{"id":"https://openalex.org/W2343733730","doi":"https://doi.org/10.1109/bhi.2016.7455881","title":"Network analysis with PubChem BioAssay: Preliminary study on drug abuse","display_name":"Network analysis with PubChem BioAssay: Preliminary study on drug abuse","publication_year":2016,"publication_date":"2016-02-01","ids":{"openalex":"https://openalex.org/W2343733730","doi":"https://doi.org/10.1109/bhi.2016.7455881","mag":"2343733730"},"language":"en","primary_location":{"id":"doi:10.1109/bhi.2016.7455881","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bhi.2016.7455881","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101468489","display_name":"Weijian Qin","orcid":"https://orcid.org/0009-0000-2191-8839"},"institutions":[{"id":"https://openalex.org/I79272384","display_name":"University of Maryland, Baltimore County","ror":"https://ror.org/02qskvh78","country_code":"US","type":"education","lineage":["https://openalex.org/I79272384"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Weijian Qin","raw_affiliation_strings":["Dept. of Information System, University of Maryland Baltimore County, Baltimore, MD, USA"],"affiliations":[{"raw_affiliation_string":"Dept. of Information System, University of Maryland Baltimore County, Baltimore, MD, USA","institution_ids":["https://openalex.org/I79272384"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073074181","display_name":"Qian Zhu","orcid":"https://orcid.org/0000-0002-4858-6333"},"institutions":[{"id":"https://openalex.org/I79272384","display_name":"University of Maryland, Baltimore County","ror":"https://ror.org/02qskvh78","country_code":"US","type":"education","lineage":["https://openalex.org/I79272384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qian Zhu","raw_affiliation_strings":["Dept. of Information System, University of Maryland Baltimore County, Baltimore, MD, USA"],"affiliations":[{"raw_affiliation_string":"Dept. of Information System, University of Maryland Baltimore County, Baltimore, MD, USA","institution_ids":["https://openalex.org/I79272384"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101468489"],"corresponding_institution_ids":["https://openalex.org/I79272384"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04225699,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":null,"first_page":"248","last_page":"251"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bioassay","display_name":"Bioassay","score":0.8778578042984009},{"id":"https://openalex.org/keywords/pubchem","display_name":"PubChem","score":0.8324957489967346},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.5473067164421082},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.5460938215255737},{"id":"https://openalex.org/keywords/centrality","display_name":"Centrality","score":0.483534574508667},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3775014579296112},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.32734403014183044},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.30652540922164917},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.29587322473526},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.12160536646842957}],"concepts":[{"id":"https://openalex.org/C104488531","wikidata":"https://www.wikidata.org/wiki/Q864212","display_name":"Bioassay","level":2,"score":0.8778578042984009},{"id":"https://openalex.org/C158180186","wikidata":"https://www.wikidata.org/wiki/Q278487","display_name":"PubChem","level":2,"score":0.8324957489967346},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5473067164421082},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5460938215255737},{"id":"https://openalex.org/C53811970","wikidata":"https://www.wikidata.org/wiki/Q5062194","display_name":"Centrality","level":2,"score":0.483534574508667},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3775014579296112},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32734403014183044},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30652540922164917},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.29587322473526},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.12160536646842957},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bhi.2016.7455881","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bhi.2016.7455881","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8700000047683716,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1544009106","https://openalex.org/W1550258693","https://openalex.org/W1575184037","https://openalex.org/W1863753810","https://openalex.org/W1964670939","https://openalex.org/W1979488516","https://openalex.org/W1980409763","https://openalex.org/W1984084871","https://openalex.org/W2017514322","https://openalex.org/W2023839852","https://openalex.org/W2029460685","https://openalex.org/W2085598673","https://openalex.org/W2125910575","https://openalex.org/W2129916980","https://openalex.org/W2148679377","https://openalex.org/W2159675211","https://openalex.org/W2165398609","https://openalex.org/W2395114800","https://openalex.org/W2620621575","https://openalex.org/W4302315946","https://openalex.org/W6632766574","https://openalex.org/W6634420174"],"related_works":["https://openalex.org/W2104366126","https://openalex.org/W2547231910","https://openalex.org/W2235675062","https://openalex.org/W2177317049","https://openalex.org/W4293208996","https://openalex.org/W2169546341","https://openalex.org/W2127553917","https://openalex.org/W1505362105","https://openalex.org/W1982769922","https://openalex.org/W2085398335"],"abstract_inverted_index":{"BioAssay":[0,54],"involves":[1],"the":[2,19,48,53,63,86,127,131,146],"use":[3],"of":[4,22,38,58,66,71,76,89,149],"live":[5],"animal":[6],"or":[7,11,13,28],"plant":[8],"(in":[9,15],"vivo)":[10],"tissue":[12],"cell":[14],"vitro)":[16],"to":[17,45,83,116,129,144,153],"determine":[18],"biological":[20,49,60,87,103],"activity":[21],"a":[23,32,102],"substance,":[24],"such":[25],"as":[26],"hormone":[27],"drug,":[29],"which":[30,113],"plays":[31],"key":[33],"role":[34],"especially":[35],"in":[36,52],"evaluation":[37],"clinical":[39],"efficacy":[40],"for":[41,55,92],"drug":[42,90,117,154],"development.":[43],"How":[44],"better":[46,84],"utilize":[47],"information":[50,107],"contained":[51],"systematical":[56],"identification":[57],"novel":[59,150],"associations":[61,151],"is":[62,79],"primary":[64],"focus":[65],"this":[67],"study.":[68],"As":[69],"one":[70],"top":[72],"10":[73],"leading":[74],"cause":[75],"death,":[77],"there":[78],"an":[80],"urgent":[81],"need":[82],"understand":[85],"mechanism":[88],"abuse":[91],"its":[93],"further":[94],"prevention":[95],"and":[96,111,139],"management.":[97],"More":[98],"specifically,":[99],"we":[100,141],"developed":[101],"network":[104,124,128],"by":[105],"integrating":[106],"about":[108],"chemical,":[109],"gene,":[110],"disease,":[112],"are":[114],"relevant":[115],"abuse,":[118],"from":[119],"PubChem":[120],"BioAssay.":[121],"We":[122],"performed":[123],"analysis":[125],"over":[126],"identify":[130],"high-influence":[132],"nodes":[133],"based":[134],"on":[135],"common":[136],"centrality":[137],"measures,":[138],"subsequently,":[140],"conducted":[142],"perturbation":[143],"prioritize":[145],"final":[147],"list":[148],"specific":[152],"abuse.":[155]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}