{"id":"https://openalex.org/W4417250935","doi":"https://doi.org/10.1109/bibe66822.2025.00009","title":"Recommending Safe and Effective Drug Combinations with Principal Component Analysis","display_name":"Recommending Safe and Effective Drug Combinations with Principal Component Analysis","publication_year":2025,"publication_date":"2025-11-06","ids":{"openalex":"https://openalex.org/W4417250935","doi":"https://doi.org/10.1109/bibe66822.2025.00009"},"language":null,"primary_location":{"id":"doi:10.1109/bibe66822.2025.00009","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe66822.2025.00009","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 25th International Conference on Bioinformatics and Bioengineering (BIBE)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004690613","display_name":"Panagiotis Symeonidis","orcid":"https://orcid.org/0000-0003-0685-3568"},"institutions":[{"id":"https://openalex.org/I98805295","display_name":"University of the Aegean","ror":"https://ror.org/03zsp3p94","country_code":"GR","type":"education","lineage":["https://openalex.org/I98805295"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Panagiotis Symeonidis","raw_affiliation_strings":["University of the Aegean,Samos,Greece"],"affiliations":[{"raw_affiliation_string":"University of the Aegean,Samos,Greece","institution_ids":["https://openalex.org/I98805295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109674507","display_name":"\u0415 \u0413 \u041a\u043e\u043d\u0442\u043e\u0441","orcid":null},"institutions":[{"id":"https://openalex.org/I231025917","display_name":"Hellenic Open University","ror":"https://ror.org/02kq26x23","country_code":"GR","type":"education","lineage":["https://openalex.org/I231025917"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Elias Kontos","raw_affiliation_strings":["Hellenic Open University,Patra,Greece"],"affiliations":[{"raw_affiliation_string":"Hellenic Open University,Patra,Greece","institution_ids":["https://openalex.org/I231025917"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5004690613"],"corresponding_institution_ids":["https://openalex.org/I98805295"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.42737235,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.33320000767707825,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.33320000767707825,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.27900001406669617,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.07540000230073929,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.7511000037193298},{"id":"https://openalex.org/keywords/safer","display_name":"SAFER","score":0.6904000043869019},{"id":"https://openalex.org/keywords/clinical-trial","display_name":"Clinical trial","score":0.4203000068664551},{"id":"https://openalex.org/keywords/principal-component-analysis","display_name":"Principal component analysis","score":0.3903999924659729},{"id":"https://openalex.org/keywords/side-effect","display_name":"Side effect (computer science)","score":0.3481000065803528},{"id":"https://openalex.org/keywords/component","display_name":"Component (thermodynamics)","score":0.33149999380111694}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.7511000037193298},{"id":"https://openalex.org/C2776654903","wikidata":"https://www.wikidata.org/wiki/Q2601463","display_name":"SAFER","level":2,"score":0.6904000043869019},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6313999891281128},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5012999773025513},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.4733999967575073},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4203000068664551},{"id":"https://openalex.org/C27438332","wikidata":"https://www.wikidata.org/wiki/Q2873","display_name":"Principal component analysis","level":2,"score":0.3903999924659729},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.35339999198913574},{"id":"https://openalex.org/C3454156","wikidata":"https://www.wikidata.org/wiki/Q1144241","display_name":"Side effect (computer science)","level":2,"score":0.3481000065803528},{"id":"https://openalex.org/C168167062","wikidata":"https://www.wikidata.org/wiki/Q1117970","display_name":"Component (thermodynamics)","level":2,"score":0.33149999380111694},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.31459999084472656},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.2685999870300293},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.26649999618530273},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.26409998536109924},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2605000138282776},{"id":"https://openalex.org/C545542383","wikidata":"https://www.wikidata.org/wiki/Q2751242","display_name":"Medical emergency","level":1,"score":0.25360000133514404},{"id":"https://openalex.org/C110875604","wikidata":"https://www.wikidata.org/wiki/Q75","display_name":"The Internet","level":2,"score":0.25060001015663147},{"id":"https://openalex.org/C2776376669","wikidata":"https://www.wikidata.org/wiki/Q5094647","display_name":"Intensive care unit","level":2,"score":0.2502000033855438}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibe66822.2025.00009","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe66822.2025.00009","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 25th International Conference on Bioinformatics and Bioengineering (BIBE)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1902027874","https://openalex.org/W2042281163","https://openalex.org/W2119002393","https://openalex.org/W2605350416","https://openalex.org/W2744140371","https://openalex.org/W2945435617","https://openalex.org/W2963806310","https://openalex.org/W2964068143","https://openalex.org/W2983825113","https://openalex.org/W3003635389"],"related_works":[],"abstract_inverted_index":{"In":[0,39],"the":[1,6,8,27,62,66,86,106,109,114,131],"intensive":[2],"care":[3],"units":[4],"of":[5,16,30,89,108,113,135,141],"hospitals,":[7],"critically":[9],"ill":[10],"patients":[11,74],"follow":[12],"complex":[13],"treatments":[14],"consisting":[15],"drug":[17,28,70,81,116,142],"combinations":[18,29,71,117],"to":[19,61],"avoid":[20],"mortality":[21],"and":[22,65,68,92,133,152],"have":[23,99,129],"fast":[24],"recovery.":[25],"However,":[26],"a":[31],"patient's":[32],"treatment":[33,50],"may":[34,98],"cause":[35],"unwanted":[36,94,110],"side":[37,83,95,111],"effects.":[38],"this":[40],"paper,":[41],"we":[42,55,77],"apply":[43],"Principal":[44],"Component":[45],"Analysis":[46],"(PCA)":[47],"over":[48],"patients'":[49],"medical":[51],"data,":[52],"so":[53],"that":[54,72],"can":[56],"identify":[57],"similar":[58],"clinical":[59,87],"cases":[60],"target":[63],"patient":[64],"effective":[67],"safe":[69],"these":[73],"received.":[75],"Moreover,":[76],"employ":[78],"from":[79],"internet":[80],"databases":[82],"information":[84],"regarding":[85],"trials":[88],"new":[90],"drugs":[91,121],"their":[93,123],"effects":[96,112],"they":[97],"with":[100,122,145],"other":[101],"drugs.":[102],"Our":[103,126],"goal":[104],"is":[105],"reduction":[107],"recommended":[115],"by":[118],"replacing":[119],"some":[120],"safer":[124],"substitutes.":[125],"experimental":[127],"results":[128],"shown":[130],"effectiveness":[132],"safety":[134],"our":[136],"PCA":[137],"method":[138],"in":[139],"terms":[140],"recommendations":[143],"compared":[144],"classic":[146],"algorithms":[147],"such":[148],"as":[149],"SVD,":[150],"NMF":[151],"user-KNN.":[153]},"counts_by_year":[],"updated_date":"2026-03-07T16:01:11.037858","created_date":"2025-12-11T00:00:00"}
