{"id":"https://openalex.org/W2121542901","doi":"https://doi.org/10.1109/bibe.2007.4375598","title":"Identifying Genomic Regulators of Set-Wise Co-Expression","display_name":"Identifying Genomic Regulators of Set-Wise Co-Expression","publication_year":2007,"publication_date":"2007-10-01","ids":{"openalex":"https://openalex.org/W2121542901","doi":"https://doi.org/10.1109/bibe.2007.4375598","mag":"2121542901","pmid":"https://pubmed.ncbi.nlm.nih.gov/20651944"},"language":"en","primary_location":{"id":"doi:10.1109/bibe.2007.4375598","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe.2007.4375598","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2007 IEEE 7th International Symposium on BioInformatics and BioEngineering","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2907905","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108609942","display_name":"Jung Hoon Woo","orcid":null},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jung Hoon Woo","raw_affiliation_strings":["Seoul National University Biomedical Informatics (SNUBI), Seoul National University College of Medicine, Seoul 110-799, Korea","College of Medicine, Seoul National University, Seoul, South Korea"],"affiliations":[{"raw_affiliation_string":"Seoul National University Biomedical Informatics (SNUBI), Seoul National University College of Medicine, Seoul 110-799, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"College of Medicine, Seoul National University, Seoul, South Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044625906","display_name":"Tian Zheng","orcid":"https://orcid.org/0000-0003-4889-0391"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tian Zheng","raw_affiliation_strings":["Department of Statistics, Columbia University, New York, NY, USA"],"affiliations":[{"raw_affiliation_string":"Department of Statistics, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101730979","display_name":"Ju Han Kim","orcid":"https://orcid.org/0000-0003-1522-9038"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ju Han Kim","raw_affiliation_strings":["College of Medicine, Seoul National University, Seoul, South Korea"],"affiliations":[{"raw_affiliation_string":"College of Medicine, Seoul National University, Seoul, South Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5108609942"],"corresponding_institution_ids":["https://openalex.org/I139264467"],"apc_list":null,"apc_paid":null,"fwci":0.134,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.54240615,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2007","issue":null,"first_page":"433","last_page":"439"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9943000078201294,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.7627097964286804},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7586606740951538},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6448574066162109},{"id":"https://openalex.org/keywords/functional-genomics","display_name":"Functional genomics","score":0.6362308263778687},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6053972244262695},{"id":"https://openalex.org/keywords/expression-quantitative-trait-loci","display_name":"Expression quantitative trait loci","score":0.5683437585830688},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5576728582382202},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.4925597310066223},{"id":"https://openalex.org/keywords/heritability","display_name":"Heritability","score":0.48161882162094116},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.4750625789165497},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.4316679537296295},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.26035404205322266},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.09102699160575867}],"concepts":[{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.7627097964286804},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7586606740951538},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6448574066162109},{"id":"https://openalex.org/C161078062","wikidata":"https://www.wikidata.org/wiki/Q1068690","display_name":"Functional genomics","level":5,"score":0.6362308263778687},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6053972244262695},{"id":"https://openalex.org/C168393362","wikidata":"https://www.wikidata.org/wiki/Q5421706","display_name":"Expression quantitative trait loci","level":5,"score":0.5683437585830688},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5576728582382202},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4925597310066223},{"id":"https://openalex.org/C161890455","wikidata":"https://www.wikidata.org/wiki/Q1503548","display_name":"Heritability","level":2,"score":0.48161882162094116},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4750625789165497},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4316679537296295},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.26035404205322266},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.09102699160575867},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/bibe.2007.4375598","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe.2007.4375598","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2007 IEEE 7th International Symposium on BioInformatics and BioEngineering","raw_type":"proceedings-article"},{"id":"pmid:20651944","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20651944","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings. IEEE International Symposium on Bioinformatics and Bioengineering","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:2907905","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2907905","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc IEEE Int Symp Bioinformatics Bioeng","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2907905","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2907905","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc IEEE Int Symp Bioinformatics Bioeng","raw_type":"Text"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W404240460","https://openalex.org/W1988648841","https://openalex.org/W1988930747","https://openalex.org/W2067245109","https://openalex.org/W2094239847","https://openalex.org/W2094248448","https://openalex.org/W2103017472","https://openalex.org/W2108334325","https://openalex.org/W2109972881","https://openalex.org/W2110065044","https://openalex.org/W2110876263","https://openalex.org/W2118308505","https://openalex.org/W2123106337","https://openalex.org/W2148860875","https://openalex.org/W2150926065","https://openalex.org/W2167190345","https://openalex.org/W2168561598","https://openalex.org/W2168790777","https://openalex.org/W2171070506","https://openalex.org/W2327188017","https://openalex.org/W2989912302","https://openalex.org/W6647417050"],"related_works":["https://openalex.org/W2360935227","https://openalex.org/W2364993072","https://openalex.org/W2115576822","https://openalex.org/W2356429006","https://openalex.org/W2155595079","https://openalex.org/W2380568150","https://openalex.org/W2385787406","https://openalex.org/W2411510900","https://openalex.org/W2263355832","https://openalex.org/W284518807"],"abstract_inverted_index":{"The":[0,30,127],"genetical":[1,92,154],"genomics":[2,93,155],"approach":[3],"has":[4],"been":[5],"used":[6],"to":[7,68],"study":[8],"the":[9,56,80,123,137],"genetic":[10,26,31],"basis":[11],"of":[12,21,60,83,86,102,136,139,160],"variation":[13],"in":[14,48,130],"gene":[15],"expression,":[16],"where":[17],"putative":[18],"transcriptional":[19],"regulators":[20,32,82,101],"genes":[22,47],"are":[23,62],"identified":[24,33],"via":[25],"quantitative":[27],"trait":[28],"mapping.":[29],"through":[34],"such":[35],"efforts":[36],"can":[37,162],"partially":[38],"account":[39],"for":[40,79,106,122],"an":[41,66],"individual":[42],"gene's":[43],"natural":[44],"variation.":[45],"However,":[46],"a":[49,75,107],"molecular":[50],"pathway":[51],"often":[52],"exhibit":[53],"coordinated":[54],"activities,":[55],"patterns":[57],"and":[58],"levels":[59],"which":[61],"also":[63],"regulated.":[64],"In":[65],"effort":[67],"understand":[69],"these":[70],"complicated":[71],"mechanisms,":[72],"we":[73,98,115],"propose":[74],"method":[76],"that":[77],"searches":[78],"genomic":[81,100],"set-wise":[84],"co-expression":[85,141,161],"related":[87],"genes,":[88],"based":[89],"on":[90,158],"current":[91],"data.":[94],"Using":[95],"this":[96,131],"method,":[97],"studied":[99],"233":[103],"biological":[104],"pathways":[105],"BXD":[108],"RI":[109],"data":[110],"set.":[111],"For":[112],"15":[113],"pathways,":[114],"obtained":[116],"significant":[117],"regulatory":[118],"loci":[119],"after":[120],"controlling":[121],"false":[124],"discovery":[125],"rate.":[126],"results":[128],"presented":[129],"paper":[132],"constitute":[133],"important":[134],"evidence":[135,157],"heritability":[138],"mRNA":[140],"between":[142],"individuals.":[143],"We":[144],"have":[145],"shown":[146],"that,":[147],"by":[148],"defining":[149],"new":[150],"phenotypes":[151],"using":[152],"existing":[153],"data,":[156],"regulation":[159],"be":[163],"derived.":[164]},"counts_by_year":[],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}