{"id":"https://openalex.org/W2038773332","doi":"https://doi.org/10.1109/bibe.2008.4696698","title":"Large-scale approximate intervention strategies for Probabilistic Boolean Networks as models of gene regulation","display_name":"Large-scale approximate intervention strategies for Probabilistic Boolean Networks as models of gene regulation","publication_year":2008,"publication_date":"2008-10-01","ids":{"openalex":"https://openalex.org/W2038773332","doi":"https://doi.org/10.1109/bibe.2008.4696698","mag":"2038773332"},"language":"en","primary_location":{"id":"doi:10.1109/bibe.2008.4696698","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe.2008.4696698","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008 8th IEEE International Conference on BioInformatics and BioEngineering","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/11511/47547","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034886708","display_name":"Mehmet Tan","orcid":"https://orcid.org/0000-0002-1741-0570"},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]},{"id":"https://openalex.org/I201799495","display_name":"Middle East Technical University","ror":"https://ror.org/014weej12","country_code":"TR","type":"education","lineage":["https://openalex.org/I201799495"]}],"countries":["CA","TR"],"is_corresponding":true,"raw_author_name":"Mehmet Tan","raw_affiliation_strings":["Department of Computer Engineering, Middle East Technical University, Ankara, Turkey","The Department of Computer Science, University of Calgary, Calgary, AB, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Computer Engineering, Middle East Technical University, Ankara, Turkey","institution_ids":["https://openalex.org/I201799495"]},{"raw_affiliation_string":"The Department of Computer Science, University of Calgary, Calgary, AB, Canada","institution_ids":["https://openalex.org/I168635309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066265052","display_name":"Reda Alhajj","orcid":"https://orcid.org/0000-0001-6657-9738"},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]},{"id":"https://openalex.org/I904090387","display_name":"Global University","ror":"https://ror.org/04frhb927","country_code":"LB","type":"education","lineage":["https://openalex.org/I904090387"]}],"countries":["CA","LB"],"is_corresponding":false,"raw_author_name":"Reda Alhajj","raw_affiliation_strings":["Department of Computer Science, Global University, Beirut, Lebanon","Department of Computer Science, University of Calgary, Calgary, AB, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Global University, Beirut, Lebanon","institution_ids":["https://openalex.org/I904090387"]},{"raw_affiliation_string":"Department of Computer Science, University of Calgary, Calgary, AB, Canada","institution_ids":["https://openalex.org/I168635309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016249943","display_name":"Faruk Polat","orcid":"https://orcid.org/0000-0003-0509-9153"},"institutions":[{"id":"https://openalex.org/I201799495","display_name":"Middle East Technical University","ror":"https://ror.org/014weej12","country_code":"TR","type":"education","lineage":["https://openalex.org/I201799495"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Faruk Polat","raw_affiliation_strings":["Department of Computer Engineering, Middle East Technical University, Ankara, Turkey"],"affiliations":[{"raw_affiliation_string":"Department of Computer Engineering, Middle East Technical University, Ankara, Turkey","institution_ids":["https://openalex.org/I201799495"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5034886708"],"corresponding_institution_ids":["https://openalex.org/I168635309","https://openalex.org/I201799495"],"apc_list":null,"apc_paid":null,"fwci":0.2757,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.59771134,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"7","issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9879999756813049,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9713000059127808,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.699216902256012},{"id":"https://openalex.org/keywords/probabilistic-logic","display_name":"Probabilistic logic","score":0.6861760020256042},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.684064507484436},{"id":"https://openalex.org/keywords/boolean-network","display_name":"Boolean network","score":0.6138384938240051},{"id":"https://openalex.org/keywords/bayesian-network","display_name":"Bayesian network","score":0.570180356502533},{"id":"https://openalex.org/keywords/state-space","display_name":"State space","score":0.5306792855262756},{"id":"https://openalex.org/keywords/markov-decision-process","display_name":"Markov decision process","score":0.5223939418792725},{"id":"https://openalex.org/keywords/dynamic-bayesian-network","display_name":"Dynamic Bayesian network","score":0.46752288937568665},{"id":"https://openalex.org/keywords/markov-chain","display_name":"Markov chain","score":0.4128701686859131},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.382518470287323},{"id":"https://openalex.org/keywords/markov-process","display_name":"Markov process","score":0.3815552890300751},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.37230685353279114},{"id":"https://openalex.org/keywords/boolean-function","display_name":"Boolean function","score":0.26127755641937256},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.21787124872207642},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2175564169883728},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.21740293502807617},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.15782317519187927},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.1418379247188568},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.10030403733253479},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.08767178654670715}],"concepts":[{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.699216902256012},{"id":"https://openalex.org/C49937458","wikidata":"https://www.wikidata.org/wiki/Q2599292","display_name":"Probabilistic logic","level":2,"score":0.6861760020256042},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.684064507484436},{"id":"https://openalex.org/C134444547","wikidata":"https://www.wikidata.org/wiki/Q585230","display_name":"Boolean network","level":3,"score":0.6138384938240051},{"id":"https://openalex.org/C33724603","wikidata":"https://www.wikidata.org/wiki/Q812540","display_name":"Bayesian network","level":2,"score":0.570180356502533},{"id":"https://openalex.org/C72434380","wikidata":"https://www.wikidata.org/wiki/Q230930","display_name":"State space","level":2,"score":0.5306792855262756},{"id":"https://openalex.org/C106189395","wikidata":"https://www.wikidata.org/wiki/Q176789","display_name":"Markov decision process","level":3,"score":0.5223939418792725},{"id":"https://openalex.org/C82142266","wikidata":"https://www.wikidata.org/wiki/Q3456604","display_name":"Dynamic Bayesian network","level":3,"score":0.46752288937568665},{"id":"https://openalex.org/C98763669","wikidata":"https://www.wikidata.org/wiki/Q176645","display_name":"Markov chain","level":2,"score":0.4128701686859131},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.382518470287323},{"id":"https://openalex.org/C159886148","wikidata":"https://www.wikidata.org/wiki/Q176645","display_name":"Markov process","level":2,"score":0.3815552890300751},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.37230685353279114},{"id":"https://openalex.org/C187455244","wikidata":"https://www.wikidata.org/wiki/Q942353","display_name":"Boolean function","level":2,"score":0.26127755641937256},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.21787124872207642},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2175564169883728},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.21740293502807617},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15782317519187927},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.1418379247188568},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.10030403733253479},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08767178654670715},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/bibe.2008.4696698","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe.2008.4696698","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008 8th IEEE International Conference on BioInformatics and BioEngineering","raw_type":"proceedings-article"},{"id":"pmh:oai:open.metu.edu.tr:11511/47547","is_oa":true,"landing_page_url":"https://hdl.handle.net/11511/47547","pdf_url":null,"source":{"id":"https://openalex.org/S4306402495","display_name":"OpenMETU (Middle East Technical University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I201799495","host_organization_name":"Middle East Technical University","host_organization_lineage":["https://openalex.org/I201799495"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Conference Paper"}],"best_oa_location":{"id":"pmh:oai:open.metu.edu.tr:11511/47547","is_oa":true,"landing_page_url":"https://hdl.handle.net/11511/47547","pdf_url":null,"source":{"id":"https://openalex.org/S4306402495","display_name":"OpenMETU (Middle East Technical University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I201799495","host_organization_name":"Middle East Technical University","host_organization_lineage":["https://openalex.org/I201799495"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Conference Paper"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/16","score":0.7699999809265137,"display_name":"Peace, Justice and strong institutions"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1530444831","https://openalex.org/W1532781952","https://openalex.org/W1599602125","https://openalex.org/W1600339875","https://openalex.org/W1650504995","https://openalex.org/W1807981783","https://openalex.org/W1976157781","https://openalex.org/W1997477668","https://openalex.org/W2020294948","https://openalex.org/W2026368892","https://openalex.org/W2030387392","https://openalex.org/W2041020361","https://openalex.org/W2086150890","https://openalex.org/W2092284137","https://openalex.org/W2108020239","https://openalex.org/W2119567691","https://openalex.org/W2120406836","https://openalex.org/W2131441237","https://openalex.org/W2136628513","https://openalex.org/W2147065644","https://openalex.org/W2155619559","https://openalex.org/W2159638256","https://openalex.org/W2160533336","https://openalex.org/W2160904474","https://openalex.org/W2167435507","https://openalex.org/W2168399023","https://openalex.org/W2334782222","https://openalex.org/W2341171179","https://openalex.org/W4246239274","https://openalex.org/W4388252848","https://openalex.org/W6631910770","https://openalex.org/W6636774213"],"related_works":["https://openalex.org/W2544242547","https://openalex.org/W2119218276","https://openalex.org/W2369018153","https://openalex.org/W2530648058","https://openalex.org/W1422717320","https://openalex.org/W1604786655","https://openalex.org/W2794960257","https://openalex.org/W2330768201","https://openalex.org/W2108120899","https://openalex.org/W2349909726"],"abstract_inverted_index":{"Control":[0],"of":[1,7,32,67,71,98,149],"Probabilistic":[2],"Boolean":[3],"Networks":[4],"as":[5,24],"models":[6,103],"gene":[8,37,116,141],"regulation":[9],"is":[10,40,53],"an":[11,72],"important":[12],"problem;":[13,51],"the":[14,30,33,50,56,60,68,89,95,145,150],"solution":[15,48],"may":[16],"help":[17],"researchers":[18],"in":[19,36,59,77],"various":[20],"different":[21],"areas.":[22],"But":[23],"generally":[25],"applies":[26],"to":[27,43,49,115],"control":[28,78],"problems,":[29],"size":[31],"state":[34,91,99],"space":[35,92],"regulatory":[38,117],"networks":[39],"too":[41],"large":[42],"be":[44,75],"considered":[45],"for":[46],"comprehensive":[47],"this":[52,109],"evident":[54],"from":[55],"work":[57],"done":[58],"field,":[61],"where":[62],"only":[63],"very":[64],"small":[65],"portions":[66],"whole":[69,90],"genome":[70],"organism":[73],"could":[74],"used":[76],"applications.":[79],"The":[80,137],"Factored":[81],"Markov":[82],"Decision":[83],"Problem":[84],"(FMDP)":[85],"framework":[86],"avoids":[87],"enumerating":[88],"by":[93,132],"representing":[94],"probability":[96],"distribution":[97],"transitions":[100],"using":[101,133],"compact":[102],"like":[104],"dynamic":[105],"bayesian":[106],"networks.":[107],"In":[108],"paper,":[110],"we":[111],"successfully":[112],"applied":[113],"FMDP":[114,135],"network":[118],"control,":[119],"and":[120,147],"proposed":[121,151],"a":[122],"model":[123],"minimization":[124],"method":[125],"that":[126],"helps":[127],"finding":[128],"better":[129],"approximate":[130],"policies":[131],"existing":[134],"solvers.":[136],"results":[138],"reported":[139],"on":[140],"expression":[142],"data":[143],"demonstrate":[144],"applicability":[146],"effectiveness":[148],"approach.":[152]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}