{"id":"https://openalex.org/W4200156396","doi":"https://doi.org/10.1109/bibe52308.2021.9635428","title":"Computational Modeling of Sarcomere Protein Mutations and Drug Effects on Cardiac Muscle Behavior","display_name":"Computational Modeling of Sarcomere Protein Mutations and Drug Effects on Cardiac Muscle Behavior","publication_year":2021,"publication_date":"2021-10-25","ids":{"openalex":"https://openalex.org/W4200156396","doi":"https://doi.org/10.1109/bibe52308.2021.9635428"},"language":"en","primary_location":{"id":"doi:10.1109/bibe52308.2021.9635428","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe52308.2021.9635428","pdf_url":null,"source":{"id":"https://openalex.org/S4363608533","display_name":"2021 IEEE 21st International Conference on Bioinformatics and Bioengineering (BIBE)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE 21st International Conference on Bioinformatics and Bioengineering (BIBE)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041796439","display_name":"Mom\u010dilo Prodanovi\u0107","orcid":"https://orcid.org/0000-0003-0556-1213"},"institutions":[{"id":"https://openalex.org/I14245010","display_name":"University of Kragujevac","ror":"https://ror.org/04f7vj627","country_code":"RS","type":"education","lineage":["https://openalex.org/I14245010"]}],"countries":["RS"],"is_corresponding":true,"raw_author_name":"Momcilo Prodanovic","raw_affiliation_strings":["University of Kragujevac, Institute for Information Technologies Bioengineering Research and Development Center (BioIRC), Kragujevac, Serbia"],"raw_orcid":"https://orcid.org/0000-0003-0556-1213","affiliations":[{"raw_affiliation_string":"University of Kragujevac, Institute for Information Technologies Bioengineering Research and Development Center (BioIRC), Kragujevac, Serbia","institution_ids":["https://openalex.org/I14245010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074739854","display_name":"Boban Stojanovi\u0107","orcid":"https://orcid.org/0000-0003-2901-0061"},"institutions":[{"id":"https://openalex.org/I14245010","display_name":"University of Kragujevac","ror":"https://ror.org/04f7vj627","country_code":"RS","type":"education","lineage":["https://openalex.org/I14245010"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Boban Stojanovic","raw_affiliation_strings":["Faculty of Science, University of Kragujevac, Bioengineering Research and Development Center (BioIRC), Kragujevac, Serbia"],"raw_orcid":"https://orcid.org/0000-0003-2901-0061","affiliations":[{"raw_affiliation_string":"Faculty of Science, University of Kragujevac, Bioengineering Research and Development Center (BioIRC), Kragujevac, Serbia","institution_ids":["https://openalex.org/I14245010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043172989","display_name":"Danica Prodanovic","orcid":"https://orcid.org/0000-0002-4770-5468"},"institutions":[{"id":"https://openalex.org/I14245010","display_name":"University of Kragujevac","ror":"https://ror.org/04f7vj627","country_code":"RS","type":"education","lineage":["https://openalex.org/I14245010"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Danica Prodanovic","raw_affiliation_strings":["Faculty of Science, University of Kragujevac, Bioengineering Research and Development Center (BioIRC), Kragujevac, Serbia"],"raw_orcid":"https://orcid.org/0000-0002-4770-5468","affiliations":[{"raw_affiliation_string":"Faculty of Science, University of Kragujevac, Bioengineering Research and Development Center (BioIRC), Kragujevac, Serbia","institution_ids":["https://openalex.org/I14245010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006131395","display_name":"Nenad Filipovi\u0107","orcid":"https://orcid.org/0000-0001-9964-5615"},"institutions":[{"id":"https://openalex.org/I14245010","display_name":"University of Kragujevac","ror":"https://ror.org/04f7vj627","country_code":"RS","type":"education","lineage":["https://openalex.org/I14245010"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Nenad Filipovic","raw_affiliation_strings":["Faculty of Engineering, University of Kragujevac, Bioengineering Research and Development Center (BioIRC), Kragujevac, Serbia"],"raw_orcid":"https://orcid.org/0000-0001-9964-5615","affiliations":[{"raw_affiliation_string":"Faculty of Engineering, University of Kragujevac, Bioengineering Research and Development Center (BioIRC), Kragujevac, Serbia","institution_ids":["https://openalex.org/I14245010"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041031779","display_name":"Srboljub M. Mijailovich","orcid":"https://orcid.org/0000-0003-2640-3548"},"institutions":[{"id":"https://openalex.org/I180949307","display_name":"Illinois Institute of Technology","ror":"https://ror.org/037t3ry66","country_code":"US","type":"education","lineage":["https://openalex.org/I180949307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Srboljub M. Mijailovich","raw_affiliation_strings":["Illinois Institute of Technology, Chicago, IL, USA"],"raw_orcid":"https://orcid.org/0000-0003-2640-3548","affiliations":[{"raw_affiliation_string":"Illinois Institute of Technology, Chicago, IL, USA","institution_ids":["https://openalex.org/I180949307"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5041796439"],"corresponding_institution_ids":["https://openalex.org/I14245010"],"apc_list":null,"apc_paid":null,"fwci":1.3826,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.78035714,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"6","issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11922","display_name":"Cardiovascular Effects of Exercise","score":0.9894999861717224,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9886999726295471,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sarcomere","display_name":"Sarcomere","score":0.8744332790374756},{"id":"https://openalex.org/keywords/contractility","display_name":"Contractility","score":0.7504312992095947},{"id":"https://openalex.org/keywords/myosin","display_name":"Myosin","score":0.6613351106643677},{"id":"https://openalex.org/keywords/tropomyosin","display_name":"Tropomyosin","score":0.6183348894119263},{"id":"https://openalex.org/keywords/troponin","display_name":"Troponin","score":0.5507100224494934},{"id":"https://openalex.org/keywords/cardiac-muscle","display_name":"Cardiac muscle","score":0.5059437155723572},{"id":"https://openalex.org/keywords/myh7","display_name":"MYH7","score":0.4945087134838104},{"id":"https://openalex.org/keywords/myofilament","display_name":"Myofilament","score":0.4915820062160492},{"id":"https://openalex.org/keywords/muscle-contraction","display_name":"Muscle contraction","score":0.418123722076416},{"id":"https://openalex.org/keywords/myocyte","display_name":"Myocyte","score":0.4115694761276245},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.36099886894226074},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.35218679904937744},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3476080596446991},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.34624379873275757},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3325969874858856},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.32209792733192444},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3091943860054016},{"id":"https://openalex.org/keywords/myosin-light-chain-kinase","display_name":"Myosin light-chain kinase","score":0.2111188769340515}],"concepts":[{"id":"https://openalex.org/C68731436","wikidata":"https://www.wikidata.org/wiki/Q1337087","display_name":"Sarcomere","level":3,"score":0.8744332790374756},{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.7504312992095947},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.6613351106643677},{"id":"https://openalex.org/C205875245","wikidata":"https://www.wikidata.org/wiki/Q418454","display_name":"Tropomyosin","level":3,"score":0.6183348894119263},{"id":"https://openalex.org/C36036425","wikidata":"https://www.wikidata.org/wiki/Q7846262","display_name":"Troponin","level":3,"score":0.5507100224494934},{"id":"https://openalex.org/C2778996579","wikidata":"https://www.wikidata.org/wiki/Q10334846","display_name":"Cardiac muscle","level":2,"score":0.5059437155723572},{"id":"https://openalex.org/C74581901","wikidata":"https://www.wikidata.org/wiki/Q14876107","display_name":"MYH7","level":4,"score":0.4945087134838104},{"id":"https://openalex.org/C174054327","wikidata":"https://www.wikidata.org/wiki/Q6947920","display_name":"Myofilament","level":3,"score":0.4915820062160492},{"id":"https://openalex.org/C2776050358","wikidata":"https://www.wikidata.org/wiki/Q127006","display_name":"Muscle contraction","level":2,"score":0.418123722076416},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.4115694761276245},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.36099886894226074},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35218679904937744},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3476080596446991},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34624379873275757},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3325969874858856},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32209792733192444},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3091943860054016},{"id":"https://openalex.org/C8035138","wikidata":"https://www.wikidata.org/wiki/Q6017854","display_name":"Myosin light-chain kinase","level":3,"score":0.2111188769340515},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibe52308.2021.9635428","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe52308.2021.9635428","pdf_url":null,"source":{"id":"https://openalex.org/S4363608533","display_name":"2021 IEEE 21st International Conference on Bioinformatics and Bioengineering (BIBE)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE 21st International Conference on Bioinformatics and Bioengineering (BIBE)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6899999976158142}],"awards":[{"id":"https://openalex.org/G2590404485","display_name":null,"funder_award_id":"451-03-9/2021-14/200378","funder_id":"https://openalex.org/F4320322729","funder_display_name":"Ministarstvo Prosvete, Nauke i Tehnolo\u0161kog Razvoja"},{"id":"https://openalex.org/G7573173050","display_name":null,"funder_award_id":"777204","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"}],"funders":[{"id":"https://openalex.org/F4320322729","display_name":"Ministarstvo Prosvete, Nauke i Tehnolo\u0161kog Razvoja","ror":"https://ror.org/01znas443"},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W342730161","https://openalex.org/W1992100033","https://openalex.org/W2018375125","https://openalex.org/W2019201408","https://openalex.org/W2025666521","https://openalex.org/W2031129844","https://openalex.org/W2037576214","https://openalex.org/W2075174490","https://openalex.org/W2091137020","https://openalex.org/W2163133881","https://openalex.org/W2340059643","https://openalex.org/W2556378489","https://openalex.org/W2579673837","https://openalex.org/W2605370065","https://openalex.org/W2606113495","https://openalex.org/W2801397054","https://openalex.org/W2923525281","https://openalex.org/W2926802907","https://openalex.org/W2966576580","https://openalex.org/W2977464806","https://openalex.org/W2980147512","https://openalex.org/W2990437078","https://openalex.org/W2995523948","https://openalex.org/W3004506483","https://openalex.org/W3011165445","https://openalex.org/W3081778241","https://openalex.org/W3124625267","https://openalex.org/W3129556747","https://openalex.org/W3170556234","https://openalex.org/W7037685740"],"related_works":["https://openalex.org/W1979286094","https://openalex.org/W2079130687","https://openalex.org/W2782843407","https://openalex.org/W2102036742","https://openalex.org/W2012305640","https://openalex.org/W2914415696","https://openalex.org/W2026461827","https://openalex.org/W4312988498","https://openalex.org/W3048851789","https://openalex.org/W2087514996"],"abstract_inverted_index":{"Hypertrophic":[0],"and":[1,18,32,37,54,76,96,102,119],"Dilated":[2],"Cardiomyopathies":[3],"are":[4],"caused":[5],"by":[6],"inherited":[7],"mutations":[8,28,93],"in":[9,44,94],"sarcomeric":[10],"proteins:":[11],"Myosin":[12,19],"(M),":[13],"Troponin":[14],"(Tn),":[15],"Tropomyosin":[16],"(Tm)":[17],"Binding":[20],"Protein-C":[21],"(MyBP-C).":[22],"A":[23],"quantitative":[24],"understanding":[25],"of":[26,50,92,112],"how":[27,38],"change":[29],"protein":[30,117],"behaviour,":[31],"hence":[33],"cardiac":[34,99,120],"muscle":[35,100,121],"contraction,":[36],"adaptations":[39],"to":[40,69],"these":[41,85],"changes":[42],"result":[43],"disease,":[45],"could":[46],"accelerate":[47],"the":[48,71,82,90,110],"design":[49],"novel":[51],"personalized":[52],"treatments":[53],"therapeutics.":[55],"Newly":[56],"developed":[57],"multiscale":[58],"computational":[59,86],"tools,":[60,87],"tightly":[61],"interlaced":[62],"with":[63,74],"multiple":[64],"experiments,":[65],"can":[66],"enhance":[67],"efforts":[68],"correct":[70],"problems":[72],"associated":[73],"cardiomyopathies":[75],"prevent":[77],"or":[78],"more":[79],"effectively":[80],"manage":[81],"disease.":[83],"Using":[84],"we":[88],"examined":[89,109],"effects":[91,111],"myosin":[95],"troponin":[97],"on":[98],"contractility":[101],"overall":[103],"heart":[104],"functional":[105],"behaviour.":[106],"We":[107],"also":[108],"potential":[113],"therapeutics":[114],"that":[115],"modulate":[116],"interactions":[118],"contractility.":[122]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
