{"id":"https://openalex.org/W2034239767","doi":"https://doi.org/10.1109/bhi.2014.6864461","title":"Simultaneous chemiluminescence detection of multiple tumor markers using bio-functionlized magnetic nanocomposites","display_name":"Simultaneous chemiluminescence detection of multiple tumor markers using bio-functionlized magnetic nanocomposites","publication_year":2014,"publication_date":"2014-06-01","ids":{"openalex":"https://openalex.org/W2034239767","doi":"https://doi.org/10.1109/bhi.2014.6864461","mag":"2034239767"},"language":"en","primary_location":{"id":"doi:10.1109/bhi.2014.6864461","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bhi.2014.6864461","pdf_url":null,"source":{"id":"https://openalex.org/S4393918972","display_name":"IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI ...)","issn_l":"2641-3590","issn":["2641-3590"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038288893","display_name":"Jinping Luo","orcid":"https://orcid.org/0000-0002-7900-9512"},"institutions":[{"id":"https://openalex.org/I4210107198","display_name":"State Key Laboratory of Transducer Technology","ror":"https://ror.org/01qg56n75","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366","https://openalex.org/I19820366","https://openalex.org/I4210107198","https://openalex.org/I4210110458","https://openalex.org/I4210147322"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"JinPing Luo","raw_affiliation_strings":["State Key Laboratory of Transducer Technology, Chinese Academy of Sciences, Beijing, China","State Key Lab. of Transducer Technol., Inst. of Electron., Beijing, China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Transducer Technology, Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210107198","https://openalex.org/I19820366"]},{"raw_affiliation_string":"State Key Lab. of Transducer Technol., Inst. of Electron., Beijing, China","institution_ids":["https://openalex.org/I4210107198"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100621523","display_name":"Juntao Liu","orcid":"https://orcid.org/0000-0002-5368-398X"},"institutions":[{"id":"https://openalex.org/I4210107198","display_name":"State Key Laboratory of Transducer Technology","ror":"https://ror.org/01qg56n75","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366","https://openalex.org/I19820366","https://openalex.org/I4210107198","https://openalex.org/I4210110458","https://openalex.org/I4210147322"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"JunTao Liu","raw_affiliation_strings":["State Key Laboratory of Transducer Technology, Chinese Academy of Sciences, Beijing, China","State Key Lab. of Transducer Technol., Inst. of Electron., Beijing, China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Transducer Technology, Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210107198","https://openalex.org/I19820366"]},{"raw_affiliation_string":"State Key Lab. of Transducer Technol., Inst. of Electron., Beijing, China","institution_ids":["https://openalex.org/I4210107198"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100659473","display_name":"Yan Shi","orcid":"https://orcid.org/0000-0003-4119-3702"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shi Yan","raw_affiliation_strings":["Breast Cancer Surgery, Peking University Cancer Hospital, Beijing, China","Breast Cancer Surg., Peking Univ. Cancer Hosp., Beijing, China"],"affiliations":[{"raw_affiliation_string":"Breast Cancer Surgery, Peking University Cancer Hospital, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210093964"]},{"raw_affiliation_string":"Breast Cancer Surg., Peking Univ. Cancer Hosp., Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100734685","display_name":"Yue Yang","orcid":null},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Yang","raw_affiliation_strings":["Breast Cancer Surgery, Peking University Cancer Hospital, Beijing, China","Breast Cancer Surg., Peking Univ. Cancer Hosp., Beijing, China"],"affiliations":[{"raw_affiliation_string":"Breast Cancer Surgery, Peking University Cancer Hospital, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210093964"]},{"raw_affiliation_string":"Breast Cancer Surg., Peking Univ. Cancer Hosp., Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111695012","display_name":"Xinxia Cai","orcid":"https://orcid.org/0000-0001-5997-7252"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210107198","display_name":"State Key Laboratory of Transducer Technology","ror":"https://ror.org/01qg56n75","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366","https://openalex.org/I19820366","https://openalex.org/I4210107198","https://openalex.org/I4210110458","https://openalex.org/I4210147322"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"XinXia Cai","raw_affiliation_strings":["State Key Laboratory of Transducer Technology, Chinese Academy of Sciences, Beijing, China","State Key Lab. of Transducer Technol., Inst. of Electron., Beijing, China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Transducer Technology, Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210107198","https://openalex.org/I19820366"]},{"raw_affiliation_string":"State Key Lab. of Transducer Technol., Inst. of Electron., Beijing, China","institution_ids":["https://openalex.org/I4210107198"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5038288893"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210107198"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.11111111,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"293","issue":null,"first_page":"705","last_page":"708"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.9884999990463257,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemiluminescence","display_name":"Chemiluminescence","score":0.8354010581970215},{"id":"https://openalex.org/keywords/carcinoembryonic-antigen","display_name":"Carcinoembryonic antigen","score":0.8176217079162598},{"id":"https://openalex.org/keywords/detection-limit","display_name":"Detection limit","score":0.5961548686027527},{"id":"https://openalex.org/keywords/immunoassay","display_name":"Immunoassay","score":0.5301802158355713},{"id":"https://openalex.org/keywords/enolase","display_name":"Enolase","score":0.5187644958496094},{"id":"https://openalex.org/keywords/tumor-marker","display_name":"Tumor marker","score":0.5109378695487976},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.4840680658817291},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.36658775806427},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.34871381521224976},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.32891055941581726},{"id":"https://openalex.org/keywords/antibody","display_name":"Antibody","score":0.2797614336013794},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.2617006003856659},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.21556499600410461},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.15784573554992676},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"Immunohistochemistry","score":0.15355557203292847},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.12487319111824036},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.06755200028419495}],"concepts":[{"id":"https://openalex.org/C145802702","wikidata":"https://www.wikidata.org/wiki/Q2931725","display_name":"Chemiluminescence","level":2,"score":0.8354010581970215},{"id":"https://openalex.org/C2777387746","wikidata":"https://www.wikidata.org/wiki/Q769706","display_name":"Carcinoembryonic antigen","level":3,"score":0.8176217079162598},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.5961548686027527},{"id":"https://openalex.org/C2780420688","wikidata":"https://www.wikidata.org/wiki/Q759183","display_name":"Immunoassay","level":3,"score":0.5301802158355713},{"id":"https://openalex.org/C188618488","wikidata":"https://www.wikidata.org/wiki/Q24776639","display_name":"Enolase","level":3,"score":0.5187644958496094},{"id":"https://openalex.org/C2781447364","wikidata":"https://www.wikidata.org/wiki/Q584992","display_name":"Tumor marker","level":3,"score":0.5109378695487976},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4840680658817291},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.36658775806427},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34871381521224976},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.32891055941581726},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2797614336013794},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2617006003856659},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.21556499600410461},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15784573554992676},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.15355557203292847},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.12487319111824036},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.06755200028419495}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bhi.2014.6864461","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bhi.2014.6864461","pdf_url":null,"source":{"id":"https://openalex.org/S4393918972","display_name":"IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI ...)","issn_l":"2641-3590","issn":["2641-3590"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W130099911","https://openalex.org/W1596283410","https://openalex.org/W1965540811","https://openalex.org/W1970457630","https://openalex.org/W1971486598","https://openalex.org/W1998951921","https://openalex.org/W2020695972","https://openalex.org/W2053818523","https://openalex.org/W2078419129","https://openalex.org/W2121055577","https://openalex.org/W2360624534","https://openalex.org/W2532128562"],"related_works":["https://openalex.org/W2403094844","https://openalex.org/W2418757228","https://openalex.org/W1998435831","https://openalex.org/W1998150326","https://openalex.org/W2466402651","https://openalex.org/W126283279","https://openalex.org/W1813410749","https://openalex.org/W2102242707","https://openalex.org/W949275","https://openalex.org/W4205638391"],"abstract_inverted_index":{"Detection":[0],"of":[1,15,44,159,187,206],"tumor":[2,20,46,189,208],"marker":[3],"is":[4,129],"an":[5],"effective":[6],"and":[7,55,81,96,113,138,161,173,201,210],"low":[8],"cost":[9],"means":[10],"in":[11,69,142,214],"the":[12,25,63,93,114,135,139,143,157,168,171,174],"early":[13],"diagnosis":[14],"lung":[16],"cancer,":[17],"especially":[18],"multiple":[19,45,207],"markers":[21,190,209],"combined":[22],"can":[23],"improve":[24],"diagnostic":[26],"value.":[27],"In":[28],"this":[29],"paper,":[30],"a":[31,84,103,120,130,198],"chemiluminescence":[32,136],"immunoassay":[33],"using":[34,83],"bio-functionlized":[35],"magnetic":[36,76],"nanocomposites":[37],"(BFMNs)":[38],"was":[39],"proposed":[40,195],"for":[41,156,204],"simultaneous":[42,185],"detection":[43,64,158,165,177,186,205],"markers.":[47],"Carcinoembryonic":[48],"antigen":[49,95],"(CEA),":[50],"neuron":[51],"specific":[52],"enolase":[53],"(NSE)":[54],"cytokeratin":[56],"19":[57],"fragment":[58],"(CYFRA21-1)":[59],"were":[60,67,117],"chose":[61],"as":[62,150,152],"models.":[65],"BFMNs":[66,89],"prepared":[68],"advance":[70],"by":[71,119],"loading":[72],"different":[73],"antibodies":[74,100],"to":[75,147,182],"beads":[77],"containing":[78],"Fe2O3":[79],"nanoparticles,":[80],"characterized":[82],"scanning":[85],"electron":[86],"microscope.":[87],"The":[88,106,163,194],"could":[90,179],"specifically":[91],"capture":[92],"corresponding":[94],"its":[97],"HRP":[98],"labeled":[99],"based":[101],"on":[102],"sandwich-type":[104],"immunoreaction.":[105],"immunocomplex":[107],"further":[108],"reacts":[109],"with":[110,153],"chemiluminescent":[111],"substrate":[112],"produced":[115],"chemiluminescences":[116],"detected":[118],"homemade":[121],"three-channel":[122],"luminometer.":[123],"Preliminary":[124],"results":[125,155],"show":[126],"that":[127],"there":[128],"good":[131],"linear":[132],"relationship":[133],"between":[134],"intensity":[137],"CEA":[140],"concentration":[141],"range":[144],"from":[145],"5":[146],"200":[148],"ng/mL,":[149],"well":[151],"similar":[154],"NSE":[160],"CYFRA21-1.":[162],"whole":[164],"process,":[166],"including":[167],"immune":[169],"response,":[170],"washing":[172],"optical":[175],"signal":[176],"steps,":[178],"be":[180],"performed":[181],"carry":[183],"out":[184],"three":[188],"within":[191],"35":[192],"min.":[193],"method":[196],"offers":[197],"simple,":[199],"noninvasive":[200],"rapid":[202],"tool":[203],"has":[211],"potential":[212],"application":[213],"clinical":[215],"testing.":[216]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}