{"id":"https://openalex.org/W2062296985","doi":"https://doi.org/10.1109/acssc.2011.6190167","title":"Surface-constrained 3D reconstruction in cryo-EM","display_name":"Surface-constrained 3D reconstruction in cryo-EM","publication_year":2011,"publication_date":"2011-11-01","ids":{"openalex":"https://openalex.org/W2062296985","doi":"https://doi.org/10.1109/acssc.2011.6190167","mag":"2062296985","pmid":"https://pubmed.ncbi.nlm.nih.gov/24477184"},"language":"en","primary_location":{"id":"doi:10.1109/acssc.2011.6190167","is_oa":false,"landing_page_url":"https://doi.org/10.1109/acssc.2011.6190167","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 Conference Record of the Forty Fifth Asilomar Conference on Signals, Systems and Computers (ASILOMAR)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073857000","display_name":"Andrew Barthel","orcid":null},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew C. Barthel","raw_affiliation_strings":["Department of Biomedical Engineering, Yale University, New Haven, Connecticut, 06520","Department of Biomedical Engineering, Yale University, New Haven,Connecticut 06520,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Yale University, New Haven, Connecticut, 06520","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Yale University, New Haven,Connecticut 06520,USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015914293","display_name":"Hemant D. Tagare","orcid":"https://orcid.org/0000-0001-9421-0612"},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hemant Tagare","raw_affiliation_strings":["Department of Biomedical Engineering, Department of Diagnostic Radiology, Yale University, New Haven, Connecticut, 06520","Department of Biomedical Engineering, Department of Diagnostic Radiology, Yale University, New Haven, Connecticut, 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Department of Diagnostic Radiology, Yale University, New Haven, Connecticut, 06520","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Department of Diagnostic Radiology, Yale University, New Haven, Connecticut, 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051541998","display_name":"Fred J. Sigworth","orcid":"https://orcid.org/0000-0002-7178-8494"},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fred J. Sigworth","raw_affiliation_strings":["Department of Biomedical Engineering, Department of Cellular and Molecular Physiology, Yale University, New Haven, Connecticut, 06520","Department of Biomedical Engineering, Department of Cellular and Molecular Physiology, Yale University, New Haven, Connecticut, 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Department of Cellular and Molecular Physiology, Yale University, New Haven, Connecticut, 06520","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Department of Cellular and Molecular Physiology, Yale University, New Haven, Connecticut, 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.10215054,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"73","issue":null,"first_page":"1026","last_page":"1030"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9921000003814697,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.9914000034332275,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/particle","display_name":"Particle (ecology)","score":0.6199578642845154},{"id":"https://openalex.org/keywords/surface","display_name":"Surface (topology)","score":0.5404570698738098},{"id":"https://openalex.org/keywords/projection","display_name":"Projection (relational algebra)","score":0.5366997122764587},{"id":"https://openalex.org/keywords/orientation","display_name":"Orientation (vector space)","score":0.5306115746498108},{"id":"https://openalex.org/keywords/surface-reconstruction","display_name":"Surface reconstruction","score":0.5034427046775818},{"id":"https://openalex.org/keywords/manifold","display_name":"Manifold (fluid mechanics)","score":0.48837655782699585},{"id":"https://openalex.org/keywords/3d-reconstruction","display_name":"3D reconstruction","score":0.4703284204006195},{"id":"https://openalex.org/keywords/iterative-reconstruction","display_name":"Iterative reconstruction","score":0.42521220445632935},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.4174094796180725},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.4022446870803833},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.399206280708313},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3731367290019989},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.36382102966308594},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.35430675745010376},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.28009939193725586},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1939336359500885},{"id":"https://openalex.org/keywords/geometry","display_name":"Geometry","score":0.18695372343063354},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.12188524007797241},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.12187585234642029},{"id":"https://openalex.org/keywords/combinatorics","display_name":"Combinatorics","score":0.0932898223400116}],"concepts":[{"id":"https://openalex.org/C2778517922","wikidata":"https://www.wikidata.org/wiki/Q7140482","display_name":"Particle (ecology)","level":2,"score":0.6199578642845154},{"id":"https://openalex.org/C2776799497","wikidata":"https://www.wikidata.org/wiki/Q484298","display_name":"Surface (topology)","level":2,"score":0.5404570698738098},{"id":"https://openalex.org/C57493831","wikidata":"https://www.wikidata.org/wiki/Q3134666","display_name":"Projection (relational algebra)","level":2,"score":0.5366997122764587},{"id":"https://openalex.org/C16345878","wikidata":"https://www.wikidata.org/wiki/Q107472979","display_name":"Orientation (vector space)","level":2,"score":0.5306115746498108},{"id":"https://openalex.org/C20885615","wikidata":"https://www.wikidata.org/wiki/Q825595","display_name":"Surface reconstruction","level":3,"score":0.5034427046775818},{"id":"https://openalex.org/C529865628","wikidata":"https://www.wikidata.org/wiki/Q1790740","display_name":"Manifold (fluid mechanics)","level":2,"score":0.48837655782699585},{"id":"https://openalex.org/C109950114","wikidata":"https://www.wikidata.org/wiki/Q4464732","display_name":"3D reconstruction","level":2,"score":0.4703284204006195},{"id":"https://openalex.org/C141379421","wikidata":"https://www.wikidata.org/wiki/Q6094427","display_name":"Iterative reconstruction","level":2,"score":0.42521220445632935},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.4174094796180725},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.4022446870803833},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.399206280708313},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3731367290019989},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.36382102966308594},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.35430675745010376},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.28009939193725586},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1939336359500885},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.18695372343063354},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12188524007797241},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.12187585234642029},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0932898223400116},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/acssc.2011.6190167","is_oa":false,"landing_page_url":"https://doi.org/10.1109/acssc.2011.6190167","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 Conference Record of the Forty Fifth Asilomar Conference on Signals, Systems and Computers (ASILOMAR)","raw_type":"proceedings-article"},{"id":"pmid:24477184","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24477184","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Conference record. Asilomar Conference on Signals, Systems & Computers","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2887323","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3903049","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G324496362","display_name":null,"funder_award_id":"R01 LM010142","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G414697780","display_name":null,"funder_award_id":"R01 NS021501","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W36187607","https://openalex.org/W636061944","https://openalex.org/W1492556495","https://openalex.org/W1967135938","https://openalex.org/W2005240547","https://openalex.org/W2017508876","https://openalex.org/W2024120282","https://openalex.org/W2058716938","https://openalex.org/W2091240944","https://openalex.org/W2118940870","https://openalex.org/W2125379827","https://openalex.org/W2152562710","https://openalex.org/W6601468767"],"related_works":["https://openalex.org/W2004988775","https://openalex.org/W4386533624","https://openalex.org/W2138227936","https://openalex.org/W2368534456","https://openalex.org/W4205750591","https://openalex.org/W2374267922","https://openalex.org/W2361733956","https://openalex.org/W2366389387","https://openalex.org/W2369612397","https://openalex.org/W2462010885"],"abstract_inverted_index":{"Random":[0],"spherically-constrained":[1],"(RSC)":[2],"reconstruction":[3,11],"is":[4],"a":[5,26,39,104],"new":[6],"form":[7],"of":[8,16,50,62,92,103,112],"single":[9],"particle":[10],"(SPR)":[12],"using":[13,119],"cryo-EM":[14],"images":[15,91],"membrane":[17,63],"proteins":[18,64],"embedded":[19,94],"in":[20,115],"spherical":[21,117],"lipid":[22],"vesicles":[23],"to":[24,59,83,89,99],"generate":[25],"3D":[27],"protein":[28,44],"structure.":[29],"The":[30],"method":[31],"has":[32],"many":[33],"advantages":[34],"over":[35],"conventional":[36,81],"SPR,":[37],"including":[38],"more":[40,71],"native":[41],"environment":[42],"for":[43],"particles":[45,93],"and":[46,69,87],"an":[47,77,96],"initial":[48],"estimate":[49],"the":[51,84,100,110,116],"particle's":[52],"angular":[53],"orientation.":[54],"These":[55],"advances":[56],"allow":[57],"us":[58],"determine":[60],"structures":[61],"such":[65],"as":[66],"ion":[67],"channels":[68],"derive":[70],"reliable":[72],"structure":[73],"estimates.":[74],"We":[75,108],"present":[76],"algorithm":[78,114],"that":[79],"relates":[80],"SPR":[82],"RSC":[85],"model,":[86],"generally,":[88],"projection":[90],"with":[95],"axis":[97],"parallel":[98],"local":[101],"normal":[102],"general":[105],"2D":[106],"manifold.":[107],"illustrate":[109],"performance":[111],"this":[113],"system":[118],"synthetic":[120],"data.":[121]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}