{"id":"https://openalex.org/W1991425774","doi":"https://doi.org/10.1109/bibe.2008.4696793","title":"Segmentation of nuclei in cancer tissue images: Contrasting active contours with morphology-based approach","display_name":"Segmentation of nuclei in cancer tissue images: Contrasting active contours with morphology-based approach","publication_year":2008,"publication_date":"2008-10-01","ids":{"openalex":"https://openalex.org/W1991425774","doi":"https://doi.org/10.1109/bibe.2008.4696793","mag":"1991425774"},"language":"en","primary_location":{"id":"doi:10.1109/bibe.2008.4696793","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe.2008.4696793","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008 8th IEEE International Conference on BioInformatics and BioEngineering","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11380/1240358","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028610334","display_name":"Santa Di Cataldo","orcid":"https://orcid.org/0000-0002-6239-8945"},"institutions":[{"id":"https://openalex.org/I177477856","display_name":"Polytechnic University of Turin","ror":"https://ror.org/00bgk9508","country_code":"IT","type":"education","lineage":["https://openalex.org/I177477856"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Santa Di Cataldo","raw_affiliation_strings":["Department of Control and Computer Engineering, Politecnico di Turino, Italy","Dept. of Control & Comput. Eng., Politec. di Torino, Torino"],"affiliations":[{"raw_affiliation_string":"Department of Control and Computer Engineering, Politecnico di Turino, Italy","institution_ids":["https://openalex.org/I177477856"]},{"raw_affiliation_string":"Dept. of Control & Comput. Eng., Politec. di Torino, Torino","institution_ids":["https://openalex.org/I177477856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068452817","display_name":"Elisa Ficarra","orcid":"https://orcid.org/0000-0002-8061-2124"},"institutions":[{"id":"https://openalex.org/I177477856","display_name":"Polytechnic University of Turin","ror":"https://ror.org/00bgk9508","country_code":"IT","type":"education","lineage":["https://openalex.org/I177477856"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elisa Ficarra","raw_affiliation_strings":["Department of Control and Computer Engineering, Politecnico di Turino, Italy","Dept. of Control & Comput. Eng., Politec. di Torino, Torino"],"affiliations":[{"raw_affiliation_string":"Department of Control and Computer Engineering, Politecnico di Turino, Italy","institution_ids":["https://openalex.org/I177477856"]},{"raw_affiliation_string":"Dept. of Control & Comput. Eng., Politec. di Torino, Torino","institution_ids":["https://openalex.org/I177477856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031653904","display_name":"Andrea Acquaviva","orcid":"https://orcid.org/0000-0002-7323-759X"},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Andrea Acquaviva","raw_affiliation_strings":["Department of Computer Science, Universit\u00e0 di Verona, Italy","Dept. of Comput. Sci., Univ. di Verona, Verona"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Universit\u00e0 di Verona, Italy","institution_ids":["https://openalex.org/I119439378"]},{"raw_affiliation_string":"Dept. of Comput. Sci., Univ. di Verona, Verona","institution_ids":["https://openalex.org/I119439378"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108136013","display_name":"Enrico Macii","orcid":null},"institutions":[{"id":"https://openalex.org/I177477856","display_name":"Polytechnic University of Turin","ror":"https://ror.org/00bgk9508","country_code":"IT","type":"education","lineage":["https://openalex.org/I177477856"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Enrico Macii","raw_affiliation_strings":["Department of Control and Computer Engineering, Politecnico di Turino, Italy","Dept. of Control & Comput. Eng., Politec. di Torino, Torino"],"affiliations":[{"raw_affiliation_string":"Department of Control and Computer Engineering, Politecnico di Turino, Italy","institution_ids":["https://openalex.org/I177477856"]},{"raw_affiliation_string":"Dept. of Control & Comput. Eng., Politec. di Torino, Torino","institution_ids":["https://openalex.org/I177477856"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5028610334"],"corresponding_institution_ids":["https://openalex.org/I177477856"],"apc_list":null,"apc_paid":null,"fwci":0.7105,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.72273989,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"41","issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9941999912261963,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7184333205223083},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6622906923294067},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.6570065021514893},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.6169908046722412},{"id":"https://openalex.org/keywords/active-contour-model","display_name":"Active contour model","score":0.6034271121025085},{"id":"https://openalex.org/keywords/mathematical-morphology","display_name":"Mathematical morphology","score":0.5904351472854614},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.5316318273544312},{"id":"https://openalex.org/keywords/noise","display_name":"Noise (video)","score":0.47152289748191833},{"id":"https://openalex.org/keywords/image-processing","display_name":"Image processing","score":0.4633738398551941},{"id":"https://openalex.org/keywords/morphology","display_name":"Morphology (biology)","score":0.4353765547275543},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.42848795652389526},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.25319451093673706},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1113034188747406}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7184333205223083},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6622906923294067},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.6570065021514893},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.6169908046722412},{"id":"https://openalex.org/C112353826","wikidata":"https://www.wikidata.org/wiki/Q127313","display_name":"Active contour model","level":4,"score":0.6034271121025085},{"id":"https://openalex.org/C185568154","wikidata":"https://www.wikidata.org/wiki/Q530242","display_name":"Mathematical morphology","level":4,"score":0.5904351472854614},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.5316318273544312},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.47152289748191833},{"id":"https://openalex.org/C9417928","wikidata":"https://www.wikidata.org/wiki/Q1070689","display_name":"Image processing","level":3,"score":0.4633738398551941},{"id":"https://openalex.org/C499950583","wikidata":"https://www.wikidata.org/wiki/Q183252","display_name":"Morphology (biology)","level":2,"score":0.4353765547275543},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.42848795652389526},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.25319451093673706},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1113034188747406},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/bibe.2008.4696793","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe.2008.4696793","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008 8th IEEE International Conference on BioInformatics and BioEngineering","raw_type":"proceedings-article"},{"id":"pmh:oai:iris.unimore.it:11380/1240358","is_oa":true,"landing_page_url":"http://hdl.handle.net/11380/1240358","pdf_url":null,"source":{"id":"https://openalex.org/S4306400718","display_name":"IRIS UNIMORE (University of Modena and Reggio Emilia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I122346577","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/I122346577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":{"id":"pmh:oai:iris.unimore.it:11380/1240358","is_oa":true,"landing_page_url":"http://hdl.handle.net/11380/1240358","pdf_url":null,"source":{"id":"https://openalex.org/S4306400718","display_name":"IRIS UNIMORE (University of Modena and Reggio Emilia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I122346577","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/I122346577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1480873147","https://openalex.org/W1547714734","https://openalex.org/W1597336200","https://openalex.org/W1652775531","https://openalex.org/W1991113069","https://openalex.org/W1992781276","https://openalex.org/W2003362831","https://openalex.org/W2056263701","https://openalex.org/W2092827709","https://openalex.org/W2098152234","https://openalex.org/W2098408658","https://openalex.org/W2099290282","https://openalex.org/W2102549524","https://openalex.org/W2104095591","https://openalex.org/W2104360130","https://openalex.org/W2104773967","https://openalex.org/W2104816793","https://openalex.org/W2105744867","https://openalex.org/W2106356653","https://openalex.org/W2111009828","https://openalex.org/W2116040950","https://openalex.org/W2118997832","https://openalex.org/W2119743834","https://openalex.org/W2120616072","https://openalex.org/W2125882530","https://openalex.org/W2134820502","https://openalex.org/W2147427282","https://openalex.org/W2151139983","https://openalex.org/W2155296963","https://openalex.org/W2163303168","https://openalex.org/W2167338900","https://openalex.org/W2167809092","https://openalex.org/W6628806528","https://openalex.org/W6632729973","https://openalex.org/W6675963863","https://openalex.org/W6684050132","https://openalex.org/W7053343595"],"related_works":["https://openalex.org/W2382904344","https://openalex.org/W3120329059","https://openalex.org/W2058740282","https://openalex.org/W2461976178","https://openalex.org/W1503542570","https://openalex.org/W2041406494","https://openalex.org/W2163448995","https://openalex.org/W2375111338","https://openalex.org/W4210537690","https://openalex.org/W2885157826"],"abstract_inverted_index":{"In":[0],"this":[1],"paper":[2],"we":[3,19,82],"present":[4],"a":[5,23,74],"fully":[6,75,91],"automated":[7,76,92],"morphology-based":[8,93],"technique":[9,25],"for":[10,26],"segmentation":[11],"of":[12,37,43,58,69],"nuclei":[13],"in":[14,40,62,73],"cancer":[15],"tissue":[16,60],"images":[17,45],"and":[18,52,84],"compare":[20],"it":[21],"with":[22],"common":[24],"biomedical":[27],"image":[28],"processing,":[29],"namely":[30],"active":[31,38,101],"contours.":[32],"We":[33,65],"discuss":[34],"the":[35,41,56,63,67,70],"limitations":[36],"contours":[39,102],"processing":[42],"immunohistochemical":[44],"characterized":[46],"by":[47,55],"heterogeneously":[48],"stained":[49],"nuclear":[50],"region":[51],"noise":[53],"caused":[54],"presence":[57],"multiple":[59],"layers":[61],"sample.":[64],"describe":[66],"integration":[68],"proposed":[71],"approach":[72,94],"protein":[77],"activity":[78],"quantification":[79],"tool.":[80],"Finally,":[81],"demonstrate":[83],"motivate":[85],"through":[86],"extensive":[87],"experiments":[88],"that":[89],"our":[90],"provides":[95],"better":[96],"accuracy":[97],"compared":[98],"to":[99],"various":[100],"implementations.":[103]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2016-06-24T00:00:00"}