{"id":"https://openalex.org/W2139869106","doi":"https://doi.org/10.1109/bibm.2010.5706618","title":"Metabolomic profiling for biomarker discovery in pancreatic cancer","display_name":"Metabolomic profiling for biomarker discovery in pancreatic cancer","publication_year":2010,"publication_date":"2010-12-01","ids":{"openalex":"https://openalex.org/W2139869106","doi":"https://doi.org/10.1109/bibm.2010.5706618","mag":"2139869106"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2010.5706618","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2010.5706618","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105352719","display_name":"Prabhjit Kaur","orcid":"https://orcid.org/0009-0001-6555-1204"},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Prabhjit Kaur","raw_affiliation_strings":["Department of Oncology, Georgetown University Medical Center, Washington D.C., DC, USA","Department of Oncology, LCCC at Georgetown University Medical Center, Washington, D.C. 20057, USA"],"affiliations":[{"raw_affiliation_string":"Department of Oncology, Georgetown University Medical Center, Washington D.C., DC, USA","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I184565670"]},{"raw_affiliation_string":"Department of Oncology, LCCC at Georgetown University Medical Center, Washington, D.C. 20057, USA","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016346283","display_name":"Kathryn Sheikh","orcid":null},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn Sheikh","raw_affiliation_strings":["Department of Oncology, Georgetown University Medical Center, Washington D.C., DC, USA","Department of Oncology, LCCC at Georgetown University Medical Center, Washington, D.C. 20057, USA"],"affiliations":[{"raw_affiliation_string":"Department of Oncology, Georgetown University Medical Center, Washington D.C., DC, USA","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I184565670"]},{"raw_affiliation_string":"Department of Oncology, LCCC at Georgetown University Medical Center, Washington, D.C. 20057, USA","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051523645","display_name":"Alexander Kirilyuk","orcid":"https://orcid.org/0000-0001-6403-8882"},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Kirilyuk","raw_affiliation_strings":["Department of Oncology, Georgetown University Medical Center, Washington D.C., DC, USA","Department of Oncology, LCCC at Georgetown University Medical Center, Washington, D.C. 20057, USA"],"affiliations":[{"raw_affiliation_string":"Department of Oncology, Georgetown University Medical Center, Washington D.C., DC, USA","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I184565670"]},{"raw_affiliation_string":"Department of Oncology, LCCC at Georgetown University Medical Center, Washington, D.C. 20057, USA","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030791382","display_name":"Ksenia Kirilyuk","orcid":null},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ksenia Kirilyuk","raw_affiliation_strings":["Department of Oncology, Georgetown University Medical Center, Washington D.C., DC, USA","Department of Oncology, LCCC at Georgetown University Medical Center, Washington, D.C. 20057, USA"],"affiliations":[{"raw_affiliation_string":"Department of Oncology, Georgetown University Medical Center, Washington D.C., DC, USA","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I184565670"]},{"raw_affiliation_string":"Department of Oncology, LCCC at Georgetown University Medical Center, Washington, D.C. 20057, USA","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025125310","display_name":"Habtom W. Ressom","orcid":"https://orcid.org/0000-0001-9296-2132"},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Habtom W. Ressom","raw_affiliation_strings":["Department of Oncology, Georgetown University Medical Center, Washington D.C., DC, USA","Department of Oncology, LCCC at Georgetown University Medical Center, Washington, D.C. 20057, USA"],"affiliations":[{"raw_affiliation_string":"Department of Oncology, Georgetown University Medical Center, Washington D.C., DC, USA","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I184565670"]},{"raw_affiliation_string":"Department of Oncology, LCCC at Georgetown University Medical Center, Washington, D.C. 20057, USA","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003800447","display_name":"Amrita K. Cheema","orcid":"https://orcid.org/0000-0003-4877-7583"},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amrita K Cheema","raw_affiliation_strings":["Department of Oncology, Georgetown University Medical Center, Washington D.C., DC, USA","Department of Oncology, LCCC at Georgetown University Medical Center, Washington, D.C. 20057, USA"],"affiliations":[{"raw_affiliation_string":"Department of Oncology, Georgetown University Medical Center, Washington D.C., DC, USA","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I184565670"]},{"raw_affiliation_string":"Department of Oncology, LCCC at Georgetown University Medical Center, Washington, D.C. 20057, USA","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I184565670"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010153046","display_name":"Bhaskar Kallakury","orcid":"https://orcid.org/0000-0002-1298-2983"},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bhaskar Kallakury","raw_affiliation_strings":["Department of Pathology, Georgetown University Medical Center, Washington D.C., DC, USA","Department of Pathology, LCCC at Georgetown University Medical Center, Washington, D.C. 20057, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pathology, Georgetown University Medical Center, Washington D.C., DC, USA","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I184565670"]},{"raw_affiliation_string":"Department of Pathology, LCCC at Georgetown University Medical Center, Washington, D.C. 20057, USA","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I184565670"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5105352719"],"corresponding_institution_ids":["https://openalex.org/I184565670","https://openalex.org/I2799903593"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.13316291,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"7","issue":null,"first_page":"505","last_page":"509"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolomics","display_name":"Metabolomics","score":0.8296838402748108},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"Pancreatic cancer","score":0.8215349912643433},{"id":"https://openalex.org/keywords/metabolome","display_name":"Metabolome","score":0.8027048110961914},{"id":"https://openalex.org/keywords/biomarker-discovery","display_name":"Biomarker discovery","score":0.751833438873291},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5869857668876648},{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.5683301687240601},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.4873660206794739},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.47610530257225037},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.4494950473308563},{"id":"https://openalex.org/keywords/profiling","display_name":"Profiling (computer programming)","score":0.4287121593952179},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.4126582145690918},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3629487156867981},{"id":"https://openalex.org/keywords/proteomics","display_name":"Proteomics","score":0.2428789734840393},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.20292049646377563},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.09866616129875183}],"concepts":[{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.8296838402748108},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.8215349912643433},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.8027048110961914},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.751833438873291},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5869857668876648},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5683301687240601},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4873660206794739},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.47610530257225037},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4494950473308563},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.4287121593952179},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4126582145690918},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3629487156867981},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.2428789734840393},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20292049646377563},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.09866616129875183},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2010.5706618","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2010.5706618","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8700000047683716,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1801184284","https://openalex.org/W1992771869","https://openalex.org/W2003839740","https://openalex.org/W2028240481","https://openalex.org/W2040124349","https://openalex.org/W2043151436","https://openalex.org/W2048867608","https://openalex.org/W2058132219","https://openalex.org/W2062222093","https://openalex.org/W2081095347","https://openalex.org/W2094223456","https://openalex.org/W2101995865","https://openalex.org/W2108488321","https://openalex.org/W2121121711","https://openalex.org/W2132591766","https://openalex.org/W2135926882","https://openalex.org/W2139782977","https://openalex.org/W2145867542","https://openalex.org/W2155680682","https://openalex.org/W2163847576","https://openalex.org/W2409881099","https://openalex.org/W2911964244"],"related_works":["https://openalex.org/W1996644818","https://openalex.org/W1965468642","https://openalex.org/W2093500216","https://openalex.org/W2053588008","https://openalex.org/W2916376502","https://openalex.org/W3101161779","https://openalex.org/W423371831","https://openalex.org/W2777729175","https://openalex.org/W2260452057","https://openalex.org/W4295779760"],"abstract_inverted_index":{"Pancreatic":[0],"cancer":[1,9,25],"(PC)":[2],"is":[3,35],"the":[4,12,33,74,77,83],"fourth":[5],"leading":[6],"cause":[7],"of":[8,60,76],"death":[10],"in":[11,73],"United":[13],"States,":[14],"with":[15,23,95],"4%":[16],"survival":[17],"5":[18],"years":[19],"after":[20],"diagnosis.":[21],"Patients":[22],"pancreatic":[24,62],"are":[26,42],"usually":[27],"diagnosed":[28],"at":[29],"late":[30],"stages,":[31],"when":[32],"disease":[34],"incurable.":[36],"Sensitive":[37],"and":[38,64],"more":[39],"specific":[40],"biomarkers":[41,94],"thus":[43],"critical":[44],"for":[45,91,97],"supporting":[46],"new":[47],"prevention,":[48],"diagnostic":[49,98],"or":[50,99],"therapeutic":[51],"strategies.":[52],"Here,":[53],"we":[54],"report":[55],"mass":[56],"spectrometry-based":[57],"metabolomic":[58],"profiling":[59],"human":[61],"tumor":[63,78],"normal":[65],"tissue.":[66],"Multivariate":[67],"data":[68],"analysis":[69],"shows":[70],"significant":[71],"alterations":[72],"profiles":[75],"metabolome":[79],"as":[80],"compared":[81],"to":[82],"normal.":[84],"These":[85],"findings":[86],"offer":[87],"an":[88],"information-rich":[89],"matrix":[90],"discovering":[92],"novel":[93],"potential":[96],"prognostic":[100],"purposes.":[101]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}