{"id":"https://openalex.org/W4416366557","doi":"https://doi.org/10.1109/access.2025.3634757","title":"A Hybrid Diffusion-VAE for High-Fidelity Tissue Doppler Imaging Augmentation in Cardiotoxicity Detection","display_name":"A Hybrid Diffusion-VAE for High-Fidelity Tissue Doppler Imaging Augmentation in Cardiotoxicity Detection","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4416366557","doi":"https://doi.org/10.1109/access.2025.3634757"},"language":null,"primary_location":{"id":"doi:10.1109/access.2025.3634757","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2025.3634757","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1109/access.2025.3634757","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5116867898","display_name":"Ahmed Bouatmane","orcid":"https://orcid.org/0000-0002-1732-551X"},"institutions":[{"id":"https://openalex.org/I4210164065","display_name":"Universit\u00e9 Hassan II Mohammedia","ror":"https://ror.org/058gnfy87","country_code":"MA","type":"education","lineage":["https://openalex.org/I4210164065"]},{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Ahmed Bouatmane","raw_affiliation_strings":["2IACS Laboratory, ENSET Mohammedia, Hassan II University of Casablanca, Mohammedia, Morocco","2IACS Laboratory, ENSET Mohammedia Hassan II University, Casablanca, Morocco"],"raw_orcid":"https://orcid.org/0000-0002-1732-551X","affiliations":[{"raw_affiliation_string":"2IACS Laboratory, ENSET Mohammedia, Hassan II University of Casablanca, Mohammedia, Morocco","institution_ids":["https://openalex.org/I4210164065"]},{"raw_affiliation_string":"2IACS Laboratory, ENSET Mohammedia Hassan II University, Casablanca, Morocco","institution_ids":["https://openalex.org/I4210164065","https://openalex.org/I99297268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046591901","display_name":"Abdelmajid Bousselham","orcid":"https://orcid.org/0000-0001-5458-2294"},"institutions":[{"id":"https://openalex.org/I4210164065","display_name":"Universit\u00e9 Hassan II Mohammedia","ror":"https://ror.org/058gnfy87","country_code":"MA","type":"education","lineage":["https://openalex.org/I4210164065"]},{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Abdelmajid Bousselham","raw_affiliation_strings":["2IACS Laboratory, ENSET Mohammedia, Hassan II University of Casablanca, Mohammedia, Morocco","2IACS Laboratory, ENSET Mohammedia Hassan II University, Casablanca, Morocco"],"raw_orcid":"https://orcid.org/0000-0001-5458-2294","affiliations":[{"raw_affiliation_string":"2IACS Laboratory, ENSET Mohammedia, Hassan II University of Casablanca, Mohammedia, Morocco","institution_ids":["https://openalex.org/I4210164065"]},{"raw_affiliation_string":"2IACS Laboratory, ENSET Mohammedia Hassan II University, Casablanca, Morocco","institution_ids":["https://openalex.org/I4210164065","https://openalex.org/I99297268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001386060","display_name":"Abdelaziz Daaif","orcid":"https://orcid.org/0000-0002-8380-2935"},"institutions":[{"id":"https://openalex.org/I4210164065","display_name":"Universit\u00e9 Hassan II Mohammedia","ror":"https://ror.org/058gnfy87","country_code":"MA","type":"education","lineage":["https://openalex.org/I4210164065"]},{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Abdelaziz Daaif","raw_affiliation_strings":["2IACS Laboratory, ENSET Mohammedia, Hassan II University of Casablanca, Mohammedia, Morocco","2IACS Laboratory, ENSET Mohammedia Hassan II University, Casablanca, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2IACS Laboratory, ENSET Mohammedia, Hassan II University of Casablanca, Mohammedia, Morocco","institution_ids":["https://openalex.org/I4210164065"]},{"raw_affiliation_string":"2IACS Laboratory, ENSET Mohammedia Hassan II University, Casablanca, Morocco","institution_ids":["https://openalex.org/I4210164065","https://openalex.org/I99297268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044834421","display_name":"Mohamed Youssfi","orcid":"https://orcid.org/0000-0003-2842-9880"},"institutions":[{"id":"https://openalex.org/I4210164065","display_name":"Universit\u00e9 Hassan II Mohammedia","ror":"https://ror.org/058gnfy87","country_code":"MA","type":"education","lineage":["https://openalex.org/I4210164065"]},{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Mohamed Youssfi","raw_affiliation_strings":["2IACS Laboratory, ENSET Mohammedia, Hassan II University of Casablanca, Mohammedia, Morocco","2IACS Laboratory, ENSET Mohammedia Hassan II University, Casablanca, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2IACS Laboratory, ENSET Mohammedia, Hassan II University of Casablanca, Mohammedia, Morocco","institution_ids":["https://openalex.org/I4210164065"]},{"raw_affiliation_string":"2IACS Laboratory, ENSET Mohammedia Hassan II University, Casablanca, Morocco","institution_ids":["https://openalex.org/I4210164065","https://openalex.org/I99297268"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031916963","display_name":"Omar Bouattane","orcid":"https://orcid.org/0000-0002-1207-2779"},"institutions":[{"id":"https://openalex.org/I4210121980","display_name":"\u00c9cole Normale Sup\u00e9rieure de l'Enseignement Technique de Mohammedia","ror":"https://ror.org/035pp4j25","country_code":"MA","type":"education","lineage":["https://openalex.org/I4210121980"]},{"id":"https://openalex.org/I4210164065","display_name":"Universit\u00e9 Hassan II Mohammedia","ror":"https://ror.org/058gnfy87","country_code":"MA","type":"education","lineage":["https://openalex.org/I4210164065"]},{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Omar Bouattane","raw_affiliation_strings":["EEIS Laboratory, ENSET Mohammedia, Hassan II University of Casablanca, Mohammedia, Morocco","IESI Laboratory, ENSET Mohammedia Hassan II University, Casablanca, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EEIS Laboratory, ENSET Mohammedia, Hassan II University of Casablanca, Mohammedia, Morocco","institution_ids":["https://openalex.org/I4210121980","https://openalex.org/I4210164065"]},{"raw_affiliation_string":"IESI Laboratory, ENSET Mohammedia Hassan II University, Casablanca, Morocco","institution_ids":["https://openalex.org/I4210164065","https://openalex.org/I99297268"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.43307975,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":null,"first_page":"204337","last_page":"204354"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.7095999717712402,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.7095999717712402,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.04259999841451645,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.029600000008940697,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.5217000246047974},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"Cardiotoxicity","score":0.48559999465942383},{"id":"https://openalex.org/keywords/doppler-imaging","display_name":"Doppler imaging","score":0.37549999356269836},{"id":"https://openalex.org/keywords/modality","display_name":"Modality (human\u2013computer interaction)","score":0.37549999356269836},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.37209999561309814},{"id":"https://openalex.org/keywords/representation","display_name":"Representation (politics)","score":0.34060001373291016},{"id":"https://openalex.org/keywords/scalability","display_name":"Scalability","score":0.3382999897003174}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6287000179290771},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.5217000246047974},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5033000111579895},{"id":"https://openalex.org/C2778233292","wikidata":"https://www.wikidata.org/wiki/Q2118956","display_name":"Cardiotoxicity","level":3,"score":0.48559999465942383},{"id":"https://openalex.org/C109982973","wikidata":"https://www.wikidata.org/wiki/Q5297353","display_name":"Doppler imaging","level":4,"score":0.37549999356269836},{"id":"https://openalex.org/C2780226545","wikidata":"https://www.wikidata.org/wiki/Q6888030","display_name":"Modality (human\u2013computer interaction)","level":2,"score":0.37549999356269836},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.37209999561309814},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.34060001373291016},{"id":"https://openalex.org/C48044578","wikidata":"https://www.wikidata.org/wiki/Q727490","display_name":"Scalability","level":2,"score":0.3382999897003174},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.3361000120639801},{"id":"https://openalex.org/C41608201","wikidata":"https://www.wikidata.org/wiki/Q980509","display_name":"Embedding","level":2,"score":0.3287000060081482},{"id":"https://openalex.org/C111335779","wikidata":"https://www.wikidata.org/wiki/Q3454686","display_name":"Reduction (mathematics)","level":2,"score":0.3084000051021576},{"id":"https://openalex.org/C176217482","wikidata":"https://www.wikidata.org/wiki/Q860554","display_name":"Metric (unit)","level":2,"score":0.29809999465942383},{"id":"https://openalex.org/C142757262","wikidata":"https://www.wikidata.org/wiki/Q76436","display_name":"Doppler effect","level":2,"score":0.2655999958515167},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.2556999921798706},{"id":"https://openalex.org/C160920958","wikidata":"https://www.wikidata.org/wiki/Q7662746","display_name":"Synthetic data","level":2,"score":0.2540000081062317},{"id":"https://openalex.org/C2776459999","wikidata":"https://www.wikidata.org/wiki/Q2119376","display_name":"Fidelity","level":2,"score":0.2506999969482422}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/access.2025.3634757","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2025.3634757","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1109/access.2025.3634757","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2025.3634757","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W2133304247","https://openalex.org/W4205204006","https://openalex.org/W4290802352","https://openalex.org/W4293217929","https://openalex.org/W4311415873","https://openalex.org/W4312933868","https://openalex.org/W4385663127","https://openalex.org/W4399621028","https://openalex.org/W4400859776","https://openalex.org/W4404438297","https://openalex.org/W4409049629","https://openalex.org/W4409260735"],"related_works":[],"abstract_inverted_index":{"Early":[0],"detection":[1],"of":[2,13,153,203],"chemotherapy-induced":[3],"cardiotoxicity":[4,48],"remains":[5],"a":[6,29,62,75,96,104,145,223],"critical":[7],"challenge,":[8],"hindered":[9],"by":[10],"the":[11,73,89,92,151,166,201,204],"scarcity":[12],"large":[14],"and":[15,23,112,125,134,155,161,175,183,197],"balanced":[16],"datasets":[17],"combining":[18,214],"Tissue":[19],"Doppler":[20,172],"Imaging":[21],"(TDI)":[22],"clinical":[24,41,83,177],"information.":[25],"This":[26,211],"study":[27],"introduces":[28],"conditional":[30],"Diffusion-VAE":[31,94],"hybrid":[32,212],"that":[33,165],"generates":[34],"high-fidelity":[35],"synthetic":[36,190],"TDI":[37,59],"images":[38],"conditioned":[39],"on":[40,189],"vectors,":[42],"enabling":[43],"robust":[44],"data":[45,191,209],"augmentation":[46,226],"for":[47,207],"prediction.":[49],"A":[50],"skip-connected":[51],"Convolutional":[52],"VAE":[53],"(ConvVAE)":[54],"first":[55],"encodes":[56],"each":[57],"2D":[58],"scan":[60],"into":[61],"structured":[63,216],"256":[64],"\u00d7":[65,67],"10":[66],"24":[68],"latent":[69],"tensor.":[70],"After":[71],"freezing":[72],"encoder,":[74],"cross-attention\u2013conditioned":[76],"U-Net":[77],"iteratively":[78],"denoises":[79],"these":[80],"latents":[81],"under":[82],"guidance":[84],"(27":[85],"features).":[86],"Compared":[87],"to":[88,102,110,117,122,128,169,228],"ConvVAE":[90],"alone,":[91],"proposed":[93,205],"achieves":[95],"55%":[97],"reduction":[98],"in":[99,107,114,232],"MSE":[100],"(0.0022":[101],"0.0010),":[103],"20%":[105],"improvement":[106],"FID":[108],"(10.2":[109],"8.7),":[111],"gains":[113],"SSIM":[115],"(0.96":[116],"0.98),":[118],"PSNR":[119],"(32.0":[120],"dB":[121],"34.5":[123],"dB),":[124],"LPIPS":[126],"(0.083":[127],"0.058),":[129],"validating":[130],"its":[131],"superior":[132],"fidelity":[133],"diversity.":[135],"Bootstrap":[136],"confidence":[137],"intervals":[138],"(1,000":[139],"resamples)":[140],"confirmed":[141],"statistical":[142],"robustness,":[143],"while":[144],"permutation":[146],"test":[147],"(10,000":[148],"shuffles)":[149],"demonstrated":[150],"significance":[152],"AUC":[154],"PR-AUC":[156],"improvements":[157],"(p<":[158],"0.01).":[159],"Grad-CAM":[160],"SHAP":[162],"visualizations":[163],"highlight":[164],"model":[167,206],"attends":[168],"physiologically":[170],"meaningful":[171],"envelope":[173],"regions":[174],"influential":[176],"variables":[178],"such":[179],"as":[180],"heart":[181],"rate":[182],"ejection":[184],"fraction.":[185],"Classifiers":[186],"retrained":[187],"solely":[188],"achieved":[192],"97.9%":[193],"accuracy,":[194],"0.991":[195],"ROC-AUC,":[196],"0.982":[198],"PR-AUC,":[199],"underscoring":[200],"utility":[202],"overcoming":[208],"scarcity.":[210],"architecture,":[213],"VAE\u2019s":[215],"representation":[217],"with":[218],"diffusion\u2019s":[219],"refinement":[220],"capabilities,":[221],"offers":[222],"scalable":[224],"multimodal":[225],"engine":[227],"advance":[229],"reliable":[230],"AI":[231],"cardiovascular":[233],"oncology.":[234]},"counts_by_year":[],"updated_date":"2026-07-29T09:40:50.615796","created_date":"2025-11-19T00:00:00"}
