{"id":"https://openalex.org/W4200343154","doi":"https://doi.org/10.1109/bibe52308.2021.9635339","title":"Machine Learning Predicts Treatment Response in Bipolar & Major Depression Disorders","display_name":"Machine Learning Predicts Treatment Response in Bipolar & Major Depression Disorders","publication_year":2021,"publication_date":"2021-10-25","ids":{"openalex":"https://openalex.org/W4200343154","doi":"https://doi.org/10.1109/bibe52308.2021.9635339"},"language":"en","primary_location":{"id":"doi:10.1109/bibe52308.2021.9635339","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe52308.2021.9635339","pdf_url":null,"source":{"id":"https://openalex.org/S4363608533","display_name":"2021 IEEE 21st International Conference on Bioinformatics and Bioengineering (BIBE)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE 21st International Conference on Bioinformatics and Bioengineering (BIBE)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022073041","display_name":"Mustafa S. Salman","orcid":"https://orcid.org/0000-0002-3545-3195"},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]},{"id":"https://openalex.org/I4210133909","display_name":"Center for Translational Research in Neuroimaging and Data Science","ror":"https://ror.org/02qx6zf82","country_code":"US","type":"facility","lineage":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I181565077","https://openalex.org/I4210133909"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mustafa S. Salman","raw_affiliation_strings":["School of Electrical & Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA","Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS) Georgia State University, Georgia Institute of Technology, and Emory University, Atlanta, GA, USA"],"affiliations":[{"raw_affiliation_string":"School of Electrical & Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA","institution_ids":["https://openalex.org/I130701444"]},{"raw_affiliation_string":"Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS) Georgia State University, Georgia Institute of Technology, and Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I4210133909","https://openalex.org/I130701444","https://openalex.org/I181565077","https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078906766","display_name":"Eric Verner","orcid":"https://orcid.org/0000-0002-1461-4818"},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I4210133909","display_name":"Center for Translational Research in Neuroimaging and Data Science","ror":"https://ror.org/02qx6zf82","country_code":"US","type":"facility","lineage":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I181565077","https://openalex.org/I4210133909"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Verner","raw_affiliation_strings":["Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS) Georgia State University, Georgia Institute of Technology, and Emory University, Atlanta, GA, USA"],"affiliations":[{"raw_affiliation_string":"Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS) Georgia State University, Georgia Institute of Technology, and Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I4210133909","https://openalex.org/I130701444","https://openalex.org/I181565077","https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085796625","display_name":"H. Jeremy Bockholt","orcid":null},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I4210133909","display_name":"Center for Translational Research in Neuroimaging and Data Science","ror":"https://ror.org/02qx6zf82","country_code":"US","type":"facility","lineage":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I181565077","https://openalex.org/I4210133909"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Jeremy Bockholt","raw_affiliation_strings":["Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS) Georgia State University, Georgia Institute of Technology, and Emory University, Atlanta, GA, USA"],"affiliations":[{"raw_affiliation_string":"Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS) Georgia State University, Georgia Institute of Technology, and Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I4210133909","https://openalex.org/I130701444","https://openalex.org/I181565077","https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019983016","display_name":"Zening Fu","orcid":"https://orcid.org/0000-0002-1591-4900"},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]},{"id":"https://openalex.org/I4210133909","display_name":"Center for Translational Research in Neuroimaging and Data Science","ror":"https://ror.org/02qx6zf82","country_code":"US","type":"facility","lineage":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I181565077","https://openalex.org/I4210133909"]},{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zening Fu","raw_affiliation_strings":["Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS) Georgia State University, Georgia Institute of Technology, and Emory University, Atlanta, GA, USA"],"affiliations":[{"raw_affiliation_string":"Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS) Georgia State University, Georgia Institute of Technology, and Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I4210133909","https://openalex.org/I130701444","https://openalex.org/I181565077","https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032850756","display_name":"Vince D. Calhoun","orcid":"https://orcid.org/0000-0001-9058-0747"},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I4210133909","display_name":"Center for Translational Research in Neuroimaging and Data Science","ror":"https://ror.org/02qx6zf82","country_code":"US","type":"facility","lineage":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I181565077","https://openalex.org/I4210133909"]},{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vince D. Calhoun","raw_affiliation_strings":["School of Electrical & Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA","Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS) Georgia State University, Georgia Institute of Technology, and Emory University, Atlanta, GA, USA"],"affiliations":[{"raw_affiliation_string":"School of Electrical & Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA","institution_ids":["https://openalex.org/I130701444"]},{"raw_affiliation_string":"Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS) Georgia State University, Georgia Institute of Technology, and Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I4210133909","https://openalex.org/I130701444","https://openalex.org/I181565077","https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5022073041"],"corresponding_institution_ids":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I181565077","https://openalex.org/I4210133909"],"apc_list":null,"apc_paid":null,"fwci":1.1073,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.85616438,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.965499997138977,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13283","display_name":"Mental Health Research Topics","score":0.945900022983551,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"Major depressive disorder","score":0.6982458829879761},{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.667597770690918},{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"Bipolar disorder","score":0.6322630643844604},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6246225237846375},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5896473526954651},{"id":"https://openalex.org/keywords/mood","display_name":"Mood","score":0.4623379111289978},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4601585865020752},{"id":"https://openalex.org/keywords/mania","display_name":"Mania","score":0.45456555485725403},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.3002368211746216},{"id":"https://openalex.org/keywords/psychiatry","display_name":"Psychiatry","score":0.2954826056957245}],"concepts":[{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.6982458829879761},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.667597770690918},{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.6322630643844604},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6246225237846375},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5896473526954651},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.4623379111289978},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4601585865020752},{"id":"https://openalex.org/C2776809841","wikidata":"https://www.wikidata.org/wiki/Q185935","display_name":"Mania","level":4,"score":0.45456555485725403},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3002368211746216},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2954826056957245}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibe52308.2021.9635339","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe52308.2021.9635339","pdf_url":null,"source":{"id":"https://openalex.org/S4363608533","display_name":"2021 IEEE 21st International Conference on Bioinformatics and Bioengineering (BIBE)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE 21st International Conference on Bioinformatics and Bioengineering (BIBE)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7400000095367432,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G2322238585","display_name":null,"funder_award_id":"5R41MH122201,R01MH118695","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306080","display_name":"Foundation for the National Institutes of Health","ror":"https://ror.org/00k86s890"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1528119265","https://openalex.org/W1966717548","https://openalex.org/W1985311190","https://openalex.org/W2091177453","https://openalex.org/W2096672020","https://openalex.org/W2098787985","https://openalex.org/W2107665951","https://openalex.org/W2109743529","https://openalex.org/W2115971978","https://openalex.org/W2145394798","https://openalex.org/W2152773535","https://openalex.org/W2161282771","https://openalex.org/W2167386819","https://openalex.org/W2298299786","https://openalex.org/W2886208406","https://openalex.org/W2950030754","https://openalex.org/W2950086191","https://openalex.org/W2952766316","https://openalex.org/W3048396787","https://openalex.org/W3087237868","https://openalex.org/W3088350896","https://openalex.org/W3174654239","https://openalex.org/W4398418205"],"related_works":["https://openalex.org/W2462983098","https://openalex.org/W2132014094","https://openalex.org/W3198313168","https://openalex.org/W2390951968","https://openalex.org/W3176398639","https://openalex.org/W2059519261","https://openalex.org/W2102123970","https://openalex.org/W2414753374","https://openalex.org/W4232489090","https://openalex.org/W1992641180"],"abstract_inverted_index":{"Diagnosis":[0],"of":[1,42,44,69,100,194,217,219],"bipolar":[2,172],"disorder":[3,16,173,178],"(BD)":[4,174],"patients":[5],"without":[6,202],"evident":[7],"mania":[8],"can":[9,36,54,212],"lead":[10,37],"to":[11,38,96,126,196],"misdiagnosis":[12],"as":[13],"major":[14,176],"depressive":[15,177],"(MDD).":[17],"The":[18,148],"current":[19],"Diagnostic":[20],"and":[21,30,71,134,175],"Statistical":[22],"Manual":[23],"(DSM)":[24],"is":[25,82],"not":[26],"based":[27,33,79,141],"on":[28,34,142,186],"pathopsychology,":[29],"the":[31,52,98,155,183],"diagnosis":[32],"DSM":[35,53],"an":[39],"imperfect":[40],"prediction":[41],"medication-class":[43,99,218],"response":[45,101,220],"in":[46,130,153,190,224],"such":[47],"complex":[48],"cases.":[49],"Clinicians":[50],"using":[51,66,203],"spend":[55],"months":[56],"or":[57,206],"even":[58],"years":[59],"choosing":[60],"a":[61,64,67,77,89,117,131,136,191],"medication":[62],"for":[63,139],"patient":[65,104],"process":[68],"trial":[70],"error.":[72],"To":[73],"improve":[74],"this":[75],"situation,":[76],"biologically":[78],"classification":[80],"algorithm":[81,95,185],"needed.":[83],"Osuch":[84],"et":[85],"al.":[86],"(2018)":[87],"presented":[88],"kernel":[90,137],"support":[91],"vector":[92],"machine":[93],"(SVM)-based":[94],"predict":[97],"from":[102,145],"new":[103],"samples":[105],"whose":[106],"diagnoses":[107],"were":[108],"unclear.":[109],"Here":[110],"we":[111],"extend":[112],"their":[113],"work":[114],"by":[115],"applying":[116],"robust,":[118],"fully":[119],"automated":[120],"Neu-romark":[121],"independent":[122],"component":[123],"analysis":[124],"framework":[125,150],"extract":[127],"comparable":[128],"features":[129],"multi-dataset":[132],"setting":[133],"learning":[135],"function":[138],"SVM":[140],"different":[143],"subspaces":[144],"multiple":[146],"modalities.":[147],"Neuromark":[149],"was":[151],"successful":[152],"replicating":[154],"prior":[156],"result":[157],"with":[158],"95.45%":[159],"accuracy":[160,193],"(sensitivity":[161,198],"90.24%,":[162],"specificity":[163,200],"92.3%).":[164],"We":[165,181],"further":[166],"incorporated":[167],"two":[168],"additional":[169],"datasets":[170],"comprising":[171],"(MDD)":[179],"patients.":[180],"validated":[182],"trained":[184],"these":[187],"datasets,":[188],"resulting":[189],"testing":[192],"up":[195],"87.48%":[197],"95%,":[199],"91.36%)":[201],"any":[204],"site":[205],"scanner":[207],"harmonization":[208],"techniques.":[209],"This":[210],"approach":[211],"help":[213],"reveal":[214],"biological":[215],"markers":[216],"within":[221],"mood":[222],"disorders":[223],"clinical":[225],"settings.":[226]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-01-03T23:08:47.215875","created_date":"2025-10-10T00:00:00"}