{"id":"https://openalex.org/W1980137883","doi":"https://doi.org/10.1109/acssc.2011.6190309","title":"Statistical design of position-encoded microsphere arrays at low target concentrations","display_name":"Statistical design of position-encoded microsphere arrays at low target concentrations","publication_year":2011,"publication_date":"2011-11-01","ids":{"openalex":"https://openalex.org/W1980137883","doi":"https://doi.org/10.1109/acssc.2011.6190309","mag":"1980137883"},"language":"en","primary_location":{"id":"doi:10.1109/acssc.2011.6190309","is_oa":false,"landing_page_url":"https://doi.org/10.1109/acssc.2011.6190309","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 Conference Record of the Forty Fifth Asilomar Conference on Signals, Systems and Computers (ASILOMAR)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101078118","display_name":"Xiaoxiao Xu","orcid":null},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoxiao Xu","raw_affiliation_strings":["Department of Electrical and Systems Engineering, Washington University of Saint Louis, Saint Louis, MO, USA","Department of Electrical and Systems Engineering, Washington University in St. Louis, MO, 63130 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Systems Engineering, Washington University of Saint Louis, Saint Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Electrical and Systems Engineering, Washington University in St. Louis, MO, 63130 USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044061952","display_name":"Pinaki Sarder","orcid":"https://orcid.org/0000-0003-2450-5233"},"institutions":[{"id":"https://openalex.org/I4210102181","display_name":"Mallinckrodt (United States)","ror":"https://ror.org/01akman82","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pinaki Sarder","raw_affiliation_strings":["Mallinckrodt Institute of Radiology, Washington University School of Medicine, MO, USA","Mallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, MO 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mallinckrodt Institute of Radiology, Washington University School of Medicine, MO, USA","institution_ids":["https://openalex.org/I4210102181"]},{"raw_affiliation_string":"Mallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I4210102181"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031212309","display_name":"Arye Nehorai","orcid":"https://orcid.org/0000-0002-9055-9865"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arye Nehorai","raw_affiliation_strings":["Department of Electrical and Systems Engineering, Washington University of Saint Louis, Saint Louis, MO, USA","Department of Electrical and Systems Engineering, Washington University in St. Louis, MO, 63130 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Systems Engineering, Washington University of Saint Louis, Saint Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Electrical and Systems Engineering, Washington University in St. Louis, MO, 63130 USA","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1694","last_page":"1698"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.9944000244140625,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10936","display_name":"Millimeter-Wave Propagation and Modeling","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microsphere","display_name":"Microsphere","score":0.7135565280914307},{"id":"https://openalex.org/keywords/position","display_name":"Position (finance)","score":0.6415897011756897},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6172499656677246},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.45844388008117676},{"id":"https://openalex.org/keywords/point","display_name":"Point (geometry)","score":0.43771129846572876},{"id":"https://openalex.org/keywords/key","display_name":"Key (lock)","score":0.43486297130584717},{"id":"https://openalex.org/keywords/optimal-design","display_name":"Optimal design","score":0.4294644296169281},{"id":"https://openalex.org/keywords/fluorescence","display_name":"Fluorescence","score":0.42289212346076965},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.4200962781906128},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.38065576553344727},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1912139356136322},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.1575634777545929},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.1514112949371338},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.15006858110427856}],"concepts":[{"id":"https://openalex.org/C189942447","wikidata":"https://www.wikidata.org/wiki/Q61186","display_name":"Microsphere","level":2,"score":0.7135565280914307},{"id":"https://openalex.org/C198082294","wikidata":"https://www.wikidata.org/wiki/Q3399648","display_name":"Position (finance)","level":2,"score":0.6415897011756897},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6172499656677246},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.45844388008117676},{"id":"https://openalex.org/C28719098","wikidata":"https://www.wikidata.org/wiki/Q44946","display_name":"Point (geometry)","level":2,"score":0.43771129846572876},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.43486297130584717},{"id":"https://openalex.org/C186394612","wikidata":"https://www.wikidata.org/wiki/Q7098942","display_name":"Optimal design","level":2,"score":0.4294644296169281},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.42289212346076965},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.4200962781906128},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.38065576553344727},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1912139356136322},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.1575634777545929},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1514112949371338},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.15006858110427856},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.0},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/acssc.2011.6190309","is_oa":false,"landing_page_url":"https://doi.org/10.1109/acssc.2011.6190309","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 Conference Record of the Forty Fifth Asilomar Conference on Signals, Systems and Computers (ASILOMAR)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W594546823","https://openalex.org/W1500551892","https://openalex.org/W1967053372","https://openalex.org/W1981731850","https://openalex.org/W2032756919","https://openalex.org/W2103774556","https://openalex.org/W2113889318","https://openalex.org/W2119227377","https://openalex.org/W2120886429","https://openalex.org/W2158261643","https://openalex.org/W2167439109","https://openalex.org/W2168816122"],"related_works":["https://openalex.org/W2030130858","https://openalex.org/W2382309260","https://openalex.org/W2057785520","https://openalex.org/W2369913389","https://openalex.org/W2361857728","https://openalex.org/W2319236220","https://openalex.org/W1968431014","https://openalex.org/W2060661386","https://openalex.org/W2353900815","https://openalex.org/W2149482486"],"abstract_inverted_index":{"We":[0,34,58,82],"design":[1,18,38,68,96,105],"microsphere":[2,114],"arrays":[3,115],"with":[4],"predetermined":[5],"positions":[6],"of":[7,56,88,111],"microspheres,":[8],"for":[9,52],"capturing":[10],"targets":[11],"at":[12,62],"low":[13,63],"concentrations.":[14,33],"To":[15],"optimize":[16],"the":[17,22,27,31,41,45,48,66,70,78,86,89,95,103,112],"parameters,":[19],"we":[20],"compute":[21],"Ziv-Zakai":[23],"bound":[24],"(ZZB)":[25],"on":[26,94],"errors":[28],"in":[29],"estimating":[30],"target":[32,64,118],"numerically":[35],"demonstrate":[36],"our":[37],"by":[39],"computing":[40],"minimal":[42],"distance":[43],"between":[44],"microspheres":[46],"and":[47,106,126],"optimal":[49],"imaging":[50],"temperature,":[51],"a":[53],"desired":[54],"level":[55],"errors.":[57],"also":[59],"validate":[60],"that,":[61],"concentrations,":[65],"statistical":[67],"using":[69,77],"ZZB":[71],"is":[72],"more":[73],"precise":[74],"than":[75],"that":[76],"posterior":[79],"Cram\u00e9r-Rao":[80],"bound.":[81],"further":[83],"quantitatively":[84],"evaluate":[85],"effect":[87],"fluorescence":[90],"microscope":[91],"point-spread":[92],"function":[93],"performance,":[97],"which":[98],"provide":[99],"useful":[100],"guides":[101],"to":[102],"device":[104],"implementation.":[107],"The":[108],"key":[109],"advantages":[110],"proposed":[113],"are":[116],"error-free":[117],"identification,":[119],"simplified":[120],"data":[121],"analysis,":[122],"high":[123],"packing":[124],"density,":[125],"reduced":[127],"cost.":[128]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}