{"id":"https://openalex.org/W2071876621","doi":"https://doi.org/10.1109/bibe.2007.4375610","title":"Engineering Multifunctional Biologically-Amenable Nanomaterials for Interfacial Therapeutic Delivery and Substrate-Based Cellular Interrogation","display_name":"Engineering Multifunctional Biologically-Amenable Nanomaterials for Interfacial Therapeutic Delivery and Substrate-Based Cellular Interrogation","publication_year":2007,"publication_date":"2007-10-01","ids":{"openalex":"https://openalex.org/W2071876621","doi":"https://doi.org/10.1109/bibe.2007.4375610","mag":"2071876621"},"language":"en","primary_location":{"id":"doi:10.1109/bibe.2007.4375610","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe.2007.4375610","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2007 IEEE 7th International Symposium on BioInformatics and BioEngineering","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018263077","display_name":"Mark A. Chen","orcid":"https://orcid.org/0000-0003-3605-2198"},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Chen","raw_affiliation_strings":["Departments of Biomedical and Mechanical Engineering, Northwestern University, USA","[Northwestern Univ., Evanston]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biomedical and Mechanical Engineering, Northwestern University, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"[Northwestern Univ., Evanston]","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027301454","display_name":"Brian Huang","orcid":"https://orcid.org/0000-0003-0556-9821"},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Huang","raw_affiliation_strings":["Departments of Biomedical and Mechanical Engineering, Northwestern University, USA","[Northwestern Univ., Evanston]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biomedical and Mechanical Engineering, Northwestern University, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"[Northwestern Univ., Evanston]","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039730819","display_name":"Eric Shin","orcid":"https://orcid.org/0000-0001-6034-5738"},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Shin","raw_affiliation_strings":["Departments of Biomedical and Mechanical Engineering, Northwestern University, USA","[Northwestern Univ., Evanston]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biomedical and Mechanical Engineering, Northwestern University, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"[Northwestern Univ., Evanston]","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022627502","display_name":"Erik Robinson","orcid":null},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erik Robinson","raw_affiliation_strings":["Departments of Biomedical and Mechanical Engineering, Northwestern University, USA","[Northwestern Univ., Evanston]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biomedical and Mechanical Engineering, Northwestern University, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"[Northwestern Univ., Evanston]","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019949606","display_name":"Erik Pierstorff","orcid":null},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erik Pierstorff","raw_affiliation_strings":["Departments of Biomedical and Mechanical Engineering, Northwestern University, USA","[Northwestern Univ., Evanston]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biomedical and Mechanical Engineering, Northwestern University, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"[Northwestern Univ., Evanston]","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103448591","display_name":"Houjin Huang","orcid":null},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Houjin Huang","raw_affiliation_strings":["Departments of Biomedical and Mechanical Engineering, Northwestern University, USA","[Northwestern Univ., Evanston]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biomedical and Mechanical Engineering, Northwestern University, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"[Northwestern Univ., Evanston]","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014473511","display_name":"Dean Ho","orcid":"https://orcid.org/0000-0002-7337-296X"},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dean Ho","raw_affiliation_strings":["Departments of Biomedical and Mechanical Engineering, Northwestern University, USA","[Northwestern Univ., Evanston]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biomedical and Mechanical Engineering, Northwestern University, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"[Northwestern Univ., Evanston]","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I111979921"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"406","issue":null,"first_page":"517","last_page":"523"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.5723220109939575},{"id":"https://openalex.org/keywords/interfacing","display_name":"Interfacing","score":0.5685945153236389},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.5461665987968445},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"Drug delivery","score":0.532603919506073},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5100269913673401},{"id":"https://openalex.org/keywords/biocompatibility","display_name":"Biocompatibility","score":0.44924986362457275},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.4197113811969757},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.08288812637329102}],"concepts":[{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5723220109939575},{"id":"https://openalex.org/C2776303644","wikidata":"https://www.wikidata.org/wiki/Q1020499","display_name":"Interfacing","level":2,"score":0.5685945153236389},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5461665987968445},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.532603919506073},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5100269913673401},{"id":"https://openalex.org/C2777230088","wikidata":"https://www.wikidata.org/wiki/Q864426","display_name":"Biocompatibility","level":2,"score":0.44924986362457275},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4197113811969757},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08288812637329102},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C9390403","wikidata":"https://www.wikidata.org/wiki/Q3966","display_name":"Computer hardware","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibe.2007.4375610","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe.2007.4375610","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2007 IEEE 7th International Symposium on BioInformatics and BioEngineering","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6399999856948853,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320309475","display_name":"Northwestern University","ror":"https://ror.org/000e0be47"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1969245917","https://openalex.org/W1992912767","https://openalex.org/W2002664146","https://openalex.org/W2033708409","https://openalex.org/W2037603180","https://openalex.org/W2075244463","https://openalex.org/W2082731263","https://openalex.org/W2083308747","https://openalex.org/W2110504976","https://openalex.org/W2110937841","https://openalex.org/W2129170329","https://openalex.org/W2159977835","https://openalex.org/W2169233819","https://openalex.org/W2171937023","https://openalex.org/W6669336067"],"related_works":["https://openalex.org/W2136647108","https://openalex.org/W2350029007","https://openalex.org/W2152662857","https://openalex.org/W1965180958","https://openalex.org/W1973428399","https://openalex.org/W2182594080","https://openalex.org/W2484987020","https://openalex.org/W2017757432","https://openalex.org/W2076500439","https://openalex.org/W2088595294"],"abstract_inverted_index":{"The":[0],"advent":[1],"of":[2,23,39,48,79,118,123,130],"materials":[3],"that":[4,42,66],"can":[5,43,67],"enhance":[6],"the":[7,21,142],"interfaces":[8],"between":[9],"biological":[10],"tissue":[11],"and":[12,26,76],"engineered":[13],"devices":[14],"will":[15,97],"enable":[16],"unprecedented":[17],"medical":[18],"capabilities":[19],"in":[20,91,115],"context":[22],"prolonged":[24],"implantation,":[25],"novel":[27,40],"information":[28],"gleaned":[29],"from":[30,53],"cellular":[31],"interrogation,":[32],"etc.":[33],"This":[34],"work":[35],"addresses":[36,126],"a":[37,45,127],"spectrum":[38],"technologies":[41],"serve":[44],"broad":[46],"range":[47],"therapeutically":[49],"relevant":[50],"scenarios":[51],"ranging":[52],"inflammation":[54],"attenuation":[55],"to":[56,107],"stand-alone":[57],"chemotherapeutic":[58],"delivery":[59],"systems.":[60],"They":[61],"include":[62],"copolymer-based":[63],"multifunctional":[64],"platforms":[65,90,96],"be":[68,98],"applied":[69],"towards":[70],"dynamic":[71],"cell":[72],"adhesion/patterning,":[73],"drug":[74],"delivery,":[75],"localized":[77],"manipulation":[78],"key":[80,128],"cyto-regulatory":[81],"networks":[82],"for":[83],"clinical":[84,148],"applications.":[85],"In":[86,105],"addition,":[87],"soluble":[88],"nanodiamond":[89],"free-floating":[92],"or":[93],"thin":[94],"film":[95],"addressed":[99],"as":[100,112,114],"next":[101],"generation":[102],"therapeutic":[103],"vehicles.":[104],"addition":[106],"cytokine":[108],"expression":[109],"knockdown":[110],"studies":[111],"well":[113],"vivo":[116],"validation":[117],"their":[119,146],"efficacy,":[120],"this":[121],"suite":[122],"modalities":[124],"successfully":[125],"element":[129],"optimized":[131],"interfacing":[132],"based":[133],"upon":[134],"innate":[135],"biocompatibility":[136],"which":[137],"has":[138],"been":[139],"verified":[140],"at":[141],"genetic":[143],"level,":[144],"confirming":[145],"potential":[147],"significance.":[149]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}
