{"id":"https://openalex.org/W7114795407","doi":"https://doi.org/10.1109/access.2025.3643311","title":"Early Detection of Parkinson\u2019s Disease Through a Combination of Facial Expression and Hand Movements and Asymmetry-Related Features Using Machine Learning","display_name":"Early Detection of Parkinson\u2019s Disease Through a Combination of Facial Expression and Hand Movements and Asymmetry-Related Features Using Machine Learning","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W7114795407","doi":"https://doi.org/10.1109/access.2025.3643311"},"language":"en","primary_location":{"id":"doi:10.1109/access.2025.3643311","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2025.3643311","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1109/access.2025.3643311","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Anastasiia A. Moshkova","orcid":"https://orcid.org/0009-0000-9698-8655"},"institutions":[{"id":"https://openalex.org/I177537411","display_name":"Bauman Moscow State Technical University","ror":"https://ror.org/00pb8h375","country_code":"RU","type":"education","lineage":["https://openalex.org/I177537411"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Anastasiia A. Moshkova","raw_affiliation_strings":["Biomedical Technique Department, Bauman Moscow State Technical University (BMSTU), Moscow, Russia"],"raw_orcid":"https://orcid.org/0009-0000-9698-8655","affiliations":[{"raw_affiliation_string":"Biomedical Technique Department, Bauman Moscow State Technical University (BMSTU), Moscow, Russia","institution_ids":["https://openalex.org/I177537411"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Margarita V. Ershova","orcid":null},"institutions":[{"id":"https://openalex.org/I4210123128","display_name":"Center for Neurosciences","ror":"https://ror.org/03b5vk392","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210123128"]},{"id":"https://openalex.org/I4210159010","display_name":"Research Center of Neurology","ror":"https://ror.org/05b74sw86","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210159010"]}],"countries":["RU","US"],"is_corresponding":false,"raw_author_name":"Margarita V. Ershova","raw_affiliation_strings":["Russian Center of Neurology and Neurosciences, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Russian Center of Neurology and Neurosciences, Moscow, Russia","institution_ids":["https://openalex.org/I4210123128","https://openalex.org/I4210159010"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ekaterina O. Ivanova","orcid":null},"institutions":[{"id":"https://openalex.org/I4210123128","display_name":"Center for Neurosciences","ror":"https://ror.org/03b5vk392","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210123128"]},{"id":"https://openalex.org/I4210159010","display_name":"Research Center of Neurology","ror":"https://ror.org/05b74sw86","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210159010"]}],"countries":["RU","US"],"is_corresponding":false,"raw_author_name":"Ekaterina O. Ivanova","raw_affiliation_strings":["Russian Center of Neurology and Neurosciences, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Russian Center of Neurology and Neurosciences, Moscow, Russia","institution_ids":["https://openalex.org/I4210123128","https://openalex.org/I4210159010"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ekaterina Yu. Fedotova","orcid":null},"institutions":[{"id":"https://openalex.org/I4210123128","display_name":"Center for Neurosciences","ror":"https://ror.org/03b5vk392","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210123128"]},{"id":"https://openalex.org/I4210159010","display_name":"Research Center of Neurology","ror":"https://ror.org/05b74sw86","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210159010"]}],"countries":["RU","US"],"is_corresponding":false,"raw_author_name":"Ekaterina Yu. Fedotova","raw_affiliation_strings":["Russian Center of Neurology and Neurosciences, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Russian Center of Neurology and Neurosciences, Moscow, Russia","institution_ids":["https://openalex.org/I4210123128","https://openalex.org/I4210159010"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Natalia A. Voinova","orcid":null},"institutions":[{"id":"https://openalex.org/I4210087337","display_name":"Moscow Clinical Scientific Center","ror":"https://ror.org/000wnz761","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210087337"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Natalia A. Voinova","raw_affiliation_strings":["Scientific and Educational Medical and Technology Center, BMSTU, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scientific and Educational Medical and Technology Center, BMSTU, Moscow, Russia","institution_ids":["https://openalex.org/I4210087337"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Alexander K. Volkov","orcid":null},"institutions":[{"id":"https://openalex.org/I4210087337","display_name":"Moscow Clinical Scientific Center","ror":"https://ror.org/000wnz761","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210087337"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alexander K. Volkov","raw_affiliation_strings":["Scientific and Educational Medical and Technology Center, BMSTU, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scientific and Educational Medical and Technology Center, BMSTU, Moscow, Russia","institution_ids":["https://openalex.org/I4210087337"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Maxim I. Polguev","orcid":null},"institutions":[{"id":"https://openalex.org/I177537411","display_name":"Bauman Moscow State Technical University","ror":"https://ror.org/00pb8h375","country_code":"RU","type":"education","lineage":["https://openalex.org/I177537411"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Maxim I. Polguev","raw_affiliation_strings":["Biomedical Technique Department, Bauman Moscow State Technical University (BMSTU), Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Technique Department, Bauman Moscow State Technical University (BMSTU), Moscow, Russia","institution_ids":["https://openalex.org/I177537411"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Diana D. Kubinskaya","orcid":null},"institutions":[{"id":"https://openalex.org/I177537411","display_name":"Bauman Moscow State Technical University","ror":"https://ror.org/00pb8h375","country_code":"RU","type":"education","lineage":["https://openalex.org/I177537411"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Diana D. Kubinskaya","raw_affiliation_strings":["Biomedical Technique Department, Bauman Moscow State Technical University (BMSTU), Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Technique Department, Bauman Moscow State Technical University (BMSTU), Moscow, Russia","institution_ids":["https://openalex.org/I177537411"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Stanislav O. Yurchenko","orcid":"https://orcid.org/0000-0001-6821-904X"},"institutions":[{"id":"https://openalex.org/I177537411","display_name":"Bauman Moscow State Technical University","ror":"https://ror.org/00pb8h375","country_code":"RU","type":"education","lineage":["https://openalex.org/I177537411"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Stanislav O. Yurchenko","raw_affiliation_strings":["Biomedical Technique Department, Bauman Moscow State Technical University (BMSTU), Moscow, Russia"],"raw_orcid":"https://orcid.org/0000-0001-6821-904X","affiliations":[{"raw_affiliation_string":"Biomedical Technique Department, Bauman Moscow State Technical University (BMSTU), Moscow, Russia","institution_ids":["https://openalex.org/I177537411"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sergey N. Illarioshkin","orcid":null},"institutions":[{"id":"https://openalex.org/I4210123128","display_name":"Center for Neurosciences","ror":"https://ror.org/03b5vk392","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210123128"]},{"id":"https://openalex.org/I4210159010","display_name":"Research Center of Neurology","ror":"https://ror.org/05b74sw86","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210159010"]}],"countries":["RU","US"],"is_corresponding":false,"raw_author_name":"Sergey N. Illarioshkin","raw_affiliation_strings":["Russian Center of Neurology and Neurosciences, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Russian Center of Neurology and Neurosciences, Moscow, Russia","institution_ids":["https://openalex.org/I4210123128","https://openalex.org/I4210159010"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Andrey V. Samorodov","orcid":null},"institutions":[{"id":"https://openalex.org/I177537411","display_name":"Bauman Moscow State Technical University","ror":"https://ror.org/00pb8h375","country_code":"RU","type":"education","lineage":["https://openalex.org/I177537411"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Andrey V. Samorodov","raw_affiliation_strings":["Biomedical Technique Department, Bauman Moscow State Technical University (BMSTU), Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Technique Department, Bauman Moscow State Technical University (BMSTU), Moscow, Russia","institution_ids":["https://openalex.org/I177537411"]}]},{"author_position":"last","author":{"id":null,"display_name":"Mikhael A. Piradov","orcid":null},"institutions":[{"id":"https://openalex.org/I4210123128","display_name":"Center for Neurosciences","ror":"https://ror.org/03b5vk392","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210123128"]},{"id":"https://openalex.org/I4210159010","display_name":"Research Center of Neurology","ror":"https://ror.org/05b74sw86","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210159010"]}],"countries":["RU","US"],"is_corresponding":false,"raw_author_name":"Mikhael A. Piradov","raw_affiliation_strings":["Russian Center of Neurology and Neurosciences, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Russian Center of Neurology and Neurosciences, Moscow, Russia","institution_ids":["https://openalex.org/I4210123128","https://openalex.org/I4210159010"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":0.7441,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.77733538,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"13","issue":null,"first_page":"210607","last_page":"210623"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.7257000207901001,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.7257000207901001,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10863","display_name":"Voice and Speech Disorders","score":0.20260000228881836,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.014499999582767487,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/facial-expression","display_name":"Facial expression","score":0.6550999879837036},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.5496000051498413},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.4948999881744385},{"id":"https://openalex.org/keywords/kinematics","display_name":"Kinematics","score":0.4645000100135803},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.4377000033855438},{"id":"https://openalex.org/keywords/feature-extraction","display_name":"Feature extraction","score":0.43470001220703125},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.4092000126838684}],"concepts":[{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6937000155448914},{"id":"https://openalex.org/C195704467","wikidata":"https://www.wikidata.org/wiki/Q327968","display_name":"Facial expression","level":2,"score":0.6550999879837036},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5831999778747559},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.5496000051498413},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5135999917984009},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4948999881744385},{"id":"https://openalex.org/C39920418","wikidata":"https://www.wikidata.org/wiki/Q11476","display_name":"Kinematics","level":2,"score":0.4645000100135803},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.4377000033855438},{"id":"https://openalex.org/C52622490","wikidata":"https://www.wikidata.org/wiki/Q1026626","display_name":"Feature extraction","level":2,"score":0.43470001220703125},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4092000126838684},{"id":"https://openalex.org/C2779106727","wikidata":"https://www.wikidata.org/wiki/Q22907079","display_name":"Movement assessment","level":3,"score":0.38589999079704285},{"id":"https://openalex.org/C58489278","wikidata":"https://www.wikidata.org/wiki/Q1172284","display_name":"Data set","level":2,"score":0.3752000033855438},{"id":"https://openalex.org/C110083411","wikidata":"https://www.wikidata.org/wiki/Q1744628","display_name":"Statistical classification","level":2,"score":0.3747999966144562},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.3472999930381775},{"id":"https://openalex.org/C2987714656","wikidata":"https://www.wikidata.org/wiki/Q1185804","display_name":"Facial expression recognition","level":4,"score":0.335099995136261},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.3093000054359436},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.3068000078201294},{"id":"https://openalex.org/C28490314","wikidata":"https://www.wikidata.org/wiki/Q189436","display_name":"Speech recognition","level":1,"score":0.3059999942779541},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.2955999970436096}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/access.2025.3643311","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2025.3643311","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:38aa6298ddb34c1ebc0394db1962769a","is_oa":true,"landing_page_url":"https://doaj.org/article/38aa6298ddb34c1ebc0394db1962769a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Access, Vol 13, Pp 210607-210623 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1109/access.2025.3643311","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2025.3643311","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.40753689408302307,"display_name":"Quality Education","id":"https://metadata.un.org/sdg/4"}],"awards":[{"id":"https://openalex.org/G944786427","display_name":null,"funder_award_id":"075\u201015\u20102024\u2010638","funder_id":"https://openalex.org/F4320327494","funder_display_name":"Ministry of Science and Higher Education of the Russian Federation"}],"funders":[{"id":"https://openalex.org/F4320327494","display_name":"Ministry of Science and Higher Education of the Russian Federation","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Parkinson\u2019s":[0],"disease":[1,56],"(PD)":[2],"ranks":[3],"among":[4],"the":[5],"most":[6],"prevalent":[7],"neurodegenerative":[8],"disorders":[9],"worldwide.":[10],"Despite":[11],"substantial":[12],"research":[13],"focused":[14],"on":[15],"identifying":[16],"early":[17,52,116,129,140],"motor":[18],"symptoms":[19],"in":[20,79],"PD,":[21],"accurate":[22],"detection":[23,54],"remains":[24],"challenging.":[25],"This":[26],"study":[27],"introduces":[28],"a":[29,87],"novel":[30],"multimodal":[31],"framework":[32,108],"that":[33,86],"integrates":[34],"facial":[35,92],"expression":[36],"analysis":[37],"with":[38],"hand":[39,48,94],"movement":[40,49],"kinematics":[41],"and":[42,55,70,74,96,124,130],"uniquely":[43],"incorporates":[44],"quantitative":[45],"assessment":[46],"of":[47,113],"asymmetry":[50],"for":[51,115,120,126],"PD":[53,66,117,122,132,141],"staging.":[57],"We":[58],"utilized":[59],"data":[60],"from":[61],"109":[62],"participants,":[63],"including":[64],"93":[65],"patients":[67],"across":[68,103],"Hoehn":[69],"Yahr":[71],"stages":[72],"1-3":[73],"16":[75],"healthy":[76],"controls,":[77],"resulting":[78],"549":[80],"total":[81],"recordings.":[82],"Our":[83],"findings":[84],"demonstrate":[85],"combined":[88],"feature":[89],"set":[90],"incorporating":[91],"expressions,":[93],"movements,":[95],"asymmetry-related":[97],"features":[98],"consistently":[99],"outperforms":[100],"unimodal":[101],"approaches":[102],"all":[104],"classification":[105,136],"tasks.":[106],"The":[107],"achieved":[109],"balanced":[110,147],"accuracy":[111],"scores":[112],"90.1%":[114],"detection,":[118,123],"92.2%":[119],"general":[121],"66.4%":[125],"distinguishing":[127],"between":[128],"moderate":[131,143],"stages.":[133],"Additionally,":[134],"three-class":[135],"(healthy":[137],"controls":[138],"vs.":[139,142],"PD)":[144],"attained":[145],"74.0%":[146],"accuracy.":[148],"All":[149],"results":[150],"were":[151],"validated":[152],"using":[153],"three-fold":[154],"nested":[155],"cross-validation.":[156]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2025-12-11T00:00:00"}