{"id":"https://openalex.org/W2074560088","doi":"https://doi.org/10.1109/bhi.2014.6864468","title":"Combining brain imaging data with electronic health records to non-invasively quantify [<sup>11</sup>C]DASB binding","display_name":"Combining brain imaging data with electronic health records to non-invasively quantify [<sup>11</sup>C]DASB binding","publication_year":2014,"publication_date":"2014-06-01","ids":{"openalex":"https://openalex.org/W2074560088","doi":"https://doi.org/10.1109/bhi.2014.6864468","mag":"2074560088"},"language":"en","primary_location":{"id":"doi:10.1109/bhi.2014.6864468","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bhi.2014.6864468","pdf_url":null,"source":{"id":"https://openalex.org/S4393918972","display_name":"IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI ...)","issn_l":"2641-3590","issn":["2641-3590"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://zenodo.org/record/1265316","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023657790","display_name":"Arthur Mikhno","orcid":"https://orcid.org/0000-0002-7271-4868"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arthur Mikhno","raw_affiliation_strings":["Department of Biomedical Engineering, Columbia University, NY","Dept. of Biomed. Eng., Columbia Univ., Columbia, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Columbia University, NY","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Dept. of Biomed. Eng., Columbia Univ., Columbia, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034108863","display_name":"Francesca Zanderigo","orcid":"https://orcid.org/0000-0001-6510-0676"},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francesca Zanderigo","raw_affiliation_strings":["Department of Psychiatry, Stony Brook University, NY","Department of Psychiatry. Stony Brook University, Stony Brook, NY. USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Stony Brook University, NY","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Department of Psychiatry. Stony Brook University, Stony Brook, NY. USA","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081965846","display_name":"R. Todd Ogden","orcid":"https://orcid.org/0009-0008-0005-446X"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Todd Ogden","raw_affiliation_strings":["Department of Psychiatry, Columbia University, NY","Dept. of Psychiatry, Columbia Univ., Columbia, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Columbia University, NY","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Dept. of Psychiatry, Columbia Univ., Columbia, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087579801","display_name":"Michelle Mikhno","orcid":null},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle Mikhno","raw_affiliation_strings":["Rutgers University, New Jersey","Rutgers University , Piscataway, NJ , USA ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rutgers University, New Jersey","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Rutgers University , Piscataway, NJ , USA ,","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042516831","display_name":"H. Nagendra","orcid":null},"institutions":[{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"education","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harry Nagendra","raw_affiliation_strings":["SUNY Downstate Medical Center, New York","Downstate Med. Center, SUNY, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SUNY Downstate Medical Center, New York","institution_ids":["https://openalex.org/I181697535"]},{"raw_affiliation_string":"Downstate Med. Center, SUNY, New York, NY, USA","institution_ids":["https://openalex.org/I181697535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054705832","display_name":"J. John Mann","orcid":"https://orcid.org/0000-0002-0265-6586"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. John Mann","raw_affiliation_strings":["Department of Psychiatry, Columbia University, NY","Dept. of Psychiatry, Columbia Univ., Columbia, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Columbia University, NY","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Dept. of Psychiatry, Columbia Univ., Columbia, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090489079","display_name":"Andrew F. Laine","orcid":"https://orcid.org/0000-0003-3797-0628"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew F. Laine","raw_affiliation_strings":["Department of Biomedical Engineering, Columbia University, NY","Dept. of Biomed. Eng., Columbia Univ., Columbia, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Columbia University, NY","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Dept. of Biomed. Eng., Columbia Univ., Columbia, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023581810","display_name":"Ramin V. Parsey","orcid":"https://orcid.org/0000-0001-9898-5415"},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramin V. Parsey","raw_affiliation_strings":["Department of Psychiatry, Stony Brook University, NY","Department of Psychiatry. Stony Brook University, Stony Brook, NY. USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Stony Brook University, NY","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Department of Psychiatry. Stony Brook University, Stony Brook, NY. USA","institution_ids":["https://openalex.org/I59553526"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8295,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.81875,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"732","last_page":"735"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11279","display_name":"Lanthanide and Transition Metal Complexes","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/positron-emission-tomography","display_name":"Positron emission tomography","score":0.46583905816078186},{"id":"https://openalex.org/keywords/binding-potential","display_name":"Binding potential","score":0.45168715715408325},{"id":"https://openalex.org/keywords/identifiability","display_name":"Identifiability","score":0.42941606044769287},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.40573981404304504},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.39538562297821045},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3944891095161438},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.3500463664531708},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3067612648010254},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2979137897491455}],"concepts":[{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.46583905816078186},{"id":"https://openalex.org/C60592354","wikidata":"https://www.wikidata.org/wiki/Q4914018","display_name":"Binding potential","level":3,"score":0.45168715715408325},{"id":"https://openalex.org/C122770356","wikidata":"https://www.wikidata.org/wiki/Q1656753","display_name":"Identifiability","level":2,"score":0.42941606044769287},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.40573981404304504},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.39538562297821045},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3944891095161438},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.3500463664531708},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3067612648010254},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2979137897491455}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/bhi.2014.6864468","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bhi.2014.6864468","pdf_url":null,"source":{"id":"https://openalex.org/S4393918972","display_name":"IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI ...)","issn_l":"2641-3590","issn":["2641-3590"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI)","raw_type":"proceedings-article"},{"id":"pmh:oai:zenodo.org:1265316","is_oa":true,"landing_page_url":"https://zenodo.org/record/1265316","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/conferencePaper"}],"best_oa_location":{"id":"pmh:oai:zenodo.org:1265316","is_oa":true,"landing_page_url":"https://zenodo.org/record/1265316","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/conferencePaper"},"sustainable_development_goals":[{"score":0.5899999737739563,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1979843284","https://openalex.org/W2076147201","https://openalex.org/W2092415400","https://openalex.org/W2112278807","https://openalex.org/W2121144107","https://openalex.org/W2321904707"],"related_works":["https://openalex.org/W2724847603","https://openalex.org/W2034041141","https://openalex.org/W2184661725","https://openalex.org/W112856298","https://openalex.org/W2573470972","https://openalex.org/W2105626102","https://openalex.org/W2131038454","https://openalex.org/W4240568257","https://openalex.org/W2900187352","https://openalex.org/W3092530164"],"abstract_inverted_index":{"Quantitative":[0],"analysis":[1,178],"of":[2,14,61,129],"PET":[3,32,76],"data":[4,123],"requires":[5],"a":[6,71,96,101,144,169],"metabolite-corrected":[7],"arterial":[8,22,46],"input":[9],"function":[10],"(AIF)":[11],"for":[12,93,176],"estimation":[13,37,42],"distribution":[15],"volume":[16],"and":[17,28,107,155],"related":[18],"outcome":[19],"measures.":[20],"Collecting":[21],"blood":[23,47,79,149,181],"samples":[24],"adds":[25],"risk,":[26],"cost,":[27],"patient":[29],"discomfort":[30],"to":[31,51,58,127,168],"studies.":[33],"Minimally":[34],"invasive":[35],"AIF":[36],"is":[38,49,81],"possible":[39],"with":[40,100,179],"simultaneous":[41],"(SIME),":[43],"but":[44],"one":[45],"sample":[48,80],"necessary":[50],"be":[52,141],"used":[53,73],"as":[54],"an":[55,91],"anchor":[56,99,139],"value":[57,103],"ensure":[59],"identifiability":[60],"each":[62],"individuals":[63],"AIF.":[64],"For":[65],"[":[66,133],"<sup":[67,116,134],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[68,117,135],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">11</sup>":[69,136],"C]DASB,":[70],"widely":[72],"serotonin":[74],"transporter":[75],"tracer,":[77],"this":[78],"optimally":[82],"taken":[83],"50":[84],"minutes":[85],"after":[86],"injection.":[87],"We":[88],"present":[89],"here":[90],"approach":[92],"replacing":[94],"such":[95],"single":[97],"time-point":[98],"predicted":[102],"using":[104],"brain":[105],"imaging":[106],"electronic":[108],"health":[109],"record":[110],"(EHR)":[111],"data.":[112],"Average":[113],"bootstrap":[114],"R":[115],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">2</sup>":[118],">":[119],"0.8":[120],"in":[121,132],"training":[122],"suggest":[124],"that":[125,163],"up":[126],"80%":[128],"the":[130],"variance":[131],"C]DASB":[137],"SIME":[138],"may":[140,174],"explained":[142],"by":[143],"model":[145],"including":[146],"heart":[147],"rate,":[148],"pressure,":[150],"tracer":[151],"dose,":[152],"body":[153],"size":[154],"cerebellar":[156],"gray":[157],"matter":[158],"uptake.":[159],"Preliminary":[160],"results":[161],"show":[162],"these":[164],"models":[165],"generalize":[166],"well":[167],"small":[170],"test":[171],"dataset.":[172],"This":[173],"allow":[175],"quantitative":[177],"no":[180],"sampling.":[182]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
