{"id":"https://openalex.org/W2107319156","doi":"https://doi.org/10.1109/bibe.2008.4696657","title":"Physical understanding via reduction of complex multiscale models: Glycolysis in saccharomyces cerevisiae","display_name":"Physical understanding via reduction of complex multiscale models: Glycolysis in saccharomyces cerevisiae","publication_year":2008,"publication_date":"2008-10-01","ids":{"openalex":"https://openalex.org/W2107319156","doi":"https://doi.org/10.1109/bibe.2008.4696657","mag":"2107319156"},"language":"en","primary_location":{"id":"doi:10.1109/bibe.2008.4696657","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe.2008.4696657","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008 8th IEEE International Conference on BioInformatics and BioEngineering","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://doi.org/10.1109/BIBE.2008.4696657","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021694632","display_name":"Panayotis D. Kourdis","orcid":"https://orcid.org/0000-0002-4430-532X"},"institutions":[{"id":"https://openalex.org/I174458059","display_name":"National Technical University of Athens","ror":"https://ror.org/03cx6bg69","country_code":"GR","type":"education","lineage":["https://openalex.org/I174458059"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Panayotis D. Kourdis","raw_affiliation_strings":["School of Applied Mathematics and Physics, National and Technical University of Athens, Athens, Greece","Sch. of Appl. Math. & Phys., Nat. Tech. Univ., Athens"],"affiliations":[{"raw_affiliation_string":"School of Applied Mathematics and Physics, National and Technical University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I174458059"]},{"raw_affiliation_string":"Sch. of Appl. Math. & Phys., Nat. Tech. Univ., Athens","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030085333","display_name":"Dimitris A. Goussis","orcid":"https://orcid.org/0000-0002-9674-9491"},"institutions":[{"id":"https://openalex.org/I174458059","display_name":"National Technical University of Athens","ror":"https://ror.org/03cx6bg69","country_code":"GR","type":"education","lineage":["https://openalex.org/I174458059"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Dimitris A. Goussis","raw_affiliation_strings":["School of Applied Mathematics and Physics, National and Technical University of Athens, Athens, Greece","Sch. of Appl. Math. & Phys., Nat. Tech. Univ., Athens"],"affiliations":[{"raw_affiliation_string":"School of Applied Mathematics and Physics, National and Technical University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I174458059"]},{"raw_affiliation_string":"Sch. of Appl. Math. & Phys., Nat. Tech. Univ., Athens","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050212918","display_name":"Ralf Steuer","orcid":"https://orcid.org/0000-0003-2217-1655"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ralf Steuer","raw_affiliation_strings":["Manchester Interdisciplinary Biocentre, University of Manchester, Institute of Science and Technology, Manchester, UK","Manchester Interdiscipl. Biocentre, Univ. of Manchester, Manchester"],"affiliations":[{"raw_affiliation_string":"Manchester Interdisciplinary Biocentre, University of Manchester, Institute of Science and Technology, Manchester, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Manchester Interdiscipl. Biocentre, Univ. of Manchester, Manchester","institution_ids":["https://openalex.org/I28407311"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5021694632"],"corresponding_institution_ids":["https://openalex.org/I174458059"],"apc_list":null,"apc_paid":null,"fwci":0.4136,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.64443208,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"94","issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9836000204086304,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9797999858856201,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/limit","display_name":"Limit (mathematics)","score":0.6733368635177612},{"id":"https://openalex.org/keywords/reduction","display_name":"Reduction (mathematics)","score":0.6443109512329102},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.575253427028656},{"id":"https://openalex.org/keywords/limit-cycle","display_name":"Limit cycle","score":0.5555089116096497},{"id":"https://openalex.org/keywords/physical-system","display_name":"Physical system","score":0.5135612487792969},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.5070581436157227},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.42542409896850586},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.4057149887084961},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.3551830053329468},{"id":"https://openalex.org/keywords/applied-mathematics","display_name":"Applied mathematics","score":0.340567409992218},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.34000545740127563},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.27207690477371216},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.2643682062625885},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.15517622232437134},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.14044013619422913},{"id":"https://openalex.org/keywords/mathematical-analysis","display_name":"Mathematical analysis","score":0.11259758472442627}],"concepts":[{"id":"https://openalex.org/C151201525","wikidata":"https://www.wikidata.org/wiki/Q177239","display_name":"Limit (mathematics)","level":2,"score":0.6733368635177612},{"id":"https://openalex.org/C111335779","wikidata":"https://www.wikidata.org/wiki/Q3454686","display_name":"Reduction (mathematics)","level":2,"score":0.6443109512329102},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.575253427028656},{"id":"https://openalex.org/C93357160","wikidata":"https://www.wikidata.org/wiki/Q1545916","display_name":"Limit cycle","level":3,"score":0.5555089116096497},{"id":"https://openalex.org/C116672817","wikidata":"https://www.wikidata.org/wiki/Q1454986","display_name":"Physical system","level":2,"score":0.5135612487792969},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.5070581436157227},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.42542409896850586},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4057149887084961},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.3551830053329468},{"id":"https://openalex.org/C28826006","wikidata":"https://www.wikidata.org/wiki/Q33521","display_name":"Applied mathematics","level":1,"score":0.340567409992218},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.34000545740127563},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.27207690477371216},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2643682062625885},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.15517622232437134},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14044013619422913},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.11259758472442627},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/bibe.2008.4696657","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe.2008.4696657","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008 8th IEEE International Conference on BioInformatics and BioEngineering","raw_type":"proceedings-article"},{"id":"pmh:oai:dspace.lib.ntua.gr:123456789/32358","is_oa":true,"landing_page_url":"http://doi.org/10.1109/BIBE.2008.4696657","pdf_url":null,"source":{"id":"https://openalex.org/S4377196837","display_name":"DSpace - NTUA (National Technical University of Athens)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I174458059","host_organization_name":"National Technical University of Athens","host_organization_lineage":["https://openalex.org/I174458059"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"8th IEEE International Conference on BioInformatics and BioEngineering, BIBE 2008","raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":{"id":"pmh:oai:dspace.lib.ntua.gr:123456789/32358","is_oa":true,"landing_page_url":"http://doi.org/10.1109/BIBE.2008.4696657","pdf_url":null,"source":{"id":"https://openalex.org/S4377196837","display_name":"DSpace - NTUA (National Technical University of Athens)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I174458059","host_organization_name":"National Technical University of Athens","host_organization_lineage":["https://openalex.org/I174458059"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"8th IEEE International Conference on BioInformatics and BioEngineering, BIBE 2008","raw_type":"info:eu-repo/semantics/conferenceObject"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W200565028","https://openalex.org/W1511267714","https://openalex.org/W1525349614","https://openalex.org/W1534151975","https://openalex.org/W1562360371","https://openalex.org/W1665145671","https://openalex.org/W1966113499","https://openalex.org/W1976262122","https://openalex.org/W1997586090","https://openalex.org/W2001698066","https://openalex.org/W2014681825","https://openalex.org/W2016767879","https://openalex.org/W2017551827","https://openalex.org/W2019685954","https://openalex.org/W2020506589","https://openalex.org/W2024056314","https://openalex.org/W2035502912","https://openalex.org/W2036752995","https://openalex.org/W2044484168","https://openalex.org/W2051755619","https://openalex.org/W2092652574","https://openalex.org/W2093549234","https://openalex.org/W2110841752","https://openalex.org/W2141906015","https://openalex.org/W2154882140","https://openalex.org/W2155177740","https://openalex.org/W2157166164","https://openalex.org/W2161317287","https://openalex.org/W2171112614","https://openalex.org/W2319973481","https://openalex.org/W2591853258","https://openalex.org/W2952016911","https://openalex.org/W4205597578","https://openalex.org/W6630484808"],"related_works":["https://openalex.org/W4388297534","https://openalex.org/W2051439117","https://openalex.org/W1673883441","https://openalex.org/W4298109871","https://openalex.org/W2313188567","https://openalex.org/W4248124207","https://openalex.org/W2083477739","https://openalex.org/W2089966216","https://openalex.org/W2017930464","https://openalex.org/W2017252923"],"abstract_inverted_index":{"We":[0],"consider":[1],"complex":[2],"mathematical":[3],"models":[4],"that":[5,40],"are":[6,19,54],"characterized":[7],"by":[8],"a":[9,77,87],"wide":[10],"spectrum":[11],"of":[12,17,71,82],"time":[13],"scales,":[14],"the":[15,22,27,32,49,80],"fastest":[16],"which":[18,83],"operative":[20],"during":[21],"initial":[23],"state":[24],"only,":[25],"leaving":[26],"slower":[28],"ones":[29],"to":[30],"drive":[31],"system":[33],"at":[34],"later":[35],"times.":[36],"It":[37],"is":[38,74],"shown":[39],"very":[41],"useful":[42],"physical":[43],"understanding":[44],"can":[45,63],"be":[46,64],"acquired":[47],"if":[48],"fast":[50],"and":[51,57],"slow":[52],"dynamics":[53],"first":[55],"separated":[56],"then":[58],"analyzed.":[59],"Existing":[60],"algorithmic":[61],"methodologies":[62],"applied":[65],"for":[66,76],"this":[67,72],"purpose.":[68],"A":[69],"demonstration":[70],"approach":[73],"presented":[75],"glycolysis":[78],"model,":[79],"solution":[81],"asymptotically":[84],"evolves":[85],"around":[86],"limit":[88],"cycle.":[89]},"counts_by_year":[{"year":2017,"cited_by_count":2}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}