{"id":"https://openalex.org/W2117480996","doi":"https://doi.org/10.1109/bibm.2010.5706562","title":"Overcoming drug resistance by co-targeting","display_name":"Overcoming drug resistance by co-targeting","publication_year":2010,"publication_date":"2010-12-01","ids":{"openalex":"https://openalex.org/W2117480996","doi":"https://doi.org/10.1109/bibm.2010.5706562","mag":"2117480996"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2010.5706562","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2010.5706562","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051701852","display_name":"Marzieh Ayati","orcid":"https://orcid.org/0000-0002-5280-5738"},"institutions":[{"id":"https://openalex.org/I133529467","display_name":"Sharif University of Technology","ror":"https://ror.org/024c2fq17","country_code":"IR","type":"education","lineage":["https://openalex.org/I133529467"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Marzieh Ayati","raw_affiliation_strings":["Sharif University of Technology, Tehran, Tehran, IR"],"affiliations":[{"raw_affiliation_string":"Sharif University of Technology, Tehran, Tehran, IR","institution_ids":["https://openalex.org/I133529467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028094685","display_name":"Golnaz Taheri","orcid":"https://orcid.org/0000-0002-2741-0355"},"institutions":[{"id":"https://openalex.org/I133529467","display_name":"Sharif University of Technology","ror":"https://ror.org/024c2fq17","country_code":"IR","type":"education","lineage":["https://openalex.org/I133529467"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Golnaz Taheri","raw_affiliation_strings":["Department of Computer Science, Sharif University of Technology, Iran"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Sharif University of Technology, Iran","institution_ids":["https://openalex.org/I133529467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003496440","display_name":"Seyed Shahriar Arab","orcid":"https://orcid.org/0000-0002-2739-1617"},"institutions":[{"id":"https://openalex.org/I4210146419","display_name":"Institute for Research in Fundamental Sciences","ror":"https://ror.org/04xreqs31","country_code":"IR","type":"facility","lineage":["https://openalex.org/I4210146419"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Shahriar Arab","raw_affiliation_strings":["School of Computer Science, Institute for Research in Fundamental Sciences, Iran"],"affiliations":[{"raw_affiliation_string":"School of Computer Science, Institute for Research in Fundamental Sciences, Iran","institution_ids":["https://openalex.org/I4210146419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012381970","display_name":"Limsoon Wong","orcid":"https://orcid.org/0000-0003-1241-5441"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Limsoon Wong","raw_affiliation_strings":["Department of Computer Science, National University of Singapore, Singapore"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035605233","display_name":"Changiz Eslahchi","orcid":"https://orcid.org/0000-0002-8913-3904"},"institutions":[{"id":"https://openalex.org/I23946033","display_name":"University of Tehran","ror":"https://ror.org/05vf56z40","country_code":"IR","type":"education","lineage":["https://openalex.org/I23946033"]},{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Changiz Eslahchi","raw_affiliation_strings":["Center of Excellence in Biomathematics, School of Mathematics, Statistics and Computer Science, University of Tehran, Tehran, Iran","Department of Mathematics, Shahid Beheshti University, Iran"],"affiliations":[{"raw_affiliation_string":"Center of Excellence in Biomathematics, School of Mathematics, Statistics and Computer Science, University of Tehran, Tehran, Iran","institution_ids":["https://openalex.org/I23946033"]},{"raw_affiliation_string":"Department of Mathematics, Shahid Beheshti University, Iran","institution_ids":["https://openalex.org/I48379061"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5051701852"],"corresponding_institution_ids":["https://openalex.org/I133529467"],"apc_list":null,"apc_paid":null,"fwci":0.3417,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.64449787,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":95},"biblio":{"volume":"36","issue":null,"first_page":"198","last_page":"202"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9926000237464905,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.9898999929428101,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.6048623919487},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"Drug resistance","score":0.5286341905593872},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4550517499446869},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.2739065885543823},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.25911909341812134},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.16237899661064148},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.09082695841789246}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6048623919487},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.5286341905593872},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4550517499446869},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2739065885543823},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25911909341812134},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16237899661064148},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09082695841789246}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/bibm.2010.5706562","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2010.5706562","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/40639","is_oa":false,"landing_page_url":"http://scholarbank.nus.edu.sg/handle/10635/40639","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus","raw_type":"Conference Paper"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.310.1987","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.310.1987","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.comp.nus.edu.sg/~wongls/psZ/v14-cotargeting-bibm2010.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8399999737739563}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W149287402","https://openalex.org/W1893039775","https://openalex.org/W2009313526","https://openalex.org/W2010000580","https://openalex.org/W2011039300","https://openalex.org/W2032694615","https://openalex.org/W2052936935","https://openalex.org/W2073890622","https://openalex.org/W2074443723","https://openalex.org/W2077159940","https://openalex.org/W2086121836","https://openalex.org/W2111795091","https://openalex.org/W2113513143","https://openalex.org/W2130790725","https://openalex.org/W2145996426","https://openalex.org/W2150318080","https://openalex.org/W2152285853","https://openalex.org/W2155320925","https://openalex.org/W2156345326","https://openalex.org/W2158920494","https://openalex.org/W2170146596","https://openalex.org/W3198460963","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052","https://openalex.org/W4402327032","https://openalex.org/W2086452998"],"abstract_inverted_index":{"Removal":[0],"or":[1],"suppression":[2],"of":[3,10,37,69,83,97,110,118,120,170,192,194,205,213],"key":[4],"proteins":[5,180],"in":[6,101,124,172,181,188,209],"an":[7],"essential":[8,31],"pathway":[9,18,99,123],"a":[11,25,38,51,65,74,121,230],"pathogen":[12,22,39],"is":[13,73,114,127,153,196],"expected":[14],"to":[15,46,90,132],"disrupt":[16,34,60],"the":[17,21,35,54,79,84,95,105,108,111,116,134,142,173,182,210],"and":[19,162,190,203,216],"prohibit":[20],"from":[23],"performing":[24],"vital":[26],"function.":[27],"Thus":[28],"disconnecting":[29],"multiple":[30,44],"pathways":[32,45,56],"should":[33,228],"survival":[36],"even":[40],"when":[41],"it":[42],"has":[43,222],"drug":[47,232],"resistance.":[48,233],"We":[49,140,155,165],"consider":[50,64],"scenario":[52],"where":[53,71],"drug-resistance":[55],"are":[57,100,176,208],"unknown.":[58],"To":[59],"these":[61],"pathways,":[62],"we":[63,130],"cut":[66,174,183,212],"set":[67],"S":[68],"G,":[70],"G":[72],"connected":[75],"simple":[76],"graph":[77,135],"representing":[78],"protein":[80],"interaction":[81],"network":[82],"pathogen,":[85],"so":[86],"that":[87,94,167],"G-S":[88],"splits":[89],"two":[91,112,137],"partitions":[92,113],"such":[93],"endpoints":[96],"each":[98,193],"different":[102],"partitions.":[103,139],"If":[104],"difference":[106],"between":[107],"sizes":[109],"high,":[115],"probability":[117],"existence":[119],"functioning":[122],"one":[125],"partition":[126,133],"increased.":[128],"Thus,":[129],"need":[131],"into":[136],"balanced":[138,143],"approximate":[141],"bipartitioning":[144,148],"problem":[145],"with":[146],"spectral":[147],"since":[149],"finding":[150],"(2,":[151],"1)-separator":[152],"NP-complete.":[154],"test":[156],"our":[157,220],"technique":[158],"on":[159],"E.":[160,214],"coli":[161,215],"C.":[163,217],"jejuni.":[164,218],"show":[166],"over":[168],"50%":[169],"genes":[171],"sets":[175,184],"essential.":[177],"Moreover,":[178],"all":[179],"have":[185],"fundamental":[186],"roles":[187],"cell":[189,199],"inhibition":[191,227],"them":[195],"harmful":[197],"for":[198],"survival.":[200],"Also,":[201],"20%":[202],"17%":[204],"known":[206],"targets":[207],"vertex":[211],"Hence":[219],"approach":[221],"produced":[223],"plausible":[224],"\u201cco-targets\u201d":[225],"whose":[226],"counter":[229],"pathogen's":[231]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}
