{"id":"https://openalex.org/W1969871151","doi":"https://doi.org/10.1109/bibe.2007.4375647","title":"To fuse or not to fuse","display_name":"To fuse or not to fuse","publication_year":2007,"publication_date":"2007-10-01","ids":{"openalex":"https://openalex.org/W1969871151","doi":"https://doi.org/10.1109/bibe.2007.4375647","mag":"1969871151"},"language":"en","primary_location":{"id":"doi:10.1109/bibe.2007.4375647","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe.2007.4375647","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2007 IEEE 7th International Symposium on BioInformatics and BioEngineering","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113170523","display_name":"Kishore R. Sakharkar","orcid":null},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Kishore R. Sakharkar","raw_affiliation_strings":["NUMI, YLL School of Medicine, National University of Singapore, Singapore","Nat. Univ. of Singapore, Singapore"],"affiliations":[{"raw_affiliation_string":"NUMI, YLL School of Medicine, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Nat. Univ. of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043323519","display_name":"Meena Kishore Sakharkar","orcid":"https://orcid.org/0000-0002-9289-3314"},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Meena Kishore Sakharkar","raw_affiliation_strings":["School of MAE, Nanyang Technological University, Singapore","School of MAE, Nanyang Technological University, Singapore. mmeena@ntu.edu.sg"],"affiliations":[{"raw_affiliation_string":"School of MAE, Nanyang Technological University, Singapore","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"School of MAE, Nanyang Technological University, Singapore. mmeena@ntu.edu.sg","institution_ids":["https://openalex.org/I172675005"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5113170523"],"corresponding_institution_ids":["https://openalex.org/I165932596"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06528664,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"470","issue":null,"first_page":"766","last_page":"773"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.7051998376846313},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.6682323217391968},{"id":"https://openalex.org/keywords/transposon-mutagenesis","display_name":"Transposon mutagenesis","score":0.6336030960083008},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.6296634078025818},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6285004615783691},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.6200122237205505},{"id":"https://openalex.org/keywords/transposable-element","display_name":"Transposable element","score":0.575316309928894},{"id":"https://openalex.org/keywords/fusion-gene","display_name":"Fusion gene","score":0.5205346345901489},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5066095590591431},{"id":"https://openalex.org/keywords/mutagenesis","display_name":"Mutagenesis","score":0.41962963342666626},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.31078529357910156}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7051998376846313},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.6682323217391968},{"id":"https://openalex.org/C28693550","wikidata":"https://www.wikidata.org/wiki/Q7835335","display_name":"Transposon mutagenesis","level":5,"score":0.6336030960083008},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6296634078025818},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6285004615783691},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6200122237205505},{"id":"https://openalex.org/C4918238","wikidata":"https://www.wikidata.org/wiki/Q121438","display_name":"Transposable element","level":4,"score":0.575316309928894},{"id":"https://openalex.org/C111829193","wikidata":"https://www.wikidata.org/wiki/Q1108970","display_name":"Fusion gene","level":3,"score":0.5205346345901489},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5066095590591431},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.41962963342666626},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.31078529357910156}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/bibe.2007.4375647","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe.2007.4375647","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2007 IEEE 7th International Symposium on BioInformatics and BioEngineering","raw_type":"proceedings-article"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/30129","is_oa":false,"landing_page_url":"http://scholarbank.nus.edu.sg/handle/10635/30129","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus","raw_type":"Conference Paper"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1973010815","https://openalex.org/W2014761342","https://openalex.org/W2016299826","https://openalex.org/W2106391842","https://openalex.org/W2107644337","https://openalex.org/W4235934833"],"related_works":["https://openalex.org/W2040654308","https://openalex.org/W4313471483","https://openalex.org/W2144107911","https://openalex.org/W2073449104","https://openalex.org/W4327811729","https://openalex.org/W2031970716","https://openalex.org/W2112662535","https://openalex.org/W2088136581","https://openalex.org/W1568225189","https://openalex.org/W2761375181"],"abstract_inverted_index":{"Fusion":[0],"genes":[1,23,39,70,82,107],"have":[2],"been":[3],"reported":[4,79],"as":[5,43,72,80,108],"a":[6],"means":[7],"of":[8,12,27,63,92,102,105,118],"enabling":[9],"the":[10,25,53,69,87,100,103,116,135],"development":[11],"novel":[13],"or":[14],"enhanced":[15],"functions.":[16],"In":[17],"this":[18,76,84],"report,":[19],"we":[20],"analyzed":[21],"fusion":[22,38,65,73,106],"in":[24,45,52,75,83,86,129,134],"genomes":[26],"two":[28],"Helicobacter":[29],"pylori":[30,94],"strains":[31],"(26695":[32],"and":[33,35,49,56,127],"J99)":[34],"identified":[36,71],"32":[37],"that":[40],"are":[41,50],"present":[42],"neighbours":[44],"one":[46],"strain":[47,95],"(components)":[48],"fused":[51],"second":[54],"(composite),":[55],"vice-versa.":[57],"The":[58],"mechanism":[59],"for":[60,123,128],"each":[61],"case":[62],"gene":[64,125],"is":[66],"explored.":[67],"All":[68],"products":[74,104],"analysis":[77],"were":[78],"essential":[81],"bacterium":[85],"previously":[88],"documented":[89],"transposon":[90],"mutagenesis":[91],"H.":[93],"G27.":[96],"This":[97],"observation":[98],"suggests":[99],"potential":[101],"putative":[109],"microbial":[110],"drug":[111,131],"targets.":[112],"These":[113],"results":[114],"underscore":[115],"utility":[117],"bacterial":[119],"genomic":[120],"sequence":[121],"comparisons":[122],"understanding":[124],"evolution":[126],"silico":[130],"target":[132],"identification":[133],"post-genomic":[136],"era.":[137]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}