{"id":"https://openalex.org/W2048939361","doi":"https://doi.org/10.1109/bibe.2013.6701690","title":"Towards an integrated framework for clinico-biological data management and analysis: The case of Chronic Lymphocytic Leukemia","display_name":"Towards an integrated framework for clinico-biological data management and analysis: The case of Chronic Lymphocytic Leukemia","publication_year":2013,"publication_date":"2013-11-01","ids":{"openalex":"https://openalex.org/W2048939361","doi":"https://doi.org/10.1109/bibe.2013.6701690","mag":"2048939361"},"language":"en","primary_location":{"id":"doi:10.1109/bibe.2013.6701690","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe.2013.6701690","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"13th IEEE International Conference on BioInformatics and BioEngineering","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008465692","display_name":"Evangelia Minga","orcid":null},"institutions":[{"id":"https://openalex.org/I4210134249","display_name":"Centre for Research and Technology Hellas","ror":"https://ror.org/03bndpq63","country_code":"GR","type":"facility","lineage":["https://openalex.org/I4210134249"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Evangelia Minga","raw_affiliation_strings":["Institute of Applied Biosciences (INAB), Center for Research and Technology Hellas (CERTH), Thessaloniki, Greece","Center for Res. & Technol. Hellas (CERTH), Inst. of Appl. Biosci. (INAB), Thessaloniki, Greece"],"affiliations":[{"raw_affiliation_string":"Institute of Applied Biosciences (INAB), Center for Research and Technology Hellas (CERTH), Thessaloniki, Greece","institution_ids":["https://openalex.org/I4210134249"]},{"raw_affiliation_string":"Center for Res. & Technol. Hellas (CERTH), Inst. of Appl. Biosci. (INAB), Thessaloniki, Greece","institution_ids":["https://openalex.org/I4210134249"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053965730","display_name":"Athanasios Gkoufas","orcid":null},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Athanasios Gkoufas","raw_affiliation_strings":["Lab of Medical Informatics, Aristotle University of Thessaloniki, Greece","Lab. of Med. Inf., Aristotle Univ. of Thessaloniki, Thessaloniki, Greece#TAB#"],"affiliations":[{"raw_affiliation_string":"Lab of Medical Informatics, Aristotle University of Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]},{"raw_affiliation_string":"Lab. of Med. Inf., Aristotle Univ. of Thessaloniki, Thessaloniki, Greece#TAB#","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083412701","display_name":"Anna Vardi","orcid":"https://orcid.org/0000-0002-1927-4242"},"institutions":[{"id":"https://openalex.org/I4210134249","display_name":"Centre for Research and Technology Hellas","ror":"https://ror.org/03bndpq63","country_code":"GR","type":"facility","lineage":["https://openalex.org/I4210134249"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Anna Vardi","raw_affiliation_strings":["Institute of Applied Biosciences (INAB), Center for Research and Technology Hellas (CERTH), Thessaloniki, Greece","Center for Res. & Technol. Hellas (CERTH), Inst. of Appl. Biosci. (INAB), Thessaloniki, Greece"],"affiliations":[{"raw_affiliation_string":"Institute of Applied Biosciences (INAB), Center for Research and Technology Hellas (CERTH), Thessaloniki, Greece","institution_ids":["https://openalex.org/I4210134249"]},{"raw_affiliation_string":"Center for Res. & Technol. Hellas (CERTH), Inst. of Appl. Biosci. (INAB), Thessaloniki, Greece","institution_ids":["https://openalex.org/I4210134249"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023652883","display_name":"Evangelia Stalika","orcid":"https://orcid.org/0000-0001-7856-5480"},"institutions":[{"id":"https://openalex.org/I4210134249","display_name":"Centre for Research and Technology Hellas","ror":"https://ror.org/03bndpq63","country_code":"GR","type":"facility","lineage":["https://openalex.org/I4210134249"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Evangelia Stalika","raw_affiliation_strings":["Institute of Applied Biosciences (INAB), Center for Research and Technology Hellas (CERTH), Thessaloniki, Greece","Center for Res. & Technol. Hellas (CERTH), Inst. of Appl. Biosci. (INAB), Thessaloniki, Greece"],"affiliations":[{"raw_affiliation_string":"Institute of Applied Biosciences (INAB), Center for Research and Technology Hellas (CERTH), Thessaloniki, Greece","institution_ids":["https://openalex.org/I4210134249"]},{"raw_affiliation_string":"Center for Res. & Technol. Hellas (CERTH), Inst. of Appl. Biosci. (INAB), Thessaloniki, Greece","institution_ids":["https://openalex.org/I4210134249"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002784304","display_name":"Anastasia Hadzidimitriou","orcid":"https://orcid.org/0000-0002-6575-4036"},"institutions":[{"id":"https://openalex.org/I4210134249","display_name":"Centre for Research and Technology Hellas","ror":"https://ror.org/03bndpq63","country_code":"GR","type":"facility","lineage":["https://openalex.org/I4210134249"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Anastasia Hadzidimitriou","raw_affiliation_strings":["Institute of Applied Biosciences (INAB), Center for Research and Technology Hellas (CERTH), Thessaloniki, Greece","Center for Res. & Technol. Hellas (CERTH), Inst. of Appl. Biosci. (INAB), Thessaloniki, Greece"],"affiliations":[{"raw_affiliation_string":"Institute of Applied Biosciences (INAB), Center for Research and Technology Hellas (CERTH), Thessaloniki, Greece","institution_ids":["https://openalex.org/I4210134249"]},{"raw_affiliation_string":"Center for Res. & Technol. Hellas (CERTH), Inst. of Appl. Biosci. (INAB), Thessaloniki, Greece","institution_ids":["https://openalex.org/I4210134249"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044130307","display_name":"\u039a\u03ce\u03c3\u03c4\u03b1\u03c2 \u03a3\u03c4\u03b1\u03bc\u03b1\u03c4\u03cc\u03c0\u03bf\u03c5\u03bb\u03bf\u03c2","orcid":"https://orcid.org/0000-0001-8529-640X"},"institutions":[{"id":"https://openalex.org/I4210134249","display_name":"Centre for Research and Technology Hellas","ror":"https://ror.org/03bndpq63","country_code":"GR","type":"facility","lineage":["https://openalex.org/I4210134249"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Kostas Stamatopoulos","raw_affiliation_strings":["Institute of Applied Biosciences (INAB), Center for Research and Technology Hellas (CERTH), Thessaloniki, Greece","Center for Res. & Technol. Hellas (CERTH), Inst. of Appl. Biosci. (INAB), Thessaloniki, Greece"],"affiliations":[{"raw_affiliation_string":"Institute of Applied Biosciences (INAB), Center for Research and Technology Hellas (CERTH), Thessaloniki, Greece","institution_ids":["https://openalex.org/I4210134249"]},{"raw_affiliation_string":"Center for Res. & Technol. Hellas (CERTH), Inst. of Appl. Biosci. (INAB), Thessaloniki, Greece","institution_ids":["https://openalex.org/I4210134249"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082929636","display_name":"Nicos Maglaveras","orcid":"https://orcid.org/0000-0002-4919-0664"},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Nicos Maglaveras","raw_affiliation_strings":["Lab of Medical Informatics, Aristotle University of Thessaloniki, Greece","Lab. of Med. Inf., Aristotle Univ. of Thessaloniki, Thessaloniki, Greece#TAB#"],"affiliations":[{"raw_affiliation_string":"Lab of Medical Informatics, Aristotle University of Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]},{"raw_affiliation_string":"Lab. of Med. Inf., Aristotle Univ. of Thessaloniki, Thessaloniki, Greece#TAB#","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078023454","display_name":"Ioanna Chouvarda","orcid":"https://orcid.org/0000-0001-8915-6658"},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Ioanna Chouvarda","raw_affiliation_strings":["Lab of Medical Informatics, Aristotle University of Thessaloniki, Greece","Lab. of Med. Inf., Aristotle Univ. of Thessaloniki, Thessaloniki, Greece#TAB#"],"affiliations":[{"raw_affiliation_string":"Lab of Medical Informatics, Aristotle University of Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]},{"raw_affiliation_string":"Lab. of Med. Inf., Aristotle Univ. of Thessaloniki, Thessaloniki, Greece#TAB#","institution_ids":["https://openalex.org/I21370196"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5008465692"],"corresponding_institution_ids":["https://openalex.org/I4210134249"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.09073371,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.979200005531311,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.9606000185012817,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"Chronic lymphocytic leukemia","score":0.8070068359375},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.559742271900177},{"id":"https://openalex.org/keywords/leukemia","display_name":"Leukemia","score":0.5349544286727905},{"id":"https://openalex.org/keywords/data-integration","display_name":"Data integration","score":0.5145494341850281},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.49066030979156494},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.44704747200012207},{"id":"https://openalex.org/keywords/throughput","display_name":"Throughput","score":0.4301326274871826},{"id":"https://openalex.org/keywords/biological-data","display_name":"Biological data","score":0.4264349639415741},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.36857303977012634},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.33885419368743896},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3115178942680359},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.28575390577316284},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1782517433166504},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.12947353720664978},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.11525419354438782}],"concepts":[{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.8070068359375},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.559742271900177},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5349544286727905},{"id":"https://openalex.org/C72634772","wikidata":"https://www.wikidata.org/wiki/Q386824","display_name":"Data integration","level":2,"score":0.5145494341850281},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.49066030979156494},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44704747200012207},{"id":"https://openalex.org/C157764524","wikidata":"https://www.wikidata.org/wiki/Q1383412","display_name":"Throughput","level":3,"score":0.4301326274871826},{"id":"https://openalex.org/C201797286","wikidata":"https://www.wikidata.org/wiki/Q4914986","display_name":"Biological data","level":2,"score":0.4264349639415741},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.36857303977012634},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.33885419368743896},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3115178942680359},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.28575390577316284},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1782517433166504},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.12947353720664978},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11525419354438782},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C555944384","wikidata":"https://www.wikidata.org/wiki/Q249","display_name":"Wireless","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibe.2013.6701690","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe.2013.6701690","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"13th IEEE International Conference on BioInformatics and BioEngineering","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W6276835","https://openalex.org/W135571511","https://openalex.org/W1243376384","https://openalex.org/W1551566597","https://openalex.org/W2070232733","https://openalex.org/W2081930221","https://openalex.org/W2091670726","https://openalex.org/W2111609050","https://openalex.org/W2129047745","https://openalex.org/W6600241767"],"related_works":["https://openalex.org/W579273576","https://openalex.org/W2418031697","https://openalex.org/W2307569040","https://openalex.org/W2131941936","https://openalex.org/W2366067673","https://openalex.org/W2060096282","https://openalex.org/W2541393756","https://openalex.org/W2385643360","https://openalex.org/W4375944314","https://openalex.org/W19972923"],"abstract_inverted_index":{"This":[0],"paper":[1],"addresses":[2],"the":[3,15,28,49,61,72],"challenges":[4],"of":[5,17,33,36,51],"gathering,":[6],"analyzing":[7],"and":[8,31,60,66],"employing":[9],"clinically":[10],"meaningful":[11],"biological":[12],"information,":[13],"for":[14,27,63],"advancement":[16],"translational":[18],"medicine.":[19],"In":[20],"this":[21],"respect":[22],"we":[23],"propose":[24],"an":[25],"approach":[26],"integrated":[29],"management":[30],"analysis":[32,68],"large":[34],"quantities":[35],"clinico-biological":[37],"data,":[38],"including":[39],"high-throughput":[40],"sequencing":[41],"data.":[42],"The":[43],"proposed":[44],"concepts":[45],"are":[46,69],"applied":[47],"in":[48],"case":[50],"Chronic":[52],"Lymphocytic":[53],"Leukemia,":[54],"a":[55],"paradigmatic":[56],"age-related":[57],"hematologic":[58],"cancer,":[59],"steps":[62],"data":[64],"integration":[65],"information":[67],"illustrated":[70],"via":[71],"CLL-BIND":[73],"framework.":[74]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
