{"id":"https://openalex.org/W4410294618","doi":"https://doi.org/10.1109/access.2025.3569186","title":"Development of a Multi-Channel Wireless Deep Brain Stimulation and Signal Acquisition System for Neurostimulation and Biomarker Monitoring","display_name":"Development of a Multi-Channel Wireless Deep Brain Stimulation and Signal Acquisition System for Neurostimulation and Biomarker Monitoring","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4410294618","doi":"https://doi.org/10.1109/access.2025.3569186"},"language":"en","primary_location":{"id":"doi:10.1109/access.2025.3569186","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2025.3569186","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1109/access.2025.3569186","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040279794","display_name":"Chang-Lin Hu","orcid":"https://orcid.org/0000-0002-3635-1182"},"institutions":[{"id":"https://openalex.org/I4210148468","display_name":"Industrial Technology Research Institute","ror":"https://ror.org/05szzwt63","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210148468"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chang-Lin Hu","raw_affiliation_strings":["Industrial Technology Research Institute, Hsinchu, Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-3635-1182","affiliations":[{"raw_affiliation_string":"Industrial Technology Research Institute, Hsinchu, Taiwan","institution_ids":["https://openalex.org/I4210148468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045403803","display_name":"Guan-Yi Lu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210148468","display_name":"Industrial Technology Research Institute","ror":"https://ror.org/05szzwt63","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210148468"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Guan-Yi Lu","raw_affiliation_strings":["Industrial Technology Research Institute, Hsinchu, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Industrial Technology Research Institute, Hsinchu, Taiwan","institution_ids":["https://openalex.org/I4210148468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103644674","display_name":"Po Soon Kang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210148468","display_name":"Industrial Technology Research Institute","ror":"https://ror.org/05szzwt63","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210148468"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Pei-Ling Kang","raw_affiliation_strings":["Industrial Technology Research Institute, Hsinchu, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Industrial Technology Research Institute, Hsinchu, Taiwan","institution_ids":["https://openalex.org/I4210148468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018529828","display_name":"Chien-Ju Li","orcid":null},"institutions":[{"id":"https://openalex.org/I4210148468","display_name":"Industrial Technology Research Institute","ror":"https://ror.org/05szzwt63","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210148468"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chien-Ju Li","raw_affiliation_strings":["Industrial Technology Research Institute, Hsinchu, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Industrial Technology Research Institute, Hsinchu, Taiwan","institution_ids":["https://openalex.org/I4210148468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076425424","display_name":"Meimei Lin","orcid":null},"institutions":[{"id":"https://openalex.org/I4210148468","display_name":"Industrial Technology Research Institute","ror":"https://ror.org/05szzwt63","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210148468"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ming-Jhe Lin","raw_affiliation_strings":["Industrial Technology Research Institute, Hsinchu, Taiwan"],"raw_orcid":"https://orcid.org/0009-0008-1225-7635","affiliations":[{"raw_affiliation_string":"Industrial Technology Research Institute, Hsinchu, Taiwan","institution_ids":["https://openalex.org/I4210148468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071374084","display_name":"Guan-Lun Li","orcid":null},"institutions":[{"id":"https://openalex.org/I4210148468","display_name":"Industrial Technology Research Institute","ror":"https://ror.org/05szzwt63","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210148468"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Guan-Lun Li","raw_affiliation_strings":["Industrial Technology Research Institute, Hsinchu, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Industrial Technology Research Institute, Hsinchu, Taiwan","institution_ids":["https://openalex.org/I4210148468"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112391703","display_name":"Fang-Yi Su","orcid":null},"institutions":[{"id":"https://openalex.org/I4210148468","display_name":"Industrial Technology Research Institute","ror":"https://ror.org/05szzwt63","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210148468"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Fang-Yi Su","raw_affiliation_strings":["Industrial Technology Research Institute, Hsinchu, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Industrial Technology Research Institute, Hsinchu, Taiwan","institution_ids":["https://openalex.org/I4210148468"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210148468"],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08219334,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":null,"first_page":"87241","last_page":"87253"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11932","display_name":"Wireless Body Area Networks","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11932","display_name":"Wireless Body Area Networks","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9034000039100647,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurostimulation","display_name":"Neurostimulation","score":0.842232346534729},{"id":"https://openalex.org/keywords/deep-brain-stimulation","display_name":"Deep brain stimulation","score":0.5583460330963135},{"id":"https://openalex.org/keywords/wireless","display_name":"Wireless","score":0.5470222234725952},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5391841530799866},{"id":"https://openalex.org/keywords/signal","display_name":"SIGNAL (programming language)","score":0.5030567049980164},{"id":"https://openalex.org/keywords/wireless-sensor-network","display_name":"Wireless sensor network","score":0.469809353351593},{"id":"https://openalex.org/keywords/channel","display_name":"Channel (broadcasting)","score":0.43171894550323486},{"id":"https://openalex.org/keywords/stimulation","display_name":"Stimulation","score":0.3969038426876068},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.3629215955734253},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2740930914878845},{"id":"https://openalex.org/keywords/telecommunications","display_name":"Telecommunications","score":0.17926296591758728},{"id":"https://openalex.org/keywords/computer-network","display_name":"Computer network","score":0.16454583406448364},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.1291312277317047},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.12874510884284973}],"concepts":[{"id":"https://openalex.org/C2776443511","wikidata":"https://www.wikidata.org/wiki/Q1724687","display_name":"Neurostimulation","level":3,"score":0.842232346534729},{"id":"https://openalex.org/C2778542668","wikidata":"https://www.wikidata.org/wiki/Q618076","display_name":"Deep brain stimulation","level":4,"score":0.5583460330963135},{"id":"https://openalex.org/C555944384","wikidata":"https://www.wikidata.org/wiki/Q249","display_name":"Wireless","level":2,"score":0.5470222234725952},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5391841530799866},{"id":"https://openalex.org/C2779843651","wikidata":"https://www.wikidata.org/wiki/Q7390335","display_name":"SIGNAL (programming language)","level":2,"score":0.5030567049980164},{"id":"https://openalex.org/C24590314","wikidata":"https://www.wikidata.org/wiki/Q336038","display_name":"Wireless sensor network","level":2,"score":0.469809353351593},{"id":"https://openalex.org/C127162648","wikidata":"https://www.wikidata.org/wiki/Q16858953","display_name":"Channel (broadcasting)","level":2,"score":0.43171894550323486},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.3969038426876068},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3629215955734253},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2740930914878845},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.17926296591758728},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.16454583406448364},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1291312277317047},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.12874510884284973},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/access.2025.3569186","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2025.3569186","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:b313d25085994f038064e26cb9bf68a9","is_oa":true,"landing_page_url":"https://doaj.org/article/b313d25085994f038064e26cb9bf68a9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Access, Vol 13, Pp 87241-87253 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1109/access.2025.3569186","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2025.3569186","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322214","display_name":"Industrial Technology Research Institute","ror":"https://ror.org/05szzwt63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1631356348","https://openalex.org/W1829183563","https://openalex.org/W1967428268","https://openalex.org/W1967619230","https://openalex.org/W1972879677","https://openalex.org/W2002785976","https://openalex.org/W2038591487","https://openalex.org/W2041782669","https://openalex.org/W2055523610","https://openalex.org/W2055557007","https://openalex.org/W2097072002","https://openalex.org/W2515990420","https://openalex.org/W2588429935","https://openalex.org/W2622294281","https://openalex.org/W2722020113","https://openalex.org/W2744294942","https://openalex.org/W2761386162","https://openalex.org/W2764335780","https://openalex.org/W2769152833","https://openalex.org/W2769207344","https://openalex.org/W2895214289","https://openalex.org/W2913766627","https://openalex.org/W2950693530","https://openalex.org/W2993286681","https://openalex.org/W3107060429","https://openalex.org/W3109080428","https://openalex.org/W3118897545","https://openalex.org/W3128863783","https://openalex.org/W3201459899","https://openalex.org/W4211044101","https://openalex.org/W4211123396","https://openalex.org/W4239102366","https://openalex.org/W4321494451","https://openalex.org/W4388772194","https://openalex.org/W4392018844","https://openalex.org/W4394819461","https://openalex.org/W4400230898","https://openalex.org/W4401783082","https://openalex.org/W4402389438","https://openalex.org/W4405709889","https://openalex.org/W4407097655","https://openalex.org/W4408812300","https://openalex.org/W4409882854"],"related_works":["https://openalex.org/W4214563745","https://openalex.org/W4256510171","https://openalex.org/W2791717398","https://openalex.org/W622158969","https://openalex.org/W2944375777","https://openalex.org/W2137484429","https://openalex.org/W2117151692","https://openalex.org/W2013769480","https://openalex.org/W2093044760","https://openalex.org/W2431651879"],"abstract_inverted_index":{"This":[0,148],"study":[1,149],"presents":[2],"the":[3,58,75,146,151],"design,":[4],"development,":[5],"and":[6,15,22,38,66,83,117,138,161],"validation":[7,140],"of":[8,60,106,126,153],"a":[9,42,111,163],"multi-channel":[10,39],"wireless":[11,154],"deep":[12],"brain":[13],"stimulation":[14],"signal":[16],"acquisition":[17],"system":[18,29],"designed":[19],"for":[20,45,157,165],"neurostimulation":[21,170],"biomarker":[23],"monitoring":[24],"in":[25,69,113,120,145],"preclinical":[26],"models.":[27],"The":[28,49],"integrates":[30],"real-time":[31],"Bluetooth-based":[32],"data":[33],"transmission,":[34],"adaptive":[35,155],"closed-loop":[36],"control,":[37],"recording,":[40],"providing":[41],"versatile":[43],"platform":[44],"studying":[46],"neuromodulation":[47],"therapies.":[48,171],"MitoPark":[50],"transgenic":[51],"mouse":[52],"model":[53],"was":[54],"used":[55],"to":[56],"evaluate":[57],"effects":[59],"subthalamic":[61],"nucleus":[62],"(STN)-DBS":[63],"on":[64,168],"motor":[65,96,159],"cognitive":[67,133],"functions":[68],"Parkinson\u2019s":[70],"disease.":[71],"Behavioral":[72],"assessments,":[73],"including":[74],"Narrow":[76],"Beam":[77],"Walking":[78],"Test,":[79,87],"Open":[80],"Field":[81],"Task,":[82],"Novel":[84],"Object":[85],"Recognition":[86],"were":[88,135],"conducted.":[89],"Results":[90],"demonstrated":[91,110],"that":[92],"STN-DBS":[93],"significantly":[94],"improved":[95],"coordination,":[97],"as":[98],"evidenced":[99],"by":[100],"enhanced":[101],"beam-walking":[102],"performance.":[103],"Spectral":[104],"analysis":[105],"local":[107],"field":[108],"potentials":[109],"reduction":[112],"pathological":[114],"beta-band":[115],"activity":[116],"an":[118],"increase":[119],"gamma-band":[121],"power":[122],"post-DBS,":[123],"suggesting":[124],"restoration":[125],"neural":[127],"network":[128],"dynamics.":[129],"However,":[130],"no":[131],"significant":[132],"improvements":[134],"observed.":[136],"Histological":[137],"MRI":[139],"confirmed":[141],"accurate":[142],"electrode":[143],"placement":[144],"STN.":[147],"highlights":[150],"potential":[152],"DBS":[156],"improving":[158],"symptoms":[160],"provides":[162],"foundation":[164],"future":[166],"research":[167],"personalized":[169]},"counts_by_year":[],"updated_date":"2026-06-26T08:34:08.712188","created_date":"2025-10-10T00:00:00"}
