{"id":"https://openalex.org/W4200133681","doi":"https://doi.org/10.1109/bibe52308.2021.9635163","title":"A novel Greedy approach for Sequence based Computational prediction of Binding-Sites in Protein-Protein Interaction","display_name":"A novel Greedy approach for Sequence based Computational prediction of Binding-Sites in Protein-Protein Interaction","publication_year":2021,"publication_date":"2021-10-25","ids":{"openalex":"https://openalex.org/W4200133681","doi":"https://doi.org/10.1109/bibe52308.2021.9635163"},"language":"en","primary_location":{"id":"doi:10.1109/bibe52308.2021.9635163","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe52308.2021.9635163","pdf_url":null,"source":{"id":"https://openalex.org/S4363608533","display_name":"2021 IEEE 21st International Conference on Bioinformatics and Bioengineering (BIBE)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE 21st International Conference on Bioinformatics and Bioengineering (BIBE)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051048333","display_name":"Aishwarya Purohit","orcid":null},"institutions":[{"id":"https://openalex.org/I67031392","display_name":"Carleton University","ror":"https://ror.org/02qtvee93","country_code":"CA","type":"education","lineage":["https://openalex.org/I67031392"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Aishwarya Purohit","raw_affiliation_strings":["Carleton University,Systems & Computer Engineering"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carleton University,Systems & Computer Engineering","institution_ids":["https://openalex.org/I67031392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110486236","display_name":"Shrinivas Acharya","orcid":null},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shrinivas Acharya","raw_affiliation_strings":["University Of Washington,Computer Science & Engineering"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Of Washington,Computer Science & Engineering","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100779586","display_name":"James Green","orcid":"https://orcid.org/0000-0002-4625-9216"},"institutions":[{"id":"https://openalex.org/I67031392","display_name":"Carleton University","ror":"https://ror.org/02qtvee93","country_code":"CA","type":"education","lineage":["https://openalex.org/I67031392"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"James Green","raw_affiliation_strings":["Carleton University,Systems & Computer Engineering"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carleton University,Systems & Computer Engineering","institution_ids":["https://openalex.org/I67031392"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5203,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.53351955,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.991599977016449,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.7125393152236938},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5812894105911255},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.5391979217529297},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.5030214190483093},{"id":"https://openalex.org/keywords/software","display_name":"Software","score":0.4408474862575531},{"id":"https://openalex.org/keywords/protein-sequencing","display_name":"Protein sequencing","score":0.4353238046169281},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.416670560836792},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.35922980308532715},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2117404043674469},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.17537832260131836},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.09287703037261963},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.0844271183013916}],"concepts":[{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.7125393152236938},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5812894105911255},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.5391979217529297},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.5030214190483093},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.4408474862575531},{"id":"https://openalex.org/C10010492","wikidata":"https://www.wikidata.org/wiki/Q3142557","display_name":"Protein sequencing","level":4,"score":0.4353238046169281},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.416670560836792},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35922980308532715},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2117404043674469},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.17537832260131836},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09287703037261963},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0844271183013916},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibe52308.2021.9635163","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe52308.2021.9635163","pdf_url":null,"source":{"id":"https://openalex.org/S4363608533","display_name":"2021 IEEE 21st International Conference on Bioinformatics and Bioengineering (BIBE)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE 21st International Conference on Bioinformatics and Bioengineering (BIBE)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W2031616673","https://openalex.org/W2103729016","https://openalex.org/W2144811782","https://openalex.org/W2161701113","https://openalex.org/W2163485494","https://openalex.org/W2287383879","https://openalex.org/W2483001990","https://openalex.org/W2618265628","https://openalex.org/W2739999456","https://openalex.org/W2793720977","https://openalex.org/W2887551661","https://openalex.org/W2944679105","https://openalex.org/W2955690154","https://openalex.org/W2969584133","https://openalex.org/W2971405760","https://openalex.org/W2981562839","https://openalex.org/W3003975929","https://openalex.org/W3004238495","https://openalex.org/W6749403042","https://openalex.org/W6769575729","https://openalex.org/W6772994721"],"related_works":["https://openalex.org/W2375480909","https://openalex.org/W2353314428","https://openalex.org/W2012019886","https://openalex.org/W2166090428","https://openalex.org/W2381021552","https://openalex.org/W2354749003","https://openalex.org/W2377121353","https://openalex.org/W2350529538","https://openalex.org/W2076713575","https://openalex.org/W2095784700"],"abstract_inverted_index":{"Computational":[0],"prediction":[1,115],"of":[2,36,58,63,88],"protein-protein":[3],"interaction":[4,37],"(PPI)":[5],"from":[6],"protein":[7],"sequence":[8],"is":[9,38,52],"important":[10],"as":[11],"many":[12],"cellular":[13],"functions":[14],"are":[15,93],"made":[16],"possible":[17],"through":[18,55],"PPI.":[19],"The":[20,33],"Protein":[21],"Interaction":[22],"Prediction":[23],"Engine":[24],"(PIPE)":[25],"software":[26],"suite":[27],"was":[28],"developed":[29,74],"for":[30,85],"such":[31],"predictions.":[32],"specific":[34],"location":[35],"predicted":[39],"by":[40],"the":[41,56,86],"PIPE-Sites":[42,50,92],"predictor,":[43],"which":[44],"depends":[45],"on":[46,137],"PIPE":[47],"engine.":[48],"This":[49,119],"predictor":[51],"here":[53,106],"updated":[54],"use":[57],"a":[59,68,110],"large":[60],"high-quality":[61],"dataset":[62],"known":[64],"PPI":[65,89,113,150],"sites.":[66],"Additionally,":[67],"similarity-weighted":[69,101,123],"score":[70,102,124],"had":[71],"been":[72,79],"recently":[73],"in":[75],"PIPE4":[76],"and":[77,108,144],"has":[78],"proven":[80],"to":[81,95,100,126],"be":[82,96],"more":[83],"accurate":[84],"likelihood":[87],"prediction.":[90],"However,":[91],"shown":[94],"ineffective":[97],"when":[98,135],"applied":[99],"data.":[103,152],"Thus,":[104],"we":[105],"propose":[107],"evaluate":[109],"new":[111,120],"sequence-based":[112],"site":[114,151],"method,":[116],"named":[117],"Panorama.":[118],"method":[121],"leverages":[122],"data":[125],"further":[127],"increase":[128],"performance":[129,133],"over":[130],"two":[131],"different":[132],"metrics":[134],"evaluated":[136],"both":[138],"<tex":[139,145],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[140,146],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$\\boldsymbol{H}$</tex>":[141],".":[142],"sapiens":[143],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$\\boldsymbol{S}$</tex>":[147],",":[148],"cerevisiae":[149]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}