{"id":"https://openalex.org/W2109970024","doi":"https://doi.org/10.1109/bibe.2003.1188929","title":"An open multiple instance learning framework and its application in drug activity prediction problems","display_name":"An open multiple instance learning framework and its application in drug activity prediction problems","publication_year":2003,"publication_date":"2003-11-20","ids":{"openalex":"https://openalex.org/W2109970024","doi":"https://doi.org/10.1109/bibe.2003.1188929","mag":"2109970024"},"language":"en","primary_location":{"id":"doi:10.1109/bibe.2003.1188929","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe.2003.1188929","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Third IEEE Symposium on Bioinformatics and Bioengineering, 2003. Proceedings.","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058488736","display_name":"Xin Huang","orcid":"https://orcid.org/0000-0002-3650-0301"},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I19700959","display_name":"Florida International University","ror":"https://ror.org/02gz6gg07","country_code":"US","type":"education","lineage":["https://openalex.org/I19700959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xin Huang","raw_affiliation_strings":["Distributed Multimedia Information System Laboratory, School of Computer Science, Florida International University, Miami, FL, USA","Distributed Multimedia. Inf. Syst. Lab., Florida Int. Univ., Miami, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Distributed Multimedia Information System Laboratory, School of Computer Science, Florida International University, Miami, FL, USA","institution_ids":["https://openalex.org/I19700959"]},{"raw_affiliation_string":"Distributed Multimedia. Inf. Syst. Lab., Florida Int. Univ., Miami, FL, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049219173","display_name":"Shu\u2010Ching Chen","orcid":"https://orcid.org/0000-0001-9209-390X"},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I19700959","display_name":"Florida International University","ror":"https://ror.org/02gz6gg07","country_code":"US","type":"education","lineage":["https://openalex.org/I19700959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shu-Ching Chen","raw_affiliation_strings":["Distributed Multimedia Information System Laboratory, School of Computer Science, Florida International University, Miami, FL, USA","Distributed Multimedia. Inf. Syst. Lab., Florida Int. Univ., Miami, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Distributed Multimedia Information System Laboratory, School of Computer Science, Florida International University, Miami, FL, USA","institution_ids":["https://openalex.org/I19700959"]},{"raw_affiliation_string":"Distributed Multimedia. Inf. Syst. Lab., Florida Int. Univ., Miami, FL, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036221136","display_name":"Mei\u2010Ling Shyu","orcid":"https://orcid.org/0000-0003-0902-0844"},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mei-Ling Shyu","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Miami, Coral Gables, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Miami, Coral Gables, FL, USA","institution_ids":["https://openalex.org/I145608581"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"10","issue":null,"first_page":"53","last_page":"59"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10824","display_name":"Image Retrieval and Classification Techniques","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10824","display_name":"Image Retrieval and Classification Techniques","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7296192646026611},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5358477830886841},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.511310338973999},{"id":"https://openalex.org/keywords/exponential-function","display_name":"Exponential function","score":0.42958569526672363},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3732219338417053},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.18765217065811157}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7296192646026611},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5358477830886841},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.511310338973999},{"id":"https://openalex.org/C151376022","wikidata":"https://www.wikidata.org/wiki/Q168698","display_name":"Exponential function","level":2,"score":0.42958569526672363},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3732219338417053},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.18765217065811157},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/bibe.2003.1188929","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe.2003.1188929","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Third IEEE Symposium on Bioinformatics and Bioengineering, 2003. Proceedings.","raw_type":"proceedings-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.68.7767","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.68.7767","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.cs.fiu.edu/~chens/PDF/BIBE2003.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7200000286102295}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W24402856","https://openalex.org/W1492698999","https://openalex.org/W1946852907","https://openalex.org/W2110119381","https://openalex.org/W2118697091","https://openalex.org/W2124410428","https://openalex.org/W2151209730","https://openalex.org/W2154318594","https://openalex.org/W4293029936","https://openalex.org/W6600987510","https://openalex.org/W6640496116","https://openalex.org/W6677574362","https://openalex.org/W6678697068","https://openalex.org/W6683033130","https://openalex.org/W6841802948"],"related_works":["https://openalex.org/W2961085424","https://openalex.org/W4306674287","https://openalex.org/W3046775127","https://openalex.org/W3107602296","https://openalex.org/W4394896187","https://openalex.org/W3170094116","https://openalex.org/W4386462264","https://openalex.org/W4364306694","https://openalex.org/W4312192474","https://openalex.org/W4283697347"],"abstract_inverted_index":{"In":[0,36,109],"this":[1],"paper,":[2],"a":[3,148],"powerful":[4,18],"open":[5,15,69],"Multiple":[6,32,41,79],"Instance":[7,33,42,80],"Learning":[8,34,43,81],"(MIL)":[9],"framework":[10,16,27,63,82,133,146],"is":[11,17,45,83,123],"proposed.":[12],"Such":[13],"an":[14,49,68,112],"since":[19],"different":[20,30],"sub-methods":[21],"can":[22,64],"be":[23,65],"plugged":[24],"into":[25,125],"the":[26,40,54,62,86,98,103,110,115,120,139,155],"to":[28,48,85,101],"generate":[29],"specific":[31],"algorithms.":[35],"our":[37,126,131,144,160],"proposed":[38,78,127,132,145],"framework,":[39],"problem":[44,52],"first":[46],"converted":[47],"unconstrained":[50],"optimization":[51],"by":[53],"Minimum":[55],"Square":[56],"Error":[57],"(MSE)":[58],"criterion,":[59],"and":[60,73,119,138,157],"then":[61],"constructed":[66],"with":[67,114,134],"form":[70],"of":[71,106,151,159],"hypothesis":[72,117],"gradient":[74],"search":[75],"method.":[76],"The":[77],"applied":[84],"drug":[87,107],"activity":[88,105],"problems":[89],"in":[90],"bioinformatics":[91],"applications.":[92],"Specifically,":[93],"experiments":[94],"are":[95],"conducted":[96],"on":[97],"Musk-I":[99],"dataset":[100],"predict":[102],"binding":[104],"molecules.":[108],"experiments,":[111],"algorithm":[113],"exponential":[116],"model":[118],"Quasi-Newton":[121],"method":[122],"embedded":[124],"framework.":[128,161],"We":[129],"compare":[130],"other":[135],"existing":[136],"algorithms":[137],"experimental":[140],"results":[141],"show":[142],"that":[143],"yields":[147],"good":[149],"accuracy":[150],"classification,":[152],"which":[153],"demonstrates":[154],"feasibility":[156],"effectiveness":[158]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}