{"id":"https://openalex.org/W2073537815","doi":"https://doi.org/10.1109/bibe.2012.6399768","title":"Influence of algorithmic parameters on marker selection in genomic datasets","display_name":"Influence of algorithmic parameters on marker selection in genomic datasets","publication_year":2012,"publication_date":"2012-11-01","ids":{"openalex":"https://openalex.org/W2073537815","doi":"https://doi.org/10.1109/bibe.2012.6399768","mag":"2073537815"},"language":"en","primary_location":{"id":"doi:10.1109/bibe.2012.6399768","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe.2012.6399768","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011644665","display_name":"T. Vigdideli","orcid":null},"institutions":[{"id":"https://openalex.org/I55741626","display_name":"Technical University of Crete","ror":"https://ror.org/03f8bz564","country_code":"GR","type":"education","lineage":["https://openalex.org/I55741626"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"T. Vigdideli","raw_affiliation_strings":["Department of Electronic and Computer Engineering, Technical University of Crete, Chania Crete, Greece","Department of Electronic & Computer Engineering, Technical University of Crete, Chania, Crete, Greece#TAB#"],"affiliations":[{"raw_affiliation_string":"Department of Electronic and Computer Engineering, Technical University of Crete, Chania Crete, Greece","institution_ids":["https://openalex.org/I55741626"]},{"raw_affiliation_string":"Department of Electronic & Computer Engineering, Technical University of Crete, Chania, Crete, Greece#TAB#","institution_ids":["https://openalex.org/I55741626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086247449","display_name":"Ekaterini S. Bei","orcid":null},"institutions":[{"id":"https://openalex.org/I55741626","display_name":"Technical University of Crete","ror":"https://ror.org/03f8bz564","country_code":"GR","type":"education","lineage":["https://openalex.org/I55741626"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"E. S. Bei","raw_affiliation_strings":["Department of Electronic and Computer Engineering, Technical University of Crete, Chania Crete, Greece","Department of Electronic & Computer Engineering, Technical University of Crete, Chania, Crete, Greece#TAB#"],"affiliations":[{"raw_affiliation_string":"Department of Electronic and Computer Engineering, Technical University of Crete, Chania Crete, Greece","institution_ids":["https://openalex.org/I55741626"]},{"raw_affiliation_string":"Department of Electronic & Computer Engineering, Technical University of Crete, Chania, Crete, Greece#TAB#","institution_ids":["https://openalex.org/I55741626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031391584","display_name":"Michalis Zervakis","orcid":"https://orcid.org/0000-0002-0705-631X"},"institutions":[{"id":"https://openalex.org/I55741626","display_name":"Technical University of Crete","ror":"https://ror.org/03f8bz564","country_code":"GR","type":"education","lineage":["https://openalex.org/I55741626"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"M. Zervakis","raw_affiliation_strings":["Department of Electronic and Computer Engineering, Technical University of Crete, Chania Crete, Greece","Department of Electronic & Computer Engineering, Technical University of Crete, Chania, Crete, Greece#TAB#"],"affiliations":[{"raw_affiliation_string":"Department of Electronic and Computer Engineering, Technical University of Crete, Chania Crete, Greece","institution_ids":["https://openalex.org/I55741626"]},{"raw_affiliation_string":"Department of Electronic & Computer Engineering, Technical University of Crete, Chania, Crete, Greece#TAB#","institution_ids":["https://openalex.org/I55741626"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024607981","display_name":"Dimitrios Kafetzopoulos","orcid":"https://orcid.org/0000-0002-0081-9409"},"institutions":[{"id":"https://openalex.org/I8901234","display_name":"Foundation for Research and Technology Hellas","ror":"https://ror.org/052rphn09","country_code":"GR","type":"facility","lineage":["https://openalex.org/I8901234"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"D. Kafetzopoulos","raw_affiliation_strings":["Institute of Molecular Biology and Biotechnology Foundation of Research and Technology Hellas (FORTH), Heraklion Crete, Greece","Institute of Molecular Biology and Biotechnology, Foundation of Research and Technology Hellas (FORTH), Heraklion Crete, Greece"],"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology and Biotechnology Foundation of Research and Technology Hellas (FORTH), Heraklion Crete, Greece","institution_ids":["https://openalex.org/I8901234"]},{"raw_affiliation_string":"Institute of Molecular Biology and Biotechnology, Foundation of Research and Technology Hellas (FORTH), Heraklion Crete, Greece","institution_ids":["https://openalex.org/I8901234"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5011644665"],"corresponding_institution_ids":["https://openalex.org/I55741626"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09637744,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":null,"first_page":"523","last_page":"528"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9933000206947327,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.647739052772522},{"id":"https://openalex.org/keywords/classifier","display_name":"Classifier (UML)","score":0.5727055072784424},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5670948624610901},{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.543976366519928},{"id":"https://openalex.org/keywords/kernel","display_name":"Kernel (algebra)","score":0.49994540214538574},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.49721768498420715},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.48234933614730835},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.4782894253730774},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.42422887682914734},{"id":"https://openalex.org/keywords/cross-validation","display_name":"Cross-validation","score":0.4218611419200897},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.20789217948913574}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.647739052772522},{"id":"https://openalex.org/C95623464","wikidata":"https://www.wikidata.org/wiki/Q1096149","display_name":"Classifier (UML)","level":2,"score":0.5727055072784424},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5670948624610901},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.543976366519928},{"id":"https://openalex.org/C74193536","wikidata":"https://www.wikidata.org/wiki/Q574844","display_name":"Kernel (algebra)","level":2,"score":0.49994540214538574},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.49721768498420715},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.48234933614730835},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.4782894253730774},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.42422887682914734},{"id":"https://openalex.org/C27181475","wikidata":"https://www.wikidata.org/wiki/Q541014","display_name":"Cross-validation","level":2,"score":0.4218611419200897},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.20789217948913574},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibe.2012.6399768","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe.2012.6399768","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1972582950","https://openalex.org/W1973435266","https://openalex.org/W2003147081","https://openalex.org/W2032475954","https://openalex.org/W2038290035","https://openalex.org/W2049047355","https://openalex.org/W2049222570","https://openalex.org/W2099832063","https://openalex.org/W2128660010","https://openalex.org/W2133105369","https://openalex.org/W2137917513","https://openalex.org/W2142387771","https://openalex.org/W2143426320","https://openalex.org/W2150884987","https://openalex.org/W2150926065","https://openalex.org/W2302890511","https://openalex.org/W6662572928","https://openalex.org/W6679651930"],"related_works":["https://openalex.org/W2090763504","https://openalex.org/W816105089","https://openalex.org/W148178222","https://openalex.org/W2104657898","https://openalex.org/W1948992892","https://openalex.org/W1886884218","https://openalex.org/W1910826599","https://openalex.org/W2550904580","https://openalex.org/W2963653239","https://openalex.org/W2048917867"],"abstract_inverted_index":{"The":[0],"biological":[1,201,289],"processes":[2,290],"are":[3,291],"widely":[4],"studied":[5],"by":[6,105,112,238],"genome":[7],"analysis":[8],"leading":[9],"to":[10,151,155,179,230],"a":[11,40,61,85,173,215,219,263],"large":[12],"number":[13,220],"of":[14,21,32,39,48,63,97,100,162,186,192,203,218,221,240,249,266,281,301],"genes,":[15,205],"thus":[16],"making":[17],"necessary":[18],"the":[19,30,36,45,49,64,75,78,94,98,120,156,159,167,181,184,190,200,207,231,234,247,250,272,279,287,298],"use":[20],"automated":[22],"evaluation":[23],"methods.":[24],"In":[25,81,164],"this":[26],"study,":[27],"we":[28,83,118,277,284],"examine":[29],"influence":[31,76],"algorithmic":[33],"parameters":[34,72,139],"in":[35,44,149,177,262,271,297],"prediction":[37],"power":[38,96,229],"gene":[41,56,196,267],"signature":[42,50,283],"and":[43,73,131,198],"selection":[46,57,168,259],"process":[47,89,169],"itself.":[51],"We":[52,143,188,211,253],"focus":[53],"on":[54,60,77,183,195],"one":[55,248],"approach":[58],"applied":[59],"dataset":[62],"budding":[65],"yeast":[66],"Saccharomyces":[67],"cerevisiae,":[68],"using":[69,206],"quite":[70],"different":[71,107,138,258],"evaluate":[74],"selected":[79,204,273],"signature.":[80],"particular,":[82],"adopt":[84],"recursive":[86],"feature":[87],"elimination":[88],"where":[90],"at":[91],"each":[92,282],"step":[93],"prognostic":[95,160],"set":[99],"remaining":[101],"genes":[102,224,280],"is":[103,170],"evaluated":[104],"five":[106],"classifiers,":[108],"as":[109,111,135],"well":[110],"four":[113,146],"classifier-fusions":[114],"schemes.":[115],"More":[116],"specifically,":[117],"consider":[119,189],"logistic-sigmoid,":[121],"kernel":[122,125,129,141],"nearest":[123],"centroid,":[124],"minimum":[126],"squared":[127],"error,":[128],"subspace,":[130],"support":[132],"vector":[133],"machines":[134],"classifiers":[136],"with":[137,269,293],"and/or":[140],"functions.":[142],"also":[144,199,254],"study":[145],"fusion":[147],"methods":[148],"order":[150,178],"reduce":[152],"uncertainties":[153],"related":[154],"classifier":[157],"evaluating":[158],"significance":[161],"genes.":[163,274],"all":[165],"cases,":[166],"embedded":[171],"into":[172],"cross":[174],"validation":[175],"scheme":[176],"enhance":[180],"confidence":[182],"generalization":[185],"results.":[187],"differences":[191,270,296],"signatures":[193],"based":[194],"overlap":[197],"annotation":[202],"MIPS":[208],"FunCat":[209],"architecture.":[210],"found":[212],"out":[213,256],"that":[214,257,286],"robust":[216],"identification":[217],"highly":[222],"differential":[223],"can":[225,242],"offer":[226],"\u201cgood\u201d":[227],"predictive":[228],"models.":[232],"Furthermore,":[233],"classification":[235],"accuracy":[236],"achieved":[237],"mixtures":[239],"experts":[241],"be":[243],"significantly":[244],"better":[245],"than":[246],"individual":[251],"classifiers.":[252],"pointed":[255],"schemes":[260],"result":[261],"diverse":[264],"size":[265],"signature,":[268],"Nevertheless,":[275],"when":[276],"annotate":[278],"find":[285],"same":[288],"invoked,":[292],"possibly":[294],"small":[295],"relative":[299],"frequency":[300],"participation.":[302]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}