{"id":"https://openalex.org/W2014926209","doi":"https://doi.org/10.1109/bibe.2012.6399772","title":"Model-based control of tumor progression","display_name":"Model-based control of tumor progression","publication_year":2012,"publication_date":"2012-11-01","ids":{"openalex":"https://openalex.org/W2014926209","doi":"https://doi.org/10.1109/bibe.2012.6399772","mag":"2014926209"},"language":"en","primary_location":{"id":"doi:10.1109/bibe.2012.6399772","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe.2012.6399772","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071755418","display_name":"Marios M. Hadjiandreou","orcid":null},"institutions":[{"id":"https://openalex.org/I34771391","display_name":"University of Cyprus","ror":"https://ror.org/02qjrjx09","country_code":"CY","type":"education","lineage":["https://openalex.org/I34771391"]}],"countries":["CY"],"is_corresponding":true,"raw_author_name":"Marios M. Hadjiandreou","raw_affiliation_strings":["Department of Electrical & Computer Engineering, University of Cyprus, Nicosia, Cyprus","[Dept. of Electrical and Computer Engineering, University of Cyprus, Nicosia, Cyprus]"],"affiliations":[{"raw_affiliation_string":"Department of Electrical & Computer Engineering, University of Cyprus, Nicosia, Cyprus","institution_ids":["https://openalex.org/I34771391"]},{"raw_affiliation_string":"[Dept. of Electrical and Computer Engineering, University of Cyprus, Nicosia, Cyprus]","institution_ids":["https://openalex.org/I34771391"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062820435","display_name":"Georgios D. Mitsis","orcid":"https://orcid.org/0000-0001-9975-5128"},"institutions":[{"id":"https://openalex.org/I34771391","display_name":"University of Cyprus","ror":"https://ror.org/02qjrjx09","country_code":"CY","type":"education","lineage":["https://openalex.org/I34771391"]}],"countries":["CY"],"is_corresponding":false,"raw_author_name":"Georgios D. Mitsis","raw_affiliation_strings":["Department of Electrical & Computer Engineering, University of Cyprus, Nicosia, Cyprus","[Dept. of Electrical and Computer Engineering, University of Cyprus, Nicosia, Cyprus]"],"affiliations":[{"raw_affiliation_string":"Department of Electrical & Computer Engineering, University of Cyprus, Nicosia, Cyprus","institution_ids":["https://openalex.org/I34771391"]},{"raw_affiliation_string":"[Dept. of Electrical and Computer Engineering, University of Cyprus, Nicosia, Cyprus]","institution_ids":["https://openalex.org/I34771391"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5071755418"],"corresponding_institution_ids":["https://openalex.org/I34771391"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.07671419,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"17","issue":null,"first_page":"614","last_page":"619"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.993399977684021,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"Pharmacokinetics","score":0.6758924722671509},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"Tumor progression","score":0.6060092449188232},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"Pharmacodynamics","score":0.6000823974609375},{"id":"https://openalex.org/keywords/optimal-control","display_name":"Optimal control","score":0.5807180404663086},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"Colorectal cancer","score":0.5600103735923767},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5340465903282166},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"Drug resistance","score":0.4397461712360382},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.4327583312988281},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3733435273170471},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3597410023212433},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.25797879695892334},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.19795390963554382},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.15101727843284607},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.11427149176597595},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.09568735957145691}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6758924722671509},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.6060092449188232},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.6000823974609375},{"id":"https://openalex.org/C91575142","wikidata":"https://www.wikidata.org/wiki/Q1971426","display_name":"Optimal control","level":2,"score":0.5807180404663086},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5600103735923767},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5340465903282166},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.4397461712360382},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4327583312988281},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3733435273170471},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3597410023212433},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.25797879695892334},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19795390963554382},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15101727843284607},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.11427149176597595},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.09568735957145691},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibe.2012.6399772","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe.2012.6399772","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8500000238418579}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W45211202","https://openalex.org/W139331474","https://openalex.org/W279664450","https://openalex.org/W1169555688","https://openalex.org/W1520015039","https://openalex.org/W1559733560","https://openalex.org/W1567204338","https://openalex.org/W1964231254","https://openalex.org/W1975047856","https://openalex.org/W1976915041","https://openalex.org/W1985757076","https://openalex.org/W1992661182","https://openalex.org/W2000200648","https://openalex.org/W2009660703","https://openalex.org/W2013304036","https://openalex.org/W2016908937","https://openalex.org/W2020192629","https://openalex.org/W2036132399","https://openalex.org/W2037975214","https://openalex.org/W2041706603","https://openalex.org/W2046572400","https://openalex.org/W2046933315","https://openalex.org/W2050089788","https://openalex.org/W2054639371","https://openalex.org/W2055324643","https://openalex.org/W2074642772","https://openalex.org/W2078115349","https://openalex.org/W2083278156","https://openalex.org/W2112443004","https://openalex.org/W2140814172","https://openalex.org/W2144418840","https://openalex.org/W2325281333","https://openalex.org/W2492590527","https://openalex.org/W4302615404","https://openalex.org/W6633518185","https://openalex.org/W6646761414","https://openalex.org/W6681251169","https://openalex.org/W6700964757"],"related_works":["https://openalex.org/W2352350815","https://openalex.org/W2991030316","https://openalex.org/W2908757458","https://openalex.org/W2887865523","https://openalex.org/W2189230703","https://openalex.org/W2114878163","https://openalex.org/W2012213756","https://openalex.org/W2162888433","https://openalex.org/W2254638634","https://openalex.org/W2369345461"],"abstract_inverted_index":{"This":[0],"paper":[1],"presents":[2],"our":[3],"work":[4],"on":[5],"the":[6,16,31,64,68,77,105,109],"application":[7],"of":[8,18,33,79,108,113],"mathematical":[9],"modeling":[10,17,32],"and":[11,21,111,125],"optimal":[12,22,100,106],"control":[13,120],"techniques":[14],"in":[15,36,44,67,91,121,130],"tumor":[19,34],"progression":[20,35,43,90],"treatment":[23,114],"planning.":[24],"We":[25,56],"present":[26,59],"a":[27,58,84],"pharmacokinetic-pharmacodynamic":[28],"approach":[29],"to":[30,62,75,118],"mice.":[37],"Specifically,":[38],"we":[39,82,102],"describe":[40,63,76],"colon":[41],"cancer":[42,89,119],"both":[45],"untreated":[46],"mice":[47,51,92],"as":[48,50,70,72],"well":[49,71],"treated":[52],"with":[53,93,123],"anti-cancer":[54],"agents.":[55],"also":[57],"pharmacokinetic":[60],"model":[61],"drug":[65],"kinetics":[66],"body":[69],"toxicity":[73],"models":[74],"severity":[78],"side-effects.":[80],"Lastly,":[81],"propose":[83],"promising":[85],"methodology":[86],"by":[87],"which":[88,134],"drug-resistance":[94],"can":[95],"be":[96,127],"controlled.":[97],"By":[98],"using":[99],"control,":[101],"demonstrate":[103],"that":[104],"planning":[107],"frequency":[110],"magnitude":[112],"breaks":[115],"is":[116,135],"key":[117],"subjects":[122],"resistance":[124],"should":[126],"further":[128],"investigated":[129],"an":[131],"experimental":[132],"setting,":[133],"currently":[136],"underway.":[137]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}