{"id":"https://openalex.org/W4406138634","doi":"https://doi.org/10.1109/bibe63649.2024.10820498","title":"Estimating the Effect of Danicamtiv on Human Cardiac Function","display_name":"Estimating the Effect of Danicamtiv on Human Cardiac Function","publication_year":2024,"publication_date":"2024-11-27","ids":{"openalex":"https://openalex.org/W4406138634","doi":"https://doi.org/10.1109/bibe63649.2024.10820498"},"language":"en","primary_location":{"id":"doi:10.1109/bibe63649.2024.10820498","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe63649.2024.10820498","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE 24th International Conference on Bioinformatics and Bioengineering (BIBE)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.1109/BIBE63649.2024.10820498","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041796439","display_name":"Mom\u010dilo Prodanovi\u0107","orcid":"https://orcid.org/0000-0003-0556-1213"},"institutions":[{"id":"https://openalex.org/I14245010","display_name":"University of Kragujevac","ror":"https://ror.org/04f7vj627","country_code":"RS","type":"education","lineage":["https://openalex.org/I14245010"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Momcilo Prodanovic","raw_affiliation_strings":["University of Kragujevac, Insitute for Information Technologies,Kragujevac,Serbia"],"raw_orcid":"https://orcid.org/0000-0003-0556-1213","affiliations":[{"raw_affiliation_string":"University of Kragujevac, Insitute for Information Technologies,Kragujevac,Serbia","institution_ids":["https://openalex.org/I14245010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115798916","display_name":"Vanja Cvetkovic","orcid":null},"institutions":[{"id":"https://openalex.org/I4068193","display_name":"University of Belgrade","ror":"https://ror.org/02qsmb048","country_code":"RS","type":"education","lineage":["https://openalex.org/I4068193"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Vanja Cvetkovic","raw_affiliation_strings":["University of Belgrade,Faculty of Physics,Belgrade,Serbia"],"raw_orcid":"https://orcid.org/0009-0001-7116-6636","affiliations":[{"raw_affiliation_string":"University of Belgrade,Faculty of Physics,Belgrade,Serbia","institution_ids":["https://openalex.org/I4068193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104240954","display_name":"Andjela Grujic","orcid":null},"institutions":[{"id":"https://openalex.org/I4068193","display_name":"University of Belgrade","ror":"https://ror.org/02qsmb048","country_code":"RS","type":"education","lineage":["https://openalex.org/I4068193"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Andjela Grujic","raw_affiliation_strings":["University of Belgrade,Faculty of Physics,Belgrade,Serbia"],"raw_orcid":"https://orcid.org/0009-0007-8027-0252","affiliations":[{"raw_affiliation_string":"University of Belgrade,Faculty of Physics,Belgrade,Serbia","institution_ids":["https://openalex.org/I4068193"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041031779","display_name":"Srboljub M. Mijailovich","orcid":"https://orcid.org/0000-0003-2640-3548"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Srboljub M. Mijailovich","raw_affiliation_strings":["FilamenTech, Inc.,Newton,MA,USA"],"raw_orcid":"https://orcid.org/0000-0003-2640-3548","affiliations":[{"raw_affiliation_string":"FilamenTech, Inc.,Newton,MA,USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.48999104,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.9835000038146973,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.9835000038146973,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9218000173568726,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.5132074356079102},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.460226833820343},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.09134390950202942},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.05870860815048218}],"concepts":[{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5132074356079102},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.460226833820343},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09134390950202942},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.05870860815048218}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/bibe63649.2024.10820498","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe63649.2024.10820498","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE 24th International Conference on Bioinformatics and Bioengineering (BIBE)","raw_type":"proceedings-article"},{"id":"pmh:oai:zenodo.org:18904347","is_oa":true,"landing_page_url":"https://doi.org/10.1109/BIBE63649.2024.10820498","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferencePaper"}],"best_oa_location":{"id":"pmh:oai:zenodo.org:18904347","is_oa":true,"landing_page_url":"https://doi.org/10.1109/BIBE63649.2024.10820498","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferencePaper"},"sustainable_development_goals":[{"score":0.5199999809265137,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320329307","display_name":"Science Fund of the Republic of Serbia","ror":"https://ror.org/02r531a15"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1991507611","https://openalex.org/W2011112539","https://openalex.org/W2018375125","https://openalex.org/W2025666521","https://openalex.org/W2032317093","https://openalex.org/W2075174490","https://openalex.org/W2090002414","https://openalex.org/W2130858105","https://openalex.org/W2130899200","https://openalex.org/W2301060314","https://openalex.org/W2556378489","https://openalex.org/W2791899725","https://openalex.org/W2820660720","https://openalex.org/W2897286847","https://openalex.org/W2926802907","https://openalex.org/W3011165445","https://openalex.org/W3124625267","https://openalex.org/W3129556747","https://openalex.org/W4200156396","https://openalex.org/W4206251963","https://openalex.org/W4211051044","https://openalex.org/W4307110821","https://openalex.org/W4322627838","https://openalex.org/W4323841791","https://openalex.org/W4384820229","https://openalex.org/W4388001049","https://openalex.org/W4391641671","https://openalex.org/W4401046602","https://openalex.org/W4401046624"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052"],"abstract_inverted_index":{"Dilated":[0],"cardiomyopathy":[1],"(DCM)":[2],"is":[3,198],"a":[4,22,183],"condition":[5],"characterized":[6],"by":[7,32,89,140,157],"impaired":[8],"cardiac":[9,30,60,102,177,196],"contractility":[10],"and":[11,41,52,76,100,111,129,156],"enlargement":[12],"of":[13,83,144],"the":[14,55,68,81,145,149,173],"heart":[15,109],"chambers,":[16],"leading":[17,162],"to":[18,58,79,153,163,175,200],"systolic":[19],"dysfunction.":[20],"Danicamtiv,":[21],"novel":[23],"myosin":[24,112],"activator,":[25],"shows":[26],"potential":[27,174],"in":[28,50,179,190],"restoring":[29],"function":[31,61,178],"modulating":[33],"crossbridge":[34,77,150],"cycling":[35],"affecting":[36],"positively":[37],"on":[38,85],"increasing":[39,141],"force":[40],"calcium":[42,123,127],"sensitivity.":[43],"While":[44],"promising":[45],"results":[46],"have":[47],"been":[48],"observed":[49],"mouse":[51,99],"porcine":[53,101],"models,":[54],"translational":[56],"gap":[57],"human":[59,86,180,195],"remains.":[62],"To":[63],"address":[64],"this,":[65],"we":[66],"used":[67],"MUSICO":[69,91],"computational":[70],"platform,":[71],"which":[72],"models":[73],"sarcomere":[74],"dynamics":[75],"behavior,":[78],"simulate":[80],"effects":[82,137],"Danicamtiv":[84,118,171],"trabeculae":[87],"affected":[88],"DCM.":[90],"simulations":[92,115],"were":[93],"performed":[94],"using":[95,194],"experimental":[96],"data":[97],"from":[98,148],"tissues,":[103],"incorporating":[104],"physiological":[105],"differences":[106],"such":[107],"as":[108],"rates":[110],"isoforms.":[113],"The":[114],"demonstrated":[116],"that":[117,170],"enhances":[119],"tension":[120,165],"at":[121],"high":[122],"concentrations":[124],"(pCa=4),":[125],"increases":[126],"sensitivity,":[128],"prolongs":[130],"muscle":[131],"relaxation":[132],"during":[133],"twitch":[134],"contractions.":[135],"These":[136],"are":[138],"achieved":[139],"[Ca2+]":[142],"sensitivity":[143],"transition":[146],"rate":[147],"\u201cOFF\u201d":[151],"state":[152,155],"\u201cON\u201d":[154],"decreasing":[158],"ADP":[159],"release":[160],"rate,":[161],"prolonged":[164],"development.":[166],"Our":[167],"findings":[168],"suggest":[169],"has":[172],"improve":[176],"DCM,":[181],"providing":[182],"valuable":[184],"tool":[185],"for":[186],"predicting":[187],"drug":[188],"efficacy":[189],"silico.":[191],"Further":[192],"validation":[193],"tissue":[197],"needed":[199],"confirm":[201],"its":[202],"therapeutic":[203],"impact.":[204]},"counts_by_year":[],"updated_date":"2026-08-29T07:29:34.045763","created_date":"2025-10-10T00:00:00"}
