{"id":"https://openalex.org/W3192064630","doi":"https://doi.org/10.1109/bhi50953.2021.9508487","title":"Disentangling the association between genetics and functional connectivity in Mild Cognitive Impairment","display_name":"Disentangling the association between genetics and functional connectivity in Mild Cognitive Impairment","publication_year":2021,"publication_date":"2021-07-27","ids":{"openalex":"https://openalex.org/W3192064630","doi":"https://doi.org/10.1109/bhi50953.2021.9508487","mag":"3192064630"},"language":"en","primary_location":{"id":"doi:10.1109/bhi50953.2021.9508487","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bhi50953.2021.9508487","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE EMBS International Conference on Biomedical and Health Informatics (BHI)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://discovery.ucl.ac.uk/10146360/1/BHI_2021_Heba_ConfTemp.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050015206","display_name":"Heba Elshatoury","orcid":null},"institutions":[{"id":"https://openalex.org/I56085075","display_name":"University of Tartu","ror":"https://ror.org/03z77qz90","country_code":"EE","type":"education","lineage":["https://openalex.org/I56085075"]}],"countries":["EE"],"is_corresponding":false,"raw_author_name":"Heba Elshatoury","raw_affiliation_strings":["University of Tartu,Institute of Technology,Tartu,Estonia","Institute of Technology, University of Tartu, Tartu, Estonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Tartu,Institute of Technology,Tartu,Estonia","institution_ids":["https://openalex.org/I56085075"]},{"raw_affiliation_string":"Institute of Technology, University of Tartu, Tartu, Estonia","institution_ids":["https://openalex.org/I56085075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091352402","display_name":"Federica Cruciani","orcid":"https://orcid.org/0000-0001-7258-1463"},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Federica Cruciani","raw_affiliation_strings":["University of Verona,Dept. Computer Science,Verona,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Verona,Dept. Computer Science,Verona,Italy","institution_ids":["https://openalex.org/I119439378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082320791","display_name":"Francesco Zumerle","orcid":null},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Zumerle","raw_affiliation_strings":["University of Verona,Dept. Computer Science,Verona,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Verona,Dept. Computer Science,Verona,Italy","institution_ids":["https://openalex.org/I119439378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074934100","display_name":"Silvia Francesca Storti","orcid":"https://orcid.org/0000-0002-8605-803X"},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvia F. Storti","raw_affiliation_strings":["University of Verona,Dept. Computer Science,Verona,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Verona,Dept. Computer Science,Verona,Italy","institution_ids":["https://openalex.org/I119439378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069743881","display_name":"Andr\u00e9 Altmann","orcid":"https://orcid.org/0000-0002-9265-2393"},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andre Altmann","raw_affiliation_strings":["University College London,Dept. Medical Physic and Biomedical Engineering,London,UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London,Dept. Medical Physic and Biomedical Engineering,London,UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062008937","display_name":"Marco Lorenzi","orcid":"https://orcid.org/0000-0003-0521-2881"},"institutions":[{"id":"https://openalex.org/I1326498283","display_name":"Institut national de recherche en sciences et technologies du num\u00e9rique","ror":"https://ror.org/02kvxyf05","country_code":"FR","type":"government","lineage":["https://openalex.org/I1326498283"]},{"id":"https://openalex.org/I201841394","display_name":"Universit\u00e9 C\u00f4te d'Azur","ror":"https://ror.org/019tgvf94","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marco Lorenzi","raw_affiliation_strings":["Inria Sophia Antipolis,Epione Research Project,Nice,France","Epione Research Project, Inria Sophia Antipolis, Nice, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inria Sophia Antipolis,Epione Research Project,Nice,France","institution_ids":["https://openalex.org/I1326498283","https://openalex.org/I201841394"]},{"raw_affiliation_string":"Epione Research Project, Inria Sophia Antipolis, Nice, France","institution_ids":["https://openalex.org/I1326498283"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005605270","display_name":"Gholamreza Anbarjafari","orcid":"https://orcid.org/0000-0001-8460-5717"},"institutions":[{"id":"https://openalex.org/I56085075","display_name":"University of Tartu","ror":"https://ror.org/03z77qz90","country_code":"EE","type":"education","lineage":["https://openalex.org/I56085075"]}],"countries":["EE"],"is_corresponding":false,"raw_author_name":"Gholamreza Anbarjafari","raw_affiliation_strings":["University of Tartu,Institute of Technology,Tartu,Estonia","Institute of Technology, University of Tartu, Tartu, Estonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Tartu,Institute of Technology,Tartu,Estonia","institution_ids":["https://openalex.org/I56085075"]},{"raw_affiliation_string":"Institute of Technology, University of Tartu, Tartu, Estonia","institution_ids":["https://openalex.org/I56085075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042078827","display_name":"Gloria Menegaz","orcid":"https://orcid.org/0000-0002-6889-3461"},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gloria Menegaz","raw_affiliation_strings":["University of Verona,Dept. Computer Science,Verona,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Verona,Dept. Computer Science,Verona,Italy","institution_ids":["https://openalex.org/I119439378"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082628560","display_name":"Ilaria Boscolo Galazzo","orcid":"https://orcid.org/0000-0002-4153-3749"},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ilaria Boscolo Galazzo","raw_affiliation_strings":["University of Verona,Dept. Computer Science,Verona,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Verona,Dept. Computer Science,Verona,Italy","institution_ids":["https://openalex.org/I119439378"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2467,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.761788,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9908000230789185,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/default-mode-network","display_name":"Default mode network","score":0.7873620390892029},{"id":"https://openalex.org/keywords/endophenotype","display_name":"Endophenotype","score":0.6996513605117798},{"id":"https://openalex.org/keywords/cognition","display_name":"Cognition","score":0.5867984890937805},{"id":"https://openalex.org/keywords/association","display_name":"Association (psychology)","score":0.5371554493904114},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"Cognitive impairment","score":0.5206072330474854},{"id":"https://openalex.org/keywords/lasso","display_name":"Lasso (programming language)","score":0.4589269459247589},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.43457284569740295},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.4161915183067322},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.3570014238357544},{"id":"https://openalex.org/keywords/cognitive-psychology","display_name":"Cognitive psychology","score":0.32824191451072693}],"concepts":[{"id":"https://openalex.org/C141516989","wikidata":"https://www.wikidata.org/wiki/Q1182555","display_name":"Default mode network","level":3,"score":0.7873620390892029},{"id":"https://openalex.org/C187869287","wikidata":"https://www.wikidata.org/wiki/Q2032061","display_name":"Endophenotype","level":3,"score":0.6996513605117798},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5867984890937805},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.5371554493904114},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.5206072330474854},{"id":"https://openalex.org/C37616216","wikidata":"https://www.wikidata.org/wiki/Q3218363","display_name":"Lasso (programming language)","level":2,"score":0.4589269459247589},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.43457284569740295},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4161915183067322},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3570014238357544},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.32824191451072693},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/bhi50953.2021.9508487","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bhi50953.2021.9508487","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE EMBS International Conference on Biomedical and Health Informatics (BHI)","raw_type":"proceedings-article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10146360","is_oa":true,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10146360/","pdf_url":"https://discovery.ucl.ac.uk/10146360/1/BHI_2021_Heba_ConfTemp.pdf","source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"In: 2021 IEEE EMBS International Conference on Biomedical and Health Informatics (BHI). IEEE: Athens, Greece. (2021)","raw_type":"Proceedings paper"}],"best_oa_location":{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10146360","is_oa":true,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10146360/","pdf_url":"https://discovery.ucl.ac.uk/10146360/1/BHI_2021_Heba_ConfTemp.pdf","source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"In: 2021 IEEE EMBS International Conference on Biomedical and Health Informatics (BHI). IEEE: Athens, Greece. (2021)","raw_type":"Proceedings paper"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3192064630.pdf","grobid_xml":"https://content.openalex.org/works/W3192064630.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1797408175","https://openalex.org/W1913607034","https://openalex.org/W2002562224","https://openalex.org/W2007572953","https://openalex.org/W2035678379","https://openalex.org/W2137554996","https://openalex.org/W2170765166","https://openalex.org/W2413280148","https://openalex.org/W2794167820","https://openalex.org/W2802278070","https://openalex.org/W2915132455","https://openalex.org/W2916749909","https://openalex.org/W2951617899","https://openalex.org/W2995513418","https://openalex.org/W3000313970","https://openalex.org/W3043523760","https://openalex.org/W3045704719"],"related_works":["https://openalex.org/W2495861132","https://openalex.org/W3140386247","https://openalex.org/W2913571226","https://openalex.org/W2131171966","https://openalex.org/W2506162896","https://openalex.org/W2077427362","https://openalex.org/W4206746115","https://openalex.org/W2324271132","https://openalex.org/W1893909712","https://openalex.org/W1585336261"],"abstract_inverted_index":{"Despite":[0],"the":[1,7,10,38,55,59,86,120,128,135,145,155,162,169,178,182,187,221],"increasing":[2],"effort":[3],"being":[4,203],"devoted":[5,237],"to":[6,100,119,177,238],"investigation":[8],"of":[9,40,65,89,186,229],"link":[11],"between":[12],"imaging":[13],"endophenotypes":[14],"(IDPs)":[15],"and":[16,25,33,69,81,125,138,149,195,208,242],"genetic":[17],"determinants":[18],"(GDs)":[19],"in":[20,104,235,245],"Mild":[21],"Cognitive":[22],"Impairment":[23],"(MCI)":[24],"Alzheimer\u2019s":[26],"disease":[27],"(AD),":[28],"many":[29],"issues":[30],"remain":[31],"open":[32],"deserve":[34],"investigation.":[35],"Among":[36],"these,":[37],"role":[39,103],"functional":[41],"connectivity":[42],"(FC)":[43],"is":[44],"still":[45],"blurred.":[46],"This":[47],"paper":[48],"aims":[49],"at":[50],"shading":[51],"some":[52],"light":[53],"on":[54,58],"topic":[56],"relying":[57],"ADNI":[60],"repository":[61],"(177":[62],"patients,":[63],"out":[64],"which":[66],"82":[67],"MCI":[68],"95":[70],"controls).":[71],"The":[72],"within/between-network":[73,159,231],"connectivities":[74],"were":[75,139,165,173],"derived":[76],"from":[77],"individual":[78],"FC":[79,132,160,171,188,232],"matrices":[80],"used":[82],"as":[83,212,214],"IDPs.":[84],"Conversely,":[85],"GDs":[87],"consisted":[88],"two":[90,222],"Polygenic":[91],"Risk":[92],"Scores":[93],"(PRS)":[94],"that":[95,220],"have":[96],"recently":[97],"been":[98],"proven":[99],"play":[101],"a":[102,199,226],"AD.":[105],"A":[106],"Partial":[107],"Least":[108],"Squares":[109],"(PLS)":[110],"model":[111],"equipped":[112],"with":[113,141,205,215,225],"LASSO":[114],"regularization":[115],"was":[116],"finally":[117],"fitted":[118],"data":[121],"for":[122,161],"associating":[123],"IDPs":[124],"GDs.":[126],"In":[127,181],"first":[129],"component,":[130,184],"all":[131],"coefficients":[133],"had":[134,190],"same":[136],"sign,":[137],"correlated":[140,200,224],"PRS2.":[142],"Connectivities":[143],"involving":[144],"dorsal":[146],"attention":[147],"(DAN)":[148],"frontoparietal":[150],"control":[151],"(CON)":[152],"networks":[153],"reached":[154],"highest":[156],"weights,":[157],"while":[158,202],"limbic":[163],"(LIM)":[164],"less":[166,174],"represented.":[167],"Overall,":[168],"within-network":[170],"values":[172],"pronounced":[175],"compared":[176],"between-network":[179],"ones.":[180],"second":[183],"most":[185],"features":[189],"zero":[191],"weights.":[192],"Visual":[193],"(VIS)":[194],"somatomotory":[196],"(SMN)":[197],"showed":[198],"trend,":[201],"anti-correlated":[204],"LIM,":[206],"CON":[207],"default":[209],"mode":[210],"network":[211],"well":[213],"PRS1.":[216],"Our":[217],"findings":[218],"suggest":[219],"PRSs":[223],"possible":[227],"pattern":[228],"aberrant":[230],"changes":[233],"occurring":[234],"RSNs":[236],"higher":[239],"cognitive":[240],"functions":[241],"more":[243],"vulnerable":[244],"this":[246],"pathology.":[247]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}
