{"id":"https://openalex.org/W1524558759","doi":"https://doi.org/10.1109/ascc.2015.7244639","title":"A mathematical model of tumor-immune interactions incorporated with danger model","display_name":"A mathematical model of tumor-immune interactions incorporated with danger model","publication_year":2015,"publication_date":"2015-05-01","ids":{"openalex":"https://openalex.org/W1524558759","doi":"https://doi.org/10.1109/ascc.2015.7244639","mag":"1524558759"},"language":"en","primary_location":{"id":"doi:10.1109/ascc.2015.7244639","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ascc.2015.7244639","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 10th Asian Control Conference (ASCC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101983688","display_name":"Xuefang Li","orcid":"https://orcid.org/0000-0003-3898-6509"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Xuefang Li","raw_affiliation_strings":["Department of Electrical and Computer Engineering, National University of Singapore, Singapore","[Dept. of Electrical and Computer Engineering, National University of Singapore, Singapore.]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"[Dept. of Electrical and Computer Engineering, National University of Singapore, Singapore.]","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100768355","display_name":"Jian\u2010Xin Xu","orcid":"https://orcid.org/0000-0002-9485-5880"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Jian-Xin Xu","raw_affiliation_strings":["Department of Electrical and Computer Engineering, National University of Singapore, Singapore","[Dept. of Electrical and Computer Engineering, National University of Singapore, Singapore.]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"[Dept. of Electrical and Computer Engineering, National University of Singapore, Singapore.]","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041199618","display_name":"Qinyuan Ren","orcid":"https://orcid.org/0000-0001-9487-2675"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Qinyuan Ren","raw_affiliation_strings":["Department of Electrical and Computer Engineering, National University of Singapore, Singapore","[Dept. of Electrical and Computer Engineering, National University of Singapore, Singapore.]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"[Dept. of Electrical and Computer Engineering, National University of Singapore, Singapore.]","institution_ids":["https://openalex.org/I165932596"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I165932596"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"61","issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9939000010490417,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10482","display_name":"Mathematical and Theoretical Epidemiology and Ecology Models","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.644128680229187},{"id":"https://openalex.org/keywords/cd8","display_name":"CD8","score":0.5341804027557373},{"id":"https://openalex.org/keywords/stability","display_name":"Stability (learning theory)","score":0.5322328209877014},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5121743679046631},{"id":"https://openalex.org/keywords/tumor-cells","display_name":"Tumor cells","score":0.48771461844444275},{"id":"https://openalex.org/keywords/mathematical-model","display_name":"Mathematical model","score":0.42331206798553467},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.4184165596961975},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3400435447692871},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3338433504104614},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.25600776076316833},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.22949087619781494},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.20149052143096924},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.1166718602180481}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.644128680229187},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5341804027557373},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.5322328209877014},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5121743679046631},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.48771461844444275},{"id":"https://openalex.org/C76969082","wikidata":"https://www.wikidata.org/wiki/Q486902","display_name":"Mathematical model","level":2,"score":0.42331206798553467},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.4184165596961975},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3400435447692871},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3338433504104614},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.25600776076316833},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22949087619781494},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.20149052143096924},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.1166718602180481},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/ascc.2015.7244639","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ascc.2015.7244639","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 10th Asian Control Conference (ASCC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.47999998927116394,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W83886102","https://openalex.org/W200447247","https://openalex.org/W1512208922","https://openalex.org/W1588976239","https://openalex.org/W1595098530","https://openalex.org/W1965658210","https://openalex.org/W1970191127","https://openalex.org/W1971201122","https://openalex.org/W1977466091","https://openalex.org/W2062624879","https://openalex.org/W2063404019","https://openalex.org/W2068258896","https://openalex.org/W2084697628","https://openalex.org/W2140205687","https://openalex.org/W2147342239","https://openalex.org/W2158500407","https://openalex.org/W2169169493","https://openalex.org/W6666071850"],"related_works":["https://openalex.org/W3147584709","https://openalex.org/W2977677679","https://openalex.org/W1992327129","https://openalex.org/W2381986121","https://openalex.org/W2370918718","https://openalex.org/W2256933480","https://openalex.org/W2027854990","https://openalex.org/W2370081953","https://openalex.org/W2364428742","https://openalex.org/W3189572500"],"abstract_inverted_index":{"This":[0],"paper":[1],"presents":[2],"a":[3,11,14,91],"new":[4],"mathematical":[5,27,74],"model":[6,28],"of":[7,25,32,39,83,94,103,110],"the":[8,19,26,30,33,37,72,78,95,101,106,111,130],"interactions":[9],"between":[10],"tumor":[12,53],"and":[13,66,80,99],"immune":[15,40],"system":[16,97,112],"by":[17,46,115],"incorporating":[18],"danger":[20,34],"model.":[21],"A":[22],"key":[23],"feature":[24],"is":[29,43,126],"introducing":[31],"signal":[35],"into":[36],"dynamics":[38,98],"system,":[41],"which":[42,85],"rarely":[44],"considered":[45],"previous":[47],"works.":[48],"The":[49],"populations":[50],"involved":[51],"are":[52,119],"cells,":[54],"CD8":[55],"<sup":[56],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[57],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">+</sup>":[58],"-cells,":[59],"natural":[60],"killer-cells":[61],"(NK-cells),":[62],"dendritic":[63],"cells":[64],"(DCs)":[65],"cytokine":[67],"interleukin-12":[68],"(IL-12).":[69],"Based":[70],"on":[71],"constructed":[73],"model,":[75],"we":[76],"discuss":[77],"location":[79],"stability":[81],"properties":[82],"equilibria,":[84],"will":[86],"be":[87],"helpful":[88],"to":[89,121,128],"get":[90],"broad":[92],"understanding":[93],"specific":[96,117],"guide":[100],"development":[102],"therapies.":[104],"In":[105],"end,":[107],"numerical":[108],"simulations":[109],"with":[113],"chemotherapy":[114],"using":[116],"parameters":[118],"presented":[120],"illustrate":[122],"that":[123],"proper":[124],"therapy":[125],"able":[127],"eliminate":[129],"entire":[131],"tumor.":[132]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}