{"id":"https://openalex.org/W4413371347","doi":"https://doi.org/10.1109/access.2025.3600672","title":"Size-Controllable Tumor Synthesis for Improved Detection of Small Bowel Carcinoid Tumors in CT Scans","display_name":"Size-Controllable Tumor Synthesis for Improved Detection of Small Bowel Carcinoid Tumors in CT Scans","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4413371347","doi":"https://doi.org/10.1109/access.2025.3600672"},"language":"en","primary_location":{"id":"doi:10.1109/access.2025.3600672","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2025.3600672","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1109/access.2025.3600672","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052721627","display_name":"Seung Yeon Shin","orcid":"https://orcid.org/0000-0002-5959-5761"},"institutions":[{"id":"https://openalex.org/I4575257","display_name":"Hanyang University","ror":"https://ror.org/046865y68","country_code":"KR","type":"education","lineage":["https://openalex.org/I4575257"]},{"id":"https://openalex.org/I93906172","display_name":"Anyang University","ror":"https://ror.org/018pdh902","country_code":"KR","type":"education","lineage":["https://openalex.org/I93906172"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Seung Yeon Shin","raw_affiliation_strings":["Division of Electrical Engineering, Hanyang University ERICA, Ansan, Gyeonggi-do, South Korea"],"affiliations":[{"raw_affiliation_string":"Division of Electrical Engineering, Hanyang University ERICA, Ansan, Gyeonggi-do, South Korea","institution_ids":["https://openalex.org/I4575257","https://openalex.org/I93906172"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020411590","display_name":"Stephen A. Wank","orcid":"https://orcid.org/0000-0002-9608-547X"},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen A. Wank","raw_affiliation_strings":["National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA","Digestive Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA"],"affiliations":[{"raw_affiliation_string":"National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210090567","https://openalex.org/I1299303238"]},{"raw_affiliation_string":"Digestive Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210090567","https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016047550","display_name":"Ronald M. Summers","orcid":"https://orcid.org/0000-0001-8081-7376"},"institutions":[{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald M. Summers","raw_affiliation_strings":["Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD, USA","Clinical Center, Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD, USA"],"affiliations":[{"raw_affiliation_string":"Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210155647"]},{"raw_affiliation_string":"Clinical Center, Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210155647"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5052721627"],"corresponding_institution_ids":["https://openalex.org/I4575257","https://openalex.org/I93906172"],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.29771669,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":null,"first_page":"151304","last_page":"151315"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carcinoid-tumors","display_name":"Carcinoid tumors","score":0.46527713537216187},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3657466769218445},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.36371883749961853},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.28866487741470337}],"concepts":[{"id":"https://openalex.org/C2778506435","wikidata":"https://www.wikidata.org/wiki/Q1734755","display_name":"Carcinoid tumors","level":2,"score":0.46527713537216187},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3657466769218445},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.36371883749961853},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28866487741470337}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/access.2025.3600672","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2025.3600672","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:8ea91d7eba01449688c349f0e217e5cc","is_oa":true,"landing_page_url":"https://doaj.org/article/8ea91d7eba01449688c349f0e217e5cc","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Access, Vol 13, Pp 151304-151315 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1109/access.2025.3600672","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2025.3600672","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337376","display_name":"NIH Clinical Center","ror":"https://ror.org/04vfsmv21"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1885242154","https://openalex.org/W1968783088","https://openalex.org/W2171541090","https://openalex.org/W2464708700","https://openalex.org/W2734349601","https://openalex.org/W2799738340","https://openalex.org/W2962793481","https://openalex.org/W2963073614","https://openalex.org/W2963516811","https://openalex.org/W2963890275","https://openalex.org/W2987706526","https://openalex.org/W2997408160","https://openalex.org/W3006982737","https://openalex.org/W3036339814","https://openalex.org/W3092411102","https://openalex.org/W3110137169","https://openalex.org/W3138558221","https://openalex.org/W3176659256","https://openalex.org/W3201682283","https://openalex.org/W3202823735","https://openalex.org/W3204827071","https://openalex.org/W4225011240","https://openalex.org/W4288058127","https://openalex.org/W4295940359","https://openalex.org/W4296959872","https://openalex.org/W4311993032","https://openalex.org/W4361284863","https://openalex.org/W4362663914","https://openalex.org/W4383112434","https://openalex.org/W4383218413","https://openalex.org/W4386076613","https://openalex.org/W4387327236"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052"],"abstract_inverted_index":{"Carcinoid":[0],"tumors":[1,128,156,176,194],"in":[2],"the":[3,35,83,90,98,101,117,190],"small":[4,40,197],"bowel":[5,198],"are":[6,110],"rare,":[7],"making":[8],"it":[9],"challenging":[10],"to":[11,62,96,115,139],"collect":[12],"a":[13,50,74,79,121,140,145,185],"sufficiently":[14],"large":[15,42],"dataset":[16],"of":[17,89,100,192],"lesions":[18],"with":[19,129],"diverse":[20],"sizes":[21,61],"for":[22,120,188],"training":[23,84,118,180],"detection":[24,36,64,123,171,191],"models":[25],"using":[26,162],"computed":[27],"tomography":[28],"(CT)":[29],"scans.":[30],"This":[31,182],"scarcity":[32],"particularly":[33],"affects":[34],"performance":[37,172],"on":[38],"relatively":[39],"or":[41],"tumors.":[43,103,200],"To":[44],"address":[45],"this":[46],"limitation,":[47],"we":[48],"propose":[49],"novel":[51],"image":[52],"synthesis":[53,142],"method":[54,67,126,183],"that":[55,170],"can":[56],"selectively":[57],"augment":[58],"underrepresented":[59],"tumor":[60,70,75,122],"enhance":[63],"performance.":[65],"Our":[66,125],"enables":[68],"size-controllable":[69],"generation":[71],"by":[72],"integrating":[73],"segmentation":[76],"model":[77],"and":[78],"size-aware":[80],"loss":[81],"into":[82,112],"process.":[85],"Specifically,":[86],"one":[87],"dimension":[88],"input":[91],"noise":[92],"vector":[93],"is":[94],"designated":[95],"control":[97],"size":[99,131],"synthesized":[102],"These":[104],"tumors,":[105],"generated":[106],"at":[107],"desired":[108],"sizes,":[109],"implanted":[111],"CT":[113],"scans":[114],"enrich":[116],"data":[119],"network.":[124],"produces":[127],"clearer":[130],"distinctions,":[132],"while":[133],"maintaining":[134],"comparable":[135],"visual":[136,146],"realism":[137],"compared":[138],"baseline":[141],"method.":[143],"In":[144],"Turing":[147],"test,":[148],"human":[149],"observers":[150],"could":[151],"not":[152],"reliably":[153],"distinguish":[154],"synthetic":[155,175],"from":[157],"real":[158],"ones.":[159],"Lesion-level":[160],"evaluation":[161],"free-response":[163],"receiver":[164],"operating":[165],"characteristic":[166],"(FROC)":[167],"curves":[168],"demonstrated":[169],"improved":[173],"when":[174],"were":[177],"included":[178],"during":[179],"(P=0.04).":[181],"offers":[184],"promising":[186],"direction":[187],"improving":[189],"rare":[193],"such":[195],"as":[196],"carcinoid":[199]},"counts_by_year":[],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}
