{"id":"https://openalex.org/W2028395888","doi":"https://doi.org/10.1109/bibe.2008.4696797","title":"Matrix factorization techniques for analysis of imaging mass spectrometry data","display_name":"Matrix factorization techniques for analysis of imaging mass spectrometry data","publication_year":2008,"publication_date":"2008-10-01","ids":{"openalex":"https://openalex.org/W2028395888","doi":"https://doi.org/10.1109/bibe.2008.4696797","mag":"2028395888","pmid":"https://pubmed.ncbi.nlm.nih.gov/28393151"},"language":"en","primary_location":{"id":"doi:10.1109/bibe.2008.4696797","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe.2008.4696797","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008 8th IEEE International Conference on BioInformatics and BioEngineering","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":null,"any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110051458","display_name":"Peter W Siy","orcid":null},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter W. Siy","raw_affiliation_strings":["School of Electrical and Computer Engineering, Georgia Tech, Atlanta, GA 30332 USA ( petersiy@gatech.edu )"],"affiliations":[{"raw_affiliation_string":"School of Electrical and Computer Engineering, Georgia Tech, Atlanta, GA 30332 USA ( petersiy@gatech.edu )","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054144380","display_name":"Andrea B. Moffitt","orcid":"https://orcid.org/0000-0001-5964-7851"},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard A. Moffitt","raw_affiliation_strings":["Department of Biomedical Engineering, Georgia Tech and Emory University, Atlanta, GA USA ( R.Moffitt@gatech.edu )"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Georgia Tech and Emory University, Atlanta, GA USA ( R.Moffitt@gatech.edu )","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113673988","display_name":"R. Mitchell Parry","orcid":null},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Mitchell Parry","raw_affiliation_strings":["Department of Biomedical Engineering, Georgia Tech and Emory University, Atlanta, GA USA ( parry@bme.gatech.edu )"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Georgia Tech and Emory University, Atlanta, GA USA ( parry@bme.gatech.edu )","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082902686","display_name":"Yanfeng Chen","orcid":"https://orcid.org/0000-0002-5377-2093"},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I2800444561","display_name":"Atlanta Technical College","ror":"https://ror.org/01s3vfp47","country_code":"US","type":"education","lineage":["https://openalex.org/I2800444561"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanfeng Chen","raw_affiliation_strings":["School of Chemistry & Biochemistry, Georgia Tech, Atlanta, GA USA"],"affiliations":[{"raw_affiliation_string":"School of Chemistry & Biochemistry, Georgia Tech, Atlanta, GA USA","institution_ids":["https://openalex.org/I130701444","https://openalex.org/I2800444561"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100414410","display_name":"Ying Liu","orcid":"https://orcid.org/0000-0003-1590-0995"},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I2800444561","display_name":"Atlanta Technical College","ror":"https://ror.org/01s3vfp47","country_code":"US","type":"education","lineage":["https://openalex.org/I2800444561"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Liu","raw_affiliation_strings":["School of Biology, Georgia Tech, Atlanta, GA USA"],"affiliations":[{"raw_affiliation_string":"School of Biology, Georgia Tech, Atlanta, GA USA","institution_ids":["https://openalex.org/I130701444","https://openalex.org/I2800444561"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032331390","display_name":"M. Cameron Sullards","orcid":null},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I2802629044","display_name":"Atlanta Public Schools","ror":"https://ror.org/00496yk95","country_code":"US","type":"education","lineage":["https://openalex.org/I2802629044"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Cameron Sullards","raw_affiliation_strings":["Schools of Biology and Chemistry & Biochemistry, Georgia Tech, Atlanta, GA USA"],"affiliations":[{"raw_affiliation_string":"Schools of Biology and Chemistry & Biochemistry, Georgia Tech, Atlanta, GA USA","institution_ids":["https://openalex.org/I2802629044","https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002672605","display_name":"Alfred H. Merrill","orcid":"https://orcid.org/0000-0002-6673-968X"},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alfred H. Merrill","raw_affiliation_strings":["Schools of Biology and Chemistry & Biochemistry, and the Petit Institute for Bioengineering and Biosciences, Georgia Tech, Atlanta, GA USA"],"affiliations":[{"raw_affiliation_string":"Schools of Biology and Chemistry & Biochemistry, and the Petit Institute for Bioengineering and Biosciences, Georgia Tech, Atlanta, GA USA","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030096887","display_name":"May D. Wang","orcid":"https://orcid.org/0000-0003-3961-3608"},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"May D. Wang","raw_affiliation_strings":["Department Biomedical Engineering, Georgia Tech and Emory University, the School of Electrical and Computer Engineering, and the Petit Institute for Bioengineering and Biosciences, Georgia Tech, Atlanta, GA USA (phone: 404-385-2954; fax: 404-385-4243; maywang@bme.gatech.edu )"],"affiliations":[{"raw_affiliation_string":"Department Biomedical Engineering, Georgia Tech and Emory University, the School of Electrical and Computer Engineering, and the Petit Institute for Bioengineering and Biosciences, Georgia Tech, Atlanta, GA USA (phone: 404-385-2954; fax: 404-385-4243; maywang@bme.gatech.edu )","institution_ids":["https://openalex.org/I130701444"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5110051458"],"corresponding_institution_ids":["https://openalex.org/I130701444"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.09165979,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"2008","issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10640","display_name":"Spectroscopy and Chemometric Analyses","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10640","display_name":"Spectroscopy and Chemometric Analyses","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11447","display_name":"Blind Source Separation Techniques","score":0.9882000088691711,"subfield":{"id":"https://openalex.org/subfields/1711","display_name":"Signal Processing"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12748","display_name":"Molecular spectroscopy and chirality","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/matrix-decomposition","display_name":"Matrix decomposition","score":0.8179231286048889},{"id":"https://openalex.org/keywords/mass-spectrometry-imaging","display_name":"Mass spectrometry imaging","score":0.776402473449707},{"id":"https://openalex.org/keywords/non-negative-matrix-factorization","display_name":"Non-negative matrix factorization","score":0.7014013528823853},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.698060929775238},{"id":"https://openalex.org/keywords/independent-component-analysis","display_name":"Independent component analysis","score":0.5947845578193665},{"id":"https://openalex.org/keywords/matrix","display_name":"Matrix (chemical analysis)","score":0.5533782243728638},{"id":"https://openalex.org/keywords/mass-spectrometry","display_name":"Mass spectrometry","score":0.5037783980369568},{"id":"https://openalex.org/keywords/component","display_name":"Component (thermodynamics)","score":0.48370057344436646},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4657142162322998},{"id":"https://openalex.org/keywords/factorization","display_name":"Factorization","score":0.45062050223350525},{"id":"https://openalex.org/keywords/data-matrix","display_name":"Data Matrix","score":0.4466813802719116},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.4318607449531555},{"id":"https://openalex.org/keywords/principal-component-analysis","display_name":"Principal component analysis","score":0.4193084239959717},{"id":"https://openalex.org/keywords/sample","display_name":"Sample (material)","score":0.41879206895828247},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.361985445022583},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.3039131462574005},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.17822882533073425},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.10157826542854309},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.09222671389579773}],"concepts":[{"id":"https://openalex.org/C42355184","wikidata":"https://www.wikidata.org/wiki/Q1361088","display_name":"Matrix decomposition","level":3,"score":0.8179231286048889},{"id":"https://openalex.org/C24066741","wikidata":"https://www.wikidata.org/wiki/Q3796564","display_name":"Mass spectrometry imaging","level":3,"score":0.776402473449707},{"id":"https://openalex.org/C152671427","wikidata":"https://www.wikidata.org/wiki/Q10843505","display_name":"Non-negative matrix factorization","level":4,"score":0.7014013528823853},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.698060929775238},{"id":"https://openalex.org/C51432778","wikidata":"https://www.wikidata.org/wiki/Q1259145","display_name":"Independent component analysis","level":2,"score":0.5947845578193665},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.5533782243728638},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.5037783980369568},{"id":"https://openalex.org/C168167062","wikidata":"https://www.wikidata.org/wiki/Q1117970","display_name":"Component (thermodynamics)","level":2,"score":0.48370057344436646},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4657142162322998},{"id":"https://openalex.org/C187834632","wikidata":"https://www.wikidata.org/wiki/Q188804","display_name":"Factorization","level":2,"score":0.45062050223350525},{"id":"https://openalex.org/C2780985081","wikidata":"https://www.wikidata.org/wiki/Q676502","display_name":"Data Matrix","level":5,"score":0.4466813802719116},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4318607449531555},{"id":"https://openalex.org/C27438332","wikidata":"https://www.wikidata.org/wiki/Q2873","display_name":"Principal component analysis","level":2,"score":0.4193084239959717},{"id":"https://openalex.org/C198531522","wikidata":"https://www.wikidata.org/wiki/Q485146","display_name":"Sample (material)","level":2,"score":0.41879206895828247},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.361985445022583},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3039131462574005},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.17822882533073425},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10157826542854309},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.09222671389579773},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C158693339","wikidata":"https://www.wikidata.org/wiki/Q190524","display_name":"Eigenvalues and eigenvectors","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C44465124","wikidata":"https://www.wikidata.org/wiki/Q713623","display_name":"Clade","level":4,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1109/bibe.2008.4696797","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe.2008.4696797","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008 8th IEEE International Conference on BioInformatics and BioEngineering","raw_type":"proceedings-article"},{"id":"pmid:28393151","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28393151","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings. IEEE International Symposium on Bioinformatics and Bioengineering","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:5382992","is_oa":true,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5382992","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5382992","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc IEEE Int Symp Bioinformatics Bioeng","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5382992","is_oa":true,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1548802052","https://openalex.org/W1902027874","https://openalex.org/W1968280571","https://openalex.org/W1968863791","https://openalex.org/W1969198161","https://openalex.org/W1974388905","https://openalex.org/W2002882107","https://openalex.org/W2007179004","https://openalex.org/W2019502123","https://openalex.org/W2056269170","https://openalex.org/W2061637917","https://openalex.org/W2092423825","https://openalex.org/W2099658740","https://openalex.org/W2128748524","https://openalex.org/W2135029798","https://openalex.org/W2152698810","https://openalex.org/W2158599626","https://openalex.org/W3143596294","https://openalex.org/W4205778870","https://openalex.org/W6680012447"],"related_works":["https://openalex.org/W2127243424","https://openalex.org/W4390394189","https://openalex.org/W2037504162","https://openalex.org/W2539013788","https://openalex.org/W2792706544","https://openalex.org/W1568451138","https://openalex.org/W2156699640","https://openalex.org/W2045265907","https://openalex.org/W2972997031","https://openalex.org/W2028395888"],"abstract_inverted_index":{"Imaging":[0],"mass":[1],"spectrometry":[2],"is":[3,17,33,110],"a":[4,12,20,27],"method":[5,16],"for":[6,19,47,69,112],"understanding":[7],"the":[8,74,86],"molecular":[9],"distribution":[10],"in":[11,73],"two-dimensional":[13],"sample.":[14],"This":[15],"effective":[18,103],"wide":[21],"range":[22],"of":[23,30],"molecules,":[24],"but":[25],"generates":[26],"large":[28,41],"amount":[29],"data.":[31,75],"It":[32],"difficult":[34],"to":[35,100],"extract":[36],"important":[37,49],"information":[38],"from":[39],"these":[40],"datasets":[42],"manually":[43],"and":[44,51,59,65,80,94],"automated":[45],"methods":[46],"discovering":[48],"spatial":[50],"spectral":[52],"features":[53],"are":[54,63,78,98],"needed.":[55],"Independent":[56,91],"component":[57,84,92],"analysis":[58,89,93,104],"non-negative":[60,95],"matrix":[61,96],"factorization":[62,97],"explained":[64],"explored":[66],"as":[67],"tools":[68],"identifying":[70],"underlying":[71],"factors":[72],"These":[76],"techniques":[77],"compared":[79],"contrasted":[81],"with":[82],"principle":[83],"analysis,":[85],"more":[87,102],"standard":[88],"tool.":[90],"found":[99],"be":[101],"methods.":[105],"A":[106],"mouse":[107],"cerebellum":[108],"dataset":[109],"used":[111],"testing.":[113]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
