{"id":"https://openalex.org/W2034433436","doi":"https://doi.org/10.1109/bhi.2014.6864369","title":"Neurovascular coupling study of PTZ-induced seizure in rats by simultaneous real-time 3D PAT and EEG at two wavelengths","display_name":"Neurovascular coupling study of PTZ-induced seizure in rats by simultaneous real-time 3D PAT and EEG at two wavelengths","publication_year":2014,"publication_date":"2014-06-01","ids":{"openalex":"https://openalex.org/W2034433436","doi":"https://doi.org/10.1109/bhi.2014.6864369","mag":"2034433436"},"language":"en","primary_location":{"id":"doi:10.1109/bhi.2014.6864369","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bhi.2014.6864369","pdf_url":null,"source":{"id":"https://openalex.org/S4393918972","display_name":"IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI ...)","issn_l":"2641-3590","issn":["2641-3590"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082019918","display_name":"First J. Xiao","orcid":null},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"First J. Xiao","raw_affiliation_strings":["School of Geosciences and Info-Physics Engineering, Central South University, Changsha, China","Sch. of Geosci. & Inf.-Phys. Eng., Central South Univ., Changsha, China"],"affiliations":[{"raw_affiliation_string":"School of Geosciences and Info-Physics Engineering, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"Sch. of Geosci. & Inf.-Phys. Eng., Central South Univ., Changsha, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019165833","display_name":"Second B. Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Second B. Wang","raw_affiliation_strings":["J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, USA","Pruitt Family Dept. of Biomed. Eng., Univ. of Florida, Gainesville, FL, USA"],"affiliations":[{"raw_affiliation_string":"J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Pruitt Family Dept. of Biomed. Eng., Univ. of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070342935","display_name":"Third K. Peng","orcid":null},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Third K. Peng","raw_affiliation_strings":["School of Geosciences and Info-Physics Engineering, Central South University, Changsha, China","Sch. of Geosci. & Inf.-Phys. Eng., Central South Univ., Changsha, China"],"affiliations":[{"raw_affiliation_string":"School of Geosciences and Info-Physics Engineering, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"Sch. of Geosci. & Inf.-Phys. Eng., Central South Univ., Changsha, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068323719","display_name":"Fourth Z. Zhu","orcid":null},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fourth Z. Zhu","raw_affiliation_strings":["School of Geosciences and Info-Physics Engineering, Central South University, Changsha, China","Sch. of Geosci. & Inf.-Phys. Eng., Central South Univ., Changsha, China"],"affiliations":[{"raw_affiliation_string":"School of Geosciences and Info-Physics Engineering, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"Sch. of Geosci. & Inf.-Phys. Eng., Central South Univ., Changsha, China","institution_ids":["https://openalex.org/I139660479"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5082019918"],"corresponding_institution_ids":["https://openalex.org/I139660479"],"apc_list":null,"apc_paid":null,"fwci":1.2765,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.75146542,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"19","issue":null,"first_page":"326","last_page":"329"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11667","display_name":"Advanced Chemical Sensor Technologies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.9944999814033508,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/superior-sagittal-sinus","display_name":"Superior sagittal sinus","score":0.739946722984314},{"id":"https://openalex.org/keywords/epilepsy","display_name":"Epilepsy","score":0.7072663307189941},{"id":"https://openalex.org/keywords/sss*","display_name":"SSS*","score":0.692380428314209},{"id":"https://openalex.org/keywords/electroencephalography","display_name":"Electroencephalography","score":0.6472000479698181},{"id":"https://openalex.org/keywords/hemodynamics","display_name":"Hemodynamics","score":0.5690113306045532},{"id":"https://openalex.org/keywords/neurovascular-bundle","display_name":"Neurovascular bundle","score":0.5454611778259277},{"id":"https://openalex.org/keywords/pentylenetetrazol","display_name":"Pentylenetetrazol","score":0.5432511568069458},{"id":"https://openalex.org/keywords/signal","display_name":"SIGNAL (programming language)","score":0.5338312983512878},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.4531446397304535},{"id":"https://openalex.org/keywords/coupling","display_name":"Coupling (piping)","score":0.4530768096446991},{"id":"https://openalex.org/keywords/neuroimaging","display_name":"Neuroimaging","score":0.4480106830596924},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4026896059513092},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.3914731740951538},{"id":"https://openalex.org/keywords/anesthesia","display_name":"Anesthesia","score":0.36640796065330505},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3287760615348816},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.2172355055809021},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.2045278549194336},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.19655045866966248},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.15318650007247925}],"concepts":[{"id":"https://openalex.org/C2776620988","wikidata":"https://www.wikidata.org/wiki/Q4115976","display_name":"Superior sagittal sinus","level":3,"score":0.739946722984314},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.7072663307189941},{"id":"https://openalex.org/C148699463","wikidata":"https://www.wikidata.org/wiki/Q3492668","display_name":"SSS*","level":2,"score":0.692380428314209},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.6472000479698181},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.5690113306045532},{"id":"https://openalex.org/C105572291","wikidata":"https://www.wikidata.org/wiki/Q7002775","display_name":"Neurovascular bundle","level":2,"score":0.5454611778259277},{"id":"https://openalex.org/C2776819090","wikidata":"https://www.wikidata.org/wiki/Q412391","display_name":"Pentylenetetrazol","level":4,"score":0.5432511568069458},{"id":"https://openalex.org/C2779843651","wikidata":"https://www.wikidata.org/wiki/Q7390335","display_name":"SIGNAL (programming language)","level":2,"score":0.5338312983512878},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4531446397304535},{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.4530768096446991},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.4480106830596924},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4026896059513092},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3914731740951538},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.36640796065330505},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3287760615348816},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2172355055809021},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2045278549194336},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19655045866966248},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.15318650007247925},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.0},{"id":"https://openalex.org/C2775858608","wikidata":"https://www.wikidata.org/wiki/Q576618","display_name":"Anticonvulsant","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bhi.2014.6864369","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bhi.2014.6864369","pdf_url":null,"source":{"id":"https://openalex.org/S4393918972","display_name":"IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI ...)","issn_l":"2641-3590","issn":["2641-3590"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6299999952316284,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1979635428","https://openalex.org/W1980508513","https://openalex.org/W1985921980","https://openalex.org/W1999560114","https://openalex.org/W2022480246","https://openalex.org/W2033448026","https://openalex.org/W2036078196","https://openalex.org/W2045747994","https://openalex.org/W2051021255","https://openalex.org/W2057673604","https://openalex.org/W2060277707","https://openalex.org/W2062106429","https://openalex.org/W2074030591","https://openalex.org/W2084929724","https://openalex.org/W2148967099","https://openalex.org/W2162691865","https://openalex.org/W4233722803"],"related_works":["https://openalex.org/W2971309449","https://openalex.org/W2291559116","https://openalex.org/W3005348147","https://openalex.org/W2047590315","https://openalex.org/W2058344110","https://openalex.org/W2379149973","https://openalex.org/W2301739602","https://openalex.org/W3029038830","https://openalex.org/W2990427787","https://openalex.org/W3174966026"],"abstract_inverted_index":{"Neurovascular":[0],"coupling":[1,46,184],"in":[2,20,47,61,84,125,133,176],"epilepsy":[3],"is":[4],"poorly":[5],"understood,":[6],"the":[7,21,26,42,75,85,90,95,104,110,126,130,134,144,159],"study":[8,43,185],"of":[9,14,44,65,77,94,166,186],"which":[10],"requires":[11],"simultaneous":[12],"monitoring":[13],"hemodynamic":[15,167],"changes":[16,76],"and":[17,37,80,100,129,143,173],"neural":[18],"activity":[19],"brain.":[22,87],"Here":[23],"we":[24],"for":[25,41,122,182],"first":[27,127],"time":[28],"present":[29],"a":[30,54],"combined":[31],"real-time":[32],"3D":[33],"Photoacoustic":[34],"tomography":[35],"(PAT)":[36],"electro-physiology":[38],"(EEG)":[39],"system":[40],"neurovascular":[45,183],"epilepsy,":[48],"whose":[49],"ability":[50],"was":[51],"demonstrated":[52],"with":[53,70,103,169],"pentylenetetrazol":[55],"(PTZ)":[56],"induced":[57],"generalized":[58],"seizure":[59,111],"model":[60],"rats.":[62],"Two":[63],"groups":[64],"experiments":[66],"were":[67,137,148],"carried":[68],"out":[69],"different":[71],"wavelengths":[72],"to":[73,153],"detect":[74],"oxy-hemoglobin":[78,140],"(HbO2)":[79,141],"deoxy-hemoglobin":[81,145],"(Hbr)":[82,146],"signals":[83,93],"rat":[86],"We":[88],"extracted":[89],"average":[91],"PAT":[92],"superior":[96],"sagittal":[97],"sinus":[98],"(SSS),":[99],"compared":[101],"them":[102],"EEG":[105],"signal.":[106],"Results":[107],"showed":[108],"that":[109],"process":[112],"can":[113],"be":[114],"divided":[115],"into":[116],"three":[117],"stages.":[118],"A":[119],"`dip'":[120],"lasting":[121],"1-2":[123],"minutes":[124],"stage":[128,136],"following":[131],"hyperfusion":[132],"second":[135],"observed.":[138],"The":[139],"signal":[142,147,168],"generally":[149],"negatively":[150],"correlated.":[151],"Compared":[152],"other":[154],"existing":[155],"functional":[156],"neuroimaging":[157],"tools,":[158],"proposed":[160],"method":[161],"here":[162],"enables":[163],"reliable":[164],"tracking":[165],"both":[170],"high":[171],"spatial":[172],"temporal":[174],"resolution":[175],"3D,":[177],"so":[178],"it's":[179],"more":[180],"suitable":[181],"epilepsy.":[187]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}