{"id":"https://openalex.org/W2025903895","doi":"https://doi.org/10.1109/bibm.2010.5706556","title":"Predicting ligand binding residues using multi-positional correlations and kernel canonical correlation analysis","display_name":"Predicting ligand binding residues using multi-positional correlations and kernel canonical correlation analysis","publication_year":2010,"publication_date":"2010-12-01","ids":{"openalex":"https://openalex.org/W2025903895","doi":"https://doi.org/10.1109/bibm.2010.5706556","mag":"2025903895"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2010.5706556","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2010.5706556","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051925857","display_name":"\u00c1lvaro Gonz\u00e1lez","orcid":"https://orcid.org/0000-0002-1423-273X"},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alvaro J. Gonzalez","raw_affiliation_strings":["Department of Computer and Information Sciences, University of Delaware, 101 Smith Hall, Newark, DE 19716"],"affiliations":[{"raw_affiliation_string":"Department of Computer and Information Sciences, University of Delaware, 101 Smith Hall, Newark, DE 19716","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101595032","display_name":"Li Liao","orcid":"https://orcid.org/0000-0002-1197-1879"},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Liao","raw_affiliation_strings":["Department of Computer and Information Sciences, University of Delaware, Newark, DE, USA","Department of Computer and Information Sciences, University of Delaware, 101 Smith Hall, Newark, DE 19716"],"affiliations":[{"raw_affiliation_string":"Department of Computer and Information Sciences, University of Delaware, Newark, DE, USA","institution_ids":["https://openalex.org/I86501945"]},{"raw_affiliation_string":"Department of Computer and Information Sciences, University of Delaware, 101 Smith Hall, Newark, DE 19716","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053761444","display_name":"Cathy Wu","orcid":"https://orcid.org/0000-0001-6379-8601"},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cathy H. Wu","raw_affiliation_strings":["Department of Computer and Information Sciences, University of Delaware, Newark, DE","Department of Computer and Information Sciences, University of Delaware, 101 Smith Hall, Newark, DE 19716"],"affiliations":[{"raw_affiliation_string":"Department of Computer and Information Sciences, University of Delaware, Newark, DE","institution_ids":["https://openalex.org/I86501945"]},{"raw_affiliation_string":"Department of Computer and Information Sciences, University of Delaware, 101 Smith Hall, Newark, DE 19716","institution_ids":["https://openalex.org/I86501945"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5051925857"],"corresponding_institution_ids":["https://openalex.org/I86501945"],"apc_list":null,"apc_paid":null,"fwci":0.5287,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.64886264,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"3","issue":null,"first_page":"158","last_page":"163"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/canonical-correlation","display_name":"Canonical correlation","score":0.7405713796615601},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.6575357913970947},{"id":"https://openalex.org/keywords/correlation","display_name":"Correlation","score":0.653710663318634},{"id":"https://openalex.org/keywords/kernel","display_name":"Kernel (algebra)","score":0.6107994914054871},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.43321627378463745},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.40243294835090637},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3907984495162964},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3810380697250366},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.33581507205963135},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.21379172801971436},{"id":"https://openalex.org/keywords/combinatorics","display_name":"Combinatorics","score":0.08833667635917664}],"concepts":[{"id":"https://openalex.org/C153874254","wikidata":"https://www.wikidata.org/wiki/Q115542","display_name":"Canonical correlation","level":2,"score":0.7405713796615601},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6575357913970947},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.653710663318634},{"id":"https://openalex.org/C74193536","wikidata":"https://www.wikidata.org/wiki/Q574844","display_name":"Kernel (algebra)","level":2,"score":0.6107994914054871},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.43321627378463745},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.40243294835090637},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3907984495162964},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3810380697250366},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.33581507205963135},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21379172801971436},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.08833667635917664},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2010.5706556","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2010.5706556","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6700000166893005,"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W287030404","https://openalex.org/W1497960466","https://openalex.org/W1561011671","https://openalex.org/W1588424744","https://openalex.org/W1967293793","https://openalex.org/W1982481323","https://openalex.org/W1991970046","https://openalex.org/W2022058405","https://openalex.org/W2060097376","https://openalex.org/W2078866107","https://openalex.org/W2108659514","https://openalex.org/W2121950477","https://openalex.org/W2154867574","https://openalex.org/W4285719527","https://openalex.org/W6629823275","https://openalex.org/W6634941687"],"related_works":["https://openalex.org/W2367413540","https://openalex.org/W1968846550","https://openalex.org/W4387164999","https://openalex.org/W2070623039","https://openalex.org/W1991315556","https://openalex.org/W2006749424","https://openalex.org/W2155515508","https://openalex.org/W3131670725","https://openalex.org/W2354853260","https://openalex.org/W1970646221"],"abstract_inverted_index":{"We":[0,62],"present":[1],"a":[2,59],"new":[3],"computational":[4],"method":[5,15],"for":[6],"predicting":[7],"ligand":[8],"binding":[9,26],"sites":[10,27,45],"in":[11,28,55,71],"protein":[12,29],"sequences.":[13],"The":[14],"uses":[16],"kernelbased":[17],"canonical":[18],"correlation":[19,37],"analysis":[20],"and":[21,46,74],"linear":[22],"regression":[23],"to":[24],"identify":[25],"sequences":[30,73],"as":[31],"the":[32,39,44,47,53,56,64,72,80],"residues":[33],"that":[34,76],"exhibit":[35],"strong":[36],"between":[38],"residues'":[40],"evolutionary":[41],"characterization":[42],"at":[43],"structure":[48],"based":[49],"functional":[50,60],"classification":[51],"of":[52,58,66],"proteins":[54],"context":[57],"family.":[61],"explore":[63],"effect":[65],"correlations":[67],"among":[68],"multiple":[69],"positions":[70],"show":[75],"their":[77],"inclusion":[78],"enhances":[79],"prediction":[81],"accuracy":[82],"significantly.":[83]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}