{"id":"https://openalex.org/W4200222600","doi":"https://doi.org/10.1109/bibe52308.2021.9635412","title":"Numerical modelling in assessment of different colorectal cancer cell lines behavior in treatment with cisplatin","display_name":"Numerical modelling in assessment of different colorectal cancer cell lines behavior in treatment with cisplatin","publication_year":2021,"publication_date":"2021-10-25","ids":{"openalex":"https://openalex.org/W4200222600","doi":"https://doi.org/10.1109/bibe52308.2021.9635412"},"language":"en","primary_location":{"id":"doi:10.1109/bibe52308.2021.9635412","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe52308.2021.9635412","pdf_url":null,"source":{"id":"https://openalex.org/S4363608533","display_name":"2021 IEEE 21st International Conference on Bioinformatics and Bioengineering (BIBE)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE 21st International Conference on Bioinformatics and Bioengineering (BIBE)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000220209","display_name":"Dragana \u0160ekli\u0107","orcid":"https://orcid.org/0000-0002-2093-5335"},"institutions":[{"id":"https://openalex.org/I14245010","display_name":"University of Kragujevac","ror":"https://ror.org/04f7vj627","country_code":"RS","type":"education","lineage":["https://openalex.org/I14245010"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Dragana Seklic","raw_affiliation_strings":["Institute for Information Technologies Kragujevac, University of Kragujevac,Department of Natural Sciences,Kragujevac,Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Information Technologies Kragujevac, University of Kragujevac,Department of Natural Sciences,Kragujevac,Serbia","institution_ids":["https://openalex.org/I14245010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114092454","display_name":"Tijana \u0110uki\u0107","orcid":null},"institutions":[{"id":"https://openalex.org/I14245010","display_name":"University of Kragujevac","ror":"https://ror.org/04f7vj627","country_code":"RS","type":"education","lineage":["https://openalex.org/I14245010"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Tijana Dukic","raw_affiliation_strings":["Institute for Information Technologies Kragujevac, University of Kragujevac,Department of Technical-Technological Sciences,Kragujevac,Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Information Technologies Kragujevac, University of Kragujevac,Department of Technical-Technological Sciences,Kragujevac,Serbia","institution_ids":["https://openalex.org/I14245010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032540995","display_name":"Marko \u017divanovi\u0107","orcid":"https://orcid.org/0000-0002-8833-8035"},"institutions":[{"id":"https://openalex.org/I14245010","display_name":"University of Kragujevac","ror":"https://ror.org/04f7vj627","country_code":"RS","type":"education","lineage":["https://openalex.org/I14245010"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Marko Zivanovic","raw_affiliation_strings":["Institute for Information Technologies Kragujevac, University of Kragujevac,Department of Natural Sciences,Kragujevac,Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Information Technologies Kragujevac, University of Kragujevac,Department of Natural Sciences,Kragujevac,Serbia","institution_ids":["https://openalex.org/I14245010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076104708","display_name":"Milena Jovanovi\u0107","orcid":"https://orcid.org/0000-0002-2003-8124"},"institutions":[{"id":"https://openalex.org/I14245010","display_name":"University of Kragujevac","ror":"https://ror.org/04f7vj627","country_code":"RS","type":"education","lineage":["https://openalex.org/I14245010"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Milena Jovanovic","raw_affiliation_strings":["University of Kragujevac,Faculty of Science,Department for Biology and Ecology,Kragujevac,Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kragujevac,Faculty of Science,Department for Biology and Ecology,Kragujevac,Serbia","institution_ids":["https://openalex.org/I14245010"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006131395","display_name":"Nenad Filipovi\u0107","orcid":"https://orcid.org/0000-0001-9964-5615"},"institutions":[{"id":"https://openalex.org/I14245010","display_name":"University of Kragujevac","ror":"https://ror.org/04f7vj627","country_code":"RS","type":"education","lineage":["https://openalex.org/I14245010"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Nenad Filipovic","raw_affiliation_strings":["University of Kragujevac,Faculty of Engineering Science,Department for Applied Mechanics and Automatic Control,Kragujevac,Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kragujevac,Faculty of Engineering Science,Department for Applied Mechanics and Automatic Control,Kragujevac,Serbia","institution_ids":["https://openalex.org/I14245010"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I14245010"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.22532588,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"68","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9696000218391418,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"Colorectal cancer","score":0.7080024480819702},{"id":"https://openalex.org/keywords/cisplatin","display_name":"Cisplatin","score":0.6572789549827576},{"id":"https://openalex.org/keywords/metastasis","display_name":"Metastasis","score":0.5721856951713562},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5038749575614929},{"id":"https://openalex.org/keywords/cell-culture","display_name":"Cell culture","score":0.44021567702293396},{"id":"https://openalex.org/keywords/cancer-cell","display_name":"Cancer cell","score":0.4332835078239441},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.398686945438385},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2790147364139557},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"Chemotherapy","score":0.1377166211605072},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.0974191427230835}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7080024480819702},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.6572789549827576},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5721856951713562},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5038749575614929},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.44021567702293396},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4332835078239441},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.398686945438385},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2790147364139557},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.1377166211605072},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0974191427230835}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibe52308.2021.9635412","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe52308.2021.9635412","pdf_url":null,"source":{"id":"https://openalex.org/S4363608533","display_name":"2021 IEEE 21st International Conference on Bioinformatics and Bioengineering (BIBE)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE 21st International Conference on Bioinformatics and Bioengineering (BIBE)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"awards":[{"id":"https://openalex.org/G2433653715","display_name":null,"funder_award_id":"451-03-68/2020-14/200122,451-03-09/2021-14/200378,451-03-9/2021-14/200122","funder_id":"https://openalex.org/F4320322729","funder_display_name":"Ministarstvo Prosvete, Nauke i Tehnolo\u0161kog Razvoja"}],"funders":[{"id":"https://openalex.org/F4320322729","display_name":"Ministarstvo Prosvete, Nauke i Tehnolo\u0161kog Razvoja","ror":"https://ror.org/01znas443"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W2041684917","https://openalex.org/W2095202492","https://openalex.org/W2099540110","https://openalex.org/W2171074980","https://openalex.org/W2276880920","https://openalex.org/W2592244932","https://openalex.org/W2593870963","https://openalex.org/W2756115418","https://openalex.org/W2779263916","https://openalex.org/W2974072826","https://openalex.org/W2989681357","https://openalex.org/W3033738814","https://openalex.org/W4211001330","https://openalex.org/W4389116745","https://openalex.org/W6770180862"],"related_works":["https://openalex.org/W2091461259","https://openalex.org/W2406608798","https://openalex.org/W2080420195","https://openalex.org/W2406596433","https://openalex.org/W2066496973","https://openalex.org/W2460036924","https://openalex.org/W3032784534","https://openalex.org/W2566344969","https://openalex.org/W1977499057","https://openalex.org/W4213439341"],"abstract_inverted_index":{"Colorectal":[0],"cancer":[1,10,51,69],"is":[2,20],"one":[3],"of":[4,9,32,85,94,113],"the":[5,86,110,114],"most":[6],"common":[7],"types":[8],"and":[11,39,61,96],"metastasis":[12,27],"particular":[13],"problem":[14],"in":[15,26,47,50,59,66],"anticancer":[16,76],"treatment.":[17],"Therefore,":[18],"it":[19],"crucial":[21],"to":[22,56],"understand":[23],"key":[24],"steps":[25],"formation,":[28],"such":[29],"as":[30],"loss":[31],"adherent":[33],"junctions.":[34],"<tex":[35,40,62,97],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[36,41,63,98],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$\\mathbf{E}$</tex>":[37],"-cadherin":[38],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$\\beta$</tex>":[42,64,99],"-catenin":[43,65,100],"are":[44],"proteins":[45],"involved":[46],"cell-cell":[48],"junctions":[49],"cells.":[52],"Present":[53],"study":[54],"aimed":[55],"explain":[57],"changes":[58],"E-cadherin":[60,95],"two":[67],"colorectal":[68],"cell":[70],"lines":[71],"after":[72],"treatment":[73],"with":[74],"standard":[75],"drug":[77],"cisplatin,":[78],"by":[79,91,103],"using":[80],"numerical":[81,111],"modelling.":[82],"The":[83],"validity":[84],"mathematical":[87],"model":[88,112,129],"was":[89],"tested":[90],"experimental":[92,119],"measurement":[93],"protein":[101],"expression":[102],"immunofluorescent":[104],"method.":[105],"Our":[106],"results":[107,120],"shows":[108],"that":[109],"Wnt":[115],"pathway":[116],"completely":[117],"confirms":[118],"for":[121,125],"HCT-116":[122],"cells,":[123],"while":[124],"SW-480":[126],"cells":[127],"this":[128],"should":[130],"be":[131],"adjusted.":[132]},"counts_by_year":[],"updated_date":"2026-06-26T08:34:08.712188","created_date":"2025-10-10T00:00:00"}