{"id":"https://openalex.org/W2215343687","doi":"https://doi.org/10.1109/bibe.2015.7367694","title":"Exploration of unsupervised feature selection methods in relation to the prediction of cytokine release effect correlated to antibody features in RV144 vaccines","display_name":"Exploration of unsupervised feature selection methods in relation to the prediction of cytokine release effect correlated to antibody features in RV144 vaccines","publication_year":2015,"publication_date":"2015-11-01","ids":{"openalex":"https://openalex.org/W2215343687","doi":"https://doi.org/10.1109/bibe.2015.7367694","mag":"2215343687"},"language":"en","primary_location":{"id":"doi:10.1109/bibe.2015.7367694","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe.2015.7367694","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023779408","display_name":"Ferdi Sarac","orcid":"https://orcid.org/0000-0002-7080-1634"},"institutions":[{"id":"https://openalex.org/I32394136","display_name":"Northumbria University","ror":"https://ror.org/049e6bc10","country_code":"GB","type":"education","lineage":["https://openalex.org/I32394136"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ferdi Sarac","raw_affiliation_strings":["Faculty of Engineering and Environment, The University of Northumbria at Newcastle, Newcastle-upon-Tyne, The United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Engineering and Environment, The University of Northumbria at Newcastle, Newcastle-upon-Tyne, The United Kingdom","institution_ids":["https://openalex.org/I32394136"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037936080","display_name":"Volkan Uslan","orcid":"https://orcid.org/0000-0001-6252-8853"},"institutions":[{"id":"https://openalex.org/I32394136","display_name":"Northumbria University","ror":"https://ror.org/049e6bc10","country_code":"GB","type":"education","lineage":["https://openalex.org/I32394136"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Volkan Uslan","raw_affiliation_strings":["Faculty of Engineering and Environment, The University of Northumbria at Newcastle, Newcastle-upon-Tyne, The United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Engineering and Environment, The University of Northumbria at Newcastle, Newcastle-upon-Tyne, The United Kingdom","institution_ids":["https://openalex.org/I32394136"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057405456","display_name":"H\u00fcseyin \u015eeker","orcid":"https://orcid.org/0000-0002-1255-9552"},"institutions":[{"id":"https://openalex.org/I32394136","display_name":"Northumbria University","ror":"https://ror.org/049e6bc10","country_code":"GB","type":"education","lineage":["https://openalex.org/I32394136"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Huseyin Seker","raw_affiliation_strings":["Faculty of Engineering and Environment, The University of Northumbria at Newcastle, Newcastle-upon-Tyne, The United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Engineering and Environment, The University of Northumbria at Newcastle, Newcastle-upon-Tyne, The United Kingdom","institution_ids":["https://openalex.org/I32394136"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033623398","display_name":"Ahmed Bouridane","orcid":"https://orcid.org/0000-0002-1474-2772"},"institutions":[{"id":"https://openalex.org/I32394136","display_name":"Northumbria University","ror":"https://ror.org/049e6bc10","country_code":"GB","type":"education","lineage":["https://openalex.org/I32394136"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ahmed Bouridane","raw_affiliation_strings":["Faculty of Engineering and Environment, The University of Northumbria at Newcastle, Newcastle-upon-Tyne, The United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Engineering and Environment, The University of Northumbria at Newcastle, Newcastle-upon-Tyne, The United Kingdom","institution_ids":["https://openalex.org/I32394136"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4518,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.66795732,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"9","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.9930999875068665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.815537691116333},{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.697019100189209},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.512390673160553},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.487619549036026},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.46868258714675903},{"id":"https://openalex.org/keywords/regression-analysis","display_name":"Regression analysis","score":0.4621250331401825},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.42987948656082153},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.37517672777175903},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.320828378200531}],"concepts":[{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.815537691116333},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.697019100189209},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.512390673160553},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.487619549036026},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.46868258714675903},{"id":"https://openalex.org/C152877465","wikidata":"https://www.wikidata.org/wiki/Q208042","display_name":"Regression analysis","level":2,"score":0.4621250331401825},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.42987948656082153},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.37517672777175903},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.320828378200531}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/bibe.2015.7367694","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe.2015.7367694","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE)","raw_type":"proceedings-article"},{"id":"pmh:oai:nrl.northumbria.ac.uk:26716","is_oa":false,"landing_page_url":"http://nrl.northumbria.ac.uk/26716/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401884","display_name":"Northumbria Research Link (Northumbria University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I32394136","host_organization_name":"Northumbria University","host_organization_lineage":["https://openalex.org/I32394136"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Book Section"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10","score":0.7400000095367432}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1479807131","https://openalex.org/W1528520360","https://openalex.org/W1570713908","https://openalex.org/W1852635481","https://openalex.org/W1974273518","https://openalex.org/W1983898589","https://openalex.org/W2029135056","https://openalex.org/W2034160159","https://openalex.org/W2052200679","https://openalex.org/W2057961805","https://openalex.org/W2084376194","https://openalex.org/W2096367542","https://openalex.org/W2097288560","https://openalex.org/W2110287237","https://openalex.org/W2128873747","https://openalex.org/W2133462743","https://openalex.org/W2137226992","https://openalex.org/W2143857397","https://openalex.org/W2149298154","https://openalex.org/W2149620660","https://openalex.org/W2152048324","https://openalex.org/W2152640863","https://openalex.org/W2153635508","https://openalex.org/W2158933803","https://openalex.org/W2160358721","https://openalex.org/W2164079841","https://openalex.org/W2293981868","https://openalex.org/W6681822384"],"related_works":["https://openalex.org/W2090763504","https://openalex.org/W148178222","https://openalex.org/W4298130764","https://openalex.org/W2104657898","https://openalex.org/W1948992892","https://openalex.org/W1886884218","https://openalex.org/W2804364458","https://openalex.org/W1910826599","https://openalex.org/W2012353789","https://openalex.org/W2530420969"],"abstract_inverted_index":{"Computational":[0],"methods":[1,8,100,120,136],"such":[2],"as":[3,104,157,159],"clustering,":[4],"classification":[5,171],"and":[6,24,36,63,87,92,161,170],"regression":[7,168],"can":[9],"be":[10],"applied":[11],"in":[12,54,123,139],"immunoin-formatics":[13],"to":[14,18,84,109,125,141],"construct":[15],"predictive":[16,173],"models":[17],"reveal":[19,126],"relationships":[20],"between":[21],"antibody":[22,34,77,129],"features":[23,35,78,82],"their":[25],"functional":[26,38],"outcomes.":[27],"This":[28],"paper":[29],"studies":[30],"the":[31,37,60,68,127,132,164],"effect":[32],"of":[33,57,65,81],"outcome":[39],"obtained":[40],"on":[41],"RV144":[42,46],"vaccine":[43,47,69],"recipients.":[44],"The":[45,150],"data":[48,52,73],"set":[49],"contains":[50],"100":[51],"samples":[53,62],"which":[55],"20":[56],"them":[58,66],"are":[59,67,106,121,137],"placebo":[61],"80":[64],"injected":[70],"samples.":[71],"Each":[72],"sample":[74],"has":[75],"twenty":[76],"that":[79],"consist":[80],"related":[83],"IgG":[85],"subclass":[86],"antigen":[88],"specificity.":[89],"Unlike":[90],"semi-supervised":[91],"supervised":[93],"feature":[94,98,118],"selection":[95,99,119],"methods,":[96],"unsupervised":[97,117],"provide":[101],"unbiased":[102],"approach":[103],"they":[105],"not":[107],"dependent":[108],"response":[110],"variable.":[111],"In":[112],"this":[113],"paper,":[114],"four":[115],"different":[116],"used":[122,138],"order":[124,140],"discriminating":[128],"features.":[130],"Then,":[131],"support":[133,165],"vector":[134,166],"based":[135,167],"predict":[142],"natural":[143],"killer":[144],"(NK)":[145],"cell":[146],"cytokine":[147],"release":[148],"effect.":[149],"results":[151],"yield":[152],"a":[153],"high":[154],"correlation":[155],"coefficient":[156],"much":[158],"0.59":[160],"0.72":[162],"for":[163],"(SVR)":[169],"(SVM)":[172],"models,":[174],"respectively.":[175]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}