":[25,48,69,127],"suitable":[27],"window":[28],"size":[29],"was":[30,39,58,88],"assessed":[31],"simulation.":[33],"Gene":[34],"Set":[35],"Enrichment":[36],"Analysis":[37],"(GSEA)":[38],"utilized":[40],"possible":[44],"CN,":[47,68,126],"their":[50,71,129],"correlations,":[51],"respectively.":[52],"Each":[53],"of":[54,75,94,103],"those":[55,104],"enriched":[56],"further":[59,98],"assigned":[60],"score":[62],"incorporate":[64],"information":[66],"from":[67],"correlations.":[72,130],"A":[73],"dataset":[74],"44":[76],"female":[77],"non-smoking":[78],"lung":[79],"cancer":[80],"patients":[81,106],"with":[82],"both":[83],"normal":[84],"tumor":[86],"tissues":[87],"used":[89],"performance":[93],"this":[95],"method.":[96],"appraise":[99],"predicting":[101],"abilities":[102],"pathways,":[105],"were":[107],"classified":[108],"support":[110],"vector":[111],"machines":[112],"using":[113],"identified":[116],"only":[118,121],"number,":[120],"incorporating":[125],"The":[131],"results":[132],"showed":[133],"that":[134],"proposed":[136],"earned":[138],"higher":[139],"accuracy,":[140],"sensitivity":[141],"specificity":[143],"than":[144],"traditional":[145],"methods.":[146]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}