{"id":"https://openalex.org/W2005825829","doi":"https://doi.org/10.1109/bibe.2013.6701600","title":"A Synthetic Biology approach to the realization of embedded feedback controllers for Chemical Reaction Networks","display_name":"A Synthetic Biology approach to the realization of embedded feedback controllers for Chemical Reaction Networks","publication_year":2013,"publication_date":"2013-11-01","ids":{"openalex":"https://openalex.org/W2005825829","doi":"https://doi.org/10.1109/bibe.2013.6701600","mag":"2005825829"},"language":"en","primary_location":{"id":"doi:10.1109/bibe.2013.6701600","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe.2013.6701600","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"13th IEEE International Conference on BioInformatics and BioEngineering","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085080876","display_name":"Carlo Cosentino","orcid":"https://orcid.org/0000-0001-5768-1829"},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Carlo Cosentino","raw_affiliation_strings":["School of Computer and Biomedical Engineering, Universit\u00e0 degli Studi Magna Gr\u00e6cia di Catanzaro, Catanzaro, Italy","Sch. of Comput. & Biomed. Eng., Univ. degli Studi Magna Graecia di Catanzaro, Catanzaro, Italy"],"affiliations":[{"raw_affiliation_string":"School of Computer and Biomedical Engineering, Universit\u00e0 degli Studi Magna Gr\u00e6cia di Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]},{"raw_affiliation_string":"Sch. of Comput. & Biomed. Eng., Univ. degli Studi Magna Graecia di Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051795556","display_name":"Mariaconcetta Bilotta","orcid":"https://orcid.org/0000-0002-1156-4878"},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mariaconcetta Bilotta","raw_affiliation_strings":["School of Computer and Biomedical Engineering, Universit\u00e0 degli Studi Magna Gr\u00e6cia di Catanzaro, Catanzaro, Italy","Sch. of Comput. & Biomed. Eng., Univ. degli Studi Magna Graecia di Catanzaro, Catanzaro, Italy"],"affiliations":[{"raw_affiliation_string":"School of Computer and Biomedical Engineering, Universit\u00e0 degli Studi Magna Gr\u00e6cia di Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]},{"raw_affiliation_string":"Sch. of Comput. & Biomed. Eng., Univ. degli Studi Magna Graecia di Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042934091","display_name":"Alessio Merola","orcid":"https://orcid.org/0000-0002-8728-2084"},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessio Merola","raw_affiliation_strings":["School of Computer and Biomedical Engineering, Universit\u00e0 degli Studi Magna Gr\u00e6cia di Catanzaro, Catanzaro, Italy","Sch. of Comput. & Biomed. Eng., Univ. degli Studi Magna Graecia di Catanzaro, Catanzaro, Italy"],"affiliations":[{"raw_affiliation_string":"School of Computer and Biomedical Engineering, Universit\u00e0 degli Studi Magna Gr\u00e6cia di Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]},{"raw_affiliation_string":"Sch. of Comput. & Biomed. Eng., Univ. degli Studi Magna Graecia di Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030101234","display_name":"Francesco Amato","orcid":"https://orcid.org/0000-0002-9053-3139"},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Amato","raw_affiliation_strings":["School of Computer and Biomedical Engineering, Universit\u00e0 degli Studi Magna Gr\u00e6cia di Catanzaro, Catanzaro, Italy","Sch. of Comput. & Biomed. Eng., Univ. degli Studi Magna Graecia di Catanzaro, Catanzaro, Italy"],"affiliations":[{"raw_affiliation_string":"School of Computer and Biomedical Engineering, Universit\u00e0 degli Studi Magna Gr\u00e6cia di Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]},{"raw_affiliation_string":"Sch. of Comput. & Biomed. Eng., Univ. degli Studi Magna Graecia di Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5085080876"],"corresponding_institution_ids":["https://openalex.org/I36443711"],"apc_list":null,"apc_paid":null,"fwci":0.1462,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.55034768,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13052","display_name":"Molecular Communication and Nanonetworks","score":0.9908999800682068,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9879000186920166,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/realization","display_name":"Realization (probability)","score":0.8063586950302124},{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"Synthetic biology","score":0.7409664392471313},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.7070660591125488},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.610551655292511},{"id":"https://openalex.org/keywords/controller","display_name":"Controller (irrigation)","score":0.5691872239112854},{"id":"https://openalex.org/keywords/feedback-control","display_name":"Feedback control","score":0.5594489574432373},{"id":"https://openalex.org/keywords/dynamical-systems-theory","display_name":"Dynamical systems theory","score":0.5058690905570984},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.4701918363571167},{"id":"https://openalex.org/keywords/control-engineering","display_name":"Control engineering","score":0.46330103278160095},{"id":"https://openalex.org/keywords/control-system","display_name":"Control system","score":0.4524279534816742},{"id":"https://openalex.org/keywords/work","display_name":"Work (physics)","score":0.4517861306667328},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.4232838749885559},{"id":"https://openalex.org/keywords/biochemical-engineering","display_name":"Biochemical engineering","score":0.3441241681575775},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.3408247232437134},{"id":"https://openalex.org/keywords/distributed-computing","display_name":"Distributed computing","score":0.3352201581001282},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.17073744535446167},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.15608075261116028},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.15406230092048645},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.15295329689979553},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.137610524892807},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.10708257555961609}],"concepts":[{"id":"https://openalex.org/C2781089630","wikidata":"https://www.wikidata.org/wiki/Q21856745","display_name":"Realization (probability)","level":2,"score":0.8063586950302124},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.7409664392471313},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.7070660591125488},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.610551655292511},{"id":"https://openalex.org/C203479927","wikidata":"https://www.wikidata.org/wiki/Q5165939","display_name":"Controller (irrigation)","level":2,"score":0.5691872239112854},{"id":"https://openalex.org/C3018651601","wikidata":"https://www.wikidata.org/wiki/Q183635","display_name":"Feedback control","level":2,"score":0.5594489574432373},{"id":"https://openalex.org/C79379906","wikidata":"https://www.wikidata.org/wiki/Q3174497","display_name":"Dynamical systems theory","level":2,"score":0.5058690905570984},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.4701918363571167},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.46330103278160095},{"id":"https://openalex.org/C17500928","wikidata":"https://www.wikidata.org/wiki/Q959968","display_name":"Control system","level":2,"score":0.4524279534816742},{"id":"https://openalex.org/C18762648","wikidata":"https://www.wikidata.org/wiki/Q42213","display_name":"Work (physics)","level":2,"score":0.4517861306667328},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.4232838749885559},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.3441241681575775},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.3408247232437134},{"id":"https://openalex.org/C120314980","wikidata":"https://www.wikidata.org/wiki/Q180634","display_name":"Distributed computing","level":1,"score":0.3352201581001282},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.17073744535446167},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.15608075261116028},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.15406230092048645},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.15295329689979553},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.137610524892807},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10708257555961609},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibe.2013.6701600","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe.2013.6701600","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"13th IEEE International Conference on BioInformatics and BioEngineering","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/12","display_name":"Responsible consumption and production","score":0.5600000023841858}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W353076664","https://openalex.org/W2008793553","https://openalex.org/W2060790641","https://openalex.org/W2077670298","https://openalex.org/W2094781369","https://openalex.org/W2111684295","https://openalex.org/W2126921853","https://openalex.org/W2169990865"],"related_works":["https://openalex.org/W2057769265","https://openalex.org/W2024161258","https://openalex.org/W1911418903","https://openalex.org/W2338895903","https://openalex.org/W3044523069","https://openalex.org/W19581480","https://openalex.org/W2136248167","https://openalex.org/W2126646394","https://openalex.org/W2158714033","https://openalex.org/W4212865750"],"abstract_inverted_index":{"Chemical":[0],"Reaction":[1],"Network":[2],"(CRN)":[3],"models":[4],"based":[5],"on":[6],"the":[7,15,48,51,76,105,108],"mass-action":[8],"law":[9],"play":[10],"an":[11,89],"important":[12],"role":[13],"in":[14,29],"life":[16],"sciences,":[17],"since":[18],"they":[19],"can":[20],"be":[21],"used":[22],"to":[23,40,62],"describe":[24],"dynamical":[25],"processes":[26],"of":[27,32,43,53,58,78,107],"interest":[28],"many":[30],"fields":[31],"chemistry":[33],"and":[34,55],"biology.":[35],"A":[36],"fundamental":[37],"challenge":[38],"related":[39],"this":[41,73],"kind":[42],"systems":[44,65],"is":[45,75],"represented":[46],"by":[47,72,111],"lack,":[49],"within":[50],"framework":[52],"Systems":[54],"Synthetic":[56],"Biology,":[57],"a":[59,79,99,113,118],"general":[60,80],"methodology":[61,81],"design":[63],"control":[64,86],"for":[66,82,88,117],"CRNs.":[67],"The":[68],"main":[69],"issue":[70],"addressed":[71],"work":[74],"development":[77],"designing":[83,112],"embedded":[84],"feedback":[85,115],"schemes":[87],"assigned":[90],"CRN,":[91],"i.e.":[92],"controllers":[93],"that":[94],"are":[95],"themselves":[96],"realizable":[97],"through":[98],"CRN.":[100],"In":[101],"particular,":[102],"we":[103],"illustrate":[104],"effectiveness":[106],"proposed":[109],"approach":[110],"proportional":[114],"controller":[116],"well-characterized":[119],"biochemical":[120],"system.":[121]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}