{"id":"https://openalex.org/W2001030811","doi":"https://doi.org/10.1109/bibe.2008.4696678","title":"Gene - nutrition interactions in the onset of obesity as Cardiovascular Disease risk factor based on a computational intelligence method","display_name":"Gene - nutrition interactions in the onset of obesity as Cardiovascular Disease risk factor based on a computational intelligence method","publication_year":2008,"publication_date":"2008-10-01","ids":{"openalex":"https://openalex.org/W2001030811","doi":"https://doi.org/10.1109/bibe.2008.4696678","mag":"2001030811"},"language":"en","primary_location":{"id":"doi:10.1109/bibe.2008.4696678","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe.2008.4696678","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008 8th IEEE International Conference on BioInformatics and BioEngineering","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://doi.org/10.1109/BIBE.2008.4696678","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045630754","display_name":"Ioannis Valavanis","orcid":null},"institutions":[{"id":"https://openalex.org/I174458059","display_name":"National Technical University of Athens","ror":"https://ror.org/03cx6bg69","country_code":"GR","type":"education","lineage":["https://openalex.org/I174458059"]},{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Ioannis K. Valavanis","raw_affiliation_strings":["School of Electrical and Computer Engineering, National and Technical University of Athens, Zografou, Greece","Sch. of Electr. & Comput. Eng. Nat., Tech. Univ. of Athens, Athens"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electrical and Computer Engineering, National and Technical University of Athens, Zografou, Greece","institution_ids":["https://openalex.org/I174458059"]},{"raw_affiliation_string":"Sch. of Electr. & Comput. Eng. Nat., Tech. Univ. of Athens, Athens","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033248976","display_name":"Stavroula Mougiakakou","orcid":"https://orcid.org/0000-0002-6355-9982"},"institutions":[{"id":"https://openalex.org/I174458059","display_name":"National Technical University of Athens","ror":"https://ror.org/03cx6bg69","country_code":"GR","type":"education","lineage":["https://openalex.org/I174458059"]},{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Stavroula G. Mougiakakou","raw_affiliation_strings":["School of Electrical and Computer Engineering, National and Technical University of Athens, Zografou, Greece","Sch. of Electr. & Comput. Eng. Nat., Tech. Univ. of Athens, Athens"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electrical and Computer Engineering, National and Technical University of Athens, Zografou, Greece","institution_ids":["https://openalex.org/I174458059"]},{"raw_affiliation_string":"Sch. of Electr. & Comput. Eng. Nat., Tech. Univ. of Athens, Athens","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032376210","display_name":"Stathis Marinos","orcid":null},"institutions":[{"id":"https://openalex.org/I174458059","display_name":"National Technical University of Athens","ror":"https://ror.org/03cx6bg69","country_code":"GR","type":"education","lineage":["https://openalex.org/I174458059"]},{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Stathis Marinos","raw_affiliation_strings":["School of Electrical and Computer Engineering, National and Technical University of Athens, Zografou, Greece","Sch. of Electr. & Comput. Eng. Nat., Tech. Univ. of Athens, Athens"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electrical and Computer Engineering, National and Technical University of Athens, Zografou, Greece","institution_ids":["https://openalex.org/I174458059"]},{"raw_affiliation_string":"Sch. of Electr. & Comput. Eng. Nat., Tech. Univ. of Athens, Athens","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009652525","display_name":"George Karkalis","orcid":null},"institutions":[{"id":"https://openalex.org/I174458059","display_name":"National Technical University of Athens","ror":"https://ror.org/03cx6bg69","country_code":"GR","type":"education","lineage":["https://openalex.org/I174458059"]},{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"George Karkalis","raw_affiliation_strings":["School of Electrical and Computer Engineering, National and Technical University of Athens, Zografou, Greece","Sch. of Electr. & Comput. Eng. Nat., Tech. Univ. of Athens, Athens"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electrical and Computer Engineering, National and Technical University of Athens, Zografou, Greece","institution_ids":["https://openalex.org/I174458059"]},{"raw_affiliation_string":"Sch. of Electr. & Comput. Eng. Nat., Tech. Univ. of Athens, Athens","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045722216","display_name":"Keith Grimaldi","orcid":"https://orcid.org/0000-0003-2271-5990"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keith A. Grimaldi","raw_affiliation_strings":["Sciona, Inc., CO, USA","Sciona Inc., Boulder, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sciona, Inc., CO, USA","institution_ids":[]},{"raw_affiliation_string":"Sciona Inc., Boulder, CO","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034410847","display_name":"Rosalynn Gill","orcid":"https://orcid.org/0000-0003-3034-080X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rosalynn Gill","raw_affiliation_strings":["Sciona, Inc., CO, USA","Sciona Inc., Boulder, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sciona, Inc., CO, USA","institution_ids":[]},{"raw_affiliation_string":"Sciona Inc., Boulder, CO","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082313849","display_name":"Konstantina S. Nikita","orcid":"https://orcid.org/0000-0001-8255-4354"},"institutions":[{"id":"https://openalex.org/I174458059","display_name":"National Technical University of Athens","ror":"https://ror.org/03cx6bg69","country_code":"GR","type":"education","lineage":["https://openalex.org/I174458059"]},{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Konstantina S. Nikita","raw_affiliation_strings":["School of Electrical and Computer Engineering, National and Technical University of Athens, Zografou, Greece","Sch. of Electr. & Comput. Eng. Nat., Tech. Univ. of Athens, Athens"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electrical and Computer Engineering, National and Technical University of Athens, Zografou, Greece","institution_ids":["https://openalex.org/I174458059"]},{"raw_affiliation_string":"Sch. of Electr. & Comput. Eng. Nat., Tech. Univ. of Athens, Athens","institution_ids":["https://openalex.org/I200777214"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.939300000667572,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13937","display_name":"Genetics, Bioinformatics, and Biomedical Research","score":0.9381999969482422,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/body-mass-index","display_name":"Body mass index","score":0.6949405074119568},{"id":"https://openalex.org/keywords/obesity","display_name":"Obesity","score":0.6007546186447144},{"id":"https://openalex.org/keywords/resampling","display_name":"Resampling","score":0.5991945266723633},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5802832841873169},{"id":"https://openalex.org/keywords/trait","display_name":"Trait","score":0.548401415348053},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.47427400946617126},{"id":"https://openalex.org/keywords/risk-factor","display_name":"Risk factor","score":0.46082839369773865},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.4591052532196045},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4511696994304657},{"id":"https://openalex.org/keywords/computational-intelligence","display_name":"Computational intelligence","score":0.42567354440689087},{"id":"https://openalex.org/keywords/affect","display_name":"Affect (linguistics)","score":0.4174412488937378},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.41583192348480225},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.37017181515693665},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.30966615676879883},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3066486716270447},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.22924810647964478},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2168656587600708},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.15805909037590027}],"concepts":[{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.6949405074119568},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.6007546186447144},{"id":"https://openalex.org/C150921843","wikidata":"https://www.wikidata.org/wiki/Q1170431","display_name":"Resampling","level":2,"score":0.5991945266723633},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5802832841873169},{"id":"https://openalex.org/C106934330","wikidata":"https://www.wikidata.org/wiki/Q1971873","display_name":"Trait","level":2,"score":0.548401415348053},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.47427400946617126},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.46082839369773865},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.4591052532196045},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4511696994304657},{"id":"https://openalex.org/C139502532","wikidata":"https://www.wikidata.org/wiki/Q1122090","display_name":"Computational intelligence","level":2,"score":0.42567354440689087},{"id":"https://openalex.org/C2776035688","wikidata":"https://www.wikidata.org/wiki/Q1606558","display_name":"Affect (linguistics)","level":2,"score":0.4174412488937378},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.41583192348480225},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.37017181515693665},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30966615676879883},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3066486716270447},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22924810647964478},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2168656587600708},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.15805909037590027},{"id":"https://openalex.org/C46312422","wikidata":"https://www.wikidata.org/wiki/Q11024","display_name":"Communication","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/bibe.2008.4696678","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe.2008.4696678","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008 8th IEEE International Conference on BioInformatics and BioEngineering","raw_type":"proceedings-article"},{"id":"pmh:oai:dspace.lib.ntua.gr:123456789/32259","is_oa":true,"landing_page_url":"http://doi.org/10.1109/BIBE.2008.4696678","pdf_url":null,"source":{"id":"https://openalex.org/S4377196837","display_name":"DSpace - NTUA (National Technical University of Athens)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I174458059","host_organization_name":"National Technical University of Athens","host_organization_lineage":["https://openalex.org/I174458059"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"8th IEEE International Conference on BioInformatics and BioEngineering, BIBE 2008","raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":{"id":"pmh:oai:dspace.lib.ntua.gr:123456789/32259","is_oa":true,"landing_page_url":"http://doi.org/10.1109/BIBE.2008.4696678","pdf_url":null,"source":{"id":"https://openalex.org/S4377196837","display_name":"DSpace - NTUA (National Technical University of Athens)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I174458059","host_organization_name":"National Technical University of Athens","host_organization_lineage":["https://openalex.org/I174458059"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"8th IEEE International Conference on BioInformatics and BioEngineering, BIBE 2008","raw_type":"info:eu-repo/semantics/conferenceObject"},"sustainable_development_goals":[{"score":0.6700000166893005,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W141766886","https://openalex.org/W1502653371","https://openalex.org/W1521237785","https://openalex.org/W1565095998","https://openalex.org/W1786104672","https://openalex.org/W1975396627","https://openalex.org/W1982383229","https://openalex.org/W1999681081","https://openalex.org/W2013271332","https://openalex.org/W2026155675","https://openalex.org/W2044580518","https://openalex.org/W2057082825","https://openalex.org/W2061133004","https://openalex.org/W2064954710","https://openalex.org/W2072290041","https://openalex.org/W2080418085","https://openalex.org/W2085739707","https://openalex.org/W2086099578","https://openalex.org/W2089112228","https://openalex.org/W2097364929","https://openalex.org/W2110713453","https://openalex.org/W2114001895","https://openalex.org/W2122326411","https://openalex.org/W2124728532","https://openalex.org/W2124776405","https://openalex.org/W2131878646","https://openalex.org/W2139315574","https://openalex.org/W2141063866","https://openalex.org/W2147688724","https://openalex.org/W2150531171","https://openalex.org/W3201508810","https://openalex.org/W4285719527","https://openalex.org/W4297572109"],"related_works":["https://openalex.org/W2052515325","https://openalex.org/W2050948537","https://openalex.org/W2767646790","https://openalex.org/W2352041579","https://openalex.org/W1488006380","https://openalex.org/W2138381686","https://openalex.org/W2141585124","https://openalex.org/W1998176685","https://openalex.org/W3123883311","https://openalex.org/W2032175896"],"abstract_inverted_index":{"Identification":[0],"of":[1,11,18,31,39,61,70,106,145,169],"gene-gene":[2],"and":[3,57,74,117],"gene-environment":[4],"interactions":[5],"that":[6,45,127],"contribute":[7],"in":[8,160],"the":[9,16,21,62,122,134,142,161,170],"onset":[10,69],"a":[12,29,46,67,82,88,151,166,174],"multi-factorial":[13],"disease":[14],"supports":[15],"prevention":[17],"diseases":[19],"like":[20],"Cardiovascular":[22],"Disease":[23],"(CVD).":[24],"Body":[25],"Mass":[26],"Index":[27],"(BMI),":[28],"measure":[30],"human":[32],"obesity,":[33],"is":[34,43,49,64,79,148],"an":[35,95,103],"independent":[36],"risk":[37],"factor":[38],"CVD.":[40],"Furthermore,":[41],"it":[42],"known":[44],"subjectpsilas":[47,68],"BMI":[48],"affected":[50],"both":[51],"by":[52,81,173],"his/her":[53],"lifestyle,":[54],"e.g.":[55],"nutrition,":[56],"genetic":[58,75,118],"profile.":[59],"Aim":[60],"paper":[63],"to":[65,111,120,136,180],"predict":[66],"obesity":[71],"using":[72,87],"lifestyle":[73],"information.":[76],"The":[77,100,130,163],"prediction":[78],"performed":[80],"computational":[83],"intelligence":[84],"based":[85],"system":[86,101,164,171],"Parameter":[89],"Decreasing":[90],"Method":[91],"(PDM)":[92],"combined":[93],"with":[94,138],"Artificial":[96],"Neural":[97],"Network":[98],"(ANN).":[99],"uses":[102],"initial":[104],"set":[105],"63":[107],"input":[108],"variables":[109,132],"corresponding":[110],"sex,":[112],"average":[113],"nutrition":[114],"intake":[115],"measurements,":[116],"variations":[119],"identify":[121],"32":[123],"most":[124],"important":[125],"ones":[126,135],"affect":[128],"BMI.":[129],"selected":[131],"are":[133],"interact":[137],"each":[139],"other":[140],"towards":[141],"complex":[143],"trait":[144],"BMI,":[146],"which":[147],"used":[149],"as":[150],"2-class":[152],"output":[153],"variable":[154],"(BMI":[155],"les":[156],"25":[157],"vs.":[158],"BMIges25)":[159],"ANN.":[162],"achieved":[165],"mean":[167],"accuracy":[168],"evaluated":[172],"3-cross":[175],"validation":[176],"resampling":[177],"technique":[178],"equal":[179],"77.89%.":[181]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}
