{"id":"https://openalex.org/W4413155405","doi":"https://doi.org/10.1109/access.2025.3598130","title":"Patient-Specific Digital Twins for Personalized Healthcare: A Hybrid AI and Simulation-Based Framework","display_name":"Patient-Specific Digital Twins for Personalized Healthcare: A Hybrid AI and Simulation-Based Framework","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4413155405","doi":"https://doi.org/10.1109/access.2025.3598130"},"language":"en","primary_location":{"id":"doi:10.1109/access.2025.3598130","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2025.3598130","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1109/access.2025.3598130","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102381120","display_name":"Harshit Sharma","orcid":"https://orcid.org/0009-0008-3767-9519"},"institutions":[{"id":"https://openalex.org/I83205935","display_name":"Malaviya National Institute of Technology Jaipur","ror":"https://ror.org/0077k1j32","country_code":"IN","type":"education","lineage":["https://openalex.org/I83205935"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Harshit Sharma","raw_affiliation_strings":["Department of CSE, MNIT Jaipur, Jaipur, Rajasthan, India","Department of CSE, MNIT Jaipur, Rajasthan, India"],"raw_orcid":"https://orcid.org/0009-0008-3767-9519","affiliations":[{"raw_affiliation_string":"Department of CSE, MNIT Jaipur, Jaipur, Rajasthan, India","institution_ids":["https://openalex.org/I83205935"]},{"raw_affiliation_string":"Department of CSE, MNIT Jaipur, Rajasthan, India","institution_ids":["https://openalex.org/I83205935"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101517899","display_name":"Simran Kaur","orcid":"https://orcid.org/0000-0003-1311-8393"},"institutions":[{"id":"https://openalex.org/I99552915","display_name":"University of Rajasthan","ror":"https://ror.org/05arfhc56","country_code":"IN","type":"education","lineage":["https://openalex.org/I99552915"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Simran Kaur","raw_affiliation_strings":["Department of AIML, Manipal University Jaipur, Jaipur, Rajasthan, India","Department of AIML, Manipal University Jaipur, Rajasthan, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of AIML, Manipal University Jaipur, Jaipur, Rajasthan, India","institution_ids":["https://openalex.org/I99552915"]},{"raw_affiliation_string":"Department of AIML, Manipal University Jaipur, Rajasthan, India","institution_ids":["https://openalex.org/I99552915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":8.3308,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.97951583,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"13","issue":null,"first_page":"143277","last_page":"143290"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10763","display_name":"Digital Transformation in Industry","score":0.921500027179718,"subfield":{"id":"https://openalex.org/subfields/2209","display_name":"Industrial and Manufacturing Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10763","display_name":"Digital Transformation in Industry","score":0.921500027179718,"subfield":{"id":"https://openalex.org/subfields/2209","display_name":"Industrial and Manufacturing Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7332332730293274},{"id":"https://openalex.org/keywords/health-care","display_name":"Health care","score":0.5575020909309387},{"id":"https://openalex.org/keywords/human\u2013computer-interaction","display_name":"Human\u2013computer interaction","score":0.3383384346961975}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7332332730293274},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.5575020909309387},{"id":"https://openalex.org/C107457646","wikidata":"https://www.wikidata.org/wiki/Q207434","display_name":"Human\u2013computer interaction","level":1,"score":0.3383384346961975},{"id":"https://openalex.org/C50522688","wikidata":"https://www.wikidata.org/wiki/Q189833","display_name":"Economic growth","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/access.2025.3598130","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2025.3598130","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:27bd56082069401fb53abd9e484952fa","is_oa":true,"landing_page_url":"https://doaj.org/article/27bd56082069401fb53abd9e484952fa","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Access, Vol 13, Pp 143277-143290 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1109/access.2025.3598130","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2025.3598130","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322932","display_name":"Manipal University","ror":"https://ror.org/02xzytt36"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W2092779110","https://openalex.org/W2580626871","https://openalex.org/W2775365775","https://openalex.org/W2786689981","https://openalex.org/W2890904471","https://openalex.org/W2896729774","https://openalex.org/W2904708582","https://openalex.org/W2963470017","https://openalex.org/W2982936646","https://openalex.org/W3024598020","https://openalex.org/W3034426226","https://openalex.org/W3046653923","https://openalex.org/W3051272477","https://openalex.org/W3089904848","https://openalex.org/W3109639294","https://openalex.org/W3119680904","https://openalex.org/W3136239519","https://openalex.org/W3172260675","https://openalex.org/W3184569878","https://openalex.org/W3198232464","https://openalex.org/W3211778934","https://openalex.org/W4206914990","https://openalex.org/W4225272053","https://openalex.org/W4225966689","https://openalex.org/W4226461837","https://openalex.org/W4280608208","https://openalex.org/W4281750882","https://openalex.org/W4285066477","https://openalex.org/W4285264622","https://openalex.org/W4290706000","https://openalex.org/W4295747815","https://openalex.org/W4307428701","https://openalex.org/W4315432955","https://openalex.org/W4319159963","https://openalex.org/W4321599611","https://openalex.org/W4353063229","https://openalex.org/W4367840585","https://openalex.org/W4383059036","https://openalex.org/W4385759220","https://openalex.org/W4385895844","https://openalex.org/W4386495603","https://openalex.org/W4387015497","https://openalex.org/W4387317503","https://openalex.org/W4387880578","https://openalex.org/W4390533386","https://openalex.org/W4390610387","https://openalex.org/W4391237786","https://openalex.org/W4392154734","https://openalex.org/W4392559344","https://openalex.org/W4394762712","https://openalex.org/W4396852756","https://openalex.org/W4396877927","https://openalex.org/W4400071977","https://openalex.org/W4400486362","https://openalex.org/W4402024459","https://openalex.org/W4402317866","https://openalex.org/W4402747741","https://openalex.org/W4403128237","https://openalex.org/W4403864038","https://openalex.org/W4404469630","https://openalex.org/W4404521175","https://openalex.org/W4404666966","https://openalex.org/W4404752057","https://openalex.org/W4404788223","https://openalex.org/W4404874089","https://openalex.org/W4406265097","https://openalex.org/W4407135254","https://openalex.org/W4407235601","https://openalex.org/W4408510359","https://openalex.org/W4408928985","https://openalex.org/W4409406482","https://openalex.org/W4409814480","https://openalex.org/W4412164389","https://openalex.org/W6861604865","https://openalex.org/W6875346998","https://openalex.org/W6966855096","https://openalex.org/W7017510208"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052"],"abstract_inverted_index":{"Digital":[0],"twins":[1],"(DTs)":[2],"represent":[3],"a":[4,27,48,100,160],"transformative":[5],"paradigm":[6],"in":[7],"personalized":[8],"medicine,":[9],"enabling":[10,109],"real-time,":[11],"patient-specific":[12,41],"simulations":[13],"that":[14,31,59,129],"support":[15],"precision":[16,169],"diagnosis,":[17],"continuous":[18,97],"monitoring,":[19],"and":[20,74,91,105,116,126,138,163],"adaptive":[21],"treatment":[22],"planning.":[23],"This":[24],"paper":[25],"presents":[26],"novel":[28],"hybrid":[29,131],"framework":[30,95,158],"integrates":[32],"mechanistic":[33],"physiological":[34,103,149],"modeling":[35,53],"with":[36,151],"deep":[37],"learning":[38,80,137],"to":[39],"construct":[40],"digital":[42,107,156],"twins.":[43],"The":[44,94],"proposed":[45,155],"architecture":[46],"couples":[47],"dynamic":[49],"simulation":[50],"engine\u2014capable":[51],"of":[52],"organ-system":[54],"interactions\u2014with":[55],"neural":[56],"encoder-decoder":[57],"networks":[58],"extract":[60],"latent":[61],"representations":[62],"from":[63],"heterogeneous":[64],"clinical":[65,144],"data":[66],"sources,":[67],"including":[68],"biosignals":[69],"(e.g.,":[70],"ECG),":[71],"medical":[72],"imaging,":[73],"wearable":[75],"sensor":[76],"streams.":[77],"A":[78],"probabilistic":[79],"module":[81],"further":[82],"enables":[83],"predictive":[84],"adaptation":[85],"under":[86],"uncertainty,":[87],"leveraging":[88],"Bayesian":[89],"inference":[90],"reinforcement":[92],"learning.":[93],"supports":[96],"synchronization":[98],"between":[99],"patient\u2019s":[101],"real-world":[102],"state":[104],"its":[106],"counterpart,":[108],"individualized":[110],"risk":[111],"assessment,":[112],"disease":[113],"trajectory":[114],"forecasting,":[115],"therapy":[117],"simulation.":[118],"Extensive":[119],"experiments":[120],"on":[121],"large-scale":[122],"benchmark":[123],"datasets":[124],"(MIMIC-IV":[125],"PhysioNet)":[127],"demonstrate":[128],"our":[130],"approach":[132],"significantly":[133],"outperforms":[134],"conventional":[135],"machine":[136],"standalone":[139],"AI":[140],"models":[141],"across":[142],"multiple":[143],"prediction":[145],"tasks.":[146],"By":[147],"fusing":[148],"realism":[150],"data-driven":[152],"intelligence,":[153],"the":[154],"twin":[157],"offers":[159],"scalable,":[161],"interpretable,":[162],"clinically":[164],"actionable":[165],"foundation":[166],"for":[167],"next-generation":[168],"healthcare":[170],"systems.":[171]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":4}],"updated_date":"2026-07-25T15:57:00.446498","created_date":"2025-10-10T00:00:00"}
