{"id":"https://openalex.org/W2606508329","doi":"https://doi.org/10.1109/bhi.2017.7897220","title":"Robust single cell quantification of immune cell subtypes in histological samples","display_name":"Robust single cell quantification of immune cell subtypes in histological samples","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2606508329","doi":"https://doi.org/10.1109/bhi.2017.7897220","mag":"2606508329"},"language":"en","primary_location":{"id":"doi:10.1109/bhi.2017.7897220","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bhi.2017.7897220","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE EMBS International Conference on Biomedical & Health Informatics (BHI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025131969","display_name":"Alberto Santamar\u00eda-Pang","orcid":"https://orcid.org/0000-0003-4012-8394"},"institutions":[{"id":"https://openalex.org/I4210134512","display_name":"GE Global Research (United States)","ror":"https://ror.org/03e06qt98","country_code":"US","type":"company","lineage":["https://openalex.org/I4210134512"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alberto Santamaria-Pang","raw_affiliation_strings":["GE Global Research, Niskayuna, New York"],"affiliations":[{"raw_affiliation_string":"GE Global Research, Niskayuna, New York","institution_ids":["https://openalex.org/I4210134512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108671177","display_name":"Raghav Padmanabhan","orcid":null},"institutions":[{"id":"https://openalex.org/I4210153280","display_name":"NeoGenomics (United States)","ror":"https://ror.org/04vj14y69","country_code":"US","type":"company","lineage":["https://openalex.org/I4210153280"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raghav K. Padmanabhan","raw_affiliation_strings":["Clarient Diagnostics, NeoGenomics, California"],"affiliations":[{"raw_affiliation_string":"Clarient Diagnostics, NeoGenomics, California","institution_ids":["https://openalex.org/I4210153280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003948628","display_name":"Anup Sood","orcid":"https://orcid.org/0000-0001-7768-0209"},"institutions":[{"id":"https://openalex.org/I4210134512","display_name":"GE Global Research (United States)","ror":"https://ror.org/03e06qt98","country_code":"US","type":"company","lineage":["https://openalex.org/I4210134512"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anup Sood","raw_affiliation_strings":["GE Global Research, Niskayuna, New York"],"affiliations":[{"raw_affiliation_string":"GE Global Research, Niskayuna, New York","institution_ids":["https://openalex.org/I4210134512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109601734","display_name":"Michael J. Gerdes","orcid":null},"institutions":[{"id":"https://openalex.org/I4210134512","display_name":"GE Global Research (United States)","ror":"https://ror.org/03e06qt98","country_code":"US","type":"company","lineage":["https://openalex.org/I4210134512"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Gerdes","raw_affiliation_strings":["GE Global Research, Niskayuna, New York"],"affiliations":[{"raw_affiliation_string":"GE Global Research, Niskayuna, New York","institution_ids":["https://openalex.org/I4210134512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008596094","display_name":"Chris Sevinsky","orcid":null},"institutions":[{"id":"https://openalex.org/I4210134512","display_name":"GE Global Research (United States)","ror":"https://ror.org/03e06qt98","country_code":"US","type":"company","lineage":["https://openalex.org/I4210134512"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chris Sevinsky","raw_affiliation_strings":["GE Global Research, Niskayuna, New York"],"affiliations":[{"raw_affiliation_string":"GE Global Research, Niskayuna, New York","institution_ids":["https://openalex.org/I4210134512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100404169","display_name":"Qing Li","orcid":"https://orcid.org/0000-0003-2652-6070"},"institutions":[{"id":"https://openalex.org/I4210134512","display_name":"GE Global Research (United States)","ror":"https://ror.org/03e06qt98","country_code":"US","type":"company","lineage":["https://openalex.org/I4210134512"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qing Li","raw_affiliation_strings":["GE Global Research, Niskayuna, New York"],"affiliations":[{"raw_affiliation_string":"GE Global Research, Niskayuna, New York","institution_ids":["https://openalex.org/I4210134512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047785393","display_name":"Nicole LaPlante","orcid":null},"institutions":[{"id":"https://openalex.org/I4210153280","display_name":"NeoGenomics (United States)","ror":"https://ror.org/04vj14y69","country_code":"US","type":"company","lineage":["https://openalex.org/I4210153280"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole LaPlante","raw_affiliation_strings":["Clarient Diagnostics, NeoGenomics, California"],"affiliations":[{"raw_affiliation_string":"Clarient Diagnostics, NeoGenomics, California","institution_ids":["https://openalex.org/I4210153280"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081260142","display_name":"Fiona Ginty","orcid":"https://orcid.org/0000-0001-6638-683X"},"institutions":[{"id":"https://openalex.org/I4210134512","display_name":"GE Global Research (United States)","ror":"https://ror.org/03e06qt98","country_code":"US","type":"company","lineage":["https://openalex.org/I4210134512"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fiona Ginty","raw_affiliation_strings":["GE Global Research, Niskayuna, New York"],"affiliations":[{"raw_affiliation_string":"GE Global Research, Niskayuna, New York","institution_ids":["https://openalex.org/I4210134512"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5025131969"],"corresponding_institution_ids":["https://openalex.org/I4210134512"],"apc_list":null,"apc_paid":null,"fwci":0.319,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.56974132,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9889000058174133,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.5859440565109253},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.5329262614250183},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2890312075614929},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.1830979883670807},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.06997427344322205}],"concepts":[{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5859440565109253},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5329262614250183},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2890312075614929},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1830979883670807},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06997427344322205}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bhi.2017.7897220","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bhi.2017.7897220","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE EMBS International Conference on Biomedical & Health Informatics (BHI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1479753158","https://openalex.org/W1995556249","https://openalex.org/W2002089932","https://openalex.org/W2015255108","https://openalex.org/W2027061207","https://openalex.org/W2125168731","https://openalex.org/W2146950091","https://openalex.org/W2344759984","https://openalex.org/W2574722368"],"related_works":["https://openalex.org/W3206685145","https://openalex.org/W2890187591","https://openalex.org/W4226150303","https://openalex.org/W4200189496","https://openalex.org/W3200768480","https://openalex.org/W2466978497","https://openalex.org/W2115288517","https://openalex.org/W1648324402","https://openalex.org/W4200596265","https://openalex.org/W4280596398"],"abstract_inverted_index":{"Due":[0],"to":[1,12,24],"the":[2,61,78,103],"rapid":[3],"increase":[4],"in":[5,18,46],"immunotherapies":[6],"there":[7],"is":[8,56,150],"an":[9,164],"urgent":[10],"need":[11],"develop":[13],"new":[14,37],"tools":[15],"for":[16,41,102,142,156],"robust":[17],"situ":[19],"immune":[20,43,171],"cell-typing":[21],"and":[22,28,73,93,108,113,116,125,127,132,152],"quantification":[23],"understand":[25],"disease":[26],"mechanisms":[27],"therapeutic":[29],"responses.":[30],"In":[31],"this":[32,100,178],"paper,":[33],"we":[34,82],"present":[35],"a":[36,85,91],"machine-learning":[38],"based":[39,57],"method":[40,55,136,149],"classifying":[42],"cell":[44,64,87,158,172],"types":[45],"human":[47],"tissue":[48],"from":[49,77],"highly":[50],"multiplexed":[51],"data.":[52,147],"The":[53,135],"proposed":[54],"on:":[58],"i)":[59],"identifying":[60],"most":[62],"representative":[63],"clusters":[65,79],"across":[66,169],"multiple":[67],"slides":[68],"by":[69,89],"performing":[70],"hierarchical":[71],"multi-channel":[72],"multi-slide":[74],"clustering;":[75],"ii)":[76],"of":[80,106,119,167],"interest,":[81],"then":[83],"learn":[84],"biological-phenotypical-taxonomical":[86],"model":[88],"solving":[90],"multi-class":[92],"multi-label":[94],"classification":[95,105,160,176],"problem.":[96,161],"We":[97,162],"have":[98],"applied":[99,155],"methodology":[101],"simultaneous":[104,175],"T":[107,120],"B":[109],"cells":[110,121,129],"using":[111],"CD3":[112],"CD20":[114],"markers":[115],"further":[117],"sub-classification":[118],"(CD3+)":[122],"into":[123],"CD4+":[124,133],"CD8+,":[126],"FoxP3+":[128],"(within":[130],"CD3+":[131],"cells).":[134],"allows":[137],"estimating":[138],"statistical":[139],"measurements":[140],"used":[141],"correlation":[143],"analysis":[144],"with":[145,177],"clinical":[146],"Our":[148],"generic":[151],"can":[153],"be":[154],"any":[157],"type":[159],"obtain":[163],"average":[165],"accuracy":[166],"~95%":[168],"six":[170],"types/subtypes":[173],"following":[174],"approach.":[179]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}