{"id":"https://openalex.org/W1966714038","doi":"https://doi.org/10.1109/bibe.2007.4375742","title":"Intelligent Interfaces for Mining Large-Scale RNAi-HCS Image Databases","display_name":"Intelligent Interfaces for Mining Large-Scale RNAi-HCS Image Databases","publication_year":2007,"publication_date":"2007-10-01","ids":{"openalex":"https://openalex.org/W1966714038","doi":"https://doi.org/10.1109/bibe.2007.4375742","mag":"1966714038","pmid":"https://pubmed.ncbi.nlm.nih.gov/21278820"},"language":"en","primary_location":{"id":"doi:10.1109/bibe.2007.4375742","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe.2007.4375742","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2007 IEEE 7th International Symposium on BioInformatics and BioEngineering","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3028207","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075786464","display_name":"Chen Lin","orcid":"https://orcid.org/0000-0002-9839-476X"},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chen Lin","raw_affiliation_strings":["Computer Science Department, Brandeis University, Waltham, MA 02454","Computer Science Department, Brandeis University, Waltham, USA"],"affiliations":[{"raw_affiliation_string":"Computer Science Department, Brandeis University, Waltham, MA 02454","institution_ids":[]},{"raw_affiliation_string":"Computer Science Department, Brandeis University, Waltham, USA","institution_ids":["https://openalex.org/I6902469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112761184","display_name":"Wayne Mak","orcid":null},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wayne Mak","raw_affiliation_strings":["Computer Science Department, Brandeis University, Waltham, USA"],"affiliations":[{"raw_affiliation_string":"Computer Science Department, Brandeis University, Waltham, USA","institution_ids":["https://openalex.org/I6902469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033168441","display_name":"Pengyu Hong","orcid":"https://orcid.org/0000-0002-3177-2754"},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pengyu Hong","raw_affiliation_strings":["Computer Science Department, Brandeis University, Waltham, USA"],"affiliations":[{"raw_affiliation_string":"Computer Science Department, Brandeis University, Waltham, USA","institution_ids":["https://openalex.org/I6902469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086580156","display_name":"Katharine J. Sepp","orcid":null},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katharine Sepp","raw_affiliation_strings":["Department of Genetics, Harvard Medical School, Boston, USA"],"affiliations":[{"raw_affiliation_string":"Department of Genetics, Harvard Medical School, Boston, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071083794","display_name":"Norbert Perrimon","orcid":"https://orcid.org/0000-0001-7542-472X"},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Norbert Perrimon","raw_affiliation_strings":["Department of Genetics, Harvard Medical School, Boston, USA","Howard Hughes Medical Institute, Boston, USA"],"affiliations":[{"raw_affiliation_string":"Department of Genetics, Harvard Medical School, Boston, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Boston, USA","institution_ids":["https://openalex.org/I1344073410"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5075786464"],"corresponding_institution_ids":["https://openalex.org/I6902469"],"apc_list":null,"apc_paid":null,"fwci":1.1386,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.83425905,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"6","issue":null,"first_page":"1333","last_page":"1337"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13114","display_name":"Image Processing Techniques and Applications","score":0.9947999715805054,"subfield":{"id":"https://openalex.org/subfields/2214","display_name":"Media Technology"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10824","display_name":"Image Retrieval and Classification Techniques","score":0.9883999824523926,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.76334547996521},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7392202019691467},{"id":"https://openalex.org/keywords/high-content-screening","display_name":"High-content screening","score":0.6833395957946777},{"id":"https://openalex.org/keywords/relevance","display_name":"Relevance (law)","score":0.5681881308555603},{"id":"https://openalex.org/keywords/interference","display_name":"Interference (communication)","score":0.5470349788665771},{"id":"https://openalex.org/keywords/throughput","display_name":"Throughput","score":0.47626134753227234},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3885756731033325},{"id":"https://openalex.org/keywords/information-retrieval","display_name":"Information retrieval","score":0.3774772584438324},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.28087154030799866},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.18896695971488953},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.1649051010608673},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.14861485362052917},{"id":"https://openalex.org/keywords/computer-network","display_name":"Computer network","score":0.11168673634529114},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.101683109998703},{"id":"https://openalex.org/keywords/wireless","display_name":"Wireless","score":0.07830268144607544}],"concepts":[{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.76334547996521},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7392202019691467},{"id":"https://openalex.org/C157044486","wikidata":"https://www.wikidata.org/wiki/Q5754482","display_name":"High-content screening","level":3,"score":0.6833395957946777},{"id":"https://openalex.org/C158154518","wikidata":"https://www.wikidata.org/wiki/Q7310970","display_name":"Relevance (law)","level":2,"score":0.5681881308555603},{"id":"https://openalex.org/C32022120","wikidata":"https://www.wikidata.org/wiki/Q797225","display_name":"Interference (communication)","level":3,"score":0.5470349788665771},{"id":"https://openalex.org/C157764524","wikidata":"https://www.wikidata.org/wiki/Q1383412","display_name":"Throughput","level":3,"score":0.47626134753227234},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3885756731033325},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.3774772584438324},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28087154030799866},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18896695971488953},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.1649051010608673},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.14861485362052917},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.11168673634529114},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.101683109998703},{"id":"https://openalex.org/C555944384","wikidata":"https://www.wikidata.org/wiki/Q249","display_name":"Wireless","level":2,"score":0.07830268144607544},{"id":"https://openalex.org/C127162648","wikidata":"https://www.wikidata.org/wiki/Q16858953","display_name":"Channel (broadcasting)","level":2,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/bibe.2007.4375742","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe.2007.4375742","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2007 IEEE 7th International Symposium on BioInformatics and BioEngineering","raw_type":"proceedings-article"},{"id":"pmid:21278820","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21278820","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings. IEEE International Symposium on Bioinformatics and Bioengineering","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:3028207","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3028207","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc IEEE Int Symp Bioinformatics Bioeng","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3028207","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3028207","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc IEEE Int Symp Bioinformatics Bioeng","raw_type":"Text"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W147571259","https://openalex.org/W262436420","https://openalex.org/W1489703101","https://openalex.org/W1506281249","https://openalex.org/W1956559956","https://openalex.org/W1967641913","https://openalex.org/W1984643873","https://openalex.org/W1993669821","https://openalex.org/W2006117889","https://openalex.org/W2009842679","https://openalex.org/W2030314811","https://openalex.org/W2034225957","https://openalex.org/W2038863154","https://openalex.org/W2043305993","https://openalex.org/W2045662680","https://openalex.org/W2052977543","https://openalex.org/W2065221771","https://openalex.org/W2068306188","https://openalex.org/W2091708067","https://openalex.org/W2092543424","https://openalex.org/W2097449851","https://openalex.org/W2113180829","https://openalex.org/W2129878062","https://openalex.org/W2130660124","https://openalex.org/W2133059825","https://openalex.org/W2137025720","https://openalex.org/W2138199375","https://openalex.org/W2145752049","https://openalex.org/W2158685692","https://openalex.org/W2163704252","https://openalex.org/W2164547069","https://openalex.org/W2168166653","https://openalex.org/W2799061466","https://openalex.org/W2912691530","https://openalex.org/W3103772912"],"related_works":["https://openalex.org/W2387630553","https://openalex.org/W1572871015","https://openalex.org/W2411232599","https://openalex.org/W3156756868","https://openalex.org/W2030262874","https://openalex.org/W1998876971","https://openalex.org/W2885524011","https://openalex.org/W2078249988","https://openalex.org/W2351305945","https://openalex.org/W2131861600"],"abstract_inverted_index":{"Recently,":[0],"High-content":[1],"screening":[2],"(HCS)":[3],"has":[4],"been":[5],"combined":[6],"with":[7,108,141],"RNA":[8],"interference":[9],"(RNAi)":[10],"to":[11,47,64,92,113,124,130],"become":[12],"an":[13],"essential":[14],"image-based":[15],"high-throughput":[16],"method":[17],"for":[18],"studying":[19],"genes":[20],"and":[21,72,115,128],"biological":[22],"networks":[23],"through":[24],"RNAi-induced":[25],"cellular":[26,81,134],"phenotype":[27],"analyses.":[28],"However,":[29],"a":[30,66,75],"genome-wide":[31],"RNAi-HCS":[32,69,119],"screen":[33],"typically":[34],"generates":[35],"tens":[36],"of":[37,39,42,50,77,96,133],"thousands":[38],"images,":[40],"most":[41],"which":[43],"remain":[44],"uncategorized":[45],"due":[46],"the":[48,94,97],"inadequacies":[49],"existing":[51],"HCS":[52,98],"image":[53,70,120],"analysis":[54],"tools.":[55],"Until":[56],"now,":[57],"it":[58],"still":[59],"requires":[60],"highly":[61],"trained":[62],"scientists":[63],"browse":[65],"prohibitively":[67],"large":[68],"database":[71],"produce":[73],"only":[74,112],"handful":[76],"qualitative":[78],"results":[79],"regarding":[80],"morphological":[82],"phenotypes.":[83],"For":[84],"this":[85],"reason":[86],"we":[87],"have":[88],"developed":[89],"intelligent":[90],"interfaces":[91,105],"facilitate":[93],"application":[95],"technology":[99],"in":[100],"biomedical":[101],"research.":[102],"Our":[103],"new":[104],"empower":[106],"biologists":[107],"computational":[109],"power":[110],"not":[111],"effectively":[114],"efficiently":[116],"explore":[117],"large-scale":[118],"databases,":[121],"but":[122],"also":[123],"apply":[125],"their":[126],"knowledge":[127],"experience":[129],"interactive":[131],"mining":[132],"phenotypes":[135],"using":[136],"Content-Based":[137],"Image":[138],"Retrieval":[139],"(CBIR)":[140],"Relevance":[142],"Feedback":[143],"(RF)":[144],"techniques.":[145]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}
