{"id":"https://openalex.org/W2010474182","doi":"https://doi.org/10.1109/bibe.2012.6399670","title":"SVM-based miRNA:MiRNA\u2217 duplex prediction","display_name":"SVM-based miRNA:MiRNA\u2217 duplex prediction","publication_year":2012,"publication_date":"2012-11-01","ids":{"openalex":"https://openalex.org/W2010474182","doi":"https://doi.org/10.1109/bibe.2012.6399670","mag":"2010474182"},"language":"en","primary_location":{"id":"doi:10.1109/bibe.2012.6399670","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe.2012.6399670","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061175529","display_name":"Nestoras Karathanasis","orcid":"https://orcid.org/0000-0003-4119-0851"},"institutions":[{"id":"https://openalex.org/I8901234","display_name":"Foundation for Research and Technology Hellas","ror":"https://ror.org/052rphn09","country_code":"GR","type":"facility","lineage":["https://openalex.org/I8901234"]},{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Karathanasis Nestoras","raw_affiliation_strings":["Department of Biology, Department of Computer Science, University of Crete, Heraklion, Greece","Institute of Computer Science, Institute of Molecular, Biology and Biotechnology, Foundation for Research and Technology - Hellas FORTH, Heraklion, Greece"],"affiliations":[{"raw_affiliation_string":"Department of Biology, Department of Computer Science, University of Crete, Heraklion, Greece","institution_ids":["https://openalex.org/I142617266"]},{"raw_affiliation_string":"Institute of Computer Science, Institute of Molecular, Biology and Biotechnology, Foundation for Research and Technology - Hellas FORTH, Heraklion, Greece","institution_ids":["https://openalex.org/I8901234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070582381","display_name":"Ioannis Tsamardinos","orcid":"https://orcid.org/0000-0002-2492-959X"},"institutions":[{"id":"https://openalex.org/I8901234","display_name":"Foundation for Research and Technology Hellas","ror":"https://ror.org/052rphn09","country_code":"GR","type":"facility","lineage":["https://openalex.org/I8901234"]},{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Tsamardinos Ioannis","raw_affiliation_strings":["Department of Biology, Department of Computer Science, University of Crete, Heraklion, Greece","Institute of Computer Science, Institute of Molecular, Biology and Biotechnology, Foundation for Research and Technology - Hellas FORTH, Heraklion, Greece"],"affiliations":[{"raw_affiliation_string":"Department of Biology, Department of Computer Science, University of Crete, Heraklion, Greece","institution_ids":["https://openalex.org/I142617266"]},{"raw_affiliation_string":"Institute of Computer Science, Institute of Molecular, Biology and Biotechnology, Foundation for Research and Technology - Hellas FORTH, Heraklion, Greece","institution_ids":["https://openalex.org/I8901234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047781210","display_name":"P. Armen Angelos","orcid":null},"institutions":[{"id":"https://openalex.org/I8901234","display_name":"Foundation for Research and Technology Hellas","ror":"https://ror.org/052rphn09","country_code":"GR","type":"facility","lineage":["https://openalex.org/I8901234"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"P. Armen Angelos","raw_affiliation_strings":["Institute of Computer Science, Institute of Molecular, Biology and Biotechnology, Foundation for Research and Technology - Hellas FORTH, Heraklion, Greece"],"affiliations":[{"raw_affiliation_string":"Institute of Computer Science, Institute of Molecular, Biology and Biotechnology, Foundation for Research and Technology - Hellas FORTH, Heraklion, Greece","institution_ids":["https://openalex.org/I8901234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070582381","display_name":"Ioannis Tsamardinos","orcid":"https://orcid.org/0000-0002-2492-959X"},"institutions":[{"id":"https://openalex.org/I8901234","display_name":"Foundation for Research and Technology Hellas","ror":"https://ror.org/052rphn09","country_code":"GR","type":"facility","lineage":["https://openalex.org/I8901234"]},{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Tsamardinos Ioannis","raw_affiliation_strings":["Department of Biology, Department of Computer Science, University of Crete, Heraklion, Greece","Institute of Computer Science, Institute of Molecular, Biology and Biotechnology, Foundation for Research and Technology - Hellas FORTH, Heraklion, Greece"],"affiliations":[{"raw_affiliation_string":"Department of Biology, Department of Computer Science, University of Crete, Heraklion, Greece","institution_ids":["https://openalex.org/I142617266"]},{"raw_affiliation_string":"Institute of Computer Science, Institute of Molecular, Biology and Biotechnology, Foundation for Research and Technology - Hellas FORTH, Heraklion, Greece","institution_ids":["https://openalex.org/I8901234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061175529","display_name":"Nestoras Karathanasis","orcid":"https://orcid.org/0000-0003-4119-0851"},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]},{"id":"https://openalex.org/I8901234","display_name":"Foundation for Research and Technology Hellas","ror":"https://ror.org/052rphn09","country_code":"GR","type":"facility","lineage":["https://openalex.org/I8901234"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Karathanasis Nestoras","raw_affiliation_strings":["Department of Biology, Department of Computer Science, University of Crete, Heraklion, Greece","Institute of Computer Science, Institute of Molecular, Biology and Biotechnology, Foundation for Research and Technology - Hellas FORTH, Heraklion, Greece"],"affiliations":[{"raw_affiliation_string":"Department of Biology, Department of Computer Science, University of Crete, Heraklion, Greece","institution_ids":["https://openalex.org/I142617266"]},{"raw_affiliation_string":"Institute of Computer Science, Institute of Molecular, Biology and Biotechnology, Foundation for Research and Technology - Hellas FORTH, Heraklion, Greece","institution_ids":["https://openalex.org/I8901234"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103638158","display_name":"Poirazi Panayiota","orcid":null},"institutions":[{"id":"https://openalex.org/I8901234","display_name":"Foundation for Research and Technology Hellas","ror":"https://ror.org/052rphn09","country_code":"GR","type":"facility","lineage":["https://openalex.org/I8901234"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Poirazi Panayiota","raw_affiliation_strings":["Institute of Computer Science, Institute of Molecular, Biology and Biotechnology, Foundation for Research and Technology - Hellas FORTH, Heraklion, Greece"],"affiliations":[{"raw_affiliation_string":"Institute of Computer Science, Institute of Molecular, Biology and Biotechnology, Foundation for Research and Technology - Hellas FORTH, Heraklion, Greece","institution_ids":["https://openalex.org/I8901234"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5061175529"],"corresponding_institution_ids":["https://openalex.org/I8901234","https://openalex.org/I142617266"],"apc_list":null,"apc_paid":null,"fwci":0.24755157,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.60746088,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"181","last_page":"186"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.7922548055648804},{"id":"https://openalex.org/keywords/duplex","display_name":"Duplex (building)","score":0.7644105553627014},{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.6644454598426819},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5374681353569031},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4483191967010498},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4124499559402466},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.3849882483482361},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3589310944080353},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3280586004257202},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3007676601409912},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.16856041550636292},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.15485993027687073},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.0839797854423523}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7922548055648804},{"id":"https://openalex.org/C99611785","wikidata":"https://www.wikidata.org/wiki/Q6453233","display_name":"Duplex (building)","level":3,"score":0.7644105553627014},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.6644454598426819},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5374681353569031},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4483191967010498},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4124499559402466},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3849882483482361},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3589310944080353},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3280586004257202},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3007676601409912},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16856041550636292},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15485993027687073},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.0839797854423523}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibe.2012.6399670","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe.2012.6399670","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W1978379303","https://openalex.org/W2017426710","https://openalex.org/W2047546334","https://openalex.org/W2051535323","https://openalex.org/W2071893696","https://openalex.org/W2076422568","https://openalex.org/W2098044747","https://openalex.org/W2124531879","https://openalex.org/W2136846651","https://openalex.org/W2153635508","https://openalex.org/W2156847802","https://openalex.org/W2162674813"],"related_works":["https://openalex.org/W2090763504","https://openalex.org/W2737319532","https://openalex.org/W4392896533","https://openalex.org/W2062945643","https://openalex.org/W2050308539","https://openalex.org/W3151405604","https://openalex.org/W4241694095","https://openalex.org/W2330252996","https://openalex.org/W2057742104","https://openalex.org/W4283692078"],"abstract_inverted_index":{"We":[0,52],"address":[1,24],"the":[2,6,27,37,54,59,63,71,75,116,124,127,133,138,149,159,178],"problem":[3],"of":[4,58,62,68,70,74,78,100,123,132,162],"predicting":[5],"miRNA:":[7,28,164],"miRNA\u2217":[8,29,165],"duplex":[9,30,76],"stemming":[10],"from":[11],"a":[12,20,32,97],"microRNA":[13],"(miRNA)":[14],"hairpin":[15,103],"precursor":[16,104],"and":[17,44,50,65,121,129,145,168],"we":[18],"present":[19],"SVM-based":[21],"methodology":[22],"to":[23],"it.":[25],"Predicting":[26],"is":[31,89],"first":[33],"step":[34],"towards":[35],"identifying":[36],"mature":[38],"miRNA,":[39],"suggesting":[40],"possible":[41],"miRNA":[42,102],"targets":[43],"ultimately,":[45],"reducing":[46],"experimentation":[47],"effort,":[48],"time,":[49],"cost.":[51],"measure":[53],"error":[55,85],"in":[56,126],"terms":[57],"absolute":[60,84],"difference":[61],"true":[64],"predicted":[66],"location":[67],"all":[69,87],"four":[72],"ends":[73,88],"and/or":[77],"each":[79],"end":[80],"separately.":[81],"Our":[82],"mean":[83],"over":[86],"1.61":[90],"\u00b1":[91],"2.24":[92],"nts":[93],"as":[94],"measured":[95],"on":[96,148],"hold-out":[98],"set":[99],"220":[101],"sequences.":[105],"In":[106],"addition,":[107],"our":[108,153],"tool":[109,140],"precisely":[110],"predicts":[111],"(with":[112],"0":[113],"nt":[114],"deviation)":[115],"starting":[117,160],"position":[118],"for":[119],"57%":[120],"52%":[122],"miRNAs":[125],"5'":[128],"3'":[130],"strands":[131],"same":[134,150],"dataset,":[135],"significantly":[136],"outperforming":[137,177],"state-of-the-art":[139,180],"MaturePred":[141],"which":[142],"achieves":[143],"18%":[144],"12%,":[146],"respectively,":[147],"task.":[151],"Overall,":[152],"method":[154],"accurately":[155],"identifies":[156],"not":[157],"only":[158],"nucleotide":[161],"novel":[163],"duplexes":[166],"\u2014":[167],"thus":[169],"individual":[170],"miRNAs-":[171],"but":[172],"also":[173],"their":[174],"length,":[175],"while":[176],"current":[179],"tool.":[181]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}