{"id":"https://openalex.org/W4308216548","doi":"https://doi.org/10.1109/bhi56158.2022.9926873","title":"Detection of distorted gait and wearing-off phenomenon in Parkinson's disease patients during Levodopa therapy","display_name":"Detection of distorted gait and wearing-off phenomenon in Parkinson's disease patients during Levodopa therapy","publication_year":2022,"publication_date":"2022-09-27","ids":{"openalex":"https://openalex.org/W4308216548","doi":"https://doi.org/10.1109/bhi56158.2022.9926873"},"language":"en","primary_location":{"id":"doi:10.1109/bhi56158.2022.9926873","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bhi56158.2022.9926873","pdf_url":null,"source":{"id":"https://openalex.org/S4363608521","display_name":"2022 IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102001155","display_name":"Hamid Moradi","orcid":"https://orcid.org/0009-0001-2715-8591"},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Hamid Moradi","raw_affiliation_strings":["Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU),Machine Learning and Data Analytics Lab (MaD Lab),Department of Artificial Intelligence in Biomedical Engineering (AIBE),Erlangen,Germany","Department of Artificial Intelligence in Biomedical Engineering (AIBE), Machine Learning and Data Analytics Lab (MaD Lab), Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU), Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU),Machine Learning and Data Analytics Lab (MaD Lab),Department of Artificial Intelligence in Biomedical Engineering (AIBE),Erlangen,Germany","institution_ids":["https://openalex.org/I181369854"]},{"raw_affiliation_string":"Department of Artificial Intelligence in Biomedical Engineering (AIBE), Machine Learning and Data Analytics Lab (MaD Lab), Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU), Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076484521","display_name":"Nils Roth","orcid":"https://orcid.org/0000-0002-9166-3920"},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nils Roth","raw_affiliation_strings":["Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU),Machine Learning and Data Analytics Lab (MaD Lab),Department of Artificial Intelligence in Biomedical Engineering (AIBE),Erlangen,Germany","Department of Artificial Intelligence in Biomedical Engineering (AIBE), Machine Learning and Data Analytics Lab (MaD Lab), Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU), Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU),Machine Learning and Data Analytics Lab (MaD Lab),Department of Artificial Intelligence in Biomedical Engineering (AIBE),Erlangen,Germany","institution_ids":["https://openalex.org/I181369854"]},{"raw_affiliation_string":"Department of Artificial Intelligence in Biomedical Engineering (AIBE), Machine Learning and Data Analytics Lab (MaD Lab), Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU), Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017295640","display_name":"Ann-Kristin Seifer","orcid":"https://orcid.org/0000-0002-5891-218X"},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ann-Kristin Seifer","raw_affiliation_strings":["Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU),Machine Learning and Data Analytics Lab (MaD Lab),Department of Artificial Intelligence in Biomedical Engineering (AIBE),Erlangen,Germany","Department of Artificial Intelligence in Biomedical Engineering (AIBE), Machine Learning and Data Analytics Lab (MaD Lab), Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU), Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU),Machine Learning and Data Analytics Lab (MaD Lab),Department of Artificial Intelligence in Biomedical Engineering (AIBE),Erlangen,Germany","institution_ids":["https://openalex.org/I181369854"]},{"raw_affiliation_string":"Department of Artificial Intelligence in Biomedical Engineering (AIBE), Machine Learning and Data Analytics Lab (MaD Lab), Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU), Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014144494","display_name":"Bjoern M. Eskofier","orcid":"https://orcid.org/0000-0002-0417-0336"},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bjoern M. Eskofier","raw_affiliation_strings":["Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU),Machine Learning and Data Analytics Lab (MaD Lab),Department of Artificial Intelligence in Biomedical Engineering (AIBE),Erlangen,Germany","Department of Artificial Intelligence in Biomedical Engineering (AIBE), Machine Learning and Data Analytics Lab (MaD Lab), Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU), Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU),Machine Learning and Data Analytics Lab (MaD Lab),Department of Artificial Intelligence in Biomedical Engineering (AIBE),Erlangen,Germany","institution_ids":["https://openalex.org/I181369854"]},{"raw_affiliation_string":"Department of Artificial Intelligence in Biomedical Engineering (AIBE), Machine Learning and Data Analytics Lab (MaD Lab), Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU), Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5102001155"],"corresponding_institution_ids":["https://openalex.org/I181369854"],"apc_list":null,"apc_paid":null,"fwci":3.1084,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.90944882,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"01","last_page":"04"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10114","display_name":"Balance, Gait, and Falls Prevention","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/3612","display_name":"Physical Therapy, Sports Therapy and Rehabilitation"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/levodopa","display_name":"Levodopa","score":0.7713425159454346},{"id":"https://openalex.org/keywords/parkinsons-disease","display_name":"Parkinson's disease","score":0.7501502633094788},{"id":"https://openalex.org/keywords/gait","display_name":"Gait","score":0.6788238883018494},{"id":"https://openalex.org/keywords/physical-medicine-and-rehabilitation","display_name":"Physical medicine and rehabilitation","score":0.6608096361160278},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5851384401321411},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.49909543991088867},{"id":"https://openalex.org/keywords/physical-therapy","display_name":"Physical therapy","score":0.3807200491428375},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.1493012011051178}],"concepts":[{"id":"https://openalex.org/C2780304432","wikidata":"https://www.wikidata.org/wiki/Q300989","display_name":"Levodopa","level":4,"score":0.7713425159454346},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.7501502633094788},{"id":"https://openalex.org/C151800584","wikidata":"https://www.wikidata.org/wiki/Q2370000","display_name":"Gait","level":2,"score":0.6788238883018494},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.6608096361160278},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5851384401321411},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49909543991088867},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3807200491428375},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1493012011051178}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bhi56158.2022.9926873","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bhi56158.2022.9926873","pdf_url":null,"source":{"id":"https://openalex.org/S4363608521","display_name":"2022 IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6800000071525574,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W62603772","https://openalex.org/W1976884564","https://openalex.org/W2013337604","https://openalex.org/W2080453454","https://openalex.org/W2087048290","https://openalex.org/W2091675688","https://openalex.org/W2135697279","https://openalex.org/W2138535275","https://openalex.org/W2140978740","https://openalex.org/W2470003547","https://openalex.org/W2783265305","https://openalex.org/W2972934994","https://openalex.org/W3014902804","https://openalex.org/W3085935853","https://openalex.org/W3086799551","https://openalex.org/W3118889537","https://openalex.org/W3134641921","https://openalex.org/W3161511225","https://openalex.org/W3199169454","https://openalex.org/W3216635687","https://openalex.org/W6787718333"],"related_works":["https://openalex.org/W1980588181","https://openalex.org/W4251809457","https://openalex.org/W2008860278","https://openalex.org/W2031771476","https://openalex.org/W1989734657","https://openalex.org/W4226004263","https://openalex.org/W2011324577","https://openalex.org/W4210601529","https://openalex.org/W2528228280","https://openalex.org/W2066174631"],"abstract_inverted_index":{"Levodopa":[0],"(L-dopa)":[1],"is":[2,26],"the":[3,7,13,27,39,54,57,62,65,72,76,80,123,134,149,157,162,182,188,199,218],"gold-standard":[4],"medication":[5,77,111,153],"and":[6,44,52,56,113,156],"most":[8,28,183],"commonly":[9],"used":[10],"substance":[11],"in":[12,18,38,49,79,105,122,154,187,216],"treatment":[14],"of":[15,41,47,59,64,89,125,152,165,198,201,220],"motor":[16],"complications":[17],"Parkinson's":[19],"disease":[20],"(PD)":[21],"patients.":[22,50],"The":[23],"\u201cWearing-off\u201d":[24],"phenomenon":[25],"frequent":[29],"complication":[30],"developed":[31,129],"by":[32],"long-term":[33],"L-dopa":[34,139,208],"therapy,":[35],"which":[36],"results":[37],"reemergence":[40],"PD":[42],"symptoms":[43],"lower":[45],"quality":[46],"life":[48],"Detecting":[51],"monitoring":[53,92,217],"onset":[55],"duration":[58],"wearing-off":[60,202],"alongside":[61],"persistence":[63],"symptoms,":[66],"known":[67],"as":[68],"\u201cdelayed-on\u201d,":[69],"would":[70],"enable":[71],"patients":[73],"to":[74,101,132,194],"receive":[75],"changes":[78],"required":[81],"time":[82],"while":[83],"preventing":[84],"them":[85],"from":[86,118],"extravagant":[87],"use":[88],"L-dopa.":[90],"Home":[91],"systems":[93],"using":[94,109],"inertial":[95],"measurement":[96],"units":[97],"have":[98],"enabled":[99],"us":[100],"measure":[102],"gait":[103,115,136,159,190,205],"parameters":[104,116,206],"unsupervised":[106],"environments.":[107],"By":[108],"patients'":[110],"diaries":[112],"their":[114],"obtained":[117],"continuous":[119],"real-world":[120],"data":[121],"course":[124],"two":[126,150],"weeks,":[127],"we":[128,175],"a":[130,195],"system":[131,213],"identify":[133],"distorted":[135,158,189],"spans":[137],"during":[138,207],"therapy":[140],"utilizing":[141],"personalized":[142],"machine":[143],"learning.":[144],"Our":[145],"algorithm":[146],"differentiates":[147],"between":[148],"states":[151,160],"effect":[155],"with":[161],"mean":[163],"accuracy":[164],"77%":[166],"\u00b1":[167],"3.37.":[168],"Furthermore,":[169],"through":[170],"each":[171],"model's":[172],"feature":[173,185],"importance,":[174],"found":[176],"that":[177],"maximum":[178],"sensor":[179],"lift":[180],"was":[181],"prominent":[184],"affected":[186],"sequences.":[191],"We":[192],"contribute":[193],"better":[196],"understanding":[197],"repercussions":[200],"episodes":[203,222],"on":[204],"therapy.":[209],"Moreover,":[210],"our":[211],"proposed":[212],"facilitates":[214],"clinicians":[215],"severity":[219],"these":[221],"more":[223],"efficiently.":[224]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-05-03T08:25:01.440150","created_date":"2025-10-10T00:00:00"}
