{"id":"https://openalex.org/W2972417007","doi":"https://doi.org/10.1109/bhi.2019.8834516","title":"Center-Extraction-Based Three Dimensional Nuclei Instance Segmentation of Fluorescence Microscopy Images","display_name":"Center-Extraction-Based Three Dimensional Nuclei Instance Segmentation of Fluorescence Microscopy Images","publication_year":2019,"publication_date":"2019-05-01","ids":{"openalex":"https://openalex.org/W2972417007","doi":"https://doi.org/10.1109/bhi.2019.8834516","mag":"2972417007"},"language":"en","primary_location":{"id":"doi:10.1109/bhi.2019.8834516","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bhi.2019.8834516","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 IEEE EMBS International Conference on Biomedical & Health Informatics (BHI)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["arxiv","crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://arxiv.org/pdf/1909.05992","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046514229","display_name":"David Joon Ho","orcid":"https://orcid.org/0000-0002-9124-884X"},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Joon Ho","raw_affiliation_strings":["Video and Image Processing Laboratory, Purdue University, West Lafayette, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Video and Image Processing Laboratory, Purdue University, West Lafayette, Indiana","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011257607","display_name":"Shuo Han","orcid":"https://orcid.org/0000-0003-3992-5003"},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuo Han","raw_affiliation_strings":["Video and Image Processing Laboratory, Purdue University, West Lafayette, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Video and Image Processing Laboratory, Purdue University, West Lafayette, Indiana","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011720923","display_name":"Chichen Fu","orcid":"https://orcid.org/0000-0003-1119-5205"},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chichen Fu","raw_affiliation_strings":["Video and Image Processing Laboratory, Purdue University, West Lafayette, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Video and Image Processing Laboratory, Purdue University, West Lafayette, Indiana","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026393791","display_name":"Paul Salama","orcid":"https://orcid.org/0000-0002-7643-3879"},"institutions":[{"id":"https://openalex.org/I135191193","display_name":"University of Indianapolis","ror":"https://ror.org/052133d12","country_code":"US","type":"education","lineage":["https://openalex.org/I135191193"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Salama","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Purdue University, Indianapolis, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Purdue University, Indianapolis, Indiana","institution_ids":["https://openalex.org/I135191193","https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070413882","display_name":"Kenneth W. Dunn","orcid":"https://orcid.org/0000-0003-4245-496X"},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth W. Dunn","raw_affiliation_strings":["Division of Nephrology, Indiana University, Indianapolis, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Indiana University, Indianapolis, Indiana","institution_ids":["https://openalex.org/I55769427"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089688702","display_name":"Edward J. Delp","orcid":"https://orcid.org/0000-0002-2909-7323"},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward J. Delp","raw_affiliation_strings":["Video and Image Processing Laboratory, Purdue University, West Lafayette, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Video and Image Processing Laboratory, Purdue University, West Lafayette, Indiana","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.7895062565803528},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.7375938296318054},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7166351675987244},{"id":"https://openalex.org/keywords/microscopy","display_name":"Microscopy","score":0.6863831877708435},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.6623327136039734},{"id":"https://openalex.org/keywords/fluorescence-microscope","display_name":"Fluorescence microscope","score":0.5674825310707092},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.5631675124168396},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.5073599219322205},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.43976426124572754},{"id":"https://openalex.org/keywords/feature-extraction","display_name":"Feature extraction","score":0.4356086552143097},{"id":"https://openalex.org/keywords/fluorescence","display_name":"Fluorescence","score":0.26249223947525024},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.12515732645988464},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.09642443060874939}],"concepts":[{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.7895062565803528},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.7375938296318054},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7166351675987244},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.6863831877708435},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.6623327136039734},{"id":"https://openalex.org/C169274487","wikidata":"https://www.wikidata.org/wiki/Q840211","display_name":"Fluorescence microscope","level":3,"score":0.5674825310707092},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.5631675124168396},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.5073599219322205},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.43976426124572754},{"id":"https://openalex.org/C52622490","wikidata":"https://www.wikidata.org/wiki/Q1026626","display_name":"Feature extraction","level":2,"score":0.4356086552143097},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.26249223947525024},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.12515732645988464},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09642443060874939}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1109/bhi.2019.8834516","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bhi.2019.8834516","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 IEEE EMBS International Conference on Biomedical & Health Informatics (BHI)","raw_type":"proceedings-article"},{"id":"pmh:oai:arXiv.org:1909.05992","is_oa":true,"landing_page_url":"http://arxiv.org/abs/1909.05992","pdf_url":"https://arxiv.org/pdf/1909.05992","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:scholarworks.indianapolis.iu.edu:1805/25059","is_oa":false,"landing_page_url":"https://hdl.handle.net/1805/25059","pdf_url":null,"source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ArXiv","raw_type":"Conference proceedings"},{"id":"pmh:oai:scholarworks.iupui.edu:1805/25059","is_oa":false,"landing_page_url":"http://hdl.handle.net/1805/25059","pdf_url":null,"source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ArXiv","raw_type":"Conference proceedings"}],"best_oa_location":{"id":"pmh:oai:arXiv.org:1909.05992","is_oa":true,"landing_page_url":"http://arxiv.org/abs/1909.05992","pdf_url":"https://arxiv.org/pdf/1909.05992","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W46659105","https://openalex.org/W1522301498","https://openalex.org/W1982662510","https://openalex.org/W2066960512","https://openalex.org/W2097084589","https://openalex.org/W2099471712","https://openalex.org/W2124260943","https://openalex.org/W2127890285","https://openalex.org/W2146658490","https://openalex.org/W2151538727","https://openalex.org/W2162245111","https://openalex.org/W2232735501","https://openalex.org/W2464708700","https://openalex.org/W2592929672","https://openalex.org/W2736597453","https://openalex.org/W2798976889","https://openalex.org/W2806787491","https://openalex.org/W2807612972","https://openalex.org/W2899771611","https://openalex.org/W2900936384","https://openalex.org/W2919115771","https://openalex.org/W2962793481","https://openalex.org/W2963803174","https://openalex.org/W2963840672","https://openalex.org/W2964121744","https://openalex.org/W4320013936","https://openalex.org/W6602002561","https://openalex.org/W6703702014","https://openalex.org/W6718752587","https://openalex.org/W6751838760","https://openalex.org/W6756040250"],"related_works":["https://openalex.org/W4211107619","https://openalex.org/W2161433272","https://openalex.org/W2894139091","https://openalex.org/W1637909","https://openalex.org/W1983780159","https://openalex.org/W659245948","https://openalex.org/W2094643072","https://openalex.org/W2087957833","https://openalex.org/W4206210906","https://openalex.org/W4251922430"],"abstract_inverted_index":{"Fluorescence":[0],"microscopy":[1,75,93],"is":[2,41,53,88],"an":[3],"essential":[4],"tool":[5],"for":[6,32,50,72],"the":[7,19,58,63,67],"analysis":[8],"of":[9,21,34,62],"3D":[10,64],"subcellular":[11],"structures":[12],"in":[13,18],"tissue.":[14],"An":[15],"important":[16],"step":[17],"characterization":[20],"tissue":[22],"involves":[23],"nuclei":[24,35],"segmentation.":[25],"In":[26,43],"this":[27],"paper,":[28],"a":[29,70,79],"two-stage":[30],"method":[31,71,87],"segmentation":[33,101],"using":[36],"convolutional":[37],"neural":[38],"networks":[39],"(CNNs)":[40],"described.":[42],"particular,":[44],"since":[45],"creating":[46],"labeled":[47],"volumes":[48,76],"manually":[49],"training":[51],"purposes":[52],"not":[54],"practical":[55],"due":[56],"to":[57],"size":[59],"and":[60,96],"complexity":[61],"data":[65,94],"sets,":[66],"paper":[68],"describes":[69],"generating":[73],"synthetic":[74],"based":[77],"on":[78,90],"spatially":[80],"constrained":[81],"cycle-consistent":[82],"adversarial":[83],"network.":[84],"The":[85],"proposed":[86],"tested":[89],"multiple":[91],"real":[92],"sets":[95],"outperforms":[97],"other":[98],"commonly":[99],"used":[100],"techniques.":[102]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2019-09-19T00:00:00"}