{"id":"https://openalex.org/W2293017319","doi":"https://doi.org/10.1109/aspdac.2016.7428075","title":"Sequence-pair-based placement and routing for flow-based microfluidic biochips","display_name":"Sequence-pair-based placement and routing for flow-based microfluidic biochips","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2293017319","doi":"https://doi.org/10.1109/aspdac.2016.7428075","mag":"2293017319"},"language":"en","primary_location":{"id":"doi:10.1109/aspdac.2016.7428075","is_oa":false,"landing_page_url":"https://doi.org/10.1109/aspdac.2016.7428075","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 21st Asia and South Pacific Design Automation Conference (ASP-DAC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101498763","display_name":"Qin Wang","orcid":"https://orcid.org/0000-0003-2775-5502"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qin Wang","raw_affiliation_strings":["Tsinghua University, Tsinghua National Laboratory for Information Science and Technology (TNList)"],"affiliations":[{"raw_affiliation_string":"Tsinghua University, Tsinghua National Laboratory for Information Science and Technology (TNList)","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025765742","display_name":"Yizhong Ru","orcid":null},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yizhong Ru","raw_affiliation_strings":["Tsinghua University, Tsinghua National Laboratory for Information Science and Technology (TNList)"],"affiliations":[{"raw_affiliation_string":"Tsinghua University, Tsinghua National Laboratory for Information Science and Technology (TNList)","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058812423","display_name":"Hailong Yao","orcid":"https://orcid.org/0000-0002-8750-3086"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hailong Yao","raw_affiliation_strings":["Tsinghua University, Tsinghua National Laboratory for Information Science and Technology (TNList)"],"affiliations":[{"raw_affiliation_string":"Tsinghua University, Tsinghua National Laboratory for Information Science and Technology (TNList)","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062800747","display_name":"Tsung-Yi Ho","orcid":"https://orcid.org/0000-0001-7348-5625"},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Tsung-Yi Ho","raw_affiliation_strings":["National Tsing Hua University, Tsinghua National Laboratory for Information Science and Technology (TNList)"],"affiliations":[{"raw_affiliation_string":"National Tsing Hua University, Tsinghua National Laboratory for Information Science and Technology (TNList)","institution_ids":["https://openalex.org/I25846049"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111983610","display_name":"Yici Cai","orcid":null},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yici Cai","raw_affiliation_strings":["Tsinghua University, Tsinghua National Laboratory for Information Science and Technology (TNList)"],"affiliations":[{"raw_affiliation_string":"Tsinghua University, Tsinghua National Laboratory for Information Science and Technology (TNList)","institution_ids":["https://openalex.org/I99065089"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5101498763"],"corresponding_institution_ids":["https://openalex.org/I99065089"],"apc_list":null,"apc_paid":null,"fwci":2.7565,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.90700138,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":null,"issue":null,"first_page":"587","last_page":"592"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12452","display_name":"Electrowetting and Microfluidic Technologies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12452","display_name":"Electrowetting and Microfluidic Technologies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biochip","display_name":"Biochip","score":0.886022686958313},{"id":"https://openalex.org/keywords/routing","display_name":"Routing (electronic design automation)","score":0.7919713258743286},{"id":"https://openalex.org/keywords/physical-design","display_name":"Physical design","score":0.6541022062301636},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6250466108322144},{"id":"https://openalex.org/keywords/channel","display_name":"Channel (broadcasting)","score":0.6022895574569702},{"id":"https://openalex.org/keywords/placement","display_name":"Placement","score":0.5758516788482666},{"id":"https://openalex.org/keywords/design-flow","display_name":"Design flow","score":0.5037681460380554},{"id":"https://openalex.org/keywords/component","display_name":"Component (thermodynamics)","score":0.4884563982486725},{"id":"https://openalex.org/keywords/chip","display_name":"Chip","score":0.47798413038253784},{"id":"https://openalex.org/keywords/flow","display_name":"Flow (mathematics)","score":0.4675988554954529},{"id":"https://openalex.org/keywords/reliability","display_name":"Reliability (semiconductor)","score":0.4463111162185669},{"id":"https://openalex.org/keywords/embedded-system","display_name":"Embedded system","score":0.38020214438438416},{"id":"https://openalex.org/keywords/computer-network","display_name":"Computer network","score":0.20545867085456848},{"id":"https://openalex.org/keywords/circuit-design","display_name":"Circuit design","score":0.10918471217155457},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.08746844530105591}],"concepts":[{"id":"https://openalex.org/C87892846","wikidata":"https://www.wikidata.org/wiki/Q864256","display_name":"Biochip","level":2,"score":0.886022686958313},{"id":"https://openalex.org/C74172769","wikidata":"https://www.wikidata.org/wiki/Q1446839","display_name":"Routing (electronic design automation)","level":2,"score":0.7919713258743286},{"id":"https://openalex.org/C188817802","wikidata":"https://www.wikidata.org/wiki/Q13426855","display_name":"Physical design","level":3,"score":0.6541022062301636},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6250466108322144},{"id":"https://openalex.org/C127162648","wikidata":"https://www.wikidata.org/wiki/Q16858953","display_name":"Channel (broadcasting)","level":2,"score":0.6022895574569702},{"id":"https://openalex.org/C117690923","wikidata":"https://www.wikidata.org/wiki/Q1484784","display_name":"Placement","level":4,"score":0.5758516788482666},{"id":"https://openalex.org/C37135326","wikidata":"https://www.wikidata.org/wiki/Q931942","display_name":"Design flow","level":2,"score":0.5037681460380554},{"id":"https://openalex.org/C168167062","wikidata":"https://www.wikidata.org/wiki/Q1117970","display_name":"Component (thermodynamics)","level":2,"score":0.4884563982486725},{"id":"https://openalex.org/C165005293","wikidata":"https://www.wikidata.org/wiki/Q1074500","display_name":"Chip","level":2,"score":0.47798413038253784},{"id":"https://openalex.org/C38349280","wikidata":"https://www.wikidata.org/wiki/Q1434290","display_name":"Flow (mathematics)","level":2,"score":0.4675988554954529},{"id":"https://openalex.org/C43214815","wikidata":"https://www.wikidata.org/wiki/Q7310987","display_name":"Reliability (semiconductor)","level":3,"score":0.4463111162185669},{"id":"https://openalex.org/C149635348","wikidata":"https://www.wikidata.org/wiki/Q193040","display_name":"Embedded system","level":1,"score":0.38020214438438416},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.20545867085456848},{"id":"https://openalex.org/C190560348","wikidata":"https://www.wikidata.org/wiki/Q3245116","display_name":"Circuit design","level":2,"score":0.10918471217155457},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.08746844530105591},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C163258240","wikidata":"https://www.wikidata.org/wiki/Q25342","display_name":"Power (physics)","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/aspdac.2016.7428075","is_oa":false,"landing_page_url":"https://doi.org/10.1109/aspdac.2016.7428075","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 21st Asia and South Pacific Design Automation Conference (ASP-DAC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/14","score":0.5899999737739563,"display_name":"Life below water"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1933886027","https://openalex.org/W1996296142","https://openalex.org/W1998450740","https://openalex.org/W2020438216","https://openalex.org/W2028712328","https://openalex.org/W2072910502","https://openalex.org/W2083068121","https://openalex.org/W2086187432","https://openalex.org/W2088405514","https://openalex.org/W2100588415","https://openalex.org/W2116208923","https://openalex.org/W2128427912","https://openalex.org/W2150515030","https://openalex.org/W2154347237","https://openalex.org/W2154462472","https://openalex.org/W2168482356","https://openalex.org/W2170862340","https://openalex.org/W2171414627","https://openalex.org/W2275304190","https://openalex.org/W2546748610","https://openalex.org/W3011891279","https://openalex.org/W4238524833","https://openalex.org/W6640375315","https://openalex.org/W6685333642"],"related_works":["https://openalex.org/W2547355295","https://openalex.org/W2042759115","https://openalex.org/W2159053194","https://openalex.org/W2132668926","https://openalex.org/W1964677779","https://openalex.org/W4318224776","https://openalex.org/W2169510384","https://openalex.org/W2155675690","https://openalex.org/W2099105040","https://openalex.org/W1563562883"],"abstract_inverted_index":{"Flow-based":[0],"microfluidic":[1],"biochips":[2,20],"are":[3],"attracting":[4],"increasing":[5],"attention":[6],"with":[7,90,133],"successful":[8],"applications":[9],"in":[10,87,144,149,156],"lab-on-a-chip":[11],"experiments":[12],"and":[13,27,44,63,74,97,105,117,120,153],"point-of-care":[14],"diagnosis.":[15],"Physical":[16],"design":[17,42,47,54,84,89],"for":[18],"flow-based":[19],"determines":[21],"the":[22,30,40,68,82,110,134,137],"number":[23,31,92],"of":[24,32,49,56,79,93],"flow-channel":[25,145],"intersections,":[26],"thus":[28],"affects":[29],"microvalves.":[33,98],"As":[34],"reducing":[35],"microvalves":[36],"will":[37],"significantly":[38],"improve":[39],"overall":[41],"quality":[43],"reliability,":[45],"physical":[46,53],"is":[48],"great":[50],"importance.":[51],"Typically,":[52],"consists":[55],"two":[57,83],"major":[58],"stages,":[59],"i.e.,":[60],"component":[61],"placement":[62,73,104,116,123],"routing.":[64],"Existing":[65],"works":[66],"follow":[67],"step-by-step":[69],"scheme,":[70],"which":[71,113],"perform":[72],"routing":[75,106,118,126],"separately.":[76],"The":[77],"lack":[78],"interactions":[80],"between":[81],"stages":[85,119],"results":[86,129],"degraded":[88],"large":[91],"unfavorable":[94],"channel":[95,158],"intersections":[96],"This":[99],"paper":[100],"presents":[101],"a":[102],"novel":[103],"method":[107,139],"based":[108],"on":[109],"sequence-pair":[111],"representation,":[112],"seamlessly":[114],"integrates":[115],"allows":[121],"iterative":[122],"adjustment":[124],"upon":[125],"feedbacks.":[127],"Experimental":[128],"show":[130],"that":[131],"compared":[132],"existing":[135],"work,":[136],"proposed":[138],"obtains":[140],"average":[141],"54.10%":[142],"improvement":[143,148,155],"crossings,":[146],"42.15%":[147],"total":[150,157],"chip":[151],"area,":[152],"23.43%":[154],"length.":[159]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}