{"id":"https://openalex.org/W7163005865","doi":"https://doi.org/10.1109/access.2026.3698948","title":"Control-Integrated Pipeline for Diseasome Analysis: A Case Study on Hypertension Comorbidities in U.S. Veterans","display_name":"Control-Integrated Pipeline for Diseasome Analysis: A Case Study on Hypertension Comorbidities in U.S. Veterans","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7163005865","doi":"https://doi.org/10.1109/access.2026.3698948"},"language":"en","primary_location":{"id":"doi:10.1109/access.2026.3698948","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2026.3698948","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1109/access.2026.3698948","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048055256","display_name":"A. Magnoni","orcid":null},"institutions":[{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alice Magnoni","raw_affiliation_strings":["University of Ferrara, Ferrara, Italy"],"raw_orcid":"https://orcid.org/0009-0001-1862-5514","affiliations":[{"raw_affiliation_string":"University of Ferrara, Ferrara, Italy","institution_ids":["https://openalex.org/I201324441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137558385","display_name":"M. Toccaceli Blasi","orcid":"https://orcid.org/0000-0002-1336-0932"},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Toccaceli Blasi","raw_affiliation_strings":["Sapienza University of Roma, Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0002-1336-0932","affiliations":[{"raw_affiliation_string":"Sapienza University of Roma, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137558781","display_name":"M. Salzillo","orcid":"https://orcid.org/0000-0001-7805-5173"},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Martina Salzillo","raw_affiliation_strings":["Sapienza University of Roma, Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0001-7805-5173","affiliations":[{"raw_affiliation_string":"Sapienza University of Roma, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137592686","display_name":"D. Pedrini","orcid":null},"institutions":[{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Dario Pedrini","raw_affiliation_strings":["University of Ferrara, Ferrara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Ferrara, Ferrara, Italy","institution_ids":["https://openalex.org/I201324441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017248771","display_name":"C. Pistolesi","orcid":null},"institutions":[{"id":"https://openalex.org/I4210129405","display_name":"Ospedale Infermi di Rimini","ror":"https://ror.org/039bxh911","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210129405"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Pistolesi","raw_affiliation_strings":["Ospedale Infermi of Rimini, Rimini, Italy"],"raw_orcid":"https://orcid.org/0009-0003-8888-0320","affiliations":[{"raw_affiliation_string":"Ospedale Infermi of Rimini, Rimini, Italy","institution_ids":["https://openalex.org/I4210129405"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137562904","display_name":"G. Brombo","orcid":"https://orcid.org/0000-0003-3907-0770"},"institutions":[{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gloria Brombo","raw_affiliation_strings":["University of Ferrara, Ferrara, Italy"],"raw_orcid":"https://orcid.org/0000-0003-3907-0770","affiliations":[{"raw_affiliation_string":"University of Ferrara, Ferrara, Italy","institution_ids":["https://openalex.org/I201324441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026875786","display_name":"G. Zuliani","orcid":null},"institutions":[{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Zuliani","raw_affiliation_strings":["University of Ferrara, Ferrara, Italy"],"raw_orcid":"https://orcid.org/0000-0003-0969-3184","affiliations":[{"raw_affiliation_string":"University of Ferrara, Ferrara, Italy","institution_ids":["https://openalex.org/I201324441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135452091","display_name":"M. Canevelli","orcid":null},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Canevelli","raw_affiliation_strings":["Sapienza University of Roma, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sapienza University of Roma, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137541236","display_name":"E. Calore","orcid":"https://orcid.org/0000-0002-2301-3838"},"institutions":[{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Enrico Calore","raw_affiliation_strings":["Stockholm University, Stockholm, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-2301-3838","affiliations":[{"raw_affiliation_string":"Stockholm University, Stockholm, Sweden","institution_ids":["https://openalex.org/I161593684"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137558018","display_name":"V. Raparelli","orcid":"https://orcid.org/0000-0002-2100-5682"},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valeria Raparelli","raw_affiliation_strings":["Sapienza University of Roma, Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0002-2100-5682","affiliations":[{"raw_affiliation_string":"Sapienza University of Roma, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137600801","display_name":"S.F. Schifano","orcid":null},"institutions":[{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sebastiano Fabio Schifano","raw_affiliation_strings":["University of Ferrara, Ferrara, Italy"],"raw_orcid":"https://orcid.org/0000-0002-0132-9196","affiliations":[{"raw_affiliation_string":"University of Ferrara, Ferrara, Italy","institution_ids":["https://openalex.org/I201324441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137516284","display_name":"J. Pi\u00f1ero","orcid":"https://orcid.org/0000-0003-1244-7654"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Janet Pi\u00f1ero","raw_affiliation_strings":["MedBioinformatics Solutions, Barcelona, Spain"],"raw_orcid":"https://orcid.org/0000-0003-1244-7654","affiliations":[{"raw_affiliation_string":"MedBioinformatics Solutions, Barcelona, Spain","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5137559663","display_name":"C. Zambelli","orcid":"https://orcid.org/0000-0001-8755-0504"},"institutions":[{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cristian Zambelli","raw_affiliation_strings":["University of Ferrara, Ferrara, Italy"],"raw_orcid":"https://orcid.org/0000-0001-8755-0504","affiliations":[{"raw_affiliation_string":"University of Ferrara, Ferrara, Italy","institution_ids":["https://openalex.org/I201324441"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":13,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.84100946,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":null,"first_page":"85263","last_page":"85285"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.15279999375343323,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.15279999375343323,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14393","display_name":"Health, Environment, Cognitive Aging","score":0.051600001752376556,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12488","display_name":"Mental Health via Writing","score":0.03739999979734421,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pipeline","display_name":"Pipeline (software)","score":0.7271000146865845},{"id":"https://openalex.org/keywords/comorbidity","display_name":"Comorbidity","score":0.36719998717308044},{"id":"https://openalex.org/keywords/pipeline-transport","display_name":"Pipeline transport","score":0.35670000314712524},{"id":"https://openalex.org/keywords/medline","display_name":"MEDLINE","score":0.25220000743865967}],"concepts":[{"id":"https://openalex.org/C43521106","wikidata":"https://www.wikidata.org/wiki/Q2165493","display_name":"Pipeline (software)","level":2,"score":0.7271000146865845},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5753999948501587},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.41440001130104065},{"id":"https://openalex.org/C545542383","wikidata":"https://www.wikidata.org/wiki/Q2751242","display_name":"Medical emergency","level":1,"score":0.41130000352859497},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.40220001339912415},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3763999938964844},{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.36719998717308044},{"id":"https://openalex.org/C175309249","wikidata":"https://www.wikidata.org/wiki/Q725864","display_name":"Pipeline transport","level":2,"score":0.35670000314712524},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.25220000743865967},{"id":"https://openalex.org/C175079658","wikidata":"https://www.wikidata.org/wiki/Q7312165","display_name":"Remote patient monitoring","level":2,"score":0.24650000035762787}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/access.2026.3698948","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2026.3698948","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:a27c4128cbc5435faa41dff73f610c1f","is_oa":true,"landing_page_url":"https://doaj.org/article/a27c4128cbc5435faa41dff73f610c1f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Access, Vol 14, Pp 85263-85285 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1109/access.2026.3698948","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2026.3698948","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Diseasomes":[0],"have":[1,22],"emerged":[2],"as":[3,149,197],"valuable":[4],"tools":[5],"for":[6,28,82,278,294],"analyzing":[7],"and":[8,38,48,56,76,163,201,235,255,291],"understanding":[9],"the":[10,34,42,50,72,113,128,158,174,204,210],"complex":[11],"comorbidities":[12],"correlations":[13],"that":[14,65,283],"characterize":[15],"chronic":[16,299],"clinical":[17,286],"conditions.":[18],"To":[19,52],"date,":[20],"they":[21],"typically":[23],"been":[24],"studied":[25],"without":[26],"accounting":[27],"distinctions":[29],"between":[30],"associations":[31,170,194],"specific":[32,199],"to":[33,168,178,200],"disease":[35,146,300],"of":[36,116,122,249],"interest":[37],"those":[39],"occurring":[40],"in":[41,173,203,265,298],"general":[43],"population,":[44],"which":[45],"significantly":[46],"weakens":[47],"limits":[49],"results.":[51],"address":[53],"this":[54],"issue":[55],"improve":[57],"methodological":[58],"robustness,":[59],"we":[60],"developed":[61],"a":[62,67,78,104,164,266,273],"novel":[63],"pipeline":[64,271],"integrates":[66],"Control":[68],"group":[69,176],"directly":[70],"into":[71],"Diseasome":[73],"analysis,":[74],"designing":[75],"implementing":[77],"straightforward":[79],"multi-step":[80],"approach":[81],"processing":[83],"patient-level":[84],"health-related":[85],"big":[86],"data,":[87],"gathered":[88],"from":[89,112,259],"either":[90],"large":[91],"cohort":[92,111,206],"studies":[93],"or":[94],"Electronic":[95],"Health":[96],"Records":[97],"(EHRs).":[98],"The":[99,140,269],"methodology":[100],"was":[101],"validated":[102],"on":[103,185],"de-identified,":[105],"publicly":[106],"available":[107],"ICD-9":[108],"code\u2013based":[109],"EHR":[110],"U.S.":[114,123],"Department":[115],"Veterans":[117],"Affairs":[118],"(VA),":[119],"predominantly":[120],"composed":[121],"veterans":[124],"receiving":[125],"care":[126],"within":[127],"VA":[129],"healthcare":[130],"system":[131],"(n=":[132],"925,639;":[133],"mean":[134],"age":[135],"64.3\u00b113.2":[136],"years;nHTN=":[137],"595,782,nControl=":[138],"329,857).":[139],"primary":[141],"outcome":[142],"measure":[143],"is":[144],"pairwise":[145],"co-occurrence":[147],"quantified":[148],"Relative":[150],"Risk":[151],"(RR)":[152],"with":[153,252],"95%confidence":[154],"intervals,":[155],"complemented":[156],"by":[157],"Matthews":[159],"Correlation":[160],"Coefficient":[161],"(\u03c6)":[162],"Label":[165],"Permutation":[166],"Test":[167],"identify":[169],"statistically":[171,198,275],"enriched":[172],"HTN":[175,205],"relative":[177],"Controls;":[179],"all":[180,248],"significance":[181],"decisions":[182],"are":[183],"based":[184],"Benjamini\u2013Hochberg":[186],"FDR-corrected":[187],"p-values":[188],"(\u03b1":[189],"=":[190,220,230,243],"0.05).":[191],"Eight":[192],"disease-disease":[193],"were":[195],"identified":[196],"stronger":[202],"(all":[207],"FDR-correctedp<":[208],"0.05),":[209],"strongest":[211],"being":[212],"Drug":[213],"Abuse":[214,241],"\u2013":[215,227,239],"Chronic":[216,236],"Liver":[217,237],"Disease":[218,238],"(RR":[219,229,242],"3.81,":[221],"95%":[222,232,245],"CI:":[223,233,246],"3.75\u20133.88),":[224],"Bipolar":[225],"Disorder":[226],"Psychosis":[228],"3.69,":[231],"3.59\u20133.80),":[234],"Alcohol":[240],"3.32,":[244],"3.27\u20133.38);":[247],"them":[250],"consistent":[251],"shared":[253],"molecular":[254],"genetic":[256],"evidence":[257],"extracted":[258],"DISGENET":[260],"databases,":[261],"providing":[262],"complementary":[263],"context":[264],"hypothesis-generating":[267],"framework.":[268],"proposed":[270],"provides":[272],"generalizable,":[274],"grounded":[276],"framework":[277],"building":[279],"disease-specific":[280],"comorbidity":[281,289],"networks":[282],"can":[284],"support":[285],"risk":[287],"stratification,":[288],"screening,":[290],"hypothesis":[292],"generation":[293],"targeted":[295],"preventive":[296],"interventions":[297],"management.":[301]},"counts_by_year":[],"updated_date":"2026-06-14T07:44:22.658603","created_date":"2026-06-02T00:00:00"}
