{"id":"https://openalex.org/W7133361458","doi":"https://doi.org/10.1109/access.2026.3670097","title":"Electronic Emulation of Neurodegenerative Disease Progression on a CMOS-Based Physical Model of Human Connectome","display_name":"Electronic Emulation of Neurodegenerative Disease Progression on a CMOS-Based Physical Model of Human Connectome","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7133361458","doi":"https://doi.org/10.1109/access.2026.3670097"},"language":"en","primary_location":{"id":"doi:10.1109/access.2026.3670097","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2026.3670097","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1109/access.2026.3670097","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010117665","display_name":"Paul Didier Kamdem Kuate","orcid":"https://orcid.org/0000-0002-9485-4044"},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Paul Didier Kamdem Kuate","raw_affiliation_strings":["School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China"],"raw_orcid":"https://orcid.org/0000-0002-9485-4044","affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021241465","display_name":"Joakim Vianney Ngamsa Tegnitsap","orcid":"https://orcid.org/0000-0002-3130-5881"},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Joakim Vianney Ngamsa Tegnitsap","raw_affiliation_strings":["School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China"],"raw_orcid":"https://orcid.org/0000-0002-3130-5881","affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038624844","display_name":"Zeric Tabekoueng Njitacke","orcid":"https://orcid.org/0000-0001-7797-8929"},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zeric Tabekoueng Njitacke","raw_affiliation_strings":["School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China"],"raw_orcid":"https://orcid.org/0000-0001-7797-8929","affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Manyu Zhao","orcid":"https://orcid.org/0009-0008-4096-8522"},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Manyu Zhao","raw_affiliation_strings":["School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China"],"raw_orcid":"https://orcid.org/0009-0008-4096-8522","affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073864992","display_name":"Th\u00e9ophile Fonzin Fozin","orcid":"https://orcid.org/0000-0001-7385-5462"},"institutions":[{"id":"https://openalex.org/I144693123","display_name":"University of Buea","ror":"https://ror.org/041kdhz15","country_code":"CM","type":"education","lineage":["https://openalex.org/I144693123"]}],"countries":["CM"],"is_corresponding":false,"raw_author_name":"Theophile Fonzin Fozin","raw_affiliation_strings":["Department of Electrical and Electronic Engineering, Faculty of Engineering and Technology, University of Buea, Buea, Cameroon"],"raw_orcid":"https://orcid.org/0000-0001-7385-5462","affiliations":[{"raw_affiliation_string":"Department of Electrical and Electronic Engineering, Faculty of Engineering and Technology, University of Buea, Buea, Cameroon","institution_ids":["https://openalex.org/I144693123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5127978151","display_name":"Pedro A. Valdes-Sosa","orcid":null},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pedro A. Valdes-Sosa","raw_affiliation_strings":["School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China"],"raw_orcid":"https://orcid.org/0000-0001-5485-2661","affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079428934","display_name":"Hiroyuki Ito","orcid":"https://orcid.org/0000-0002-5687-0019"},"institutions":[{"id":"https://openalex.org/I4210112104","display_name":"Innovative Research (United States)","ror":"https://ror.org/01zxe4w25","country_code":"US","type":"company","lineage":["https://openalex.org/I4210112104"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hiroyuki Ito","raw_affiliation_strings":["Nano Sensing Research Unit, Institute of Innovative Research, Institute of Science Tokyo, Yokohama, Japan"],"raw_orcid":"https://orcid.org/0000-0002-5687-0019","affiliations":[{"raw_affiliation_string":"Nano Sensing Research Unit, Institute of Innovative Research, Institute of Science Tokyo, Yokohama, Japan","institution_ids":["https://openalex.org/I4210112104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045809433","display_name":"Mattia Frasca","orcid":"https://orcid.org/0000-0002-4361-0576"},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mattia Frasca","raw_affiliation_strings":["Department of Electrical Electronic and Computer Engineering, University of Catania, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Electronic and Computer Engineering, University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124371587","display_name":"Federico D\u2019Agata","orcid":null},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Federico D\u2019Agata","raw_affiliation_strings":["Department of Neurosciences “Rita Levi Montalcini”, University of Turin, Turin, Italy"],"raw_orcid":"https://orcid.org/0000-0001-9432-0248","affiliations":[{"raw_affiliation_string":"Department of Neurosciences “Rita Levi Montalcini”, University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5127949675","display_name":"Ludovico Minati","orcid":null},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ludovico Minati","raw_affiliation_strings":["School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China"],"raw_orcid":"https://orcid.org/0000-0002-2532-1674","affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China","institution_ids":["https://openalex.org/I150229711"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":10,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.28908736,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":null,"first_page":"39232","last_page":"39260"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.5878999829292297,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.5878999829292297,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.12120000272989273,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.04089999943971634,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/emulation","display_name":"Emulation","score":0.6355000138282776},{"id":"https://openalex.org/keywords/connectome","display_name":"Connectome","score":0.5479000210762024},{"id":"https://openalex.org/keywords/neuromodulation","display_name":"Neuromodulation","score":0.5008999705314636},{"id":"https://openalex.org/keywords/tauopathy","display_name":"Tauopathy","score":0.45260000228881836},{"id":"https://openalex.org/keywords/neuromorphic-engineering","display_name":"Neuromorphic engineering","score":0.4124000072479248},{"id":"https://openalex.org/keywords/synchronization","display_name":"Synchronization (alternating current)","score":0.40389999747276306},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.3903999924659729},{"id":"https://openalex.org/keywords/parkinsons-disease","display_name":"Parkinson's disease","score":0.3808000087738037},{"id":"https://openalex.org/keywords/flexibility","display_name":"Flexibility (engineering)","score":0.3515999913215637}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6924999952316284},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6881999969482422},{"id":"https://openalex.org/C149810388","wikidata":"https://www.wikidata.org/wiki/Q5374873","display_name":"Emulation","level":2,"score":0.6355000138282776},{"id":"https://openalex.org/C45715564","wikidata":"https://www.wikidata.org/wiki/Q1292103","display_name":"Connectome","level":3,"score":0.5479000210762024},{"id":"https://openalex.org/C2780375056","wikidata":"https://www.wikidata.org/wiki/Q905905","display_name":"Neuromodulation","level":3,"score":0.5008999705314636},{"id":"https://openalex.org/C2777739294","wikidata":"https://www.wikidata.org/wiki/Q2397106","display_name":"Tauopathy","level":4,"score":0.45260000228881836},{"id":"https://openalex.org/C151927369","wikidata":"https://www.wikidata.org/wiki/Q1981312","display_name":"Neuromorphic engineering","level":3,"score":0.4124000072479248},{"id":"https://openalex.org/C2778562939","wikidata":"https://www.wikidata.org/wiki/Q1298791","display_name":"Synchronization (alternating current)","level":3,"score":0.40389999747276306},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3903999924659729},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.3808000087738037},{"id":"https://openalex.org/C2780598303","wikidata":"https://www.wikidata.org/wiki/Q65921492","display_name":"Flexibility (engineering)","level":2,"score":0.3515999913215637},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.34529998898506165},{"id":"https://openalex.org/C2779484449","wikidata":"https://www.wikidata.org/wiki/Q412189","display_name":"Memantine","level":4,"score":0.3407000005245209},{"id":"https://openalex.org/C152478114","wikidata":"https://www.wikidata.org/wiki/Q660910","display_name":"Neurophysiology","level":2,"score":0.32409998774528503},{"id":"https://openalex.org/C2779478453","wikidata":"https://www.wikidata.org/wiki/Q6889748","display_name":"Modularity (biology)","level":2,"score":0.3052999973297119},{"id":"https://openalex.org/C2778641062","wikidata":"https://www.wikidata.org/wiki/Q18592","display_name":"Frontotemporal dementia","level":4,"score":0.30149999260902405},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.3003000020980835},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.2849000096321106},{"id":"https://openalex.org/C2780647506","wikidata":"https://www.wikidata.org/wiki/Q190564","display_name":"Huntington's disease","level":3,"score":0.2734000086784363},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.27140000462532043},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.27090001106262207},{"id":"https://openalex.org/C2778542668","wikidata":"https://www.wikidata.org/wiki/Q618076","display_name":"Deep brain stimulation","level":4,"score":0.2689000070095062},{"id":"https://openalex.org/C123757187","wikidata":"https://www.wikidata.org/wiki/Q9195957","display_name":"Network dynamics","level":2,"score":0.25600001215934753},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.2556999921798706}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/access.2026.3670097","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2026.3670097","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:ad75fe560fb8417a8a6f07886d1f4bf5","is_oa":true,"landing_page_url":"https://doaj.org/article/ad75fe560fb8417a8a6f07886d1f4bf5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Access, Vol 14, Pp 39232-39260 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1109/access.2026.3670097","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2026.3670097","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4305432438850403}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"The":[0,177],"present":[1],"study":[2],"depicts":[3],"a":[4,14,41,104,118,135,162,185,209,226],"newframework":[5],"for":[6,197,215,251],"the":[7,21,69,148,154,174,242],"emulation":[8],"of":[9,20,72,79,107,137,150,167,244],"neurodegenerative":[10,189],"disease":[11,48,63,190,205],"built":[12],"on":[13,37,46],"Complementary":[15],"Metal-Oxide-Semiconductor":[16],"(CMOS)":[17],"device-level":[18],"model":[19],"human":[22,199],"connectome,":[23],"in":[24,85,88,96,120,131,147,181],"which":[25],"nodal":[26],"dynamics":[27,54],"is":[28,111,184,225],"implemented":[29],"using":[30],"analog":[31],"chaotic":[32],"oscillators.":[33],"SPICE":[34],"simulations":[35],"performed":[36],"this":[38,182],"platform,":[39],"following":[40],"multimodal":[42],"lesioning":[43],"protocol":[44],"based":[45],"established":[47],"trajectories,":[49],"allow":[50],"to":[51,158,188,240],"replicate":[52],"disease-specific":[53],"and":[55,64,83,90,99,123,142,164,169,192,211,220,236],"identify":[56],"functional":[57,140,171],"connectivity":[58,74,172],"biomarkers":[59,219],"correlated":[60],"with":[61,233],"Alzheimer\u2019s":[62],"Frontotemporal":[65],"dementia":[66],"staging.":[67],"Specifically,":[68],"progressive":[70],"alteration":[71],"network":[73],"mimics":[75],"anatomical":[76],"degeneration,":[77],"characteristic":[78],"these":[80],"neurological":[81],"conditions,":[82],"results":[84],"measurable":[86],"changes":[87],"synchronization":[89,156],"dynamics.":[91],"These":[92],"include":[93],"gradual":[94,165],"decrease":[95,119],"phase":[97],"coherence":[98],"dynamical":[100],"complexity,":[101],"accompanied":[102],"by":[103,114],"global":[105,124],"slowing":[106],"oscillatory":[108],"modes.":[109],"This":[110,133],"further":[112],"substantiated":[113],"graph-theoretical":[115],"analyses,":[116],"showing":[117],"clustering":[121],"coefficient":[122],"efficiency,":[125],"as":[126,128],"well":[127],"an":[129,194,203],"increase":[130],"modularity.":[132],"reflects":[134],"loss":[136,166],"balance":[138],"between":[139],"segregation":[141],"integration,":[143],"highlighting":[144],"impaired":[145],"resilience":[146],"event":[149],"structural":[151],"compromise.":[152],"Transposing":[153],"obtained":[155],"patterns":[157],"resting-state":[159],"networks":[160],"reveals":[161],"selective":[163],"intra-":[168],"inter-network":[170],"across":[173],"disruption":[175],"stages.":[176],"hardware-oriented":[178],"method":[179],"used":[180],"work":[183],"unique":[186],"approach":[187],"simulation":[191],"represents":[193],"effective":[195],"framework":[196],"investigating":[198],"connectome":[200],"vulnerabilities.":[201],"As":[202],"in-silico":[204],"model,":[206],"it":[207,224],"provides":[208],"viable":[210],"reproducible":[212],"environment":[213],"suitable":[214],"evaluating":[216],"future":[217],"diagnostic":[218],"therapeutic":[221],"interventions.":[222],"Moreover,":[223],"neuromorphic":[227],"system":[228],"that":[229],"can":[230],"be":[231],"integrated":[232],"neuroprosthetic":[234],"devices":[235],"closed-loop":[237],"brain\u2013computer":[238],"interfaces":[239],"support":[241],"development":[243],"implantable":[245],"diagnostics":[246],"or":[247],"adaptive":[248],"neuromodulation":[249],"systems":[250],"patient-specific":[252],"treatment.":[253]},"counts_by_year":[],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2026-03-04T00:00:00"}