{"id":"https://openalex.org/W2783197879","doi":"https://doi.org/10.1109/bibe.2017.00-29","title":"CALI: A Novel Visual Model for Frequent Pattern Mining in Protein-Ligand Graphs","display_name":"CALI: A Novel Visual Model for Frequent Pattern Mining in Protein-Ligand Graphs","publication_year":2017,"publication_date":"2017-10-01","ids":{"openalex":"https://openalex.org/W2783197879","doi":"https://doi.org/10.1109/bibe.2017.00-29","mag":"2783197879"},"language":"en","primary_location":{"id":"doi:10.1109/bibe.2017.00-29","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe.2017.00-29","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE 17th International Conference on Bioinformatics and Bioengineering (BIBE)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101574949","display_name":"S. Medina","orcid":"https://orcid.org/0000-0002-9679-4858"},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Susana G. Medina","raw_affiliation_strings":["Universidade Federal de Minas Gerais, Belo Horizonte, MG, BR"],"affiliations":[{"raw_affiliation_string":"Universidade Federal de Minas Gerais, Belo Horizonte, MG, BR","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004556739","display_name":"Alexandre Victor Fassio","orcid":"https://orcid.org/0000-0002-2182-4709"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexandre V. Fassio","raw_affiliation_strings":["UFMG, Belo Horizonte, Brazil"],"affiliations":[{"raw_affiliation_string":"UFMG, Belo Horizonte, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021817826","display_name":"Sabrina de Azevedo Silveira","orcid":"https://orcid.org/0000-0002-4723-2349"},"institutions":[{"id":"https://openalex.org/I146165071","display_name":"Universidade Federal de Vi\u00e7osa","ror":"https://ror.org/0409dgb37","country_code":"BR","type":"education","lineage":["https://openalex.org/I146165071"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Sabrina de A. Silveira","raw_affiliation_strings":["Universidade Federal de Vicosa, Vicosa, MG, BR"],"affiliations":[{"raw_affiliation_string":"Universidade Federal de Vicosa, Vicosa, MG, BR","institution_ids":["https://openalex.org/I146165071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081110033","display_name":"Carlos Henrique da Silveira","orcid":"https://orcid.org/0000-0001-6979-8469"},"institutions":[{"id":"https://openalex.org/I8165072","display_name":"Universidade Federal de Itajub\u00e1","ror":"https://ror.org/00235nr42","country_code":"BR","type":"education","lineage":["https://openalex.org/I8165072"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Carlos H. da Silveira","raw_affiliation_strings":["Advanced Campus of Itabira, UNIFEI, Itabira, Brazil"],"affiliations":[{"raw_affiliation_string":"Advanced Campus of Itabira, UNIFEI, Itabira, Brazil","institution_ids":["https://openalex.org/I8165072"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069672238","display_name":"Raquel C. de Melo-Minardi","orcid":"https://orcid.org/0000-0001-5190-100X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raquel C. de Melo-Minardi","raw_affiliation_strings":["UFMG, Belo Horizonte, Brazil"],"affiliations":[{"raw_affiliation_string":"UFMG, Belo Horizonte, Brazil","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5101574949"],"corresponding_institution_ids":["https://openalex.org/I110200422"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.23394307,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"352","last_page":"358"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ligand","display_name":"Ligand (biochemistry)","score":0.600652813911438},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5645566582679749},{"id":"https://openalex.org/keywords/protein-ligand","display_name":"Protein ligand","score":0.5530816912651062},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.5296767950057983},{"id":"https://openalex.org/keywords/protein\u2013protein-interaction","display_name":"Protein\u2013protein interaction","score":0.48804202675819397},{"id":"https://openalex.org/keywords/interaction-network","display_name":"Interaction network","score":0.47950273752212524},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4757537543773651},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.44280943274497986},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.33144617080688477},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3259870409965515},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.32180166244506836},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.28862255811691284},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2644624412059784},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.18961501121520996},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.13596612215042114}],"concepts":[{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.600652813911438},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5645566582679749},{"id":"https://openalex.org/C109095088","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Protein ligand","level":2,"score":0.5530816912651062},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.5296767950057983},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.48804202675819397},{"id":"https://openalex.org/C55105296","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interaction network","level":3,"score":0.47950273752212524},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4757537543773651},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.44280943274497986},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33144617080688477},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3259870409965515},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.32180166244506836},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.28862255811691284},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2644624412059784},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18961501121520996},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.13596612215042114},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibe.2017.00-29","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe.2017.00-29","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE 17th International Conference on Bioinformatics and Bioengineering (BIBE)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1964444099","https://openalex.org/W1974638435","https://openalex.org/W2004734764","https://openalex.org/W2027441504","https://openalex.org/W2043212464","https://openalex.org/W2043570667","https://openalex.org/W2068271330","https://openalex.org/W2071391537","https://openalex.org/W2074473216","https://openalex.org/W2084916586","https://openalex.org/W2087174112","https://openalex.org/W2092924973","https://openalex.org/W2096679774","https://openalex.org/W2103626206","https://openalex.org/W2104863267","https://openalex.org/W2115451817","https://openalex.org/W2124983652","https://openalex.org/W2126754352","https://openalex.org/W2130479394","https://openalex.org/W2132022337","https://openalex.org/W2145928638","https://openalex.org/W2151550848","https://openalex.org/W2205598717","https://openalex.org/W2211863317","https://openalex.org/W2251503907"],"related_works":["https://openalex.org/W4229728790","https://openalex.org/W2800059693","https://openalex.org/W37860747","https://openalex.org/W2334906681","https://openalex.org/W2066232588","https://openalex.org/W4377086792","https://openalex.org/W3087302704","https://openalex.org/W2106286319","https://openalex.org/W2767490506","https://openalex.org/W2467739942"],"abstract_inverted_index":{"Protein-ligand":[0],"interaction":[1,111],"(PLI)":[2],"networks":[3],"show":[4],"how":[5],"proteins":[6],"interact":[7,90],"with":[8,44,59,91],"small":[9],"non-protein":[10],"ligands":[11],"through":[12],"noncovalent":[13],"bonding.":[14],"Understanding":[15],"such":[16],"interactions":[17,67],"is":[18],"a":[19,39,95,106,119],"crucial":[20],"step":[21],"towards":[22],"ligand":[23],"prediction,":[24],"target":[25],"identification":[26],"and":[27,51,71,83,98],"drug":[28],"design.":[29],"We":[30,93],"propose":[31],"CALI":[32,60,77],"(Complex":[33],"network-based":[34],"Analysis":[35],"of":[36,80,86,109],"protein-Ligand":[37],"Interactions),":[38],"graph-based,":[40],"visual":[41,97],"strategy":[42,100],"coupled":[43],"complex":[45],"network":[46],"topological":[47],"properties":[48],"to":[49,63,101],"summarize":[50],"detect":[52],"frequent":[53],"patterns":[54],"in":[55],"PLIs.":[56],"Patterns":[57],"obtained":[58],"were":[61],"compared":[62],"experimentally":[64],"determined":[65],"protein-ligand":[66],"from":[68,118],"the":[69,75,87,103,110,114],"CDK2":[70],"Ricin":[72,88],"dataset.":[73],"For":[74],"CDK2,":[76],"found":[78],"90%":[79],"interacting":[81],"residues,":[82],"all":[84],"residues":[85],"that":[89],"ligands.":[92],"devised":[94],"powerful":[96],"interactive":[99],"analyze":[102],"data,":[104],"providing":[105],"general":[107],"view":[108],"dataset,":[112],"showing":[113],"most":[115],"common":[116],"PLIs":[117],"global":[120],"perspective.":[121]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}